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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Biomedicine and Translational Research WMJ (Warmadewa Medical Journal) Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Majalah Kedokteran Sriwijaya Universa Medicina Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya NurseLine Journal Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Rekonstruksi dan Estetik JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Jember Medical Journal (JMJ)
Desie Dwi Wisudanti
Departemen Farmakologi Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : Universa Medicina

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Nephroprotective effect of soy (Glycine Max (L.) Merr.) flour against diazinon-induced renal toxicity in rats Wisudanti, Desie Dwi; Normasari, Rena; Herdiyana, Firman
Universa Medicina Vol. 39 No. 3 (2020)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2020.v39.192-198

Abstract

BackgroundDiazinon is a widely used pesticide to eradicate agricultural pests globally with the potential to cause harmful effects on humans by generating free radicals and depleting endogenous antioxidants. Soy flour possesses high antioxidant effect. This study evaluated the nephroprotective effect of soy flour  on diazinon-induced nephrotoxicity in rats. MethodsAn experimental laboratory study was carried out involving 30 male Wistar rats were randomly divided into five groups of 6 rats. The normal control (Kn) and the negative control (K-) groups received normal saline, the treatment groups (K1, K2, K3) received 10%, 15%, and 20% soy flour in distilled water, respectively, on day 1 to day 28. Subsequently, for five days, all groups received diazinon 40 mg/kg, except for the normal control group. Blood urea nitrogen (BUN) and creatinine levels were measured at the end of the study. The Kruskal Wallis test with the post hoc Mann Whitney U test were used to analyze the data. ResultsBlood urea nitrogen and creatinine levels were lower in all treatment groups (K1, K2, K3) compared to the negative control group (K-), while the K3 level was the lowest (24.28 ± 1.56 mg/dL and 0.93 ± 0.14 mg/dL).  There was a significant decrease in BUN and creatinine levels in the experimental rats of the 15% and 20% soy flour groups (K2, K3) compared to the negative control group (K-).ConclusionAdministration of soy flour (Glycine max (L.) Merr.) had a nephroprotective effect in preventing increases in BUN and creatinine levels of diazinon-induced nephrotoxic male Wistar rats.
Co-Authors Adelia Handoko Afnan, Muhammad Syifaul Agnellia Maulidya Utami Andriani, Made Prasanti Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Anisa, Devisda Shafiy Annisa Nadhifa Witanto Arifa Mustika Athoillah, Nabil Azham Purwandhono Aziz, Ayu Munawaroh Barus, Marsha Zahra Adyanda Cholis Abrori Cholis Abrori, Cholis Cicih Komariah Diana Chusna Mufida Diana Chusna Mufida Dini Agustina Dwicahyandari, Winie Septhia Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Efensi, Erfan Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Enny Suswati Erfan Efendi F P H, Fransiska Nooril Firman Herdiana Firman Pratama Andraputra Hafa, Muhammad Rafi’uddin Hazbina Fauqi Ramadhan Heni Fatmawati Herdiyana, Firman Hibatulloh, Muhammad Farhan Hidayat, Noval Ida Srisurani Wiji Astuti Jauhani, Muhammad Afiful Laksmi Indreswari M. Ali Shodikin M. Ihwan Narwanto Marwah Pradani Ridlo Maulidiyah, Najma Mei Liana Wati Muhamad Hasan Muhammad Ali Shodikin Muhammad Faizal Akbar Muhammad Haikal Supriyadi Nafisa, Tsabita Nur Lintang Nabilah Sri Kusumasari Octavia, Aulia Mega Nur Pipiet Wulandari Rena Normasari Rini Riyanti Risty Pradana Linggan Wangi Rumastika, Nindya Shinta Salma Naqiyyah Tirtadevi Sarah Kinan Andalusia septa surya wahyudi, septa surya Setyaningrum, Wiwied Hary Sheilla Rachmania, Sheilla Sofi Aliyatul Himah Sugiyanta Sugiyanta Supangat Supangat Suryono Suryono Tegar Syaiful Qodar Tegar Syaiful Qodar Trinita Diyah Permatasari Ulfa Elfiah Wibsono, Sony Widanto, Cika Abadi Laily Yuli Hermansyah Yuli Hermansyah