Article Per Year (5 Year)
p-Index From 2021 - 2026
2.083
P-Index
This Author published in this journals
All Journal JURNAL GIZI INDONESIA JURNAL PENDIDIKAN TAMBUSAI Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesia Berdaya Nusantara Science and Technology Proceedings Jurnal Kesehatan Tambusai Journal of Pharmaceutical and Sciences. Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Nutrition Scientific Journal Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Herviana, Herviana
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
The Effect of Red Dragon Fruit (hylocereus polyrhizus) Juice on Leptin Levels in Sprague Dawley Rats Using an Overweight Model Solehah, Novia Zuriatun; Herviana, Herviana; Anggriany, Nissa; Anindita, Karina
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 2026: Just Accepted Manuscript and Article In Press 2026
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.0.0.%p

Abstract

Background: Obesity is strongly linked to elevate leptin levels and oxidative stress, both of which contribute to the development of various metabolic disorders. Leptin, a hormone that regulates metabolism and appetite, becomes less effective in obese individuals due to leptin resistance, thereby exacerbating metabolic dysfunction.Objective: This study aims to evaluate the effect of red dragon fruit (hylocereus polyrhizus) juice on leptin levels in Sparague Dawley rats using an overweight model.Method: This experimental study used a pre-post test control group design and involved six groups of rats (n=6 per group), including a normal group, a negative control group, a positive control group (orlistat), and three treatment groups receiving different doses of red dragon fruit juice (3.5 g, 7 g, and 10.5 g per 200 g body weight). The intervention was carried out for 14 days following a 14- day induction of obesity using a high-fat and high-carbohydrate diet. Leptin levels were measured before and after the intervention.  Results: The results showed that administration of red dragon fruit juice significantly reduced leptin levels (p<0,001) in all treatment groups. The greatest reduction was observed in the group receiving the 10.5 g dose, with an average decrease of 75.03%, which was nearly equivalent to the orlistat group that reduced leptin levels by 79.93%.Conclusion: Red dragon fruit juice has the potential to serve as a non-pharmacological agent in reducing leptin levels and oxidative stress under obesity conditions, with an effectiveness approaching that of orlistat.
Co-Authors Anggraini, Citra Dewi Anggriany, Nissa Ayu, Delvita Brian Wasita Chandra, Putra Citra Dewi Anggraini Damayanti, Melly Darwitri, Darwitri Desy Dono Indarto Fidyah Aminin, Fidyah Fitriani Lubis Gemini, Savitri Haqqelni Nur Rosyidah Ikhsan, Khairul Karina Anindita Khaitami, Raisty Novia Zuriatun Solehah Nurkholizah, Nurkholizah Pasaribu, Sudana Fatahillah Rahmadona, Rahmadona Rambe, Indah Permata Sari Reno Irwanto Ristina Rosauli Harianja Rizma, Amalina Simanjuntak, Awan Catharina Letare Siska Pratiwi Siska Pratiwi Tanjung, Pardomuan