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JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 259 Documents
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Antioxidant Properties of Various Yacon Leaf Water Extracts and Physicochemical Profile of Decoction During Refrigerated Storage Wicaksana, Firman; Hartanti, Dwi; Hamad, Alwani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.128-136

Abstract

Background: Yacon (Smallanthus sonchifolius (Poepp.) H.Rob.) leaves show promising antioxidant properties, and have traditionally been  used for diabetes management in Baturraden, Banyumas, Central Java, Indonesia. This study evaluated the effects of traditional extraction methods and crude drug-to-solvent ratios on the content and activity of antioxidants and physicochemical properties of yacon leaf water extracts during storage. Methods: Crude drugs were extracted by infusion, short-time decoction, and longer-time decoction at ratios of 1:10, 1:20, and 1:100 (w/v). Antioxidant content was analyzed using standard total flavonoid content (TFC) and total phenolic content (TPC). The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and ferric-reducing antioxidant power (FRAP) assays. Yacon leaf water extracts at a ratio of 1:20 (w/v) were stored in tightly closed bottles at 4±2°C for 26 days. The organoleptic characteristics, color, pH, TFC, TPC, and DPPH scavenging activity were evaluated on days 0,1, 3, 6, 12, 18, and 26. Results: The different methods and crude drug-to-water ratios generated different antioxidant activities and contents of the yacon extracts. Yacon leaf decoction for 15 min in a ratio of 1:20 (w/v) produced extract with the best scavenging activity (450.27±5.48 mM Trolox equivalent (TE)/100 g dry weight (DW)), TFC (6.43±0.18 mg Quercetin equivalent (QE)/g DW), and TPC (3.91±0.04 mg gallic acid equivalent (GAE)/g DW). The yacon leaf decoction started to undergo aroma and PH changes on days 3 and 6, respectively. On day 12, the TFC, TPC, and DPPH SA of yacon leaf decoction remained 93.93±3.70, 96.52±1.81, and 89.99±0.91% of the freshly prepared extract, respectively. Conclusion: Our results suggest that extraction using the decoction method for 15 min at a water-to-crude drug ratio of 1:20 (w/v) generated an extract with the best antioxidant profile, which chemically started to change on day 12 during refrigerated storage.
Network Pharmacology Approach to Acalypha indica L. and Plumbago zeylanica L. As Anti-Rheumatoid Arthritis Candidates Dini Afriliza; Rina Herowati; Ana Indrayati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.204-218

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that can reduce quality of life. Currently, the goal of therapy is to achieve remission and prevent joint damage and disability. Acalypha indica L. and Plumbago zeylanica L. are known to be involved in rheumatoid pathogenesis. Objective: This study aimed to determine the compounds in Acalypha indica L. and Plumbago zeylanica L. that correlate with target proteins and anti-rheumatoid arthritis mechanisms. Methods: Plant compound data were collected from the KNApSAcK and IMPPAT databases, target protein data were collected using the KEGG pathway, validated using UniProt, and protein-protein interactions were analyzed using STRING. Target protein prediction using SwissTarget Prediction and SEA. Visualization of network pharmacology profiles using Cytoscape software based on the correlation between plant compounds and target proteins. Results: Acalypha indica L., which correlates with target proteins, contained quinine, gallotannin, 1,4 benzoquinone, chrysin, and kaempferol. For Plumbago zeylanica L., the compounds were vanillic acid, cinnamic acid, plumbagin, isoaffinetin, isoorientin, isovitexin, methylnaphthazarin, l-tryptophan, beta-sitosterol, stigmasterol, ficusin, suberosin, and quercetin 3-ol-rhamnoside. Conclusion: Network pharmacology visualization results showed that both Acalypha indica L. and Plumbago zeylanica L. correlated with disease target proteins in their respective rheumatoid arthritis signaling pathways.
Analysis of Cayenne Pepper Fruit (Capsicum frutescens) in Inhibiting HMG-CoA Reductase Activity as a Treatment for Hypercholesterolemia La Ode Muh. Albar; Tien; Amiruddin Eso
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.230-241

Abstract

Background: Hypercholesterolemia is a major cause of cardiovascular disease and its incidence continues to increase. Statins are a group of hypercholesterolemic therapies known to trigger various side effects; therefore, statin alternatives need to be investigated. The cayenne pepper (Capsicum frutescens) contains secondary metabolites that inhibit the activity of cholesterol-forming enzymes (HMG-CoA reductase).  Objective: The aim of this study was to identify the ability of C. frutescens fruit to inhibit HMG-CoA reductase activity to prevent hypercholesterolemia. Methods: This was a true experimental study using a posttest-only control group design. The independent variables were n-hexane, methanol, and ethanol extracts of C. frutescens fruit, each with a concentration of 0.01%, with HMG-CoA reductase activity as the dependent variable. Enzymatic activity was measured enzymatically using spectrometry. Results: The mean values of % inhibition from n-hexane, methanol, and ethanol extracts of C. frutescens and pravastatin were 95.74%, 104.70%, 100.11%, and 99.27%, respectively.  The average specific activities of n-hexane, methanol, and ethanol extracts of C. frutescens and pravastatin were 0.5765, 0.6029, 0.5513, and 0.5716 units/mgP, respectively. There was a significant difference between the sample groups in the inhibition of HMG-CoA reductase activity. HMG-CoA reductase inhibitory activity was highest in the methanol extract, followed by the n-hexane extracts. The activity of these extracts was higher than that of pravastatin alone. Conclusion: The methanol extract showed the best inhibitory activity. C. frutescens has been shown to have great potential in inhibiting the activity of the enzyme HMG-CoA reductase and preventing hypercholesterolemia.
Potential of Graptophyllum pictum Leaf Decoction as an Immunomodulator: Modulation of Macrophage Phagocytosis and Lymphocyte Proliferation Anidasari Irdanita; Selvia Natasya; Yumna Alifah; Aji Winanta
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.192-203

Abstract

Background: Red pudding leaves (Graptophyllum pictum) are commonly used by the Lebong community in Bengkulu as an immune system-enhancing drink containing flavonoids, glycosides, saponins, tannins, and triterpenoids. Objective: This study aimed to evaluate the potential of red pudding leaves as immunomodulatory agents in vitro and assess their total flavonoid content. Methods: The extraction method employed was a decoction, and the flavonoid content was measured using the TLC method by calculating the resulting Rf value and utilizing the LC-MS technique. The total flavonoid content was quantified using a colorimetric method, and immunomodulatory activity was assessed based on the phagocytosis capacity, phagocytosis index, and lymphocyte proliferation. Results: The results showed that red pudding leaf contained flavonoid compounds based on the LC-MS method in the form of trans-3-Indoleacrylic acid, schaftoside, adenine, corymboside, fraxetin and 4-coumaric acid. The total flavonoid content obtained at a concentration of 7.5% amounted to 74.937 mg QE/g; at a concentration of 15%, it amounted to 75.483 mg QE/g; and at a concentration of 30%, it amounted to 97.825 mg QE/g. All red pudding leaf infusion concentrations increased macrophage phagocytosis activity and lymphocyte cell proliferation. Conclusion: In conclusion, red pudding leaves show potential for development as an alternative beverage to enhance the immune system.
An Effectiveness Test Combination of Ethanol Extracts of Buas-buas Leaves (Premna serratifolia L.) and Sappan Wood (Caesalpinia sappan L.) as Topical Antiinflammatory Agent in Male White Rats (Rattus novergicus) Isnindar; Purnamaputra, Alfred; Luliana , Sri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.356-365

Abstract

Background: Inflammation is the reaction of the immune system to tissue damage resulting from physical injury, harmful chemicals, or microbial agents. Steroid and non-steroid drugs are commonly used to treat inflammation, but long-term use can result in side effects, such as hormonal disorders and gastric ulcers. Buas-buas leaves and sappan wood has potential as traditional medicines, and based on empirical evidence, they utilize both plants as anti-inflammatory, antibacterial, antioxidant, antiallergic, and antiarthritic agents, as well as for the treatment of cardiovascular disorders, cough, and leprosy. Objective: This study aimed to evaluate the effect of combining 96% ethanol extracts from buas-buas leaves and sappan wood to deliver topical anti-inflammatory benefits. Methods: This research was experimental, using thirty male rats divided into six treatment groups: a negative control group with 2% carrageenan, Biocream® control group, a positive control group with Hydrocortisone Acetate, and three treatment groups receiving a combination of ethanol extracts from buas-buas leaves and sappan wood at concentrations of 1.67%, 2.5%, and 3.75%. The test compounds were administered after carrageenan injection. Measurement of skinfold thickness on the backs of the rats was conducted every hour for 6 h using digital calipers, and the difference in skinfold thickness of each rat, AUC value, and percentage of inflammation inhibition was calculated. Data analysis involved the Kolmogorov-Smirnov test and Levene's test to assess normality and homogeneity, respectively, and was subsequently followed by One-way ANOVA and a post-hoc test. Conclusion: The combination of ethanol extracts of Buas-Buas leaves and sappan wood can provide a topical anti-inflammatory effect, with the most effective concentration being 3.75% and an inflammation inhibition percentage of 32.77%.
Potential Combination of Dayak onion Eleutherine palmifolia L. and Chrysanthemum flower Chrysanthemum indicum L. as Anti-aging: Network Pharmacology Approach Fitriyani; Salsabila Eka Setia Ningrum; Roihatul Mutiah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.219-229

Abstract

Background: An anti-aging agent is a preparation or product used to inhibit skin aging. Aging occurs because of cell damage caused by free radicals. Therefore, anti-aging agents, which contain antioxidants to inhibit oxidative stress caused by free radicals, are needed. Dayak onion (eleutherine palmifolia (L) Merr.) and chrysanthemum flowers (Chrysanthemum indicum L.) have high antioxidant content, which has the potential to inhibit aging. Objective: To determine the anti-aging potential of dayak onion and chrysanthemum flower compounds Methods: Network pharmacology was performed using GeneCards (https://www.genecards.org) to obtain target genes, Cytoscape v3.10.1 software (https://cytoscape.org), DisGeNET (https://www.disgenet.org), STRING (https://www.string-db.org/), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) PATHWAY (https://www.genome.jp/kegg/pathway.html). Results: Based on Network Pharmacology, dayak onion and chrysanthemum flowers showed that 14 of the 200 target proteins were involved in biological processes and signaling pathways for premature aging syndrome. Conclusion: The combined compound from dayak onion and chrysanthemum flower has anti-aging activity due to seven bioactive components in the hydroxycinnamic acid group. This compound influences biological processes and longevity by regulating the CAD, SIRT1, and TP53 signaling pathways. Therefore, the combination of dayak onion and chrysanthemum flowers has potential as an anti-aging agent.
Development of an Ocular Film Containing Ofloxacin in a Chitosan Matrix Fauziah, Arsy; Suciati, Tri; Julianti, Elin
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.366-377

Abstract

Background: Chitosan is a natural polymer that is widely used in pharmaceutical applications owing to its biodegradability and biocompatibility. High molecular weight chitosan, which is commonly found in the market (Sigma Aldrich), is acid soluble and thus limits its application for ocular purposes. Objective: This study aimed to improve the characteristics of high-MW chitosan ocular films by utilizing a water-soluble, low-MW chitosan modifier for the delivery of ofloxacin post-surgery. Methods: Various film formulas were prepared using high-MW chitosan as the main polymer matrix, glycerin and polyethylene glycol 400 as plasticizers, and low-MW chitosan as film modifiers. Glycerine was the best plasticizer that produced a good film appearance when added at an appropriate ratio, 8.33 times the weight of the high MW chitosan (TGc) and 6.25 times the weight of low- and high-MW chitosan blends at (1:1) ratio (MGb). The films were further developed as TGcs and MGbs were cross-linked using sodium tripolyphosphate to control the release of ofloxacin and improve its mechanical characteristics. Water absorption capability, mechanical characteristics, in vitro drug release, and antimicrobial activity were evaluated to determine the film formula. Results: The MGb formula showed the highest water absorption (approximately 230 %), while the lowest was shown by the TGcs formula (approximately 145 %). In contrast, the TGcs formula had the highest film elasticity (141.33±8.81%), and the MGb formula had the lowest (42.55±6.11%). Surprisingly, the best controlled release of ofloxacin for up to 24 h was produced by the MGbs film, which also showed the highest antimicrobial activity. MGbs also showed moderate film characteristics, which are suitable for ocular applications. Conclusion: The research concluded that The addition of water-soluble low-MW chitosan and a cross-linker agent can improve the controlled release and characteristics of chitosan-based ocular films.
Evaluation of Adverse Drug Reactions (ADRs) in Breast Cancer Patients Who Received Doxorubicin, Cyclophosphamide (AC) and Doxorubicin, Cyclophosphamide, Paclitaxel (AC-T) Chemotherapy at West Nusa Tenggara Provincial Hospital Baiq Lenysia Puspita Anjani; Baiq Nurbaety; Baiq Leny Nopitasari; Rahma Nanda Muriani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.253-259

Abstract

Background: Chemotherapy is commonly used to treat breast cancer (BC). Chemotherapy may cause ADRs in patients, affecting their physical and psychological wellbeing. Objective: To understand the adverse drug reaction (ADR) profile in patients with breast cancer who received AC-T and AC chemotherapy at the West Nusa Tenggara Provincial Hospital. Methods: This observational study used cross-sectional data collected from medical records and direct interviews with the patients between May and June. Probability categories were measured using the Naranjo algorithm questionnaire, causality categories were measured using a causality flowchart, and the severity level of ADRs was determined using the Common Terminology Criteria for Adverse Events (CTCAE) 5.0. Results: The probability results for the AC-T regimen were as follows: possible (10 %), probable (54.44 %), and definite (35.56 %). whereas The AC regimen showed categories of possible (6.67%), probable (63.33%), and definite (30%). The causality results for the AC-T regimen were categorized as unlikely (1.11%), possible (12.22%), probable (25.56%), or certain (61.11%), whereas those for the AC regimen were categorized as possible (6.67%), probable (43.33%), or certain (50%). The most common ADRs were alopecia and nausea, with the highest probability in the probable category for AC-T (54.44%) and AC (63.33%), respectively. Conclusion: Respondents who received the AC-T regimen experienced more severe ADRs in terms of hematologic disorders (anemia, leukopenia, and thrombocytopenia) and symptoms of nausea, pain, and fever than those who received the AC regimen.
Formulation and Characterization of Analog Rice Using Arrowroot (Maranta arundinacea L.) and Hibiscus Flower (Hibiscus rosa sinensis L.) Antari, Arlita Leniseptaria; Saraswati, Indah; Eva Annisa; Anfa Adnia Fatma
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.386-394

Abstract

Background: Efforts to reduce high-carbohydrate consumption from rice include the development of analog rice from alternative sources such as arrowroot tubers (Maranta arundinacea L.). Proper formulation is crucial for producing analog rice with optimal quality, taste, and characteristics resembling conventional rice, while maintaining functional properties to meet carbohydrate and nutritional needs. Hibiscus (Hibiscus rosa-sinensis L.), which is rich in flavonoids, saponins, and anthocyanins, can enhance these formulations. Objective: The objective of this study was to evaluate the composition of a blend of arrowroot tubers (M. arundinacea L.) and hibiscus (H. rosa-sinensis L.) as a rice substitute. Methods: This study used 50 untrained panelists to conduct organoleptic tests on the shape, color, aroma, taste, and texture of rice and analog rice using five formulas (F1, F2, F3, F4, and F5). Furthermore, physical characteristics were tested, including the color index, 1000-grain weight, bulk density, and starch digestibility. Results: The characteristics test proved that all analog rice formulas had an average hedonic score in the range of 3.73-3.90; lower bulk Density than rice with a bulk density of 0.83 ± 0.02 g/mL; starch digestibility in the range of 0.62-0.67 g/mL; and has a yellow-red color range. Conclusion: The best and most preferred rice analog is Formula 5 (F5), with a composition of arrowroot tubers 57.8%, hibiscus 5.1%, mocaf 12.6%, GMS 0.6%, and water 23.9%.
Systematic Review of Green Seaweed Caulerpa racemosa as an Anti-Inflammatory Agent: Current Insights and Future Perspectives Prayogo, Ega Widya; Irawati Sholikhah; Suciati; Dej-adisai, Sukanya; Retno Widyowati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.156-173

Abstract

Background: Seaweed is a marine biota with many benefits, one of which is C. racemosa. It is one type of seaweed that is quite widely found in Indonesia. Objective This study investigated the anti-inflammatory activity of C. racemosa using various in vitro and in vivo approaches. Methods: A literature review was conducted by searching for research data on C. racemosa. The literature was obtained from PUBMED, ScienceDirect, Scopus, SpringerLink, and Google Scholar using the keywords C. racemosa, sea grapes, in vivo, in vitro, and anti-inflammatory. The search identified 1313 articles with 100 articles in Scopus, 100 articles in ScienceDirect, 0 articles in PubMed, 3 articles in SpringerLink, and 1,110 articles in Google Scholar. Results: The study showed 12 articles found C. racemosa has the ability as an anti-inflammatory both with in vitro and in vivo study approaches and supported by data on proximate composition which is quite high and substance consisting of various bioactive constituents including flavonoids, phenolics, phytosterols, terpenoids, saponins and alkaloids where the anti-inflammatory active isolate caulerpin was successfully isolated. C. racemosa is able to reduce the inflammatory response by inhibiting NO production and the release of cytokines and inflammatory mediators such as AMPK, mTOR, TNF-α and IL4. Conclusion: C. racemosa indicated that this species is a rich source of phytochemicals with many pharmacological activities, one of which is anti-inflammatory. Further research is required to explore the relationship between secondary metabolites and their activities.

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