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All Journal Althea Medical Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Journal Of Vocational Health Studies Jurnal Keperawatan Padjadjaran Jurnal Medik Veteriner PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ners SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Asian Journal of Health Research Journal of Innovation Research and Knowledge Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Fatimah, Nurmawati
Department Of Anatomy, Histology, And Pharmacology, Faculty Of Medicine, Universitas Airlangga
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Journal : Althea Medical Journal

 1 
Effects of Tamarillo (Solanum betaceum) Extract on Glutathione Peroxidase Expression and Inflammatory Reactions in Lead Acetate-Induced Lung Tissue of Mice Harjono, Shella; I’tishom, Reny; Rahniayu, Alphania; Fatimah, Nurmawati
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4460

Abstract

Background: Lead acetate exposure through oral route has a significant impact on lung tissue as lead can induces the formation of reactive oxygen species (ROS), resulting in decreased glutathione peroxidase (GPx) and triggering inflammatory responses. The induction of exogenous antioxidants may prevent this mechanism. This study aimed to evaluate the protective effect of Tamarillo ethanol extract on GPx expression and inflammatory reactions in the lung tissue of mice induced with lead acetate.Methods: This true experimental laboratory study utilized stored formalin-fixed-paraffin-embedded (FFPE) lung tissue  from 30 male mice (Mus musculus). The samples were divided into five intervention groups, each consisting of six mice. Immunohistochemistry and histopathology assessments were performed at 100x and 400x magnification to evaluate the GPx expression using the H-score and to assess inflammatory reactions based on five scoring parameters, which were summed to obtain the total lung injury score.Results: Lead exposure significantly increased inflammatory reactions, particularly in the hemorrhage parameters (p=0.041). A significant increase in GPx expression was observed following lead acetate administration (p=0.027). Administration of Tamarillo ethanol extract at a dose of 400 mg/kgBW increased GPx expression compared with the positive control group (p=0.027).Conclusion: Tamarillo ethanol extract, especially at a dose of 400 mg/kgBW, significantly increases GPx expression in lead acetate-induced lung tissue of mice. This finding highlights the potential role of Tamarillo extract as an antioxidant source to reduce lead-induced lung injury, supporting broader efforts to promote healthy lifestyle practices that protect against environmental toxin exposure.
Co-Authors A'yuni, Mila Qurotul Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Januar Er Putra Afif Nurul Hidayati Akbar Kurniawan, Mohammad Alpha Fardah Athiyyah Alphania Rahniayu Amatullah, Nida' Fahima Amustikarani, Dewa Ayu Praba Annette d’Arqom, Annette Arifa Mustika Bambang Hermanto Christian Susianto, Steven Damayanti Damayanti Dau, Daniel Dhia Farhan Taufik Dianita, Karina Putri Dimyati, Sinta Diyah Doman, Zahras Azimuth Edith Frederika Puruhito, Edith Frederika Farhan Nurdiansyah Finna Permata Putri Harjono, Shella Herisulistyo, Aldilatama Herley Windo Setiawan Herwanto, Bambang I Dewa Ayu Sudiari Dewi I'tishom, Reny Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Insyira Rayhana Irsan Irsan, Insyira Rayhana Iswandi, Cantika Marcellin Princess Izzatul Fithriyah I’tishom, Reny Khaerunnisa, Siti Kurniawan, Mohammad Akbar Kusuma Eko Purwantari Linda Dewanti Maftuchah Maftuchah Mhd Zamal Nasution Mohammad Fathul Qorib Mohammad Subkhan Muhammad Axel Arsyad Mukhoirotin Mukhoirotin Myrna Adianti Nilamsari, Karina Ayu Nurina Hasanatuludhhiyah Nurrosyidah, Iif Hanifa Paramitha, Nabilah Prabowo, Gwenny Ichsan Purba, Abdul Khairul Rizki Raden Mohamad Herdian Bhakti Rania Ratri Fauziyah Ratna Sofaria Munir, Ratna Sofaria Rini Hamsidi Sakina Sakina, Sakina Sari, Gadis Meinar Shayla Kokomi Rishardy Sri Murtiwi Sri Purwaningsih Stefanus, Lusiana Steven Christian Susianto Suhariningsih Suharno, Novianto Edi Sulistiawati Sulistiawati Sumardiko, Dwi Setiani Sutji Kuswarini Sutji Kuswarini Toyib, Muchammad Trimitasari, Kurnia Turchan, Agus Vita, Angelica Diana Wening Hapsari William Andrew Isaac Yuani Setiawati Yuliawati, Tri Hartini Yusuf, Muhtarum