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All Journal Media Kesehatan Masyarakat Indonesia Jurnal Penelitian Sains Jurnal Penelitian Kesehatan Suara Forikes As-syifaa Jurnal Farmasi JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Martabe : Jurnal Pengabdian Kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Bidang Ilmu Kesehatan J-ADIMAS (Jurnal Pengabdian kepada Masyarakat) Jurnal Midpro JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia) Lumbung Farmasi : Jurnal Ilmu Kefarmasian International Journal Of Science, Technology & Management (IJSTM) Journal Pharmasci (Journal of Pharmacy and Science) International Journal of Islamic and Complementary Medicine Indonesian Journal of Community Dedication in Health (IJCDH) Borneo Journal of Pharmacy Jurnal Teknologi dan Sains Modern (Medical Scientific Journal) MESINA Jurnal Kefarmasian Indonesia Media Penelitian dan Pengembangan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK) Strada Journal of Pharmacy
Septi Fandinata, Selly
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POLIMORFISME CYP2C19*2 TERHADAP AGREGASI PLATELET DAN KEJADIAN KARDIOVASKULAR PADA PASIEN PENYAKIT JANTUNG KORONER Primanitha Ria Utami; Ike Dhiah Rochmawati; Selly Septi Fandinata
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.405

Abstract

Coronary Heart Disease (CHD) is a cardiovascular disease that can caused by the presence of coronary artery plaque blockage. Clopidogrel is one of antiplatelet therapy in CHD patients. CYP2C19 *2 polymorphisms can reduce the effectiveness of clopidogrel active metabolites. This research was conducted at RSUD Sidoarjo East Java from November to December 2017continued monitoring of cardiovascular events to March 2018. The research method used is a method Polymerase Chain Reaction (PCR) and the Light Transmittance Aggregometry (LTA) method for platelet aggregation measurement. From 25 sample inclusion,there are wild type alleles (bp values ​​around 120 bp; 1 patient), homozygous alleles (bp values ​​around 169 bp; 18 patients) and allele heterozygotes (bp values ​​around 120bp, 169bp; 6 patients). The most common type of polymorphism is allele homozygotes. There is one patient hyperaggregation and cardiovascular events after being monitored for 3 months. Analysis relationship between CYP2C19*2 genetic polymorphisms with platelet aggregation and cardiovascular events, using the kruskal wallis test. The result is no significant relationship between CYP2C19*2 polymorphisms with platelet aggregation (p=0.512), as well as cardiovascular events did not make any difference which is also significant (p=0.426). The results of the association of platelet aggregation with cardiovascular events showed significant differences (p=0.027).
Study of Antihypertensive and Antiplatelet Use in Outpatient Preeclampsia Patients at Siti Khodijah Sepanjang Hospital Purwanti, Uchti Firda; Fandinata, Selly Septi
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.98249

Abstract

Background: Preeclampsia is a complication of pregnancy characterized by increased blood pressure and the presence of proteinuria after reaching 20 weeks of gestation. Besides that, the diagnosis of preeclampsia can be reinforced by other symptoms such as edema, impaired liver and kidney function.Objectives: This study aims to investigate the usage of antihypertensive and antiplatelet medications in outpatient preeclampsia patients at Siti Khodijah Sepanjang Hospital from January 2022 to December 2023.Methods: Data collection method is retrospective, obtained from medical records of 70 preeclampsia patients. The sampling technique using purposive sampling method according to the inclusion research criteria. Data was analyzed using Microsoft Excel 2021.Results: Data on drug usage profiles obtained during the treatment, shows that the most common combination is a combination of two antihypertensive drugs and an antiplatelet, namely metildopa (category B) + aspirin (category C), with a dosage of 500 mg + 80 mg per day. The medication regimen is S2dd1 + S1dd1, and the average duration of treatment ranges from 7 to 30 days. With this treatment, the blood pressure of preeclampsia patients experienced a change in the patient's blood pressure which decreased in 65 patients with the initial classification of mild preeclampsia being 54 patients to normal in the final preeclampsia classification of 56 patientsConclusion: This study provides several important implications for health workers in Indonesia in the management of preeclampsia disease with the use of antihypertensive and antiplatelet drugs, so that they can provide services that are in accordance with the medical needs of patients.
Association of medication adherence with clinical outcomes and quality of life in type 2 diabetes mellitus patients: a cross-sectional study Fandinata, Selly Septi; Putra, Deddy Aryanda; Lubada, Eziah Ika; Sari, Silfiana Nisa Permata; Devientasari, Chinthia; Ernawati, Iin; Suryandari, Mercyska; Berliana, Dini
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.2218

Abstract

Background: Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels. Patient adherence to medication is a critical factor in effective management, as it can reduce morbidity and mortality while improving health-related quality of life (HRQoL). Digital interventions, such as smartphone-based medication reminder applications, represent a promising strategy to enhance adherence. Objective: This study aimed to examine the relationship between medication adherence and clinical outcomes, specifically fasting blood glucose levels and HRQoL, among patients with type 2 diabetes in primary health care settings. Methods: A cross-sectional pre–post test design was employed involving 96 respondents, divided equally into control and intervention groups, selected through convenience sampling. Primary data were collected using the MARS-10 adherence questionnaire and the DQOL Brief Clinical Inventory, while secondary data were obtained from pre– and post–fasting blood glucose measurements. Results: Results showed no significant relationship between medication adherence and fasting blood glucose levels (p > 0.05), nor between adherence and HRQoL (p > 0.05), even with the implementation of the Drug Reminder App intervention. Conclusion: These findings highlight the need for additional interventions or further innovations in digital adherence support to improve clinical and quality-of-life outcomes in type 2 diabetes management.
Analysis of the Relationship Between HIV/AIDS Clinical Stage and Opportunistic Infections at Hospital X Devientasari, Chinthia; Selly Septi Fandinata
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.287

Abstract

Opportunistic infections remain a major cause of morbidity and mortality among people living with Human Immunodeficiency Virus (HIV). The progressive decline in immune function increases susceptibility to infections such as tuberculosis, candidiasis, and toxoplasmosis. The World Health Organization (WHO) clinical staging system is widely used to assess HIV disease progression and is often associated with the occurrence of opportunistic infections. This study aimed to analyze the association between HIV clinical stage and opportunistic infections among HIV/AIDS patients at Hospital X. This study employed an observational analytic design with a cross-sectional approach. Data were obtained from medical records of HIV/AIDS patients, with a total sample of 193 patients selected using total sampling. Statistical analyses included univariate and bivariate analyses using the chi-square test. The majority of patients were in clinical stage III (80.3%). The prevalence of opportunistic infections was 14.0%. The results of the chi-square test showed no significant association between clinical stage and opportunistic infections (p = 0.206). Although opportunistic infections were more frequently observed in advanced stages, the relationship was not statistically significant.
Co-Authors Agustiarini, Vitri Alfiana, Silvina Sita Amriani, Annisa Andik Isdianto Anita Purnamayanti Aristyawan, Andhika Dwi Aryanda Putra, Deddy Berliana, Dini Deddy Aryanda Putra Devi Ristian Octavia Devientasari, Chinthia Djamilah Arifiyana Ernawati, Iin Eziah Ika Lubada Fitriya, Fitriya Fitrya Fitrya Iin Ernawati Ike Dhiah Rochmawati Indra Puspitasari Indra Puspitasari, Indra Luthfiah, Annisa Mercysca Suryandari Mercyska Suryandari Ninik Mas Ulfa Nisya, Norma Novita, Rennie Puspa Permatasari, Silfiana Nisa Primanitha Ria Utami Primanitha Ria Utami Primanitha Ria Utami Puji, Kinanti Ayu Purwanti, Uchti Firda Puspa Novita, Rennie Putra, Deddy Aryanda Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan, Rizky Sari, Silfiana Nisa Permata Suryandari, Mercysca Ulfa, Ninik Mas Utari, Yunita Winda Wa Ode Sitti Zubaydah Yuni Hendrawati Zakiyah , Farah Afifatuz Zulfa, Ilil Maidatuz