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All Journal International Journal of Integrated Health Sciences Health and Medical Journal jurnal abdimas saintika Nusantara Hasana Journal BULLET : Jurnal Multidisiplin Ilmu AMMA : Jurnal Pengabdian Masyarakat Jurnal Abdimas Kesehatan
Dhuha, Alief
Universitas Baiturrahmah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Vitamin D and Traumatic Brain Injury: A Systematic Review of Preclinical Evidence Jaslindo, Lieka Nugrahi; Sari, Widia; Dhuha, Alief; Handayani, Kurnia Maidarmi; Khudri, Ghaniyyatul Nugrahi; Maribeth, Annisa Lidra
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.2096

Abstract

Traumativ Brain Injury (TBI) triggers multiple secondary injury processes, such as inflammation, oxidative stress, apoptosis, BBB disruption, and impaired autophagy. These mechanisms contribute to progressive neuronal damage and functional decline. Vitamin D has emerged as a potential multi-target neuroprotective agent due to its regulatory roles in immune signaling, oxidative balance, neuronal survival, and autophagy pathways. This systematic review synthesized preclinical evidence evaluating the effects of Vitamin D supplementation in animal models of TBI. A comprehensive search of PubMed, OVID, and ProQuest identified six eligible studies. Across diverse dosing regimens and formulations, Vitamin D consistently improved key TBI outcomes. Reported benefits included reduced apoptosis, decreased neuroinflammation, attenuation of oxidative stress, preservation of BBB integrity, restoration of autophagy flux, and enhanced cognitive performance. Mechanistically, Vitamin D influenced several pathways, including Nrf2 activation, TLR4/MyD88/NF-κB suppression, mTOR and TRPM2 normalization, and improved microglial polarization. Although methodological quality varied, most studies demonstrated moderate rigor and supported the neuroprotective actions of Vitamin D. Heterogeneity in injury models, dosing strategies, and outcome measures limits direct comparison and highlights the need for standardized experimental approaches. Overall, current preclinical evidence indicates that Vitamin D confers robust neuroprotection following TBI. Further studies examining its mechanistic pathways, optimal therapeutic windows, and translational potential are warranted to inform future clinical applications.
Co-Authors Adelin, Prima Ahmad Faried Amellia, Ade Yuli Annisa Lidra Maribeth Fajrima, Mahfira Ghaniyyatul Khudri Hansah, Rendri Bayu Helmizar, Roland Jaslindo, Lieka Nugrahi Khudri, Ghaniyyatul Nugrahi Kurnia Maidarmi Handayani liana, nana Malik, Rifkind Maribeth, Annisa Lidra Mega Pratiwi Irawan, Mega Pratiwi Melya Susanti Muhammad Faisal Muhammad Rizki Saputra Muhammad Rizki Saputra, Muhammad Rizki Muhammad Zafrullah Arifin Nani Jelmila, Sri Nurfitriani Nurfitriani, Nurfitriani Priandana Adya Eka Saputra Putri Wulandini Rahma Triyana Rahmadhoni, Berri Rizki Saputra, Muhammad Ruhsyahadati Ajisman Ruhsyahadati, Ruhsyahadati Rustam, Raihana Sari, Widia Sellia Juwita Sri Wahyuni Suharni Suharni Triyana, Rahma Yurizali, Bun Zahara, Ayuni