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Monitoring Kidney Function Through the Use of Candesartan, Telmisartan or Valsartan Antihypertensive Therapy towards Patients CKD Selly Septi Fandinata; Rizky Darmawan; Primanitha Ria Utami; Ninik Mas Ulfa
Media Kesehatan Masyarakat Indonesia Vol. 18 No. 1: MARCH 2022
Publisher : Faculty of Public Health, Hasanuddin University, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.633 KB) | DOI: 10.30597/mkmi.v18i1.17780

Abstract

Chronic Kidney Disease (CKD) lower kidney function caused by an irreversible reduction in normal nephron function. Globally, CKD contributes to the cause of death. Activation of the Renin-Angiotensin-Aldosterone system is involved in the pathogenesis. ARBs have a cardiorenal protective effect. The purpose of this study was to determine the changes in kidney function with the use of Candesartan, Telmisartan or Valsartan antihypertensive therapies in CKD patients. This research method was a prospective observational cohort study looking at changes in kidney function (BUN and Serum Creatinine) at 1 and 6 months of using Antihypertensive Drugs Valsartan, Telmisartan, and Candesartan and tested by statistical analysis. The number of samples in this study was 72 patients which are 24 patients (Candesartan), 27 patients (Telmisartan), and 21 patients (Valsartan). The results showed that the Candesartan group experienced a decrease in average BUN of 0.13±0.85 mg/dl and serum creatinine of 0.004±0.09 mg/dl with independent t-test p=0.479 (p>0.05), Serum Creatinine p= 0.809 (p>0.05). The Telmisartan group experienced a decrease in average BUN of 4.74±5.16 mg/dl and serum creatinine of 0.33±0.20 mg/dl with Wilcoxon BUN test results p=0.000 (p<0.05), Serum Creatinine p=0.000 (p<0.05). In contrast, in the valsartan group, there was no change. So, it can be said that telmisartan has the highest effectiveness in kidney function (BUN and Serum Creatinine).
Comparison of the Effect of Morning Versus Night Amlodipine Administration on Blood Pressure Reduction in Primary Hypertensive Patients: Perbandingan Pengaruh Waktu Pemberian Amlodipin Pagi Versus Malam Terhadap Penurunan Tekanan Darah Pasien Hipertensi Primer Eziah Ika Lubada; Selly Septi Fandinata; Rizky Darmawan
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.304

Abstract

Human blood pressure goes according to a circadian rhythm, blood pressure drops during sleep and increases in the morning this happens in most individuals. One of the hypertension drug therapies is Amlodipine Calcium Channel Blocker class which has a long half-life, so it can be used once a day, and amlodipine works as a long-acting antihypertensive. On reducing blood pressure in primary hypertensive patients. The design of this study was a cohort by measuring blood pressure before and after administration of amlodipine therapy in the morning or amlodipine at night in outpatients with a diagnosis of primary hypertension who received amlodipine therapy at the “X” Clinic in Surabaya with retrospective data collection. The results of this study were obtained from 20 patients who stated that there was no significant difference in difference in systolic and diastolic blood pressure between January and December 2019 in patients receiving amlodipine therapy 5 mg in the morning, 10 mg in the morning, 5 mg in the evening and 10 mg in the evening. There is an effect of giving amlodipine therapy in the morning and evening.
Changes in Mean Arterial and Blood Pressure in Using Nicardipine in Hypertensive Crisis Patients at the Hajj General Hospital Surabaya from August to December 2021 Selly Septi Fandinata; Rizky Darmawan; Ninik Mas Ulfa; Deddy Aryanda Putra
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.3493

Abstract

Hypertension crisis is one of the most common disease problems; it will cause complications and death. Therapeutic management guidelines that the calcium channel blocker group, one of which is nicardipine, can increase the achievement of goals in mean arterial pressure (MAP) in preventing the progression of organ damage. This study aimed to evaluate the use of nicardipine therapy on the MAP and blood pressure (BP) in patients with hypertension crisis. The research design was cross-sectional with statistical analysis—retrospective data collection at Hajj General Hospital Surabaya for August to December 2021. The number of samples in this study matched the inclusion criteria; 20 patients were obtained, 16 with a diagnosis of hypertension emergency, and four with hypertension urgency who received single or combined intravenous nicardipine therapy <0.005 with an average BP decrease of pre 20.375±31.492/103.50±10.400 mmHg and post 121.34±14.364/81.80±11.186 so that intravenous nicardipine therapy was significant in reducing systolic and diastolic BP. In the profile of the MAP value statistically using the paired T-test, it was found that the P-value was 0.000 < 0.005 with a decrease in the MAP pre-value of 135.028±13.8857 mmHg and post 93.650±8.9499 mmHg, showing a reduction in MAP as expected. In conclusion, using nicardipine intravenously at a 5 mg/hour dose has shown an optimal decrease in BP and MAP in hypertensive emergency and urgency patients.
Evaluation of the Adequacy Level of Nutritional Substances (Vitamins) with the Incident of Stunting in Children in the Working Area of the Surabaya City Health Center Septi Fandinata, Selly; Mas Ulfa, Ninik; Puspa Novita, Rennie; Aryanda Putra, Deddy
International Journal of Science, Technology & Management Vol. 5 No. 2 (2024): March 2024
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v5i2.1079

Abstract

Stunting is a condition where height growth disorders arise due to malnutrition, so that a child's height does not correspond to his age. The aim of this research is to evaluate the use of vitamins and minerals in stunting cases in several Surabaya Community Health Centers. The results of this research are descriptive with prospective data collection. The number of respondents obtained was 64 stunting child patients who met the inclusion criteria. Based on the results of child demographics according to age, the most stunting child patients were 32 patients aged 48 – 60 months (50%). Based on gender, the results were balanced between women and men. Based on a history of exclusive breastfeeding, the majority had a history of exclusive breastfeeding, 52 patients (81.25%). Based on birth weight, the highest number of patients with a normal weight (>2500) grams was 53 patients (82.82%). Based on disease history, the majority did not have a history of disease, 53 patients (82.82%). The vitamins and minerals used in stunting cases in several Surabaya Community Health Centers are Optima Zinc Syrup, Vitamin and Mineral Powder, Taburia, and Vitamin A Capsules, with the rules and duration of use according to those given. Based on the results of nutritional status assessments at several Surabaya Community Health Centers, it was found that the majority of children were underweight based on Z-Score BW/U, had short status based on Z-Score BH/U, and had good nutritional status based on Z-Score BW/BH. The results of the nutritional status assessment concluded that the majority of children were underweight based on Z-Score BW/U, had short status based on Z-Score BH/U, and had good nutritional status based on Z-Score BW/BH.
Penyuluhan Penggunaan Tanaman Obat Keluarga (TOGA) Daun Binahong Sebagai Anti-Bakteri Arifiyana, Djamilah; Fandinata, Selly Septi; Aristyawan, Andhika Dwi
JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia) Vol 4, No 4: November (2023)
Publisher : ICSE (Institute of Computer Science and Engineering)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak: Gaya hidup back to nature, atau kembali ke alam saat ini semakin banyak diminati seiring dengan kesadaran masyarakat akan bahaya yang ditimbulkan dari penggunaan bahan kimia. Hal ini membuat penggunaan Tanaman Obat Keluarga (TOGA) kembali populer dikalangan masyarakat di Indonesia. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan tentang pemanfaatan dan pengolahan TOGA daun Binahong sebagai bahan alami untuk membuat sediaan yang bermanfaat bagi tubuh sebagai upaya preventif dan promotif pada musim pancaroba. Metode pelaksanaan kegiatan ini adalah melalui penyuluhan yang meliputi metode ceramah, diskusi, dan praktik langsung. Masyarakat sasaran kegiatan ini adalah warga RT 13 RW 01 Kelurahan Jagir Surabaya. Kegiatan terdiri dari beberapa tahapan, yakni Pra survey dan perizinan lokasi kegiatan, Penyuluhan tentang penyakit yang muncul saat pancaroba sekaligus penyerahan TOGA, Pemantauan pertumbuhan TOGA, Penyuluhan budidaya sederhana TOGA dan pembuatan sediaan dauh binahong, serta Evaluasi kebermanfaatan pelaksanaan kegiatan pemanfaatan daun binahong sebagai anti-bakteri. Setelah serangkaian kegiatan terlaksana, diperoleh hasil kuesioner menunjukkan bahwa 100% dari warga RT 13 RW 01 Kelurahan Jagir Surabaya setuju bahwa kegiatan ini bermanfaat dan dapat diikuti dengan jelas dan baik, 97,06% setuju bahwa kegiatan ini dapat diterapkan dalam kehidupan sehari-hari, serta 100% warga setuju untuk mengaplikasikan pembuatan pestisida alami di rumah dan menyatakan bahwa bahan yang dibutuhkan dalam pembuatannya mudah didapatkan.Abstract: ‘Back to nature’ lifestyle is currently increasing in demand along with public awareness of the dangers posed by the use of chemicals. This has made the use of Tanaman Obat Keluarga (TOGA) popular again among people in Indonesia. This community service activity aims to increase knowledge about the use and processing of TOGA Binahong leaves as a natural ingredient for making preparations that are beneficial for the body as a preventive and promotive effort during the transition season, as well as providing education about TOGA cultivation in a simple way. The method for implementing this activity is through counseling which includes lecture, discussion and direct practice methods. The target community for this activity are residents of RT 13 RW 01, Jagir, Surabaya. The activity consists of several stages, namely Pre-survey and licensing of activity locations, Counseling about diseases that appear during the transition as well as handing over TOGA, Monitoring the growth of TOGA, Counseling on simple cultivation of TOGA and making binahong leaf preparations, as well as Evaluation of the usefulness of implementing activities to use binahong leaves as an anti-bacteria. After a series of activities were carried out, the results of the questionnaire showed that 100% of the residents of RT 13 RW 01, Jagir Subdistrict, Surabaya agreed that this activity was useful and could be followed clearly and well, 97.06% agreed that this activity could be applied in their daily life, and 100% of residents agreed to apply natural pesticide production at home and stated that the materials needed to make it were easy to obtain.
PRESCRIPTION PROFILE OF ANTIHYPERTENSIVE DRUGS IN PREECLAMPSIA PATIENTS AT KIRANA HOSPITAL Lubada, Eziah Ika; Fandinata, Selly Septi; Alfiana, Silvina Sita; Suryandari, Mercyska; Isdianto, Andik
International Journal of Islamic and Complementary Medicine Vol. 5 No. 1 (2024): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V5I1.87

Abstract

Preeclampsia is a complication of pregnancy with symptoms of hypertension ≥ 140/90 mmHg and proteinuria ≥ 0.3 grams/24 hours or 30 mg/dl (+1 dipstick) arising after more than 20 weeks of gestation in previously normotensive pregnant women. Maternal deaths in Indonesia in 2021 related to hypertension in pregnancy reached 1077 cases (Source: Directorate General of Public Health, Ministry of Health, 2021). Pharmacological therapy intervention, antihypertensive treatment is also needed in addition to maintaining a healthy lifestyle. The purpose of the study was to determine the description of pharmacological therapy including the pharmacological class of drugs, drug names, drug doses, rules of use, and types of antihypertensive drug therapy (single / combination) in patients with preeclampsia. This type of descriptive observational research is retrospective with total sampling obtained from medical records and patient prescriptions. The results of this study were the incidence of preeclampsia aged 35 years and over by 21 patients (36%) and the most common diagnosis was mild preeclampsia by 38 samples (66%). The use of nifedipine which is included in the CCB (Calcium Channel Blocker) group was 42 respondents (72%). Meanwhile, the use of methyldopa which is included in the central sympatholytic group was 17 respondents (28%). In the single therapy type study, 59 prescriptions (100%) used nifedipine or methyldopa. Pregnant women are encouraged to routinely conduct antenatal care checks at the hospital every month.
HUBUNGAN PENGGUNAAN ANTIPSIKOTIK DENGAN EFEK SAMPING EKSTRAPIRAMIDAL PASIEN SKIZOFRENIA novita, rennie puspa; Amriani, Annisa; Fitrya, Fitrya; Fandinata, Selly Septi; Luthfiah, Annisa
MESINA (Medical Scientific Journal) Vol 4, No 1 (2023): Medical Scientific Journal (MESINA)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v4i1.7030

Abstract

Skizofrenia adalah salah satu gangguan jiwa berat yang ditandai dengan kesulitan yang dialami pasien untuk membedakan antara hal-hal yang terjadi dalam kehidupan sehari-hari seperti halusinasi dan delusi. Antipsikotik digunakan untuk menangani skizofrenia. Salah satu efek samping terapi antipsikotik yang paling umum adalah gejala ekstrapiramidal. Tujuan penelitian ini adalah untuk mengamati pola penggunaan antipsikotik dan menentukan hubungan antara penggunaan antipsikotik dan jumlah efek samping ekstrapiramidal yang terjadi di ruang rawat inap Rumah Sakit Ernaldi Bahar Palembang dari Oktober 2021 hingga Oktober 2022. Dalam penelitian ini, teknik pengambilan sampel purposive digunakan untuk mengumpulkan data secara retrospektif. Sebanyak 103 sampel berupa rekam medis pasien skizofrenia memenuhi kriteria inklusi. Menurut pola penggunaan antipsikotik, penggunaan antipsikotik kombinasi lebih banyak (64%) daripada antipsikotik tunggal. Efek samping ekstrapiramidal paling sering terjadi dengan kombinasi haloperidol-risperidone (6,8%), dan dengan risperidone sebagai terapi tunggal, yang paling sering terjadi. Hipersalivasi adalah efek samping paling umum dari sindrom ekstrapiramidal (34,3%). Hasil uji chi-square menunjukkan nilai p = 0,022, yang menunjukkan bahwa p < 0,05. Efek samping sindrom ekstrapiramidal dapat dipengaruhi oleh penggunaan antipsikotik, baik secara tunggal maupun dalam bentuk kombinasi. 
Analisis Efektifitas Biaya Terapi Pengobatan Pasien Diabetes Mellitus Tipe 2 terhadap Kontrol Glukosa Darah Ulfa, Ninik Mas; Fandinata, Selly Septi; Puspitasari, Indra
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6170

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by blood glucose levels exceeding normal. The length of therapy in DM patients causes the large amount of treatment costs incurred, although in Indonesia BPJS insurance is used but this puts the burden of health financing on the Indonesian government, so there is a need for an analysis of costs associated with therapeutic outcomes. The purpose of this study was to analyze the Cost Effectiveness of Type 2 DM patients in a hospital in the South Surabaya area. The method used is observation, with retrospective observation on type 2 DM patients in outpatient internal polyclinics for the period April – December 2021. The results obtained were 30 patients who routinely controlled 2, 3, 4, 5, 6, 7, 8 and 9 months, receiving single therapy or a combination of antidiabetic drugs. In this study, a cost and effectiveness analysis was carried out with the measurement of therapeutic outcomes, namely pre-post GDP and pre-post GD2PP. The conclusion of this study were 30 female patients (100%), age > 45 years 24 people (80%). The effectiveness of sulfonylurea single therapy is 50% with an ACER of between Rp. 4,392.48 – Rp. 18,686.86 routine control 2, 3 and 9 months. For the treatment of 2 combinations of Thiazolidinediones + Insulin has an effectiveness value of 100% with ACER Rp. 42,490.08 routine control 6 months. While the 3 combinations that have a 100% effectiveness value are the combination of Sulfonylurea + Thiazolidinedione + Biguanide with an ACER price of Rp. 6,668.4 routine follow-up for 3 months. In 3 combinations of oral antidiabetic with insulin (Insulin + Sulfonylurea + Thiazolidioine + alpha glucosidase inhibitor) has a 100% effectiveness value, the ACER price is Rp. 36,082.36 routine control 7 months.
Identifikasi Kelengkapan Resep Anak secara Administrasi Farmasetik dan Klinis (Dosis) di Apotek X Surabaya Lubada, Eziah Ika; Fandinata, Selly Septi; Zakiyah , Farah Afifatuz
Jurnal Teknologi dan Sains Modern Vol. 1 No. 3 (2024): September-Oktober
Publisher : CV. Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/jtsm.v1i3.214

Abstract

Resep merupakan permintaan dari penulis resep untuk menyediakan dan menyerahkan obat sesuai peraturan sehingga harus tercantum informasi lengkap agar farmasis bisa mendeteksi potensi kesalahan sebelum obat disiapkan dan diberikan ke pasien. Skrining peresepan dilakukan untuk mencegah kesalahan pengobatan atau pemberian obat pada semua resep tanpa pengecualian. Penelitian ini bertujuan untuk mengidentifikasi kelengkapan resep anak di Apotek X Surabaya pada periode September-November 2023. Penelitian menggunakan observasional deskriptif secara retrospektif dengan total 313 resep yang dianalisis. Hasil penelitian menunjukkan bahwa dari aspek administrasi tidak lengkap 100% meliputi nama pasien, nomor rekam medis, nama dokter, alamat dokter, surat izin praktik, tanggal penulisan resep, usia, berat badan , jenis kelamin, alamat, nomor telepon pasien dan paraf dokter. Aspek farmasetik menunjukkan 99.36% Lengkap meliputi nama obat, aturan pakai, jumlah sediaan,  bentuk sediaan dan kekuatan sediaan. Namun, untuk aspek klinis kesesuaian dosis hanya 7,67% yang sesuai dengan dosis menurut literatur.
Education On The Potential Of Telang Flower Kombucha (Clitoria Ternatea L) As An Effort To Prevent Stunting And Diabetes Mellitus Fandinata, Selly Septi; Puji, Kinanti Ayu; Permatasari, Silfiana Nisa; Suryandari, Mercysca; Lubada, Eziah Ika
J-ADIMAS (Jurnal Pengabdian Kepada Masyarakat) Vol 12, No 2 (2024)
Publisher : (STKIP) PGRI Tulungagung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29100/j-adimas.v12i2.6796

Abstract

Stunting menjadi permasalahan karena berhubungan dengan meningkatnya risiko terjadinya kesakitan, kematian, perkembangan motorik terhambat dan juga terganggunya pertumbuhan otak. Angka kejadian diabetes mellitus pada orang dewasa juga terus bertambah. Hal tersebut perlu adanya perhatian secara khusus dari pemerintah setempat maupun negara supaya kasus stunting dan diabetes mellitus yang terjadi tidak cenderung mengalami suatu peningkatan. Salah satu upaya dalam mencegah yaitu dibutuhkan nya suatu edukasi. Salah satu keanekaragaman hayati yang dimiliki Indonesia adalah bunga telang (Clitoria ternatea L.).  ini yang mempunyai fungsi tersebut. Tujuan dari pengabdian ini adalah untuk meningkatkan pemahaman ibu-ibu PKK di Jalan Tanah Merah Surabaya tentang Pemanfaatan Kombucha Bunga Telang Sebagai Pencegahan Stunting dan Penurunan Kadar Gula Darah. Metode yang digunakan adalah dengan memberikan edukasi dan pelatihan. Hasil penyuluhan menunjukkan bahwa kegiatan sosialisasi, edukasi dan pelatihan telah berhasil meningkatkan  pemahaman mereka  mengenai  Potensi Kombucha Bunga Telang (Clitoria ternatea L) sebagai Upaya Pencegahan Stunting dan Diabetes Mellitus. Kegiatan   ini   membantu   masyarakat   untuk menghadapi permasalahan stunting dan diabetes mellitus yang saat ini masih menjadi masalah pemerintah dalam bidang Kesehatan dan meningkatkan wirausaha masyarakat. Kegiatan pengabdian kepada masyarakat ini juga berpotensi untuk dilanjutkan, dan partisipasi  peserta,  baik  secara  langsung  maupun  tidak  langsung,  sangat  diperlukan  untuk memantau kelangsungan kegiatan ini