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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 305 Documents
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Ischemic Stroke Induced by Bee Sting in Agricultural Society – A Rare Complication of Bee Sting: A Case Report Navadz, Eqiel; Aprilianto Handoko, Eko; Taufiq, Kamilka; Gemawan, Taufiq; Hakiim, Arsyzilma; Handoko, Adelia; Fortuna Sari, Putri
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53705

Abstract

Abstract Introduction: Ischemic stroke is one of the highest causes of morbidity and mortality. One of the factors that triggers ischemic stroke which is quite rare is a bee sting. Pathomechanism of this condition remain unclear. This case report will describe a rare complication of bee sting and discuss it from a pathomechanism perspective. Case Report: A 40-year old woman came to the emergency room at Dr. Koesnadi Bondowoso with the main complaint of weakness in the right face. Referral patients from community health centers. The patient's complaint occurred 7,5 hours ago after being stung by a bee on the middle finger of his left hand. Physical examination showed facial angioedema, edema of digiti manus III sinsitra, and others normal. On neurological examination, it was found: Parasis Nervus XII and VII sinistra UMN type and hemiparasis sinistra. Laboratory examination showed increased neutrophils (90.4%) and eosinophilia (0.1%). A non-contrast CT scan examination showed a hypodense lesion in the right hemisphere. The patient was given antiplatelet, antihistamin, and neuroprotectan. Discussion: One of the rare complications of bee stings is ishemic stroke. This occurs due to the toxin from bee stings which contain vasoactive, pro-inflammatory agents, thrombogenic peptides, thromboxane A2, and leukotrienes which trigger platelet aggregation and vasoconstriction. This condition can trigger trombus formation and lead to ischemic stroke. Medical personnel, especially neurologists, must be aware of pathomechanism from the quite rare complications of ischemic stroke induced by bee stings, especially in rural areas Keywords: Ischemic Stroke, Bee sting, rural area.
An An Analysis Of The Incidence Of Sensorinural Hearing Loss Based On Type 2 Diabetes Mellitus And Obesity Factor: An Analysis Of The Incidence Of Sensorinural Hearing Loss Based On Type 2 Diabetes Mellitus And Obesity Factor Dilla, Natasya Salsa; Wirayudha, Yan; Kurniati, Yuni Prastyo; Soekiswati, Siti
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53711

Abstract

Indonesia ranks fourth in Southeast Asia with a 2.3% prevalence of sensorineural hearing loss, a condition that may result from various risk factors including diabetes mellitus (DM) and obesity. DM can impair cochlear vascularization, while obesity significantly affects vascular function, potentially impacting the auditory system. This study aims to analyze the relationship between type 2 DM and obesity with sensorineural hearing loss. An observational analytic study with a cross-sectional approach was conducted on 64 participants aged 18–60 years, selected via purposive sampling. Type 2 DM was diagnosed by internal medicine consultants, and obesity was assessed using waist-to-hip ratio measurements. Data analysis employed Fisher's exact test and logistic regression. The study was ethically approved by the Health Ethics Committee of RS PKU Muhammadiyah Surakarta (No. 05/KEPK/RS.PKU/X/2024). Results showed a significant correlation between type 2 DM and sensorineural hearing loss (p=0.037) and between obesity and sensorineural hearing loss (p=0.001). The odds ratio for type 2 DM was 12.031, while for obesity it was 58.059, indicating that obesity poses a substantially higher risk. In conclusion, type 2 DM and obesity are significantly associated with the occurrence of sensorineural hearing loss, suggesting that addressing these risk factors may help reduce its prevalence. Keywords: Diabetes Melitus Tipe 2, Obesitas, Gangguan Pendengaran Sensorineural, Faktor Risiko.
The Phytochemical Identification And Antibacterial Activity Test Of Leucas Lavandulifolia Against Escherichia Coli Nidya Meilani; Dianasari, Dewi; Indah Yulia Ningsih
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53717

Abstract

Diarrhea is defined as a condition where the stool changes or becomes softer or more liquid with a frequency of 3 or 4 times a day. Based on its etiology, diarrhea is caused by several microorganisms, one of which is bacteria. The bacteria that causes diarrhea most often found in Indonesia is Escherichia coli. One type of plant that has the potential as an antibacterial is the Leucas lavandulifolia or Lenglengan plant. Based on ethnopharmaceutical studies, lenglengan leaves are commonly used to treat insomnia, pinworms, coughs with phlegm, epilepsy and digestive disorders. This research was carried out using lenglengan leaf ethanol extract with concentrations of 2.5%, 5%, 10%, 20% and 40%. In this study, phytochemical screening was also carried out using the TLC method. Antibacterial testing was carried out using the well diffusion method. The results obtained were the formation of a clear zone around the well, which indicated activity inhibiting bacterial growth. The results of testing antibacterial activity against E.coli showed that the ethanol extract of langlengan leaves at concentrations of 2.5%, 5%, 10%, 20% and 40% had antibacterial activity with clear zone results of 1.04 ± 0.33 , 12.71 ± 0.34, 13.90 ± 0.60, 15.23 ± 0.36, and 19.32 ± 0.79 mm.  The results of the phytochemical screening showed that ethanol extract of lenglengan leaves contained alkaloids, saponins, flavonoids, terpenoids/steroids and polyphenols. It can be concluded, the ethanol extract of lenglengan leaves has antibacterial activity against E.coli where the greater  sample concentration, the greater  activity.
Evaluating the Effect of Outpatient Registration Systems on Patient Recommendations Using Value Stream Mapping and Path Analysis Malik Qilsi, Fatkhur Ruli; Bukhori, Saiful; Firman, Firman
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53729

Abstract

Digital transformation in healthcare requires hospitals to adopt efficient and integrated information systems. This research aims to analyze the influence of outpatient registration information system types—conventional, Hospital Management Information System (HMIS), and Mobile JKN—on recommendations to others using Value Stream Mapping (VSM) and path analysis with SmartPLS. The study was conducted at Citra Husada Hospital Jember with 98 respondents selected through convenience sampling. The VSM results indicate that Mobile JKN has the shortest total service time (1 hour 32 minutes) and the highest efficiency value (8.6%). Statistical analysis shows that interaction with medical personnel, ease of access, ease of use, and data security significantly influence patient satisfaction. Medical information satisfaction and overall service quality are proven to be the main factors driving patient recommendations. Consequently, Mobile JKN is the most efficient registration system alternative and has the potential to improve hospital service quality. Optimization of system integration and user education is recommended to support digital-based healthcare service transformation.
An Extension Form of Chiari 1 malformation: A Case Report Wiryaning Putri, Komang Yunita; Novan Krisno Adji; Ulfa Elfiah; Muhammad Yuda Nugraha
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53709

Abstract

The updated classification of Chiari malformation includes Chiari 1.5 malformation, which explicitly denotes the tonsillar herniation characteristic of Chiari 1 malformation, accompanied by an extended brainstem and a dilated fourth ventricle. We present a Chiari 1 malformation characterized by significant downward herniation of the tonsils and the development of syringomyelia, with no indication of elongation of the fourth ventricle. This example represents an extension of Chiari 1 malformation, which is currently not classified as Chiari 1.5 malformation. A 27-year-old female exhibited cephalic and cervical discomfort for two years. The initial MRI indicated a fall of the cerebellar tonsil beneath the foramen magnum. The midsagittal MRI assessed the degree of tonsillar herniation beneath the foramen magnum. Tonsillar herniation was observed at the C2 level; a spinal MRI revealed syringomyelia affecting the C2 to C3 levels. The patient received a suboccipital craniectomy and C1-C2 laminectomy. There was dural sac pulsation at the C2 level. The patient's cervical discomfort resolved entirely following the surgical procedure. This case represents an extension of Chiari 1 malformation, which is currently not classified as adenotes explicitly 1.5 malformation. 
The Relationship between Sanitation and Personal Hygiene with Seroprevalence of Toxoplasmosis in Pregnant Women at Kaliwates and Banjarsengon Community Health Centers Nabila Putri Anissa; Yunita Armiyanti; Eny Nurmaida; Bagus Hermansyah; Erma Sulistyaningsih; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Toxoplasmosis is an infectious disease in animals that can be transmitted to humans. Sanitation and personal hygiene are risk factors for toxoplasmosis. Toxoplasmosis can be transmitted from pregnant women to their fetuses. Toxoplasmosis in pregnancy can cause pregnancy, premature birth, and congenital toxoplasmosis. According to the Jember District Health Office in 2023, access to proper sanitation and good hygienic behavior is still low. The purpose of this study was to analyze the relationship between sanitation and individual hygiene with toxoplasmosis seroprevalence in pregnant women at the Kaliwates and Banjarsengon Health Centers. This study used a crosssectional study type. The subjects of the study were 65 pregnant women at the Kaliwates and Banjarsengon Health Centers who were taken using the accidental sampling technique. The serological examination used the Toxoplasma IgM and IgG ELISA kit from Calbiotech®. The results of this study showed that 77% of pregnantwomen were detected positive for toxoplasmosis. The majority of pregnant women have good sanitation and personal hygiene categories of 87.7% and 90.8%, respectively. Based on the results of Fisher's exact test, sanitation and personal hygiene are not related to toxoplasmosis seroprevalence (p>0.05). This study concludes that sanitation and personal hygiene of pregnant women at the Kaliwates and Banjarsengon Health Centers are not significantly related to toxoplasmosis seroprevalence.  
Computational Prediction of Antimalarial Potential of Eurycoma longifolia Phytochemicals Targeting Plasmodium falciparum Awisarita, Wiwara; Farid, Muhammad
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53732

Abstract

Falciparum malaria, caused by Plasmodium falciparum, remains a major global health threat, complicated by the emergence of drug-resistant strains that undermine the efficacy of current artemisinin-based therapies. Eurycoma longifolia Jack (Pasak Bumi), a medicinal plant native to Southeast Asia, has long been used in traditional medicine for treating malaria and infectious diseases. With increasing resistance of Plasmodium falciparum to conventional drugs, the search for novel antimalarial agents is crucial. This study aimed to predicted the antimalarial potential of bioactive compounds from E. longifolia through a computational approach targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). Ten phytochemicals were selected and their 3D structures were prepared using PyRx and Open Babel. Molecular docking simulations were conducted using AutoDock Vina, with artemisinin as a control. Docking validation achieved an RMSD of 0.823 Å, confirming protocol reliability. Among the tested ligands, syringic acid showed the highest binding affinity -6.7 kcal/mol, followed by scopoletin -6.6, and fraxidin -6.4, with key interactions involving residues His185, Val532, and Phe188. Toxicological predictions indicated variability, with 1,1′-biphenyl-3,3′-dicarboxylic acid exhibiting the highest acute toxicity. Despite no compound surpassing the native ligand's binding energy -7.9 kcal/mol, several exhibited promising interactions and favorable safety profiles. This study highlights E. longifolia as a promising source of phytochemicals for antimalarial drug discovery. Further experimental studies and molecular dynamics simulations are recommended to validate these findings and optimize compound efficacy.
Occult Hepatitis B infection (OBI) in Indonesia: A Systematic Review Muhammadiy, Noer Sidqi; Senjarini, Kartika; Fajrin, Fifteen Aprila; Velavan, Thirumalaisamy P.; My, Truong Nhat; Song, Le Huu
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53733

Abstract

Hepatitis B Virus (HBV) infection remains a significant global health concern, with various genotypes exhibiting distinct clinical characteristics. Occult hepatitis B infection (OBI) is a latent form of HBV infection that is difficult to detect and poses a risk of transmission, particularly among high-risk populations such as blood donors, hemodialysis patients, and kidney transplant recipients. In Indonesia, studies on HBV genotype diversity and OBI prevalence remain limited, highlighting the need for a systematic analysis better to understand genotype distribution and its implications for public health. This systematic review was conducted using the PRISMA guidelines. Literature searches were performed on Google Scholar, Springer, ResearchGate, ScienceDirect, and PubMed using keywords related to OBI, HBV genotypes, and the Indonesian population. Studies that met the inclusion criteria were analyzed to assess genotype distribution and OBI prevalence. Among 352 screened articles, 35 studies met inclusion criteria. Genotypes B and C were identified as predominant HBV strains, with regional distribution variations. The highest OBI prevalence was recorded in eastern Indonesia (13.03%), followed by central (4.31%) and western (3.36%) regions. Nested PCR was the primary detection method for OBI. The predominance of genotype C in eastern Indonesia may contribute to higher OBI prevalence, emphasizing the need for region-specific diagnostic and management strategies. Further research is necessary to elucidate the association between HBV genotypes and clinical outcomes in OBI patients.
Liver Histopathological Analysis in The Acute Toxicity Test of Shallot (Allium cepa L.) Peel Extract in Rats (Rattus norvegicus) Aprilya Pratiwi, Nadilla; Dewi, Rosita; Agustina, Dini; Helianti, Dina; Rachmania, Sheilla
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53736

Abstract

Shallot (Allium cepa L.) contains bioactive compounds with antioxidant effects. In addition to the tuber, the shallot’s peel is a rich source of flavonoids with demonstrated capacity to mitigate oxidative stress. Prior studies have evaluated the antioxidant efficacy of shallot peel in ameliorating organ damage and have established its maximum effective dose. The subsequent step required for its potential therapeutic application is toxicity test. This study aimed to analyze the liver histopathological changes in the acute toxicity test of shallot peel extract (SPE) in rats based on OECD TG 420. This research was an experimental with a post-test-only control group design. Five female rats were used as the control group administered dimethyl sulfoxide (DMSO), while 5 female rats were used in the treatment group administered SPE at 5,000 mg/kg body weight (BW) (one of them had been used for a preliminary test with the same dosage). On day 15, a necropsy was conducted, followed by histopathological observation of the hematoxylin-eosin (HE)-stained liver histopathological slide. The damage to hepatocytes was evaluated using Manja Roenigk criteria. The average histopathological score per liver cell of the control group was 1.226 ± 0.0065 and the treatment group was 1.235±0.0079. The Mann-Whitney test showed that the liver histopathological score of the treatment group was not different from that of the control group (p>0.05). It can be concluded that SPE 5,000 mg/kg does not show acute toxic effects in rats, with LD₅₀ estimated at >5,000 mg/kg according to OECD standards.
The Forgotten Stoppa Procedure: An Alternative Approach for Incarcerated Groin Hernia Following Prior Anterior Repair Unsuitable for Laparoscopic Surgery – Case Series Normasari, Rena; Fardiansyah, Mochamad Syahroni; Lesmana, Tomy
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53739

Abstract

Incarcerated and recurrent inguinal hernias present complex surgical challenges, particularly in patients with a history of multiple anterior repairs or contraindications to laparoscopic approaches. Although minimally invasive techniques such as Transabdominal Preperitoneal (TAPP) and Totally Extraperitoneal (TEP) repair have become standard practice, not all patients are ideal candidates due to altered anatomy, dense adhesions, or comorbidities that preclude general anesthesia. In such cases, the Stoppa procedure—a classical open posterior approach with wide preperitoneal mesh placement—offers a safe and effective alternative. This case series describes two elderly male patients with incarcerated recurrent inguinal hernias following multiple prior anterior mesh repairs. Both presented in emergency settings with significant comorbidities, making laparoscopic surgery unfeasible. Surgical repair was performed using a lower midline incision and extensive preperitoneal dissection, followed by the placement of a large polypropylene mesh without extensive fixation. In both cases, the incarcerated ileal segments were viable and successfully reduced without bowel resection. Postoperative recovery was uneventful, with both patients discharged within three days and showing no recurrence or major complications during a one-year follow-up. These outcomes demonstrate that the Stoppa technique remains a valuable option in complex cases where anterior or laparoscopic approaches are unsuitable. Its anatomical logic, broad coverage, and reduced risk of chronic pain support its continued role in modern hernia surgery. Surgeons should retain proficiency in this underutilized yet highly effective method, particularly when managing high-risk or reoperative groin hernias.

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