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All Journal Bioma : Berkala Ilmiah Biologi IPTEK Journal of Proceedings Series Jurnal Kimia Riset Indonesian Journal of Chemical Science Jurnal Surya Medika Biosaintifika: Journal of Biology & Biology Education KLOROFIL: Jurnal Ilmu Biologi dan Terapan Gorontalo Agriculture Technology Journal Jurnal Respirologi Indonesia Jurnal Abdi Insani Spizaetus: Jurnal Biologi dan Pendidikan Biologi SIMBIOSA Humanism : Jurnal Pengabdian Masyarakat KLOROFIL: Jurnal Ilmu Biologi dan Terapan Journal Pharmasci (Journal of Pharmacy and Science) International Journal of Community Service Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Prosiding Seminar Nasional Biologi Jurnal Komunitas Farmasi Nasional
Umarudin, Umarudin
Akademi Farmasi Surabaya
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DS DETEKSI SENYAWA PIPERINE DARI CABE JAWA (Piper retrofractum Vahl) UNTUK TERAPI ANTI HIPERKOLESTEROLEMIA STUDI In Silico: DETEKSI SENYAWA PIPERINE DARI CABE JAWA (Piper retrofractum Vahl) UNTUK TERAPI ANTI HIPERKOLESTEROLEMIA STUDI In Silico Umarudin, Umarudin
Jurnal Komunitas Farmasi Nasional Vol. 4 No. 02 (2024): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Increased cholesterol levels in the blood characterize Hypercholesterolemia due to excessive fat consumption, leading to an imbalance between fat intake and metabolism. The plant Piper retrofractum Vahl, commonly known as Javanese long pepper, is recognized for its various benefits and properties, including its use in traditional medicine formulations and as a functional food ingredient. The secondary metabolite present in Javanese long pepper is piperine, which imparts a characteristic intense flavor and has been shown to have the potential to lower Hypercholesterolemia, necessitating an in silico study. This research aims to detect the piperine compound from Piper retrofractum Vahl as an anti-hypercholesterolemia therapy through an in silico study. The methodology involves the preparation of compounds using the Pyrx 0.8 application in PDB format, followed by preparing the HMG-CoA Reductase protein using Discovery Studio to remove ligands and water molecules. Molecular docking was conducted using an in silico approach with HEX Cuda 8.0.0 software. The results of the in silico study indicate that piperine from Javanese long pepper interacts with HMG-CoA Reductase, demonstrating a binding affinity value of -317.90 and interacting with three amino acid residues. These findings suggest that Javanese long pepper can be used as an anti-hypercholesterolemia therapy.
ED IDENTIFIKASI METABOLIT SEKUNDER EKO ENZIM LIMBAH BUAH DAN SAYUR : IDENTIFIKASI METABOLIT SEKUNDER EKO ENZIM LIMBAH BUAH DAN SAYUR Bawanda, Edward Melfin; Umarudin Umarudin; Syukrianto; Galuh Gondo Kusumo; Ramadhan Renaisansa; Widya Dara Anindya; Silvi Ayu Wulansari; Vika Ayu Devianti
Jurnal Komunitas Farmasi Nasional Vol. 5 No. 01 (2025): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Organic waste, in the form of fruit and vegetable peels from Ketintang, Surabaya City, East Java, can be processed into an eco enzyme through fermentation using a mixture of sugar and water over a period of 30 days. During this process, glucose is broken down into pyruvic acid, which, under anaerobic conditions, undergoes decarboxylation to form ethanol and carbon dioxide. This study aims to identify the secondary metabolites present in eco enzymes derived from fruit and vegetable waste. This research employed an accurate experimental method, observing colour changes in the tests for flavonoids and tannins, the presence of froth in the saponin test, the formation of rings in the steroid and terpenoid tests, and the appearance of precipitate in the alkaloid test. The analysis results indicated that the eco-enzyme from fruit and vegetable waste tested positive for flavonoids, tannins, and saponins, while alkaloids, terpenoids, and steroids were not detected (negative).
Penyuluhan Pemanfaatan Ekstrak Daun Mimba sebagai Sabun Kertas Antiseptik Wulansari, Silvi Ayu; Sa’diyah, Lailatus; Umarudin, Umarudin
Humanism : Jurnal Pengabdian Masyarakat Vol 3 No 3 (2022): Desember
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/hm.v3i3.14595

Abstract

COVID-19 (Corona Virus Diseases-19) yang ditetapkan oleh World Health Organization (WHO) sebagai pandemi di level dunia mulai tahun 2020.  Provinsi Jawa Timur memiliki jumlah kasus positif Covid-19 nomor urut dua setelah DKI Jakarta. Berbagai  upaya telah dilakukan pemerintah untuk menekan angka kasus Covid-19 dengan cara menjaga prokes seperti mencuci tangan dengan sabun. Sabun perperan penting dalam pencegahan dan penurunan angka penyebaran Covid-19, upaya penyebaran tersebut perlu adanya solusi pemanfaatan daun nimba sebagai zat aktif pada sabun. Daun mimba terdapat senyawa yang bersifat antibakteri dan antivirus, sehingga daun mimba dapat dijadikan sebagai senyawa bioaktif pada sabun kertas dengan dilakukan penyuluhan program pengabdian mengenai pemanfaatan herbal untuk pencegah penyebaran Covid-19. Program pengabdian masyarakat ini mendukung Sustainable Development Goals (SDGs). Sasaran kegiatan pengabdian ini pada siswa SMK Farmasi Kapasari Surabaya. Kegiatan ini dilakukan secara luring dengan metode penyuluhan. Target dari kegiatan pengabdian kepada siswa untuk meningkatkan kepedulian terhadap kesadaran mengenai bahan alam yang diolah untuk dapat menghasilkan suatu produk yang bermanfaat dalam ikut serta mencegah penyebaran Covid-19. Berdasarkan hasil yang didapatkan dari sepuluh aspek penilaian pada pre-test, terdapat kenaikan pada setiap aspek setelah di lakukan penyuluhan. Hal ini menunjukkan siswa dari Sekolah Menegah Farmasi lebih memahami pemanfaatan bahan alam sebagai sabun kertas untuk mencegah penyebaran Covid-19.
Identifikasi Senyawa Sekunder Ekstrak Metanol Beras Hitam (Oryza sativa L. indica) Organik Dengan Metode Ultrasonik Umarudin, Umarudin Umarudin
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 7, No 2 (2023): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v7i2.16762

Abstract

information, even though the content of black rice has many benefits, so it is necessary to investigate the early detection of secondary rehabilitate compounds. The purpose of this study was to determine the identification of secondary metabolites contained in organic black rice extract using ultrasonic methods. The method in this study is the true experiment method. This research was tested qualitatively, namely the ultrasonic extraction method and identifying the compounds contained in it, observed for changes in color, sediment, rings, and foam. The research results on determining organic black rice from Tegal, Central Java, are Oryza sativa L. indica. The identification results of organic black rice extract were positive for containing alkaloids, flavonoids, terpenoids, tannins, and saponins and negative for steroid compounds.
EDUKASI ECO ENZYME DARI LIMBAH BUAH DAN SAYUR MENJADI SABUN CAIR CUCI TANGAN SEBAGAI UPAYA MENCIPTAKAN EKONOMI MASYARAKAT PRODUKTIF DALAM MENDUKUNG SUSTAINABLE DEVELOPMENT GOALS (SDGs) DI KELURAHAN KETINTANG 4 SURABAYA Umarudin, Umarudin; Syukrianto, Syukrianto; Anidnya, Widya Dara; Wulansari, Silvi Ayu; Aryanti, Evy
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1593

Abstract

The abundance of fruit and vegetable waste in the Ketintang 4 area has a detrimental impact on the surrounding environment. Therefore, it is necessary to implement educational initiatives on utilizing this waste to produce eco-enzyme, which can be used as an active ingredient in liquid hand soap. This activity aims to educate on eco enzymes from fruit and vegetable waste into liquid hand soap as an effort for Clean and Healthy Living Behavior (PHBS) and the "Let's Wash Hands" movement to change community behavior from unhealthy to healthy. The activity method consists of 4 stages: preparation stage, material preparation stage, education and workshop stage, and evaluation stage. This activity showed that the youth organization members were enthusiastic and experienced increased knowledge from the pre-test results, with "yes" answers at 9.33% and "no" answers at 90.67%. The post-test results showed "yes" answers at 82% and "no" answers at 18%. The increase in knowledge in utilizing eco enzymes for their needs and benefits as active ingredients in liquid hand soap has become a valuable product to encourage the surrounding community to wash hands with soap, an effort to prevent the spread of microorganisms. The satisfaction questionnaire results of the community service activity showed a satisfaction rate of with 87.43% very satisfied, 2.57% satisfied, and 0% unsatisfied. This activity strongly supports the SDGs and the KEMENDIKBUD in 2021 in implementing Clean and Healthy Living Behavior (PHBS) for the Ketintang 4 Subdistrict. It can create a productive economy for the community.
EDUKASI TENTANG TANAMAN OBAT ASLI INDONESIA YANG BERPOTENSI SEBAGAI AFRODISIAK BAGI PRIA DI SMK FARMASI Umarudin, Umarudin; Ulfa, Ninik Mas; Kusumo, Galuh Gondo; Syukrianto, Syukrianto
Prosiding Seminar Nasional Biologi Vol. 13 (2025)
Publisher : Prosiding Seminar Nasional Biologi

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Abstract

Tujuan dari kegiatan ini adalah memberikan edukasi kepada siswa SMK Farmasi tentang tanaman obat asli Indonesia yang berpotensi sebagai afrodisiak. Metode pelaksanaannya meliputi sesi edukasi, sesi tanya jawab, dan diskusi. Media yang digunakan berupa slide PowerPoint, foto tanaman, dan simplisia (bahan tanaman kering) dari tanaman obat asli Indonesia yang dikenal memiliki sifat afrodisiak. Sebelum penyampaian materi, dilakukan pre-test dan dilanjutkan dengan post-test di akhir kegiatan. Hasil kedua tes dianalisis menggunakan tabulasi grafik. Hasil pre-test menunjukkan skor rata-rata 40 dari 100, yang mencerminkan pemahaman awal siswa tentang tanaman asli Indonesia yang berpotensi afrodisiak. Selanjutnya, diberikan edukasi tentang tiga tanaman herbal yang diperkenalkan kepada siswa SMK Farmasi: lada Jawa (Piper retrofractum) yang berasal dari Madura dan Jember; purwaceng (Pimpinella alpina atau Pimpinella pruatjan) yang bersumber dari Dataran Tinggi Dieng, Jawa Tengah; Gunung Semeru dan Pegunungan Tengger, Jawa Timur; Gunung Pangrango, Jawa Barat; serta Gunung Lawu dan Gunung Galunggung; dan pasak bumi (Eurycoma longifolia) yang ditemukan di Sumatra dan Kalimantan. Edukasi awal ini bertujuan mengurangi ketergantungan pada obat sintetis yang sering menimbulkan efek samping. Hasil post-test menunjukkan peningkatan dengan skor rata-rata 98. Kegiatan ini memberi kontribusi positif dengan memperluas pengetahuan siswa tentang morfologi tanaman, habitus, dan efek farmakologis sebagai afrodisiak pada pria, yang didukung oleh studi ilmiah. Selain memberi manfaat bagi siswa, inisiatif ini juga memberikan wawasan berharga bagi masyarakat luas sebagai langkah penting untuk meningkatkan kesehatan reproduksi secara menyeluruh melalui pendekatan alami dan berbasis pengetahuan.
Co-Authors Adinirekso, Gidion Anidnya, Widya Dara Anindya, Widya Dara Anisa Rizki Amalia Aristyawan, Andhika Dwi Ayu Wulandari Bawanda, Edward Melfin Devianti, Vika Ayu Evy Aryanti Frans Assa, Adrie Fredy Kurniawan Galuh Gondo Kusumo Harsini Harsini Johanis Rumambi, Freddy Jumriah Nur, Jumriah Junairiah Junairiah Lailatus Sa’diyah Madurani, Kartika Anoraga Mochammad Sulton Aziz Irawan Munifatul Izzati Ramadhan Renaisansa Reviono Reviono Sa’diyah, Lailatus Sa’diyah, Lailatus Siti Nurhaliza Surahmaida, Surahmaida Syafitri, Meyke Herina Syukrianto Syukrianto Syukrianto Syukrianto, Syukrianto Ulfa, Ninik Mas Widjaja, Daniel Wulansari, Silvi ayu Yuliarni, Floreta Fiska Yuyun Widayati