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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 259 Documents
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Pharmacy Students’ Readiness for Offline Learning in The New Normal Transmission of COVID-19: A Cross-Sectional Study Budi Suprapti; Ratri, Dinda Monika Nusantara; Mareta Rindang Andarsari; Ritonga, Fany Devita; R.R. Endang Lukitaningsih; Enda Mora; Enok Nurliawati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.34-41

Abstract

Background: Pharmacy students consist of undergraduate and professional pharmacy students. They are candidates for future pharmacist health workers who require practical experience. Offline learning with hands-on practice methods in health facilities supports their professional skills. Objective: This study aimed to determine pharmacy students' knowledge and attitude toward implementing offline learning methods during the new normal era. Methods: This study involved pharmacy students from Indonesia who were asked to participate in an e-questionnaire about the vaccination program, COVID-19 health protocols, pharmacist competence, and attitude toward implementing offline learning. The students' scores were based on their knowledge and attitude. Statistical analysis was performed to compare the scores between the two groups, and a correlation test was conducted to assess the relationship between the students' knowledge and attitudes. Results: A total of 652 pharmacy students were divided into two groups, undergraduate and professional pharmacy students, in a 3:1 ratio. About 74.6% of undergraduate students and 78.5% of professional pharmacy students had good and moderate knowledge. The level of knowledge was not different between the two groups (p=0.602; p>α). Professional pharmacy students were more ready to engage in offline learning compared to undergraduate students (p=0.001; p<α). However, there was a relatively low correlation between knowledge and attitudes, with r = 0.079 (p=0.043; p<α). Conclusion: Professional pharmacy students are more ready for offline learning methods than undergraduate students, particularly in hands-on field practice.
Skin Penetration of Corn Silk (Zea mays L.) Transdermal Patch on Wistar Mice Skin Using Franz Diffusion Cell Alzahra, Dita Fatimah; Lestari, Ayu Diah; Haryadi, Elvan; Malau, Nur Aisyah; Risanli, Vio Agister; Fitria Apriani, Elsa Fitria Apriani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.20-33

Abstract

Background: Corn silk (Zea mays L.) contains many active compounds, especially the flavonoid quercetin which has pharmacological activity as an antihyperlipidemic agent by reducing cholesterol and triglyceride levels in the body. Antihyperlipidemic treatment by oral route, such as statin drugs, has the disadvantage of experiencing a first-pass effect in the liver, which reduces the bioavailability of the drug. In addition to avoiding the first-pass effect, transdermal patches can improve patient compliance because they are easy to use. Objective: This study aims to optimize the transdermal patch formula of corn silk extract and test the penetration of the optimum formula by in vitro. Method: Optimization of the formula using the Regular Two-Level Factorial Design method on Design Expert®. This study used 2 factors, namely HPMC with a concentration of 3%-4% and PVP with a concentration of 1%-2%. The optimum formula obtained was subjected to in vitro penetration test using Franz diffusion cell. Results: Based on the results of factorial design analysis, the optimum formula of transdermal patches is at HPMC and PVP concentrations of 3.49% and 1% with moisture content, moisture uptake, percentage of elongation, and folding endurance respectively of 7.79%, 4.19%, 13.26% and 470.58 fold. The optimum formula of corn silk extract transdermal patch preparation also had an optimum percent cumulative amount of penetrated flavonoids of 96.06% and flux of 6.17 µg/cm2.hour at 3 hours. Conclusion: Transdermal patch dosage of corn silk extract with HPMC and PVP concentrations of 3.49% and 1% proved to have good characteristics and penetration rate.
Identification of Drug Related Problems (DRPs) in Rheumatoid Arthritis Patients at Palembang City Hospital Hairun Niza; Sarah Hanifah Az-Zahra Anwar; Sintya Merinda
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.112-119

Abstract

Background: Rheumatoid arthritis is a chronic systemic inflammatory arthritis disease that affects mainly synovial joints. The incident of RA can lead to the emergence of complications or comorbidities, which then allows patients to receive a variety of therapies that can trigger the incidence of DRPs during the treatment. The prevalence of RA in Indonesia itself in 2018 has reached 7.30%, with the highest percentage occurring in the elderly age group and more prevalent in women. Objective: This study aimed to determine the incidence of DRPs in RA patients in Palembang city hospitals based on the category of DRPs identified as related to drug selection and dose selection problems, as the relationship between demographic factors and the incidence of DRPs. Methods: This research is non-experimental study conducted with a retrospective cross-sectional survey. Data collection was carried out by looking at patient medical record data at X and Y Hospital in Palembang from January 2021 to March 2023. Results: The results showed that the most frequent drps in the drug selection category were drug interactions (72.03%), while in the dose selection category were insufficient dosage regimens (60.74%). The results of bivariate analysis between the incidence of DRPs and gender (p=0.809), age (p=0.879), the number of drugs used (p=0.001), and comorbidities (p=0.089). Conclusion: There is no relationship between demographic factors and comorbidities with the incidence of DRPs, and there is a relationship between the number of drugs and the incidence of DRPs.
Jatropha curcas L. Leaf Extract Effects on Blood Pressure and Lipid Levels in Hypertensive Rats with High-Fat Diet Moch. Saiful Bachri; Wiki Yuli Anita; Putri Dwi Lestari; Desi Eko Wulansari; Dwi Retno Nengtyas; Muhammad Ma'ruf; Sapto Yuliani; Wahyu Widyaningsih; Laela Hayu Nurani; Daru Estiningsih; Vivi Sofia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.61-70

Abstract

Background: One of the main risk factors for cardiovascular diseases such as coronary atherosclerotic heart disease (CAHD) is dyslipidaemia or high levels of low-density lipoprotein (LDL) and triglycerides (TG) and low levels of high-density lipoprotein (HDL). Hypertension is also a cause of cardiovascular disease. One potential plant to lower LDL levels and blood pressure is Jatropha curcas, which is known to contain saponins, polyphenols, and flavonoids. Objective: The purpose of this study was to determine the effect of the ethanol extract of Jatropha curcas leaves (EEJCL) on blood pressure, LDL levels, and HDL levels in hypertensive rats given a high-fat diet. Methods: This study is an experimental study with a pretest-posttest control group design on male Wistar strain rats. Rats were divided into seven groups, namely the normal group, control group (induced with NaCl and given a high-fat diet), Captopril group, Simvastatin group, and EEJCL groups given doses of 1.8, 2.7, and 4.05 g/kg BW. The data obtained were analysed using the One-Sample Kolmogorov-Smirnov Test, Homogeneity of Variance, One-Way ANOVA, and Tukey Test. Results: The results showed that the administration of EEJCL could significantly lower LDL levels and blood pressure and increase HDL levels (p < 0.05) at doses of 1.8, 2.7, and 4.05 g/kg BW, and the dose of 4.05 g/KgBW was the most optimal dose. Conclusion: EEJCL has a potential for development in the treatment of hypertension and dyslipidaemia.
The Effect of Education on Writing Integrated Patient Progress Notes (IPPNs) at Several Government Hospitals in Bukittinggi, Indonesia Suhaili, Serdiani; Hansen Nasif; Yelly Oktavia Sari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.101-111

Abstract

Background: The writing of Integrated Patient Progress Notes (IPPNs) by pharmacists generally does not fulfil the correct writing standards. Objective: This study aimed to analyze the effect of education on the level of knowledge and writing profile of IPPN. Methods: A prospective analytic method research design was used with data collection techniques through questionnaires and total sampling for IPPN data. The researcher developed a valid and reliable questionnaire to measure pharmacists' level of knowledge. Education was conducted through "Focus Group Discussion" with PowerPoint slides of SOAP method writing material and SOAP framework leaflets. Quantitative analysis of IPPN data was performed using the Wilcoxon test on SPSS. Results: The results showed that the highest percentage of pharmacists' knowledge level before education was A.M Hospital (87%) and after education was B Hospital (95%). The profile of IPPN writing by pharmacists before being given education showed the highest percentage of IPPN writing suitability was at A.M Hospital (21.6%), and the completeness of IPPN writing was at M.H Hospital (99%). After education, the highest percentage of IPPNs writing suitability was in B Hospital (64.3%), and the completeness of IPPNs writing was in M.H Hospital (97.9%). Education has an effect on pharmacists' knowledge level (p-value 0.029) and the appropriateness profile of IPPN writing (p-value 0.013). However, education did not affect the completeness of writing Integrated Patient Progress Notes (IPPNs) (p-value 0.285). Conclusion: Education succeeded in improving pharmacists' knowledge of writing CPPT correctly.
Molecular Docking and QSAR Study of 5-O-acylpinostrobin Derivatives as Topoisomerase IIα Inhibitors Rahmah, Siti; Widiandani, Tri; Ekowati, Juni; Adi Priatna, Puja
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.120-127

Abstract

Background: Cancer is one of the top causes of death worldwide. A wide range of illnesses known as cancer can start in almost any organ or tissue in the body when abnormal cells multiply uncontrollably. Cancer patients have higher levels of the Topo IIα protein in their cells, this protein has been proposed as a relevant target for anticancer treatment development. Objective: This study aims to predict the anticancer activity of pinostrobin and 5-O-acylpinostrobin derivatives against topoisomerase IIα by docking molecular and QSAR study. Methods: In silico analysis was performed using the structure of the topoisomerase IIα (PDB: 5GWK)) as templates. Molecular docking analysis was performed with AutoDock Vina. Result: All 5-O-acyl pinostrobin derivatives, showed lower ΔG values than the parent pinostrobin. The 5-O-acetyl pinostrobin compound showed the highest score, namely -9.14 kcal/mol. 5-O-acetyl pinostrobin is predicted as the most powerful inhibitor that can cause inhibition of topoisomerase IIα. Conclution: The results of the best QSAR equation obtained can be used as a reference for predicting the activity of the new pinostrobin derivatives to be synthesized by inserting the electronic (Etot) parameter values of the compounds into the equation.
Standardization of Myristicin in Nutmeg (Myristica fragrans Houtt.) Fruit using TLC-Densitometric Method Engel, Daniella Elizabeth; Sudjarwo; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.12-19

Abstract

Background: Myristica fragrans Houtt. (Myristicaceae family), with the main content of myristicin, has been immensely used in herbal medicine. Standardization is essential to ensure the safety of natural extracts and the quality of herbal medicines using various chemical analysis techniques. Method validation is necessary to ascertain the reliability and reproducibility of the method. Myristicin is a member of the phenylpropene group, a natural organic compound found in small amounts in nutmeg fruit, which has pharmacological effects. Objective: This study aims to determine the myristicin content in nutmeg fruit using TLC-Densitometry. Methods: Determination of myristicin in nutmeg fruit extract was performed using TLC-Densitometry with silica GF254 as stationary phase, mobile phase n-hexane: ethyl acetate (8:2 v/v), and spot visualized at 285 nm. In this study, the content of myristicin in nutmeg fruit was determined using compendial methods (AOAC), thus requiring method verification with parameters including selectivity, linearity, precision, LOD, and LOQ. Results: The validation of this method showed good linearity and selectivity with y = 0.0001x + 0.0226 (r = 0.9996) and 1.53 (>1.5), respectively. The LOD and LOQ results were low with values of 0.11 μg/spot and 0.33 μg/spot, respectively. The percentage coefficient of variation for precision was below the requirement value of not more than 4%. The average myristicin content in nutmeg fruit extract was approximately 0.0017 ± 0.0003% (w/w). Conclusion: The developed method was valid and sensitive for the quantification of myristicin content in nutmeg fruit.
Characterization and Stability Test of Hydrolyzed Collagen Glyserosomes Safiul Fitria, Nur Indah; Erawati, Tristiana; Miatmoko, Andang; Soeratri, Widji
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.71-79

Abstract

Background: Hydrolyzed collagen is a protein obtained from enzymatic denaturation of collagen with a molecular weight of about 10 kDa, and it has been reported to produce anti-aging properties. Delivering hydrolyzed collagen into the dermis becomes a great challenge due to its large molecular weight, so glycerosome, a deformable vesicle containing glycerol as the edge activator, was developed to carry it into the dermis layer. Objective: The study aimed to determine the effect of increasing the concentration of glycerol and hydrolyzed collagen on the characteristics and stability of hydrolyzed collagen glycerosomes. Methods: Glycerosomes were composed of soy lecithin and prepared using a thin film lipid method. The lipid film was hydrated with phosphate-buffered saline pH 5 containing different glycerol concentrations (20% and 40%) and hydrolyzed collagen (2.5% and 5%). Then, characteristic tests and stability tests were carried out. Results: Hydrolyzed collagen glycerosomes had vesicle sizes of 170-180 nm, polydispersity index of 0.253-0.279, zeta potential values of -23.70 to -26.50 mV with deformability indexes of 2.25-3.49. The highest percentage of entrapment efficiency was 85.72%, achieved with a glycerol concentration of 40%. During the stability test at 25°C for 12 weeks, the hydrolyzed collagen glycerosomes did not experience pH and entrapment efficiency changes, but it increased the vesicle size. Conclusion: The use of 40% glycerol produced more deformable vesicles than 20% glycerol in hydrolyzed collagen glycerosomes; however, a formula improvement is required to improve the stability of glycerosomes.
Application of the Simplex Lattice Design Method to Determine the Optimal Formula of Diclofenac Sodium Nanoemulsion Nahdhia, Nadhifatun; M. Agus Syamsur Rijal; Esti Hendradi; Riyanto Teguh Widodo
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.137-146

Abstract

Background: The success of nanoemulsion preparation, with the aim of producing good characteristic values, is determined by the ratio of each component. The design of experiments (DoE) approach using the Simplex Lattice Design (SLD) method can be used to determine the optimal formula for nanoemulsions, with variable factors consisting of oleic acid, Tween 20:ethanol (4:1), and water. The observed response variables included droplet size, PDI, and pH. Objective: DoE can help reduce the energy, cost, and time needed to make the optimal formula for diclofenac sodium nanoemulsions. Methods: Nanoemulsions were prepared using low-energy emulsification. Their characteristics were evaluated and analyzed using Design Expert software. Results: The optimal nanoemulsion formulation consisted of 4.17% oleic acid, 37.5% emulsifier (Tween 20: ethanol, 4:1), and 58.33% water. The nanoemulsion characteristics were good, with 20.37 a droplet size, 0.42 PDI, of 4.75 pH. The observed values were not significantly different from the predicted values, and the formula could effectively trap 1% diclofenac sodium. Conclusion: The simplex lattice design method is very useful for pharmaceutical development, such as nanoemulsion optimization.
A Comparative Study of Randu Honey Antimicrobial Activity from Several Regions in Java Nindya Pramesti Wardani; Primaharinastiti, Riesta; Achmad Toto Poernomo; Alfi Khatib
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.147-155

Abstract

Background: Randu honey is monofloral honey sourced from a type of plant nectar. The geographical location of randu (Ceiba pentandra) as the source of nectar is one factor that influences the antimicrobial activity of random honey. This research used randu honey from several regions in Java such as Sidoarjo (RSH), Pusat Perlebahan Nasional Bogor (RBH), Kediri (RKH), and Malang (RMH). Objective: To compare the antimicrobial activity of several random honeys (RSH,RBH,RKH, and RMH) against Gram-negative Escherichia coli ATCC 25922, Gram-positive Staphylococcus aureus ATCC 6538, methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33592, and Candida albicans ATCC 10231. Methods: This study used well diffusion and dilution antimicrobial test methods. The diameter of the inhibition zone formed by the well diffusion method was measured using a Vernier caliper. The diffusion method was used as a screening test before determining the quantitative minimum inhibitory concentration (MIC) using serial dilution at a ratio1 of 2 (v/v). Streptomycin and Ketoconazole were used as positive controls. Nutrient broth and Sabouraud broth were incubated at 37°C for 24 h (antibacterial tests) and 25°C for 48 h (antifungal test), respectively. Results: The well diffusion test revealed that all random honey samples could inhibit the test bacteria and fungi with the appearance of an inhibition zone. Diameter inhibition zone ranged from 14.66±0.52 mm to 27.86±0.43 mm. The MICs of RSH,RBH,RKH, and RMH ranged from 3.12% to 25% against all test bacteria and fungi. Conclusion: The results of this study showed randu honey from Bogor (RBH) has the highest antimicrobial activity based on diffusion and dilution tests.

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