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Pangestuti, Dewi
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Journal : Jurnal Kedokteran STM (Sains dan Teknologi Medik)

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HIPOXIA-INDUCIBLE FACTOR 1 (HIF-1) DAN ANGIOGENESIS TUMOR: MEKANISME, IMPLIKASI KLINIS, DAN POTENSI TERAPI: HIPOXIA-INDUCIBLE FACTOR 1 (HIF-1) AND TUMOR ANGIOGENESIS: MECHANISMS, CLINICAL IMPLICATIONS, AND THERAPEUTIC POTENTIAL Lestari, Ira Cinta; Bestari, Ramadhan; Pangestuti, Dewi; Mustika, Suryani Eka
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 8 No. 2 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v8i2.855

Abstract

Hypoxia plays a crucial role in tumor development and progression by inducing angiogenesis. One of the key mediators in the hypoxic response is Hypoxia-Inducible Factor-1 (HIF-1), which regulates the expression of pro-angiogenic genes such as vascular endothelial growth factor (VEGF). HIF-1 activation, whether through hypoxic conditions or genetic mutations, contributes to the formation of new blood vessels that support tumor growth and metastasis. This article is a narrative review aimed at summarizing the molecular mechanisms of HIF-1 in tumor angiogenesis and exploring its potential as a target for cancer therapy. The discussion includes HIF-1 regulation under normoxic and hypoxic conditions, its impact on the structure of tumor vasculature, and the development of therapies targeting the HIF-1 pathway, such as HIF-1α inhibitors, dimerization blockers, and degradation-inducing agents. By understanding the central role of HIF-1 in angiogenesis and tumor progression, this article aims to contribute a scientific foundation for the development of anti-angiogenic therapies and future research in the field of molecular oncology. AbstrakHipoksia merupakan kondisi yang berperan penting dalam perkembangan dan progresi tumor melalui induksi angiogenesis. Salah satu mediator utama dalam respons hipoksia adalah Hypoxia-Inducible Factor-1 (HIF-1), yang berperan sebagai regulator utama homeostasis oksigen. HIF-1 mengatur ekspresi berbagai gen yang terlibat dalam angiogenesis, termasuk vascular endothelial growth factor (VEGF), angiopoietin, dan faktor pertumbuhan lainnya. Dalam kondisi hipoksia, HIF-1α tidak mengalami degradasi, sehingga terjadi peningkatan ekspresi VEGF yang memicu pembentukan pembuluh darah baru guna memenuhi kebutuhan oksigen sel tumor. Selain itu, mutasi pada onkogen dan tumor suppressor genes dapat menyebabkan aktivasi HIF-1 yang tidak tergantung pada hipoksia, sehingga semakin meningkatkan angiogenesis tumor. Pemahaman lebih lanjut tentang peran HIF-1 dalam angiogenesis telah membuka peluang untuk pengembangan terapi target kanker yang menghambat jalur HIF-1. Terapi ini mencakup inhibisi ekspresi HIF-1α, pencegahan dimerisasi dengan HIF-1β, serta penghambatan interaksi dengan DNA. Dengan demikian, modulasi jalur HIF-1 dapat menjadi pendekatan yang menjanjikan dalam terapi kanker berbasis anti-angiogenesis.
Co-Authors AA Sudharmawan, AA Akbar, Surya Aktalina, Lucia Anayya, Miska Armansyah Armansyah Aurel, Princes Ayu, Mayang Sari Brando Lubis, Adi Raja Damanik, Rosa Zorayatamin Dania, Ira Aini Fadlil, Muhammad Raihan Hanifa, Elza Harris, Bilkes Heni Nastiti Ibarra, Florante Ira Cinta Lestari Lubis, Adi Raja Brando Lubis, Tiffani Tantina Mayasari Rahmadhani Muhammad Rafli Munasiron, Munasiron Nafilaty, Najwa Laila Nanda Novziransyah Nasution, Halimah Thania Nasution, Iizzatul Aulia Halim Ozar, Lucia Aktalina Pane, Abdul Harris Pohan, Amelya Prasetyaswati, Betty Pratiwi, Munyati Putri, Dina Rachma Rachmania, Nova Rahman, Tuti Khairani Ramadhan Bestari Ritonga, Tiara Arlini Rizkillah, Saadur RR. Ella Evrita Hestiandari Saputra, Donalry Agus Sari Ayu, Mayang Sari, Siti Kemala Senny, Nila Sri Haningsih, Sri Sumilir, Sumilir Suryani Eka Mustika Syarifah Syarifah, Syarifah Varga, Fatimah