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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 12 Documents
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Search results for , issue "Vol 29, No 3 (2024)" : 12 Documents clear
Antioxidant Assay of Kefir Peanut (Arachis hypogaea L.) with Variations in Concentration and Fermentation Time Viogenta, Pratika; Khairunnisa, Amalia; Kartinah, Nani; Rahmadati, Erfiza
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87814

Abstract

Kefir is a processed beverage produced through pasteurized milk fermentation using a starter from kefir grains. These grains contain groups of lactic acid bacteria and yeast. Peanuts can be used as a raw material for kefir products and Arachis hypogaea L. has antioxidant activity due to a high nutritional content namely vegetable oil, protein, minerals, and essential fatty acids. This study aimed to determine the highest antioxidant activity with variations in concentration and time fermentation of peanut kefir (Arachis hypogaea L.). This research on the antioxidant activity test method used the DPPH method with UV-Vis spectrophotometry. The results of testing the antioxidant activity of peanut kefir with variations in the concentration of kefir grains of 0%, 1%, 2%, and 3% had IC50 values of 64.929 ppm, 57.675 ppm, 54.742 ppm, and 51.870 ppm, respectively. The one-way ANOVA test showed a significant difference between the IC50 value and the concentration of kefir grains. The highest antioxidant in 3% concentration determined the fermentation time with 0, 12, 24, 36, 48, and 60 hours variations. The results of testing the antioxidant activity of kefir peanut with variations in the fermentation time it was had IC50 values of 64.319 ppm respectively, 62.609 ppm, 59.376 ppm, 56.321 ppm, 51.870 ppm, and 51.384 ppm. The one-way ANOVA test results showed no significance in the 0 with 12 hours completion time and 48 with 60 hours. The research results on peanut kefir show that kefir grains of 3% and the duration of fermentation for 48 hours have strong antioxidant activity.
Ursolic Acid and Polydatin in Melinjo Seeds Inhibit AKT1 and GAPDH Protein and HTB-179 Cells Migration Febriansah, Rifki; Julita, Irna
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88227

Abstract

The incidence of lung cancer in Indonesia by 2020 has reached 34.783 cases. Melinjo contains ursolic acid and polydatin, which can suppress cell proliferation and induce cell apoptosis, respectively. This study aims to determine the Melinjo seed ethyl acetate fraction (MSEAF) ability to inhibit lung cancer proliferation and migration towards HTB-179 cells using in vitro and in silico methods. Melinjo seed powder was macerated using 70% ethanol and fractionated with ethyl acetate. The fraction obtained was then analyzed using HPLC to detect the active compounds. The compounds obtained were further analyzed using bioinformatics to determine the target proteins. The docking method was performed between ursolic acid and polydatin compounds with each target protein to determine the binding affinity. The in vitro test was done using the MTT cytotoxicity assay and scratch wound healing assay methods. The results showed that MSEAF contains ursolic acid and polydatin with retention times of 12,475 minutes and 16,564 minutes, respectively. Ursolic acid protein targets were TP53 and AKT1 with docking scores of -6,3 kcal/mol and -7,4 kcal/mol, while polydatin target proteins were GAPDH and VEGFA with docking scores of -8,8 kcal/mol and -5,5 kcal/mol. The results of the MTT assay showed an IC50 value of 35,539 g/mL, and MSEAF inhibited the migration of HTB-179 cells by slowing the migration rate. This study suggested that the MSEAF contained ursolic acid and polydatin, which exhibited the ability to prevent the growth and migration of HTB-179 lung cancer, supported by the prediction of their ability to bind to TP53 and AKT1 proteins.
The Effect of Cocamide Dea on the Characteristics of Ginger and Celery Extract Shampoo Preparations Anastasia, Desy Siska; Septiani, Rahmi; Isnindar, Isnindar
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88466

Abstract

Ginger and celery extracts are recognized anti-dandruff agents. Managing dandruff can be accomplished by creating a cleanser formulation. Shampoo contains an essential cleansing ingredient known as surfactant. SLS enables good foams, but at >10% concentration, it irritates skin. Adding a nonionic surfactant like cocamide DEA reduces irritation. This study examined how cocamide DEA concentrations affected the physical qualities and hedonic evaluation of a shampoo containing ginger and celery extracts. The shampoo was produced in three formulas with differing cocamide DEA concentrations: F1 (6%), F2 (8%), and F3 (10%). The formulation is evaluated using organoleptic, homogeneity, viscosity, pH, bulk density, foam height, foam stability, cycling, hedonic, and irritant studies. The result of this study revealed that shampoo had a brownish-orange color, a ginger-mint scent, and different looks. All three formulations were homogeneous, did not separate during cycling, and had significant viscosity variances, pH, bulk density, foam height, and foam stability. The formula with an 8% cocamide DEA concentration was the most popular and did not produce irritation. In conclusion, varying cocamide DEA concentrations affect the physical properties and preferences of panelists in a shampoo formulation that includes ginger and celery extracts.
Cytotoxic Activity of Ethanol Extract of Piper aduncum L. on T47D Breast Cancer Cell Line using the MTT Method Bellatasie, Rezlie; Oktavia, Sri; Rakhmil, Hanaya Fathiha; Uyun, Hendri Satria Kamal
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88745

Abstract

Cancer treatment is known to cause side effects ranging from mild to severe, which can also affect the quality of the patient's health. Natural ingredients are an alternative source of cytotoxic substances with good anticancer activity and minimum side effects. Sirih hutan (Piper aduncum L.), also known as spiked pepper, is a medicinal plant with potential cytotoxic activity. This study aims to determine the cytotoxic activity of the ethanol extract of P. aduncum L. leaves with the Microculture Tetrazolium Test method. Phytochemical screening showed that P. aduncum L. contains alkaloids, flavonoids, saponin, phenol, and steroid/terpenoid compounds. The cytotoxic activity test was carried out on T47D cells with a concentration of 100 µg/mL, 10 µg/mL, 1 µg/mL, and 0.1 µg/mL test solution. The obtained IC50 value of the ethanol extract of P. aduncum L. was 171.2 µg/mL, belonging to the moderate toxic category. From this study, it is concluded that P. aduncum L holds potential as an anticancer agent.
Diversity and Ethnobotanical Significance of Wild Solanum Species in Odisha, India Panda, Taranisen; Mishra, Nirlipta; Rahimuddin, Shaik; Pradhan, Bikram Kumar; Apollo, Master; Mohanty, Raj Ballav
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89633

Abstract

Across the globe, individuals continue to rely on plants to meet fundamental human requirements, including sustenance, attire, housing, and healthcare. Among the diverse plant families, Solanaceae houses thousands of species worldwide, with many of them being wild and plays a pivotal role in preserving biodiversity and holds substantial ethnobotanical significance. Within this family, the Solanum genus holds particular significance in traditional medicine and human nutrition, boasting three major food crops: S. melongena (eggplant), S. lycopersicum (tomato), and S. tuberosum (potato), staples in daily diets worldwide. This study delves into the diversity of the Solanum genus in Bhadrak district, Odisha, India, with a primary focus on assessing its distribution and ethnobotanical importance. A field survey involving 97 respondents (76 male; 21 female) was conducted, involving interviews with local communities, traditional healers, and agricultural practitioners. The study documents six Solanum species with both food and medicinal applications. These species have been used to address a wide array of health issues, including asthma, coughs, bronchitis, liver problems, oral ulcers, rheumatism, skin diseases, tuberculosis, and toothaches. Various plant parts, such as leaves, roots, fruits, and seeds, are commonly employed in these remedies. Moreover, the Solanum species' remarkable adaptability to diverse environments highlights their resilience and ecological significance. The present findings serve as a platform for future research on Solanum's contributions to traditional medicine and ecological systems. Interdisciplinary collaboration among researchers, indigenous communities, and policymakers, are essential for sustainable utilization of Solanum genus, paving the way for a more healthful and harmonious coexistence with our natural world.
Formulation and Antioxidant Activity of Gotu Kola Jelly Candy with Plant-based Polymers as a Gelling Agent Devi, Dwitya Devi Nurlistyo; Darsih, Cici; Yuniarti, Nunung; Ardiningtyas, Bondan; Laksitorini, Marlyn Dian
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89699

Abstract

Centella asiatica or gotu kola has a long history as a brain supplement. Gotu kola supplements are sold as liquid and dried extract which is less attractive for a younger generation. Jelly candy is an alternative dosage form with better acceptability across ages. However, the use of animal-derived polymers such as pork gelatine in the candy restricts those who practice vegetarian and halal lifestyles from consuming the products. This study aims to explore plant-based polymers glucomannan and kappa-carrageenan as gelling agents in the preparation of gotu kola jelly candy. Preparation of the jelly candy formula was designed based on Simplex Lattice Design. Evaluation of physical characteristics of jelly candy includes organoleptic, weight uniformity, moisture content, pH, and elasticity. The antioxidant activity of gotu kola before and after the manufacturing process was evaluated. The results showed that a combination of kappa-carrageenan 1.33% and glucomannan 0.67% is the optimum formula. Adding more proportion of kappa-carrageenan reduced jelly elasticity and moisture content. While adding glucomannan improved its elasticity responses but increased moisture content. Evaluation of the antioxidant activity of gotu kola in jelly candy suggested that gotu kola experienced a significant reduction in antioxidant activity following the production process. The IC50 of the crude extract initially was129.23 ppm while post jelly candy manufacturing, the IC50 increased to 197.49 ppm. This study suggested that improvement in extraction and production processes is necessary to maintain gotu kola antioxidant activity.
Mauli Banana Stem Gel: A Potential Material for Dentin Remineralization Analyzed Using Fourier Transform Infrared Spectroscopy Carabelly, Amy Nindia; Rahman, Yajma Kamiila; Puspitasati, Dewi; Erlita, Isyana; Wydiamala, Erida
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90537

Abstract

Dental caries requires remineralizing agents to restore the dentin. Mauli banana stem gel is predicted to be an alternative material for mineral deposition during the remineralization process. Fourier transform infrared spectroscopy (FTIR) can analyze substances that indicate dentin remineralization. This study aimed to conduct an FTIR analysis of Mauli banana stem gel as a potential substitute material for dentin remineralization. The study utilized dentin slices obtained from the first premolars of the maxilla, which were demineralized using EDTA. Subsequently, the dentin slices were treated with CPP-ACP, 50% MBSG, 62,5% MBSG, and artificial saliva. A test tube containing 15 ml of artificial saliva was placed inside the smeared material, which was applied twice a day. It was left for three minutes and then rinsed with deionized water before being incubated at 37 °C. Basting was carried out for 21 days, and FTIR observations were performed. The major absorbance peaks detected were O-H and N-H stretch; C-H stretch; SCN stretch; Amide I; CO32-(v3) and collagen; Amide II; CH2 scissoring; C-H deformation; C-H stretching; Amide III; and PO43-(V3). MBSG demonstrated superior retention of dentin collagen compared to the control group, but it could not maintain the mineral content level on day 21. MBSG demonstrated a decrease in crystallinity due to a rise in carbonate content in the hydroxyapatite lattice. The study's findings indicate that MBSG remains unsuitable for dentin remineralization. Additional additives are necessary to enhance the levels of collagen and minerals in remineralized dentin.
Formulation and Physical Evaluation of Orthosiphon aristatus Leaf Extract Granule Preparation as Herbal Beverage Candidate Al-Hakim, Nur Achsan; Nur Fauziyyah, Salma Alifia; Purnamasari, Nira; Faramayuda, Fahrauk
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91009

Abstract

Developing Orthosiphon aristatus (Blume) Miq. leaf extract of purple varieties into granule dosage forms is expected to facilitate consumption, storage, and can extend the shelf life of the product. This study aims to develop the formulation and evaluation of granule preparations of O. aristatus leaf extract of purple varieties, with a comparison of lactose and maltodextrin fillers to produce the best formula. The granule dosage forms were prepared using wet granulation method. Furthermore, the variation of granule preparation formula consists of F1 (extract with lactose), F2 (extract with maltodextrin), F3 (extract with a combination of lactose and maltodextrin 1:1), F4 (freeze dried extract with lactose), F5 (freeze dried extract with maltodextrin), and F6 (freeze dried extract with a combination of lactose and maltodextrin 1:1). The physical evaluation of granules comprised moisture content testing, flowability, compressibility index, particle size distribution, and granule dissolving time. Results from the physical evaluation of granules over 28 days of storage indicated that all six formulas met the criteria for good granules, with F3 emerging as the optimal formula due to its superior physical stability and visually appealing appearance upon dissolution. To conclude, this study demonstrates that O. aristatus leaf extract can be effectively formulated into instant granule preparations suitable for herbal beverage or alternative medicine. Moreover, by modifying the filler material, the physical stability of the granule preparation can be maintained.
Antioxidant and Anti-Breast Cancer from Uncaria gambir Roxb Leaves: In Silico & In Vitro Study Iskandar, Dodi; Rollando, Rollando; Susana, Susana; Amperawati, Suharyani; Indrastuti, Y Erning; Afthoni, Muhammad Hilmi
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.92604

Abstract

Uncaria gambir Roxb (URG) is one of the plants from West Kalimantan predicted to contain antioxidant and anti-breast cancer. This study aims to test the antioxidant and anti-breast cancer potential. UGR leaves were extracted by infusion method using water for 15 minutes with 4 repetitions at a temperature 70oC. A thick extract of 96.2351 grams (29.979%) was obtained from a sample weight of 321 grams of dried UGR leaves. In vitro antioxidant assay of the extract was investigated using 2,2-diphenylpicrylhydrazyl (DPPH) with positive control using quercetin and ascorbic acid, and the Ferric Reducing Antioxidant Power (FRAP) method. In silico screening showed that the biological agents in UGR had the potential as TP53 expression enhancer, antioxidant, anticarcinogenic, chemopreventive, and free radical scavenger. The antioxidant bioassay results showed IC50 values of 81.21 μg/mL, 73.39 μg/mL, and 9.17 μg/mL in DPPH for extract samples with positive control quercetin, sample extracts with positive control Vitamin C and Vitamin C with positive control quercetin, respectively. Meanwhile, the antioxidant activity of extract samples with the FRAP method showed value of 66,05 μg/mL. Anticancer bioassay result showed that UGR leaves extract with water solvent had the stron potentgial to inhibit 4T1 cells with IC50  87.72 μg/mL.
Scoping Review: Study of Herbs Consumption for Self-Medication in Indonesia 2019-2022 Azzahra, Fatimah; Astuti, Ayun Dwi; Arifin, Bustanul; Alam, Gemini
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94091

Abstract

Indonesia is a country that has high biodiversity and is rich in traditional medicine from natural ingredients or herbs. One use of these natural ingredients is as a treatment for self-medication. Many previous studies have been carried out but none has reviewed it systematically, especially during the Covid-19 pandemic. This research was carried out systematically using the PRISMA statement approach using the Google Scholar data bank. Out of 2,214 papers in the 2019-2022 period,  45 articles/scientific papers papers met the criteria, including inclusion and exclusion criteria, for a description/profile of the use of natural ingredients or herbs as self-medication for traditional medicine. The central region of Java (D.I.Y Yogyakarta and Central Java) is the region with the largest number of articles. The distinctiveness of Indonesia's approach to self-medication lies in its utilization of various natural elements to address similar ailments, which can be attributed to geographical factors, cultural beliefs, and diverse knowledge across different regions. Meanwhile, Covid-related studies were very limited due to the availability or the preference for chemical self-medication.

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