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Desie Dwi Wisudanti
Departemen Farmakologi Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : NurseLine Journal

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LITERATURE REVIEW: THERAPEUTIC APPLICATION OF GERANIIN FROM RAMBUTAN (Nephelium lappaceum) PEEL EXTRACT AS ANTIHYPERGLYCEMIC THROUGH ITS ANTIOXCIDANT ACTIVITY IN TYPE 2 DIABETES MELLITUS Desie Dwi Wisudanti
NurseLine Journal Vol 1 No 1 (2016): May 2016
Publisher : Faculty of Nursing, Universitas Jember

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Abstract

Diabetes mellitus is a disorder in the metabolism of carbohydrates, lipids and proteins, which is characterized by hyperglycemia. Its prevalence in the world is increasing, especially type 2 diabetes, causes an increased incidence of morbidity and mortality throughout the world due to complications of hyperglycemia. Hyperglycemia stimulates the release of superoxide (O2-) at the level of mitochondria which is the trigger early onset of oxidative stress in patients with diabetes mellitus type 2. Therefore one of the therapeutic modalities that can be developed in type 2 diabetes mellitus is a substance as potent antioxidant. Geraniin of rambutan peel extract is known to have the ability as a potent antioxidant and radical scavenging, so it is possible to be a prime candidate antidiabetes in the ype 2 diabetes melitus. We searched Cochrane Library data bases, Google Scholar, Medline and PubMed, from 2006 to 2016, to assess the effect of rambutan peel extract for type 2 diabetes melitus. We obtained 17 articles in accordance with the inclusion criteria. In the peel of rambutan (Nephelium lappaceum), geraniin is the main phenolic compounds that have the potential ability as an antioxidant and antihyperglycemic through inhibition of alfa-glucosidase and alfa-amylase, preventing the polyol (aldol reductase inhibition) and prevents the formation of advanced glicosilation products (AGEs). There is a very strong correlation between the ability as an antioxidant with the ability to inhibit alfa-glucosidase and alfa-amylase, so geraniin of rambutan peel extract (Nephelium lappaceum) expressed as the ideal candidate for the management of hyperglycemia in individuals with diabetes.
Co-Authors Adelia Handoko Afnan, Muhammad Syifaul Agnellia Maulidya Utami Andriani, Made Prasanti Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Anisa, Devisda Shafiy Annisa Nadhifa Witanto Arifa Mustika Athoillah, Nabil Azham Purwandhono Aziz, Ayu Munawaroh Barus, Marsha Zahra Adyanda Cholis Abrori Cholis Abrori, Cholis Cicih Komariah Diana Chusna Mufida Diana Chusna Mufida Dini Agustina Dwicahyandari, Winie Septhia Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Efensi, Erfan Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Enny Suswati Erfan Efendi F P H, Fransiska Nooril Firman Herdiana Firman Pratama Andraputra Hafa, Muhammad Rafi’uddin Hazbina Fauqi Ramadhan Heni Fatmawati Herdiyana, Firman Hibatulloh, Muhammad Farhan Hidayat, Noval Ida Srisurani Wiji Astuti Jauhani, Muhammad Afiful Laksmi Indreswari M. Ali Shodikin M. Ihwan Narwanto Marwah Pradani Ridlo Maulidiyah, Najma Mei Liana Wati Muhamad Hasan Muhammad Ali Shodikin Muhammad Faizal Akbar Muhammad Haikal Supriyadi Nafisa, Tsabita Nur Lintang Nabilah Sri Kusumasari Octavia, Aulia Mega Nur Pipiet Wulandari Rena Normasari Rini Riyanti Risty Pradana Linggan Wangi Rumastika, Nindya Shinta Salma Naqiyyah Tirtadevi Sarah Kinan Andalusia septa surya wahyudi, septa surya Setyaningrum, Wiwied Hary Sheilla Rachmania, Sheilla Sofi Aliyatul Himah Sugiyanta Sugiyanta Supangat Supangat Suryono Suryono Tegar Syaiful Qodar Tegar Syaiful Qodar Trinita Diyah Permatasari Ulfa Elfiah Wibsono, Sony Widanto, Cika Abadi Laily Yuli Hermansyah Yuli Hermansyah