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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 278 Documents
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THE ASSESSMENT OF SERUM ADROPIN AND CATALASE LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE: ADROPIN AND CATALASE LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE Şimşek, Fatma; Aktaş, Yunus Emre; Gündoğdu, Ömer Lütfi; Kızıltunç, Ahmet
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.07

Abstract

Background: Dementia is a disease that renders performing activities of daily living difficult and has a high cost of treatment. Objective: In this context, this study was conducted to assess the adropin and catalase levels, the relationship between adropin and catalase levels, and the roles of adropin and catalase in treatment in patients diagnosed with Alzheimer's type dementia. Methods: This observational analytical study's sample consisted of 30 patients with Alzheimer’s disease (AD). Thirty individuals without dementia whose age and gender characteristics matched those with AD were included in the control group. The adropin and catalase levels in the serum samples collected from both patient and control groups were analyzed. Results: Adropin and low-density lipoprotein cholesterol (LDLC) levels were notably elevated in patients with Alzheimer's disease (AD). In contrast, levels of vitamin D, albumin, and catalase were significantly reduced in these patients. Additionally, there was no meaningful correlation between the mini-mental state examination (MMSE) scores and the results of laboratory tests in individuals with AD. Additionally, it was determined that MMSE scores were positively correlated with adropin levels and negatively correlated with catalase levels. However, both correlations were statistically insignificant. Conclusion: The low levels of catalase in patients with AD support the important role of oxidative stress in the disease. The high levels of adropin in these patients suggest that adropin acts as a defense mechanism for the body. Catalase and adropin can be used as biomarkers in the diagnosis of AD, but they are not suitable biomarkers for assessing cognitive functions.
THE ASSOCIATION BETWEEN STROKE DETERMINANT FACTORS AND SLEEP QUALITY IN POST-STROKE PATIENTS Afif, Zamroni; Arisetijono, Eko; Setijowati, Nanik; Sitompul, Boyke
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.09

Abstract

Background: Stroke is a serious condition can cause sudden loss of neurological function. Sleep disorders, such as insomnia, hypersomnia, sleep apnea, and restless leg syndrome, often occur in stroke patients and can worsen the post-stroke rehabilitation process, especially who have a history of diabetes mellitus (DM), hypertension, and heavy smoker. Effective management of post-stroke patients requires identifying and treating sleep quality disorders and associated risk factors to improve quality of life. Objective: This study aims to explore the association between DM, hypertension, and smoking in post-stroke patients and sleep quality. Methods: A cross-sectional study was conducted on post-stroke control patients at the Neurology Clinic at Dr. Saiful Anwar Hospital, East Java, from December 2023 to February 2024. Sleep quality disorder were measured using the Pittsburgh Sleep Quality Index (PSQI) within one month after outpatient treatment. Additional data were analyzed using the chi-square test and binary logistic regression. Results: Among the 74 participants, 25 patients (25.7%) had a history of DM, 68 (91.9%) with hypertension, and 20 (27%) were heavy smokers. There were 34 patients (45.9%) who experienced sleep quality disorders. There was a significant association between DM and sleep disorders (p=0.005), while hypertension and smoking did not show a significant correlation. History of DM was a significant predictor of sleep disorders (p=0.09 | OR 4.782, 95% CI 1.483–15.421). Conclusion: This study shows a significant association between history of DM in post-stroke patients and sleep quality based on PSQI.
OPTIC NEURITIS AND SEIZURES IN A PEDIATRIC PATIENT: IS IT RELATED TO NEUROMYELITIS OPTICA SPECTRUM DISORDER? Wulandari, Lely Retno; Vierlia, Wino Vrieda
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.18

Abstract

Background: Optic neuritis is a significant manifestation of central nervous system (CNS) demyelinating disorders, including Neuromyelitis Optica Spectrum Disorder (NMOSD). Pediatric cases are particularly challenging due to overlapping symptoms with other neurological conditions. Objective: This case report discusses a pediatric patient presenting with bilateral optic neuritis and seizures, raising suspicion of NMOSD. Methods: A 12-year-old male presented with acute bilateral vision loss and seizures. Comprehensive ophthalmological examinations, laboratory tests, and neuroimaging such as magnetic resonance imaging (MRI) and optical coherence tomography (OCT ) were performed. Due to financial constraints, specific NMOSD diagnostics, such as AQP4-IgG antibody testing, were not conducted. The patient was treated with high-dose intravenous methylprednisolone (IVMP) following the Optic Neuritis Treatment Trial (ONTT) protocol and valproic acid for seizure control. Results: Significant improvement in visual acuity was observed within five days of IVMP treatment. The right eye (RE) improved from hand motions to 6/48, and the left eye (LE) from hand motions to 6/144. By day eight, further improvement in visual acuity was noted. Seizures were effectively controlled with valproic acid, and no additional neurological symptoms were reported during follow-up. MRI showed no characteristic lesions, and laboratory results were within normal limits. Conclusion: The success of treatment despite diagnostic limitations suggests that with timely intervention, favorable outcomes are possible even in challenging settings. Future research should focus on developing accessible diagnostic tools and protocols that can be implemented in resource-limited environments. Additionally, awareness and training for healthcare providers in such settings are essential to improve early recognition and treatment of NMOSD.
UNRAVELING THE BEST NON-PHARMACOLOGICAL INTERVENTIONS FOR COGNITIVE FUNCTION AND DEPRESSION IN ELDERLY WITH COGNITIVE IMPAIRMENT: A NETWORK META-ANALYSIS Masykur, Umar Jundullah; Janet, Karensa Abby; Putri, Dwi Sandhi Aulia Pramesti; Jatmiko, Sarazata Indi Rozaany; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.16

Abstract

Background: Emerging evidence suggests that non-pharmacological interventions can improve cognitive function and alleviate depressive symptoms in elderly individuals with cognitive impairment. However, the comparative effectiveness of these interventions remains unclear. Objective: This network meta-analysis (NMA) compares the efficacy of eight non-pharmacological interventions—Virtual Reality (VR) or Exergame, Computerized Cognitive Training (CCT), Mind-Body Exercise (MBE), Physical Exercise, Music or Art Therapy, Health Education, Treatment as Usual (TAU), and a Control group (no intervention, placebo)—on cognitive function and depression in elderly individuals with cognitive impairment. Methods: Randomized controlled trials (RCTs) published up to August 10, 2024, were systematically searched in Web of Science, PubMed, Embase, and Cochrane Library databases. A Frequentist random-effects network meta-analysis was conducted using R. Results: Total 46 RCTs with 3043 participants were included. The pooled results showed that CCT (SMD = 2.33, 95% CI [1.34, 3.32]), Physical Exercise (SMD = 2.24, 95% CI [1.24, 3.23]), and VR or Exergame (SMD = 2.09, 95% CI [1.10, 3.08]) significantly improved global cognition. VR or Exergame was also effective in enhancing attention (SMD = -3.49, 95% CI [-6.85, -0.14]), executive function (SMD = -75.54 (95% CI [-118.24, -33.04]), and reducing depressive symptoms (SMD = -2.62, 95% CI [-4.08, -1.15]). Conclusion: This NMA highlights the superior efficacy of CCT, Physical Exercise, and VR or Exergame in improving global cognition in elderly individuals with cognitive impairment. Additionally, VR or Exergame is particularly effective for enhancing attention, executive function, and reducing depressive symptoms, suggesting it should be integrated into cognitive rehabilitation programs.
THE CORRELATION OF SLEEP QUALITY AND SHORT-TERM MEMORY FUNCTION IN MEDICAL STUDENTS Putu Emilia Dewi; I Made Oka Adnyana; Ketut Widyastuti; I Putu Eka Widyadharma
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.19

Abstract

Background: Study on the correlation of sleep quality with short-term memory function in medical students has a high urgency considering that intelligence and good memory function are essential for their performance and learning ability in the field. There are only a few related studies on medical students in the Faculty of Medicine and Health Sciences of Universitas Udayana. Objective: This study aims to determine the correlation between sleep quality and short-term memory function of medical students in the Faculty of Medicine and Health Sciences of Universitas Udayana. Methods: The sample was determined by the non-probability consecutive sampling method. The Indonesian version of the Pittsburgh Sleep Quality Index (PSQI) questionnaire and the Digit Span Backwards Task assessed sleep quality and short-term memory function respectively. The data was analyzed by Pearson correlative test and logistic regression multivariate analysis. Results: There were 75 subjects in this study. The PSQI average score of the respondents was 9.35 ± 4.45, and the Digit Span Backwards Task average was 3.75 ± 1.77. The Pearson correlative test showed a moderate correlation between sleep quality and short-term memory function (r = -0.44.; p < 0,05). The logistic regression multivariate analysis found that sleep disturbances affect short-term memory function more than other sleep quality components, with a probability value of 98%. Conclusion: There is a correlation between sleep quality and short-term memory function of medical students in the Faculty of Medicine and Health Sciences of Universitas Udayana.
DOSAGES ANALYSIS OF HYPERBARIC OXYGEN THERAPY TO IMPROVING COGNITIVE FUNCTION IN PATIENTS POST-TRAUMATIC BRAIN INJURY: A REVIEW Nuri, Almas; Edi, Djatiwidodo; Anindya, Pramita; Ilmawan, Moh. Fathi
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.24

Abstract

Background: Traumatic brain injury is a type of intracranial injury caused by a mechanical impact that causes anatomical and physiological damage to the brain. Globally, there are 50 million cases of traumatic brain injury each year that cause 10 million deaths and/or hospitalizations. Hyperbaric oxygen therapy is a therapy that uses 100% oxygen at pressures greater than 1 Atmosphere Absolute  (ATA) to increase tissue oxygenation and repair damaged tissue. This study was made to determine the effect of hyperbaric oxygen therapy on improving cognitive function in post-traumatic brain injury patients and the mechanisms underlying it. Objective: To determine the dose of hyperbaric oxygen therapy that can trigger improved cognitive function in post-traumatic brain injury patients, as well as the side effects. Methods: This research is descriptive research and uses the literature study method. In collecting data, using all journals with the search keywords "hyperbaric oxygen therapy" "traumatic brain injury" "hyperbaric oxygen therapy for TBI" "HBOT and TBI" "oxygen therapy and brain injury" published in 2017 - 2022 and indexed by Scimago Journal & Country Rank (SJR) and/or Science And Technology Index (SINTA) then new conclusions and descriptions are made. Results: After selecting 262 journals, ten journals met the inclusion and exclusion criteria. The ten journals stated that there was an effect of hyperbaric oxygen therapy on improving cognitive function in post-traumatic brain injury patients. assessment of improvement in cognitive function in the attached journal, assessed with different parameters. Conclusion: Hyperbaric oxygen therapy is a potential therapy to accelerate cognitive function improvement in post-traumatic brain injury patients.
THE ASSOCIATION OF SOCIODEMOGRAPHIC FACTORS WITH MOTOR SYMPTOMS IN PATIENTS WITH PARKINSONISM Dyson, Nathaniel Gilbert; Tiksnadi, Amanda
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.20

Abstract

Background: Motor symptoms in patients with parkinsonism severely impair daily activities. Sociodemographic factors are known to play an important role in various chronic diseases, but their relationship with parkinsonism has not been studied yet. Objective: This study aims to determine the association between sociodemographic factors and motor symptoms among patients with parkinsonism. Methods: This cross-sectional study was conducted at Dr. Cipto Mangunkusumo National Hospital Jakarta by using the MDS Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II questionnaire about daily motor symptoms. The target sample in this study were patients with parkinsonism based on a doctor's diagnosis, fluent in Indonesian, and had internet access. Results: A total of 50 respondents were recruited with the most motor symptoms being difficulty dressing (90%), followed by writing, doing hobbies, tremors, and balance (88%). Bivariate analysis found that patients with low education, low income, and married had significantly worse motor symptoms (p<0.05). Multivariate analysis revealed that low education level and married status were significant risk factors, while high income level was a protective factor against poor motor symptoms. Conclusion: Sociodemographic factors were significantly associated with motor symptoms in parkinsonism patients. This study recommends personalized patient management based on the patient's sociodemographic factors.
UNCONTROLLED DIABETES AS FACTOR AFFECTING COGNITIVE FUNCTION IN TYPE 2 DIABETES MELLITUS Simanungkalit, Astra Dea; Puspitasari, Vivien; Solansa, Tracy
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.21

Abstract

Background: Impairment or decline in cognitive function can be caused by various things, one of which is uncontrolled diabetes. In Indonesia, the research on the effect of blood sugar levels on cognitive function has been done, but still limited and less were using HbA1c. Objective: This research aims to find correlation between HbA1C level and cognitive function based on MoCA-Ina. Methods: This is a cross sectional study with a sample of 130 type 2 diabetes mellitus patients at Siloam Hospital Karawaci through a non-randomized purposive sampling method. Data collection was taken on January to May 2020 using medical record data for glycated hemoglobin (HbA1c) levels (cut off score 7%) and Montreal Cognitive Assessment ver. Indonesia (MoCA-Ina) score (cut off score 26) to evaluate the cognitive function. Statistical bivariate analysis performed using chi-square and multivariate analysis covariate variables using logistic regression. Results: Uncontrolled diabetes mellitus as shown by a high HbA1c level were significantly increase the risk of cognitive decline. The study showed a significant relationship between HbA1c levels with cognitive function (OR=5,98; CI 95% 2,25-15,58; p=0,000). A logistic regression analysis of various cognitive functions showed that memory was the most affected domain in patient with uncontrolled type 2 diabetes. Conclusion: Uncontrolled diabetes mellitus as shown by a high HbA1c level were significantly increase the risk of cognitive decline and the most affected domain was memory.
ASSOCIATION BETWEEN COGNITIVE IMPAIRMENT AND 6-12 MONTHS QUALITY OF LIFE IN ISCHEMIC STROKE Kadex Reisya Sita Damayanti; Pinzon, Rizaldy Taslim
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.22

Abstract

Background: Stroke is a major contributor to deaths and disabilities worldwide. Impaired cognitive function is often found in ischemic stroke patients. Disability due to stroke causes functional impairment in various quality of life domains. Cognitive function is one of the predictors of the quality of life. There are still not many studies on cognitive impairment and quality of life in ischaemic stroke patients in Indonesia. Objective: To compare the average quality of life of 6-12 months of stroke patients at the Bethesda Hospital Yogyakarta Neurology Center based on the presence of cognitive impairment Methods: The study used a retrospective cohort study design. Subject data were obtained from the Bethesda Hospital Yogyakarta stroke registry. All risk factor data (laboratory and clinical) and medication were obtained during admission. Cognitive impairment was measured using the Mini Mental State Examination (MMSE) and Clock Drawing Test (CDT). The questionnaire used was World Health Organization Quality Of Life BREF (WHOQOL-BREF). Results: From 113 patients, average quality of life of patients in domain 1, domain 2, and domain 3 was not significant (p > 0.05). A significant mean difference between cognitive impairment and quality of life was found in domain 4 (p = 0.025). Analysis of the confounding variables showed that a history of hypertension, National Institute of Health Stroke Scale (NIHSS) score, diabetes, and atrial fibrillation also had an effect on the patient's quality of life. Conclusion: Cognitive impairment does not have a significant effect on quality of life, especially in the domains of physical health, psychological health, and social relations, but has a significant effect on the environmental health domain of ischemic stroke patients.
APPLICATION OF NON-INVASIVE GAMMA KNIFE THERAPY IN TERM OF BRAIN TUMOR TREATMENT: A LITERATURE REVIEW Harahap, Iqbal Alaudilah; Uniplaita, Agatha Gavia; Huwae, Laura Bianca Sylvia; Aini, Tarisha Noer; Titaley, Christiana Rialine
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.25

Abstract

Gamma knife radiosurgery (GKRS) is a method of stereotactic radiosurgery (SRS) therapy that used in medical therapy for benign or malignancy brain tumor patient. The aim of this article is to know efectivity of GKRS method for brain tumor therapy based on new study that focused on therapeutic advantages, type of tumor, factors that influence therapy, side effect of therapy, complication, and new study of GKRS therapy. This study is a narative literature review that be formed based on PRISMA-P guideline in 2015 through stages collecting, analysis, and citation of related journal. Colleted journal article was founded from PubMed with the topics are gamma knife, treatment, and brain tumor that include with the topics based on publication year, language, title, and abstract. Based on the results of the analysis, GKRS is SRS therapy that common used for patient with primary brain tumor or brain metastasis. GKRS therapy for patient with brain metastasis can decrease the risk of radionecrosis (RN) than whole brain radiotherapy (WBRT). The use of GKRS most often causes several symptoms after treatment such as perilesional oedema, syncope, and anxiety. New study showed there are therapy combination between SRS and WBRT such as intensity-modulated radiation therapy (IMRT) that increasead efectivity of therapy for patient with brain tumor. GKRS therapy showed that overall this therapy is effectiveness and recommended as non-invasive therapy for patient with primary brain tumor or brain metastasis.

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