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All Journal JURNAL PROMOSI KESEHATAN INDONESIA Jurnal Kedokteran Diponegoro Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Ophthalmologica Indonesiana Indonesian Journal of Pharmacology and Therapy

Nugroho, Trilaksana

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Author-ID : 1148497

Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 24 Documents Claim Missing Document

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Title

Effect Of Topical DLBS 1425 On Tissue Plasminogen Activator (tPA) Expression In Trabecular Meshwork Of Wistar Rats Widijanto, Utami; Nugroho, Trilaksana; Cahyono, Maharani
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Introduction: Tissue plasminogen activator (tPA) in the trabecular meshwork (TM) is a serine protease that important to maintain the aquos outflow resistance by activating the matrix metalloproteinase (MMP). It can cause a degradation of the extracellular matrix, which can maintain the normal flow of aquos humor. However, the use of anti-inflammatory drugs has been shown to reduce the expression of tPA, leading to an increase in the outflow resistance. Therefore, we propose the use of DLBS 1425, an extract of Phaleria macrocarpa which has been proven to have anti-inflammatory effects. Aim : This study aims to determine the expression of tPA in Wistar rats’ TM. Methods : An experimental laboratory study with post-test only randomized controlled group design was performed. Twenty-two Wistar rats were divided into two groups, the control and the experimental. The experimental group was given topical DLBS 1425 at a dose of 6 times / day, for 4 weeks. The control group was given drops of Hyalub Minidose® 6 times / day, for 4 weeks. tPA expression on TM was examined by immunohistochemical staining. Data were collected and processed using the SPSS 15.0 for Windows. Results : The mean tPA expression in TM with Allred scores in the experimental group (0.18 ± 0.60) was significantly lower (p <0.001) than the control group (6.27 ± 0.91). Conclusion : Topical DLBS 1425 suppresses the expression of tPA on the trabecular meshwork of Wistar rats. Key words: tissue plasminogen activator, trabecular meshwork, DLBS 1425, Phaleria macrocarpa.

Dry Eyes Syndrome pada Penderita Diabetes Melitus Tipe 2 Setyorini, Desti Putri; Wildan, Arief; Nugroho, Trilaksana; Julianti, Hari Peni; HS, Heri-Nugroho
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 3 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

BACKGROUND : Type 2 diabetes mellitus patients have risk to suffer from dry eyes syndrome (DES), caused by peripheral and autonomic neuropathy, oxidative stress, and metabolic dysfunction. DES can reduce the patient’s quality of life then it could induce blindness if the patient didn’t get any therapy for DES. It is important to prevent DES by controlling its risk factors. OBJECTIVE : To investigate risk factors of DES in patients with type 2 diabetes mellitus. METHOD : . This study was an analytical observational study with cross-sectional design and purposive sampling. Subjects were examined by using questionnaire and slit lamp, then followed by deep interview in some subjects. This study was also using subject’s medical record to complete the required data. Subjects were diagnosed to suffer DES if OSDI score >12 and schirmer score <10mm. Data was analyzed by using statistic software. RESULT : . From 42 subjects, 19 subjects (45,2%) suffered from DES whereas another 23 subjects (54,8%) didn’t. There was significant relation between diabetic retinopathy (p=0.009) and DES in patients with type 2 diabetes mellitus showed by p value under 0,05 (OR 5.700, 95% CI:1.364-23.821). However, age (p=0.516), gender (p=1.000), level of knowledge (p=0.555), accessibility to health provider (p=1.000), occupation (p=0.644), economic level (p=0.105), smoke exposure (p=0.432), duration of diabetic (p=0.707), diabetic controlling (p=0.305), and history of dyslipidemia (p=0.155) had no significant relations with DES in patients with type 2 diabetes mellitus. CONCLUSION : There is a significant relation between diabetic retinopathy and DES in patients with type 2 diabetes mellitus. Diabetic retinopathy is the most dominant risk factor among the other factors in this study.

Berbagai Faktor Risiko Retinopati Diabetik pada Penderita Diabetes Melitus Tipe 2 Nafia, Nisa Khoirun; Nugroho, Trilaksana; Wildan, Arief; Julianti, Hari Peni; Purnomo, Hery Djagat
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 3 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

BACKGROUND: More than 75% of people with type 2 DM will anguish diabetic retinopathy 20 years after being diagnosed. However, the current changing of people’s lifestyle contributes to the tendency in type 2 DM that diagnosed at a younger age. This causes diabetic retinopathy can be occurred earlier and blindness will occur more quickly. It is important to prevent diabetic retinopathy by controlling some associated factors. OBJECTIVE: To investigate associated factors of diabetic retinopathy in people with type 2 DM. METHOD: Analytic observational study with cross-sectional design. Subjects were determined by purposive sampling. The subjects were interviewed using a questionnaire meanwhile, funduscopic examination is aimed to assess diabetic retinopathy and followed by deep interview. This study also used the subject’s medical record to complete the required data. The results were analyzed by using statistic software. RESULT: From 43 subjects, there wes no significant relation among age (p=0.965), gender (p=0.437), level of knowledge (p=0.640), accessibility (p=1.000), economic level (p=0.680), duration of DM (p=0.477), history of hypertension (p=0.708), and history of dyslipidemia (p=0.244) with diabetic retinopathy in people with type 2 DM. However, there was significant relation among controlling blood glucose (p=0.014) with diabetic retinopathy in people with type 2 DM. Uncontrolled blood glucose was 13 times more affected in diabetic retinopathy than controlled blood glucose (OR 13.417, 95% CI:1.474-122.117). CONCLUSION: There was a significant relation between controlling blood glucose and diabetic retinopathy in people with type 2 DM. Controlling blood glucose is the most dominant risk factor among the other factors in this study. Keywords: diabetic retinopathy; risk factor; type 2 diabetes mellitus

Pengaruh Pemberian Fenitoin Oral dan Vitamin C Oral terhadap Jumlah Kolagen dan Diameter pada Fistula Enterokutan Tikus Wistar: Effect Phenytoin and Vitamin C Therapy to Collagen Deposition and Diameter of Enterocutaneous Fistula in Wistar Rat Pambudi Utomo, Gede; Riwanto, Ignatius; Nugroho, Trilaksana
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.766

Latar Belakang : Enterocutaneous fistula (ECF) adalah salah satu tantangan bagi banyak ahli bedah di dunia. Meskipun terdapat perkembangan dalam perawatan medis dan tekhnik operasi, namun morbiditas dan mortalitas terkait ECF masih tinggi. Keberhasilan dalam tatalaksana ECF memerlukan perawatan yang komprehensif dan sumber daya yang mahal, dimana tidak terjangkau oleh sebagian masyarakat Indonesia. Fenitoin dan Vitamin C adalah obat yang murah dan telah menunjukan manfaat baik dalam penyembuhan luka. Tujuan : Penelitian ini bertujuan untuk mengetahui apakah pemberian fenitoin dan vitamin C akan meningkatkan kolagenisasi dan menurunkan diameter ECF pada tikus wistar. Kemudian untuk mengevaluasi apakah pemberian kombinasi fenitoin dan vitamin C memberikan hasil yang lebih baik dibandingkan pemberian tunggal fenitoin atau fitamin C Metode : Peneliti membuat caecostoma sebagai model ECF pada 24 ekor tikus. Tikus kemudian dibagi menjadi empat kelompok perlakuan dengan : perawatan NaCl, Kombinasi fenitoin-vitamin C, Fenitoin saja dan Vitamin C saja. Pengamatan hasil dilakukan pada hari ke-7 dengan mengamati deposisi kolagen dan mengukur diameter ECF. Hasil : Penelitian ini menunjukan perbedaan kolagenisasi dan penurunan diameter ECF bermakna secara statistik (p<0.05) pada tiap kelompok perlakuan jika dibandingkan kelompok kontrol (5,521 + 2,552 %; 9,395 ± 0,582 mm). Penelitian ini juga mengungkapkan bahwa pemberian kombinasi fenitoin dengan vitamin C (28,110 ± 6,535 %; 5,742 ± 0,394 mm) memberikan hasil yang lebih baik (p<0.05) dibanding pemberian tunggal fenitoin (15,448 ± 5,184 %; 8,101 ± 0,822 mm) atau vitamin C (19,118 ± 4,190 %; 6,883 ± 0,744 mm). Kesimpulan : Kami menyimpulkan baik fenitoin maupun vitamin C memiliki efek baik dalam penyembuhan ECF. Pemberian kombinasi Fenitoin dan vitamin C terbukti lebih bermanfaat dibandingkan pemberian tunggal. Kata Kunci : Enterocutaneous fistula, Fenitoin, Vitamin C, kolagen, Diameter fistula

Nilai Rerata Volume Trombosit, Rasio Trombosit Limfosit, Rasio Rerata Volume Trombosit-Limfosit sebagai Prediktor Tingkat Keparahan Sindrom Koroner Kronik Wijaya, Friska; Limantoro, Charles; Fitria, Indah; Suharti, Catharina; Nugroho, Trilaksana
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.813

BACKGROUND: The increase in platelet aggregation and inflammation play an essential role in atherosclerosis. Furthermore, the level of activity depends on their size, with larger platelets facilitating the thrombosis process. Severe Coronary Artery Disease (CAD) is associated with low lymphocyte count. It is also linked with Mean platelet volume [MPV], Platelet Lymphocyte Ratio [PLR], and Mean Platelet Volume to Lymphocyte Ratio [MPVLR]. OBJECTIVE: This study aims to investigate MPV, PLR, and MPVLR as predictors of the severity of Coronary Artery Lesion in Chronic Coronary Syndrome (CCS) using the Gensini score. METHOD: This is a cross sectional study conducted in Dr. Kariadi General Hospital, involving a total sample of 68 respondents. Furthermore, CCS were evaluated before conducting coronary angiography. The study comprises of two group of patients divided according to their Gensini scores, namely mild and severe, for ≤ 20 and > 20, respectively. MPV, PLR, and MPVLR were then compared between the two groups. RESULT: At a cut-off level of 3.4, MPVLR predicted the coronary artery severity with a sensitivity, specificity, positive predictive value (PPV), and negative predictive value of 80%, 50%, 82%, and 47% (area under the curve [AUC] 0.67; 95% confidence interval [CI], 0.52-0.82; p 0.029). Meanwhile, its value ≥3.4 has OR 1.55; 95% CI, 0.99-2.43; p 0.034. CONCLUSION: This study conclude that MPVLR ≥3.4 can be used as a predictor of Coronary Artery Lesion Severity based on the Gensini score in CCS cases.

The Effectiveness Of E-Backnshou Exercise To The Improvement Of Neck, Shoulder And Back Pain In Computer Vision Syndrome Patient Julianti, Hari Peni; Nugroho, Trilaksana; Kesoema, Tanti Ajoe; Susilaningsih, Neni; Rahmi, Fifin Luthfia; Pritadesya, Maharani Prizka
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.1017

BACKGROUND : Extra-ocular complaints of Computer Vision Syndrome (CVS) are neck, shoulder, back pain. The 20-20-20 rule and E-BACKNSHOU exercise are expected to improve accommodative mechanisms, ocular surface of the eye and extra ocular symptoms of CVS. AIMS : Proving the effectiveness of E-BACKNSHOU exercise for the improvement of neck, shoulder and back pain in CVS patient. METHOD : The research design was Pre-Post Test with Control Design. Subjects were 30 medical students of Faculty of Medicine, Diponegoro University, Semarang, Indonesia who experienced CVS and neck, shoulder and back pain. The treatment group got the 20-20-20 rule and E-BACKNSHOU exercise and the control group got the 20-20-20 rule for 1 month. Pain was measured by Visual Analogue Scale (VAS). Statistical test was conducted using paired t-test, unpaired t-test and chi square. Value of significance p<0.05. RESULT : There were significant differences in VAS score of neck, shoulder, upper back pain (p=0.00), and low back pain (p=0.022) before and after the intervention in the treatment group and VAS score of neck (p=0,002), shoulder (p=0.020), upper back (p=0.011), and low back pain (p=0.019) in the control group. Delta VAS score of the treatment group was greater than the control group and there was a significant difference in delta VAS score of shoulder pain (p=0,030), but there were no significant differences in delta VAS score of neck (p=0,934), upper back (p=0,356), and low back pain (p=0,150). CONCLUSION : The effectiveness of 20-20-20 rule and E-BACKNSHOU exercise is better than the 20-20-20 rule alone on treating neck, shoulder and back pain in CVS patient.

Co-Authors Amelia, Sesa Amira Azkadina Arief Wildan, Arief Astika Widy Utomo, Astika Widy Astuti, Fatimah Dyah Nur Bharadaksa, Mohammad Arya Lingga Cahyono, Maharani Catharina Suharti Charles Limantoro DEWI WULANSARI Dhafira, Farhana Dharma, Andhika Guna Donna Hermawati Fathur Nur Kholis Fifin L. Rahmi Fifin Luthfia Rahmi Fitriani, Rizky Hari Peni Julianti Haris, Nadia Husna Hermawan Istiadi Hery Djagat Purnomo HS, Heri-Nugroho Ignatius Riwanto, Ignatius Indah Fitria, Indah Ivana Tanoko Jacob, Ni Made Helen Virginia Kingwijati, Syahriza Naufal Maharani Maharani Maharani, Maharani Mahayu Dewi Ariani, Mahayu Dewi Margareth, Ezra Nafia, Nisa Khoirun Neni Susilaningsih Nizar Arif Lazuardi, Nizar Arif Nyoman Suci Widyastiti Pambudi Utomo, Gede Pritadesya, Maharani Prizka Puspita Kusuma Dewi, Puspita Kusuma Rahmi, Fifin L Reki, Winarto Rikiandraswida, Zahira Riski Prihatningtias, Riski RR Mahayu Dewi Ariani Ryamizard, Rizal Sadasih, Wisnu Saubig, Arnila Novitasari Septian, Kevin Setyorini, Desti Putri Tanti Ajoe Kesoema, Tanti Ajoe Teguh Setiawan Widijanto, Utami Widyarini, Andriati Nadhilah Wijaya, Friska Winarto Winarto Yora Nindita

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