Article Per Year (5 Year)
p-Index From 2021 - 2026
2.998
P-Index
This Author published in this journals
All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Biomedicine and Translational Research WMJ (Warmadewa Medical Journal) Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Majalah Kedokteran Sriwijaya Universa Medicina Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya NurseLine Journal Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Rekonstruksi dan Estetik JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Jember Medical Journal (JMJ)
Desie Dwi Wisudanti
Departemen Farmakologi Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

Published : 28 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Althea Medical Journal

 1 
Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat Sakinah, Elly Nurus; Supangat, Supangat; Wisudanti, Desie Dwi; Abrori, Cholis; Mustika, Arifa; Wibsono, Sony; Athoillah, Nabil
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3133

Abstract

Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals.Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software.Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p <0.05).Conclusions: There is a relationship between the duration of exposure to chlorpyrifos and butyrylcholinesterase levels in Wistar rats. This fact shows that the longer an organism is exposed to low doses of chlorpyrifos pesticides, the higher the level of neurological system toxicity that occurs in that organism.
Co-Authors Adelia Handoko Afnan, Muhammad Syifaul Agnellia Maulidya Utami Andriani, Made Prasanti Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Anisa, Devisda Shafiy Annisa Nadhifa Witanto Arifa Mustika Athoillah, Nabil Azham Purwandhono Aziz, Ayu Munawaroh Barus, Marsha Zahra Adyanda Cholis Abrori Cholis Abrori, Cholis Cicih Komariah Diana Chusna Mufida Diana Chusna Mufida Dini Agustina Dwicahyandari, Winie Septhia Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Efensi, Erfan Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Enny Suswati Erfan Efendi F P H, Fransiska Nooril Firman Herdiana Firman Pratama Andraputra Hafa, Muhammad Rafi’uddin Hazbina Fauqi Ramadhan Heni Fatmawati Herdiyana, Firman Hibatulloh, Muhammad Farhan Hidayat, Noval Ida Srisurani Wiji Astuti Jauhani, Muhammad Afiful Laksmi Indreswari M. Ali Shodikin M. Ihwan Narwanto Marwah Pradani Ridlo Maulidiyah, Najma Mei Liana Wati Muhamad Hasan Muhammad Ali Shodikin Muhammad Faizal Akbar Muhammad Haikal Supriyadi Nafisa, Tsabita Nur Lintang Nabilah Sri Kusumasari Octavia, Aulia Mega Nur Pipiet Wulandari Rena Normasari Rini Riyanti Risty Pradana Linggan Wangi Rumastika, Nindya Shinta Salma Naqiyyah Tirtadevi Sarah Kinan Andalusia septa surya wahyudi, septa surya Setyaningrum, Wiwied Hary Sheilla Rachmania, Sheilla Sofi Aliyatul Himah Sugiyanta Sugiyanta Supangat Supangat Suryono Suryono Tegar Syaiful Qodar Tegar Syaiful Qodar Trinita Diyah Permatasari Ulfa Elfiah Wibsono, Sony Widanto, Cika Abadi Laily Yuli Hermansyah Yuli Hermansyah