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Journal of Islamic Pharmacy
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 166 Documents
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Evaluation of Drug Management Before and During the COVID-19 Pandemic In The Pharmaceutical Installation of NTB Provincial Hospital Wisnu, M. Ari; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32374

Abstract

The COVID-19 pandemic that occurred from 2019 to 2023 and has spread to nearly 190 countries in the world has caused a shortage of drug supply. The need for public medicines that must be available for health services makes hospitals must try to fulfill and currently, the COVID-19 pandemic situation is continuing so hospitals must be ready to provide health services to patients. This study aims to evaluate drug management in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 and during the COVID-19 pandemic in 2020. This study used a descriptive-evaluative method. The main data was collected through documents containing specific data on drug management history. Supporting data was collected through interviews with the pharmaceutical installation. The results of the suitability of drug management in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 obtained 5 indicators that did not meet the standards and 6 indicators that met the standards while during the COVID-19 pandemic in 2020 there were 7 indicators that did not meet the standards and 4 indicators that met the standards.
Molecular Docking of Hygrophila auriculata (Schum.) Heine Compounds Targeting PBP2 Protein in Neisseria gonorrhoeae Salmasfattah, Novyananda; Prayogi, Syaiful; Prasetyawan, Fendy
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.31740

Abstract

Antibiotic resistance in gonorrhoea cases and patients is detrimental. Amidst the rising cases of gonorrhoea caused by Neisseria gonorrhoeae, Hygrophila auriculata (Schum.) Heine has activity as an antibiotic for the disease. The penicillin-binding protein 2 (PBP2) is a transpeptidase that catalyses the formation of cross-bridges on bacterial cell wall peptidoglycan, which will be the target of this plant. The purpose of molecular docking study is to see the binding affinity, compounds in Hygrophila auriculata (Schum.) Heine and ceftriaxone which is used as a comparison drug, will be targeted at PBP protein. Discovery studio visualizer v21.1.0.20298 was used for PBP2 protein preparation and visualisation. DoG Site Scorer was used to predict ligand binding sites on PBP2 proteins. PyRx 0.8 was used for virtual screening, validating of the docking method, and ligand preparation. Compounds in Hygrophila auriculata (Schum.) Heine as ligands were derived from MPDB 2.0 and the following PubChem codes; apigenin CID 5280443, luteolin CID 5280445, allagic acid CID 5281855, gallic acid CID 370, quercetin CID 5280343, lupeol CID 259846, lupenone CID 92158, betulin CID 72326, stigmasterol CID 5280794, and comparator drug ceftriaxone CID 447043. The binding affinity of ellagic acid -9,8 from Hygrophila auriculata (Schum.) Heine was lower than ceftriaxone -9,4 on the target PBP2 protein. Some of the amino acid residues that appear in protein-ligand docking include: ALA A:310, THR A:500 and 347, LYS A:313, and SER A:362. These amino acid residues owned by the PBP2 protein serve as the bonding bridge. Ellagic acid, the compound has potential as an antibiotic in gonorrhoea. Further testing and studies are needed to strengthen the evidence of the findings in this study
Antidiabetes Activity of Ethanol Extract of Pandan Leaves (Pandanus amaryllifolius Roxb) in Male White Mice (Mus musculus) Jehan, Nabilah Nauli; Hidayah, Harismayanti; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32378

Abstract

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion. This study aims to evaluate the antidiabetic effect of ethanol extract of fragrant pandan leaves (Pandanus ammarillyfolius Roxb) on aloxane-induced male white mice (Mus musculus). After alloxane induction, all test animals reached hyperglycemic conditions with blood glucose levels of ≥126 mgdL. The method used was the Paired Sample T-Test to analyze the difference in blood glucose levels before and after the treatment. The normality of the data was tested by the Shapiro-Wilk test, while the homogeneity was tested by the Leven test. The results showed that the most effective ethanol extract of fragrant pandan leaves reduced blood glucose levels at a dose of 600mgkgBB by 26%, a dose of 400mgkgBB by 21%, a dose of 200mgkgBB by 18%, a positive control using glibenclamide 0.65mgkgBB as much as 10% and a negative control using CMC-Na by 3%.
Analisis Kadar Etanol dalam Minuman Legen Menggunakan GC-FID dan Tinjauan Fatwa MUI tentang Produk Fermentasi Suhardi, Haidar Rafli Putra; Zummah, Atiqoh; Zahro, Dea Ma'rifatul; Rahmah, Firda Maghfiratur; Ainida, Anya Hayyu; Rani, Titis Eka
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32098

Abstract

Legen merupakan minuman tradisional hasil sadapan nira pohon siwalan yang berpotensi mengalami fermentasi alami sehingga menghasilkan etanol. Penelitian ini bertujuan untuk menganalisis kadar etanol dalam sampel legen yang diperoleh dari kawasan Surabaya menggunakan metode Gas Chromatography-Flame Ionization Detector (GC-FID), serta mengevaluasi kesesuaiannya dengan ketentuan halal berdasarkan fatwa Majelis Ulama Indonesia (MUI) Nomor 10 Tahun 2018. Sebanyak tujuh sampel legen dikumpulkan secara acak dari pedagang kaki lima dan dianalisis kandungan etanolnya, disertai pengamatan karakteristik organoleptik (warna, aroma, dan viskositas) untuk mendeteksi indikasi fermentasi. Hasil menunjukkan kadar etanol bervariasi antara 0,15% (3B) hingga 11,31% (4B). Sampel dengan kandungan alkohol tertinggi memiliki aroma asam yang kuat yang mengindikasikan proses fermentasi terus berlanjut serta ketersediaan gula sebagai substrat fermentasi. Tiga sampel (1B, 2A, dan 4B) melebihi ambang batas etanol halal ( 0,5%) sebagaimana ditetapkan MUI, sehingga dinyatakan tidak memenuhi kriteria halal. Penelitian ini menegaskan pentingnya pengawasan mutu pada produk minuman fermentasi tradisional untuk memastikan keamanan konsumsi dan kesesuaiannya dengan syariat Islam.Legen is a traditional beverage obtained from the sap of the lontar palm, which has the potential for natural fermentation, thereby producing ethanol. This research aims to analyze the ethanol content in legen samples obtained from the Surabaya area using the GC-FID method, and to evaluate its compliance with halal provisions based on the MUI fatwa Number 10 of 2018. Seven legen samples were randomly collected from street vendors, and their ethanol content was analyzed, accompanied by observations of organoleptic characteristics (color, aroma, and viscosity) to detect indications of fermentation. The results showed ethanol content varied from 0.15% (3B) to 11.31% (4B). Samples with the highest alcohol content had a strong sour aroma characteristic, indicating that the fermentation process continued as well as the availability of sugar as a fermentation substrate. Three samples (1B, 2A, and 4B) exceeded the halal ethanol threshold ( 0.5%) as stipulated by MUI, thus being declared non-halal. This research emphasizes the importance of quality control in traditional fermented beverage products to ensure their safety for consumption and compliance with Islamic law.
Molecular Docking: Analysis of Mahogany Plant Compounds (Swietenia macrophylla King) against the ACE2 Enzyme of SARS-CoV-2 Amrulloh, Lalu Sanik Wahyu Fadil; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32426

Abstract

Various treatment approaches have been attempted to tackle severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)  infection. One approach to develop new drugs is through the utilization of medicinal plants. Mahogany (Swietenia macrophylla King) is one of the plants that is thought to have potential as an inhibitor of SARS-CoV-2. This study aims to determine the anti-SARS-CoV-2 potential of compounds in mahogany plants that have good interactions and interaction patterns with angiotensin-converting enzime 2 (ACE2) receptors. A total of ten mahogany plant compounds were tested for drug-likeness based on Lipinski screening which will then be docked to the ACE2 molecular target, using the molecular docking method. The parameters observed were binding energy values and amino acid residues. The results of molecular docking showed that the compounds predicted to have the highest binding affinity and have similar interaction patterns with natural ligands to the ACE2 molecular target were secomahoganin and stigmasterol. The secomahoganin and stigmasterol compounds are predicted to have good interactions with the ACE2 receptor.
Pengaruh Kombinasi Kitosan dan Karbopol 940 Terhadap Karakteristik Fisik dan Stabilitas Sediaan Gel Ekstrak Daun Kelor (Moringa oleifera L) Zatalini, Dioni Fadia; Bhagawan, Weka Sidha; Norachuriya, Zedny
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32255

Abstract

Gel merupakan salah satu sediaan topikal yang memiliki keuntungan seperti bewarna jernih, memberikan sensasi dingin, tidak berminyak, mudah menyebar di kulit sehingga dapat maksimal memberikan efek teraupetik. Gelling agent merupakan komponen penting dalam pembentukan gel. Kitosan merupakan polimer alam yang dapat membentuk gel pada larutan asam. Sedangkan karbopol 940 dapat menghasilkan gel bewarna jernih dan stabilitasnya baik selama penyimpanan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kombinasi karbopol 940 dan kitosan pada sediaan gel ekstrak daun kelor terhadap karakteristik fisik dan uji stabilitas selama 4 minggu. Pembuatan gel ekstrak daun kelor menggunakan ekstrak etanol daun kelor sebesar 5%. Kombinasi gelling agent yaitu karbopol 940 1% dan kitosan 0,5%, 1%, 1,5%. Uji karakteritik dan stabilitas meliputi organoleptis, homogenitas, pH, viskositas, daya sebar dan stabilitas selama 4 minggu. Hasil menunjukkan gel ekstrak daun kelor bewarna coklat tua, kental, bau khas daun kelor serta homogen dan tidak mengalami perubahan signifikan selama disimpan 28 hari. Nilai Uji pH sediaan gel ekstrak daun kelor tidak mengalami perubahan setelah disimpan selama 4 minggu (4,94-5,20) menjadi 5,09-5,65). Stabilitas viskositas sediaan gel ekstrak daun kelor mengalami penurunan dari minggu ke-1 2,964 cps-4420 cps menjadi 2,438 cps-3556 cps setelah minggu. Pada uji daya sebar terjadi peningkatan setelah disimpan selama 4 minggu (4,2 cm- 5,9 cm menjadi (5,1 cm – 6,9 cm). Berdasarkan hasil tersebut semua formula gel kitosan-karbopol 940-ekstrak daun kelor telah memenuhi persyaratan.
Observasi Klinis Penggunaan Probiotik sebagai Terapi Pendukung pada Pasien dengan Kolitis Ulseratif dan Limfoma Non-Hodgkin Geson, Ge Recta; Kiranawati, Titi Mutiara; Putra, Galih Satrio; Setiadi, Adji Prayitno
Journal of Islamic Pharmacy Vol 10, No 2 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i2.36720

Abstract

Kolitis ulseratif merupakan penyakit inflamasi usus kronis yang memerlukan terapi jangka panjang dan pada kondisi tertentu dapat disertai komorbiditas keganasan, seperti Non-Hodgkin’s Lymphoma (NHL). Penatalaksanaan kondisi ini sering kali melibatkan terapi komprehensif yang berpotensi mempengaruhi kondisi gastrointestinal pasien dengan golden standard therapy yang dikenal sebagai R-CHOP. Studi kasus ini menyajikan observasi klinis terhadap satu pasien dengan kolitis ulseratif dengan NHL yang mendapatkan R-CHOP dan suplementasi probiotik multistain sebagai terapi pendukung selama masa perawatan. Data diperoleh dari rekam medis dan observasi klinis secara deskriptif tanpa analisis statistik. Selama periode observasi, pasien menunjukkan perbaikan kondisi klinis secara umum dan tidak mengalami perburukan gejala gastrointestinal yang bermakna setelah pemberian adjuvant therapy berupa probiotik multistain jika dibandingkan dengan sebelum pemberian probiotik multistain. Kombinasi standard kemoterapi R-CHOP pada kasus ini dengan suplementasi probiotik multistrain berpotensi menghambat progresi keganasan sel kanker NHL. Pemberian probiotik multistain dapat memberikan manfaat terapeutik dengan meningkatkan apoptosis pada sel kanker sekaligus menurunkan peradangan pada kolitis ulseratif berdasarkan hasil gambaran kolonoskopi. Meskipun demikian, temuan ini bersifat deskriptif antara pemberian probiotik dan perbaikan kondisi klinis pasien yang mengalami kolitis ulseratif dengan NHL. Penelitian lanjutan dengan desain yang lebih kuat diperlukan untuk menkonfirmasi potensi peran probiotik mutristrain sebagai terapi pendukung pada kondisi klinis serupa.
Formulasi Sediaan Mouthwash Ekstrak Daun Sirsak (Annona muricata L.) dengan Penambahan Variasi Konsentrasi Ekstrak Daun Kelor (Moringa oleifera L.) sebagai Antibakteri Nofriyaldi, Ali
Journal of Islamic Pharmacy Vol 10, No 2 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i2.32475

Abstract

Karies gigi adalah suatu kondisi kronis yang disebabkan oleh bakteri Streptococcus mutans yang dapat menyebabkan timbul plak gigi yang berlubang. Daun sirsak dan daun kelor mengandung senyawa metabolit sekunder yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk memformulasikan sediaan mouthwash kombinasi ekstrak daun sirsak dan daun kelor serta aktivitas antibakterinya terhadap Streptococcus mutans. Metode ekstraksi dengan maserasi menggunakan pelarut etanol 70%. Skrining fitokimia meliputi uji alkaloid, tanin, flavonoid, terpenoid, saponin, dan polifenol. Formulasi mouthwash ekstrak daun sirsak dikombinasikan dengan ekstrak daun kelor dengan tiga variasi konsenstrasi yaitu F1 (2,5%), F2 (5%), dan F3 (10%). Evaluasi sediaan mouthwash meliputi uji organoleptik, pH, bobot jenis, dan viskositas, sedangkan pengujian antibakteri menggunakan metode sumuran. Hasil penelitian menunjukkan senyawa yang terdapat pada daun sirsak yaitu tanin, alkaloid, steroid, favonoid, saponin, dan polifenol, sedangkan daun kelor mengandung alkaloid, polifenol, tanin, favonoid, dan saponin. Hasil evaluasi sediaan mouthwash menunjukan ketiga formula memenuhi persyaratan. Uji aktivitas antibakteri pada ketiga formula mempunyai nilai diameter zona hambat 9,75 ± 0,06 mm (F1), 12,46 ± 0,003 mm (F2), dan 14,27 ± 0,008 mm (F3). F1 termasuk dalam kategori sedang, sedangkan F2 dan F3 termasuk kategori kuat. Dapat disimpulkan bahwa penambahan ekstrak daun kelor pada sediaan mouthwash ekstrak daun sirsak dapat meningkatkan aktivitas antibakteri terhadap bakteri Streptococcus mutans. Semakin tinggi konsentrasi ekstrak daun kelor, maka semakin meningkat nilai zona hambat antibakterinya.
Tumbuhan Etnofarmakologi Antiinflamasi dan Analgesik di Suku Samin, Jawa Timur: Studi Literatur Kinasih, Meita Dewi; Suproborini, Arum; Bhagawan, Weka Sidha
Journal of Islamic Pharmacy Vol 10, No 2 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i2.36036

Abstract

Peradangan dan nyeri merupakan masalah kesehatan yang banyak dialami masyarakat dan sering kali ditangani dengan obat antiinflamasi non-steroid (OAINS) yang berisiko menimbulkan efek samping. Oleh karena itu, diperlukan alternatif pengobatan yang lebih aman, salah satunya melalui tanaman obat. Suku Samin di Jawa Timur dikenal masih mempertahankan tradisi pengobatan menggunakan tanaman herbal. Studi ini bertujuan untuk mengkaji penggunaan tumbuhan etnofarmakologis oleh masyarakat Samin sebagai agen antiinflamasi dan analgesik berdasarkan data Riset Tumbuhan Obat dan Jamu (RISTOJA) 2015. Metode penelitian menggunakan pendekatan deskriptif dengan analisis data sekunder, validasi ilmiah aktivitas farmakologis melalui telaah pustaka dari artikel ilmiah terindeks, serta validasi taksonomi melalui World Flora Online (WFO). Hasil studi menunjukkan terdapat tujuh spesies tumbuhan dari tujuh famili berbeda yang digunakan oleh masyarakat Samin untuk mengatasi peradangan dan nyeri, seperti Anredera cordifolia, Blumea balsamifera, Datura metel, Muntingia calabura, dan Sonchus arvensis. Lima dari tujuh spesies telah terbukti secara ilmiah memiliki aktivitas antiinflamasi dan analgesik melalui mekanisme penghambatan enzim siklooksigenase (COX), lipooksigenase (LOX), dan xantin oksidase, serta penurunan sitokin proinflamasi.
Level of Knowledge and Attitudes towards the Practice of Obtaining Antibiotics among Health Students Sudarko, Luthfi Nur Rohman; Rosyidah, Rosyidah; Sulistyawati, Sulistyawati; Djannah, Sitti Nur; Tukiyo, Intan Wahyuni
Journal of Islamic Pharmacy Vol 10, No 2 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i2.32665

Abstract

Antibiotics are one of the drugs used to treat disease problems caused by bacterial infections. Because they are used to treat bacterial infections, antibiotics should not be used without guidance from a doctor. As a result of inappropriate use, it will impact the emergence of antibiotic resistance. This research aims to determine the knowledge and attitudes of second-semester students regarding practice of obtaining antibiotics to and use of antibiotics at Faculty of Public Health of Ahmad Dahlan University (FKM UAD). This research is an analytical observational study conducted with a cross-sectional design. The population of this study was UAD FKM students in their second semester, from two different study programs. The number of respondents in this study was 127, obtained using accidental sampling. The instrument used in this research is an electronic questionnaire, which will be analyzed using chi-square analysis with a p-value 0.005. Student knowledge is in the low category (61.4%), and student attitudes are also negative (59.1%). Meanwhile, the chi-square test results show that knowledge (p-value: 0.025; PR: 2.5; 95% CI: 1.179-5.093) and attitude (p-value: 0.037; PR: 2.3; 95% CI: 1.112-4.713) have a relationship to practice of obtaining antibiotics in second-semester students at FKM UAD. Students' knowledge and attitudes are significantly related to the behaviour and practices regarding antibiotic use among FKM UAD students. It is hoped that related parties can create educational programs for students on the use of antibiotics and the importance of obtaining the right antibiotics.

Page 16 of 17 | Total Record : 166

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