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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Pendidikan Kimia (JPKim) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Indonesian Journal of Pharmaceutical and Clinical Research Community Development Journal: Jurnal Pengabdian Masyarakat Journal of Multidisciplinary Applied Natural Science Herbal Medicine Journal Borneo Journal of Pharmacy
Iksen, Iksen
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Studi In Silico Senyawa Bahan Alam Terhadap Biomarker Pembelahan Sel Kanker Iksen, Iksen; Sari, Hesti Yola
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.138

Abstract

Uncontrolled cancer cell division causes a high risk of death for cancer patients. One of the proteins that control cell division is CDK 4 and CDK6. The use of natural compounds as supporting therapy can reduce the toxicity symptoms of conventional chemotherapy. This study aimed to analyze the possible interactions of natural compounds such as allicin, alpha-mangoestin, curcumin and hesperetin on cancer cell division biomarkers (CDK4 and CDK6). This research process was carried out in silico using the Pyrx 0.8 program and Discovery Studio 2022. The parameters tested included binding energy, number of interactions and types of interaction. The results found that allicin, alpha-mangoestin, curcumin and hesperetin can interact with CDK4 and CDK6. The types of interactions formed between the ligand and the target protein are hydrogen bonds, hydrophobic bonds, and electrostatic bonds. In this study, it can be concluded that natural compounds such as allicin, alpha-mangoestin, curcumin and hesperetin are able to interact with CDK4 and CDK6 proteins in silico so that they are considered potential candidates for cancer drugs
Perbandingan Pengaruh Konsumsi Jus Terong Belanda Segar dan Komersil Terhadap Tikus Obesitas Syahputra, Hariyadi Dharmawan; Harahap, Daimah Wirdatus Sanaun; Iksen, Iksen; Gurning, Kasta
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.144

Abstract

Background: High yield carbohydrate diet is common in Indonesia mainly in North Sumatra province. In the long run consuming primary carbohydrate form rice may increase the risk for diabetic and its complication. Not only the amount of rice but certain beverages also such as tamarillo juice, though it’s rich amount of nutritious benefit, some product may yield more sugar to improve from its sour or bitter flavor. Objectives: studies aim to find the diet correlation between amount of carbohydrate total and Vitamin C intake in fresh and store brought tamarillo juice affect animal model with high sucrose induction. Material and Methods: Fresh tamarillo fruit grew in north Sumatra blended versus store brought juice are given daily towards obese female rats induced with 2 ml of lard and 5% sucrose orally for five weeks. Beforehand sample had its total carbohydrate and Vitamin C content with iodometric method. The last 2 weeks then rats treated with fresh blend and store brought product juice. Results: Total content value obtained from fresh compared with store brought tamarillo juice in vitamin C, (18.63 ± 7.16 mg/ml); (11.57 ± 6.8 mg/ml) and total carbohydrate (15.02 ± 2.35 mg/ml); (25.37 ± 28.17 mg/ml) respectively. During treatment increase in body weight significantly in store brought product. Histology remarks in pancreas do not show any significance damage in cell especially for fresh blend treatment group. Conclusion: Fresh blend tamarillo juice may improve health and can be considered safe for subject that like to consume high carbs in their diet.
In Vitro Test of Anticalculi Effect from Ethyl Acetate Fraction of Chives Leaf (Allium schoenoprasum L.) Iksen; Sinaga, Siti Morin; Kevin, Kevin; Hutabalian, Marshinta Romarta Uly
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.469 KB) | DOI: 10.32734/idjpcr.v2i2.3030

Abstract

Abstract. The purpose of this study was to analyze the ability of chives leaves of ethyl acetate fraction to dissolve calcium in human kidney stones. This research starts from making the ethyl acetate fraction, calibration curve for calcium and measuring dissolved calcium levels in kidney stones by using atomic absorption spectrophotometry. The results showed that the ethyl acetate fraction with a concentration of 2.5% had the greatest anti-calculi capability of 92.02%. The conclusion of this study is that the ethyl acetate fraction of chives leaf has the potential to be anticalculi in the treatment of kidney stones. Abstrak. Tujuan dari penelitian ini adalah untuk menganalisis kemampuan fraksi etil asetat daun kucai untuk melarutkan kalsium pada batu ginjal manusia. Penelitian ini dimulai dari pembuatan fraksi etil asetat, pembuatan kurva kalibrasi kalsium serta pengukuran kadar kalsium terlarut pada batu ginjal dengan menggunakan spektrofotometri serapan atom. Hasil penelitian menunjukkan bahwa fraksi etil asetat dengan konsentrasi 2,5 % memiliki kemampuan antikalkuli yang terbesar yakni 92,02%. Kesimpulan penelitian ini adalah bahwa fraksi etil asetat daun kucai berpotensi sebagai antikalkuli pada pengobatan batu ginjal.
PENYULUHAN MANFAAT POSYANDU LANSIA DI DESA UJUNG LABUHAN KECAMATAN NAMORAMBE Barus, Lydia Br; Br. Sitorus, Juniar Alpina; Sipayung, Novitri Adelia; Yanti, Yanti; Sipahutar, Dame Meldaria; Iksen, Iksen
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 4 (2024): Volume 5 No. 4 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i4.33250

Abstract

Usia lanjut atau lansia merupakan salah satu siklus hidup yang dialami oleh manusia secara alami yang ditandai dengan penuaan serta penurunan kemampuan tubuh baik secara fisik, mental, sosial dan penurunan kondisi kesehatan. Kegiatan penyuluhan posyandu lansia di Desa Ujung Labuhan Kecamatan Namorambe merupakan salah satu cara untuk mengetahui permasalahan kesehatan lansia dan sosialisasi manfaat posyandu lansia. Kegiatan dihadiri oleh 30 peserta yang terdiri dari 20 perempuan dan 10 laki-laki dengan usia > 61 dan rata-rata usia 65,8 tahun dengan keluhan masalah kesehatan seperti hipertensi, diabetes, nyeri tulang dan susah berjalan. Perlu dilakukan sosialisasi posyandu lansia secara berkala sehingga permasalahan kesehatan lansia dapat terpantau, akibatnya dapat meningkatkan usia haparan hidup lansia.
Co-Authors Aminah Dalimunthe Azizah Nasution Bayu Cakra Buana Br. Sitorus, Juniar Alpina Buana, Bayu Cakra Chiuman, Linda Dameria Siahaan Darmirani, Yosi Emanrius Lase Esther Siringo ringo FAHDI, FIRDAUS Ginda Haro Ginting, Chrismis Novalinda Harahap , Khoirunnisa Harahap, Daimah Wirdatus Sanaun Helen Anjelina Simanjuntak Hutabalian, Marshinta Romarta Uly Indah Yani Tambunan Kasta Gurning Kevin kevin Khairunnisa Lydia Br Barus Masfria Mastiur Julianti Mutiara Siahaan Purba, Hermawan Razoki, Razoki Sari , Herviani Sari, Hesti Yola Sembiring, Mahral Effendi Sihotang, Santyria Sipahutar, Dame Meldaria Sipayung, Novitri Adelia Siti Morin Sinaga Syahputra, Hariyadi Dharmawan Syahrina Syahrina Vera Estefania Kaban Vivi Asfianti Wijaya, Johanna Fransiska Wiryanto Yanti Yanti