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All Journal Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research BULETIN AL-RIBAATH Jurnal Kreativitas PKM Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) Jurnal Abdimas Mahakam Health Information : Jurnal Penelitian Jurnal Ilmiah Farmako Bahari Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Pharmacy Edu Masda Journal Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Keperawatan dan Kesehatan (JKK) Jurnal Komunitas Farmasi Nasional Pharmaceutical Science Journal Medical Sains : Jurnal Ilmiah Kefarmasian
Herdaningsih, Sulastri
Akademi Farmasi Yarsi Pontianak
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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POTENSI INTERAKSI OBAT-OBAT PADA RESEP POLIKLINIK PENYAKIT DALAM DI INSTALASI RAWAT JALAN RSUD DR. SOEDARSO PONTIANAK Herdaningsih, Sulastri; inderiyani, inderiyani; fauzan, suhaimi
Jurnal Ilmiah Pharmacy Vol 10, No 2 (2023)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v10i2.501

Abstract

Interaksi obat merupakan salah satu drug related problems (DRP’s) yang bisa mempengaruhi outcome klinis pada pasien Banyaknya jumlah obat-obatan yang dikonsumsi dalam satu resep mempunyai kecenderungan terjadinya interaksi obat sehingga meningkatkan risiko gangguan kesehatan bagi pasien. Penelitian ini bertujuan untuk mengetahui potensi interaksi antar obat dengan obat sehingga dapat mengetahui persentase potensi interaksi obat-obat pada resep poliklinik penyakit dalam di instalasi rawat jalan RSUD Dr. Soedarso Pontianak. Metode penelitian yang digunakan adalah deskriptif retrospektif yang bertujuan untuk membuat gambaran dengan mengambil resep lampau yang dilakukan pada bulan Januari sampai dengan Maret 2022. Data diidentifikasi melalui literatur terpercaya dari website www.drugs.com atau Drug Interactions Checker. Dari hasil penelitian yang telah dilakukan didapatkan persentase potensi interaksi obat adalah sebesar  34,27%, untuk interaksi mayor sebesar 7,82%, moderat 79,78%, dan minor 12,40%.Kata Kunci : Interaksi Obat-Obat, Rumah Sakit, Penyakit Dalam
AKTIVITAS MUKOLITIK EKSTRAK ETANOL KACANG PANJANG (Vigna sinensis L.) TERHADAP PUTIH TELUR BEBEK SECARA IN VITRO Inderiyani, Inderiyani; Herdaningsih, Sulastri; Muharami, Savitri
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.263

Abstract

                                                         ABSTRACT The long bean plant (Vigna sinensis L.) is a type of legume vegetable that is widely cultivated in Indonesia. This plant has secondary metabolites i.e alkaloids, flavonoids, saponins and tannins which are suspected to have activity as mucolytics. This study aims to find out whether ethanol extract of long beans with a concentration of 0.1%; 0.2% and 0.4% have activity as mucolytics. The research was carried out by processing seedless long beans into simplicia and then maceration with 96% ethanol solvent. Activity testing was carried out by mixing 100 mL of duck egg white with 100 mL of test solution (1:1). The test solution used was negative control (aquadest), positive control (acetylcysteine solution 0.2%), long bean ethanol extract solution with a concentration of 0.1%; 0.2% and 0.4%. Viscosity measurements were made using  the LVT230 Brookfield viscometer at minutes 0, 15, 30, 45 and 60. The results showed that the positive control group and all groups of long bean ethanol extract had a significant difference from the negative control group (p<0.05) so that it could be concluded that long bean ethanol extract with a concentration of 0.1%; 0.2% and 0.4% had mucolytic activity with a percentage of mucolytic effects respectively is 41.59%; 47.17% and 53.72%.                                                                                              ABSTRAKTanaman kacang panjang (Vigna sinensis L.) adalah jenis sayuran kacang- kacangan yang banyak dibudidayakan di Indonesia. Tanaman ini memiliki metabolit sekunder berupa alkaloid, flavonoid, saponin dan tanin yang diduga memiliki aktivitas sebagai mukolitik. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol kacang panjang dengan konsentrasi 0,1%; 0,2% dan 0,4%  memiliki aktivitas sebagai mukolitik. Penelitian dilakukan dengan mengolah kacang panjang tanpa biji menjadi simplisia kemudian di maserasi dengan pelarut etanol 96%. Pengujian aktivitas dilakukan dengan mencampurkan 100 mL putih telur bebek dengan 100 mL larutan uji (1:1). Larutan uji yang digunakan yaitu kontrol negatif berupa aquadest, kontrol positif berupa larutan asetilsistein 0,2%, larutan ekstrak etanol kacang panjang konsentrasi 0,1%; 0,2% dan 0,4%. Pengukuran viskositas dilakukan dengan menggunakan viskometer Brookfield LVT230 pada menit ke 0, 15, 30, 45 dan 60. Hasil penelitian menunjukkan kelompok kontrol positif dan semua kelompok ekstrak etanol kacang panjang memiliki perbedaan yang bermakna terhadap kelompok kontrol negatif  (p<0,05) sehingga dapat disimpulkan ekstrak etanol kacang panjang dengan konsentrasi 0,1%; 0,2% dan 0,4% memiliki aktivitas mukolitik dengan aktivitas tertinggi terdapat pada konsentrasi 0,4% yaitu  sebesar 53,72%.
UJI AKTIVITAS ANTIHIPERGLIKEMIA TEH BUNGA KECOMBRANG (Etlingera elatior (Jack.) R.M.Sm ) TERHADAP MENCIT PUTIH (Mus Musculus) JANTAN DENGAN METODE TOLERANSI GLUKOSA Herdaningsih, Sulastri; Nurhafizah; Hairunnisa
Jurnal Komunitas Farmasi Nasional Vol. 5 No. 01 (2025): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Diabetes mellitus is a metabolic disorder caused by pancreatic dysfunction, characterized by elevated blood glucose levels due to decreased insulin production by pancreatic beta cells. This study aimed to evaluate the antihyperglycemic activity of torch ginger tea (Etlingera elatior (Jack.) R.M.Sm.) in male white mice (Mus musculus) using the glucose tolerance method. The mice were divided into control and treatment groups, receiving torch ginger tea at doses of 1,25 gram/KgBW, 2,5 gram/KgBW, and 5 gram/KgBW. The tea was administered orally, followed by glucose induction 30 minutes later. Blood glucose levels were measured over 4 hours at 30-minute intervals. Statistical analysis showed significant differences between the treatment groups and the negative control at all tested doses (p = 0.00; p < 0.05). These results indicate that torch ginger tea at doses of 1,25 gram/KgBW, 2,5 gram/ KgBW, and 5 gram/KgBW exhibits antihyperglycemic activity in male white mice (Mus musculus) based on the glucose tolerance method.
Antioxidant Screening and Sunscreen Activity of Nanocream of Purified Extract of Kenikir Leaves (ETDK) and Tampoi Fruit Peel Extract (EKBT): Skrining Antioksidan dan Aktivitas Tabirsurya Nanokrim Ekstrak Terpurifikasi Daun Kenikir (ETDK) dan Ekstrak Kulit Buah Tampoi (EKBT) Rahman, Ika Ristia; Kartikasari, Dian; Kurnianto, Erwan; Herdaningsih, Sulastri
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 3 (2021): (December 2021
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i3.15663

Abstract

Background: UV lights are free radicals that can cause damage to the skin, such as redness, burning, pigmentation, and even cancer. Kenikir leaf purified extract (ETDK) and Tampoi fruit peel extract (EKBT) contain flavonoid compounds. Flavonoid compounds can be antioxidants and sunscreens due to the presence of chromophore groups that can absorb UV rays to reduce exposure to the skin. Objectives: This study aims to determine the antioxidant activity and the ability of sunscreen nano cream Purified extract of Kenikir leaves and Tampoi fruit peel extract. Material and metode: Nanocream is made with 3 ETDTK-EKBT combination formulas, II ETDK formulas, III EKBT formulas. The antioxidant activity test was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method and the sunscreen activity test using the UV-Vis spectrophotometric method to calculate the SPF value of the preparation (Mansur's method). Result: The results showed that the nano cream formula had a strong antioxidant activity with the per cent inhibition of formula I 78.28%, formula II 68.49%, and formula III 73.00%. The activity test results as a sunscreen formulation of purified extract nano cream from Kenikir leaves and nano cream from Tampoi fruit peel extract had extra protection ability with a sun-protecting factor value of 7 while the nano cream formula combined extract with an SPF value of 10 gave the maximum protection category. Conclusion: nano cream have potential as antioxidants and sunscreens.
UJI AKTIVITAS ANTELMINTIK SIRUP EKSTRAK ETANOL UMBI BATANG ROTAN (CALAMUS ROTANG L.) TERHADAP CACING GELANG (ASCARIDIA GALLI) SECARA IN VITRO Herdaningsih, Sulastri; Inderiyani, Inderiyani; Fauzan, Suhaimi; Aulia, Gina
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.278

Abstract

                                                   ABSTRACTAnthelmintics are drugs used to eradicate worms from the human or animal body. This study aims to determine whether ethanol extract of rattan stem tubers can be formulated as a syrup preparation and to determine how the physical evaluation of ethanol extract syrup preparation of rattan stem tubers. The research method used was laboratory experimental design. The test animals used were 75 heads, which were divided into 5 groups with 3 replications. The research was conducted with activity tests using Ascaridia galli worms soaked in rattan stem tuber extract syrup (Calamus rotang L.) with concentrations of 0.5%; 0.75%; and 1%. Piperazine citrate 0.9% was used as positive control and NaC1 0.9% physiological solution as negative control. Observations were made every 15 minutes by looking at whether lysis occurred in the worms. The results of testing the activity of rattan stem tuber extract showed that all concentrations of rattan stem tuber extract syrup (0.5%; 0.75%; and 1%) had a mortality percentage of 100%. Statistical results at concentrations of 0.75% and 1% are not significantly different from the positive control (> 0.05). This shows that rattan stem tuber extract syrup (Calamus rotang L.) has anthelmintic activity.                                       ABSTRAKABSTRAKAntelmintik merupakan obat yang digunakan untuk memberantas cacing dari dalam tubuh manusia atau hewan. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol umbi batang rotan dapat diformulasikan sebagai sediaan sirup dan untuk mengetahui bagaimana evaluasi fisik sediaan sirup ekstrak etanol umbi batang rotan. Metode penelitian yang digunakan adalah desain eksperimental laboratorium. Hewan uji yang digunakan sebanyak 75 ekor, yang dibagi menjadi 5 kelompok dengan 3 replikasi. Penelitian dilakukan dengan uji aktivitas menggunakan cacing Ascaridia galli yang direndam dalam sirup ekstrak umbi batang rotan (Calamus rotang L.) dengan konsentrasi 0,5%; 0,75%; dan 1%. Pada kontrol positif digunakan Piperazine sitrat 0,9 % dan larutan fisiologis NaC1 0,9 % sebagai kontrol negatif. Pengamatan diakukan tiap 15 menit dengan cara melihat apakah terjadi lisis pada cacing. Hasil pengujian aktivitas ekstrak umbi batang rotan menunjukkan bahwa semua konsentrasi sirup ekstrak umbi batang rotan (0,5%; 0,75%; dan 1%) memiliki persentase mortalitas sebesar 100%. Hasil statistik pada kosentrasi 0,75% dan 1% tidak berbeda makna dengan kontrol positif (> 0,05). Hal ini menunjukan bahwa sirup ekstrak umbi batang rotan (Calamus rotang L.) memiliki aktivitas sebagai antelmintik.
Co-Authors Ahmad Muhtadi Ahmad Muhtadi Asmara, Ratna Dewi Lintang Aulia, Gina Dian Kartikasari Dian Kartikasari Ervina Lili Neri Faisal Kholid Fahdi Fauzan Alfikrie Fauzan, Suhaimi Fenny Oktaviyeni Gabby Novikadarti Rahmah Hairunnisa Hairunnisa Hairunnisa Herman Herman Herman Ibnu Kahtan, Muhammad Ihsanul Arief Inderiyani, Inderiyani Ismi Utari Keri Lestari Kurnianto, Erwan M. Ali Maulana Maulana, Iksan Mela Khofifah Mita Mita Mita Muhammad Ibnu Khatan Muharami, Savitri Nurhafizah Nurhafizah Nurul Annisa Olivia Rahman, Ika Ristia Yoga Pramana