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All Journal HAYATI Journal of Biosciences Indonesian Journal of Pharmaceutical Science and Technology ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology Jurnal Sains dan Kesehatan
Muh Ikhlas Arsul
UIN Alauddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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HMG-CoA Reductase Inhibitory Activity Potential of Iota-, Kappa-, and Lambda-carrageenan: A Molecular Docking Approach Setiawansyah, Arif; Muh Ikhlas Arsul; Adliani, Nur; Wismayani, Leni
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.32721

Abstract

HMG-CoA reductase is an essential enzyme responsible for the biosynthesis of cholesterol. Hyperactivity of HMG-CoA reductase will increase cholesterol production, leading to the elevation of blood cholesterol levels. Inhibition of HMG-CoA reductase is one way to block cholesterol biosynthesis to lower blood cholesterol levels. This study evaluated the inhibitory potential of iota-, kappa-, and lambda-carrageenan against HMG-CoA reductase. The study was undertaken by in silico method using a molecular docking approach via Autodock 4.2 assisted by ADT graphical user interface. HMG-CoA reductase co-crystal structure was used as the target, and iota-, kappa-, and lambda-carrageenan as the test ligands. The result revealed that iota- and lambda-carrageenan possess an excellent affinity to HMG-CoA reductase with the free binding energy of -12.44 and -11.87 kcal/mol and Ki value of 0.765 and 2.01 nM, respectively, which is found to be better than Simvastatin and the native ligand. The compounds' chemical properties influenced the molecules' molecular interactions affecting their affinity. The number of SO4 groups is assumed to affect the HMG-CoA reductase inhibitory activity of iota-, kappa-, and lambda-carrageenan. KEYWORDS: iota-, kappa-, and lambda-carrageenan; HMG-CoA reductase; inhibitory activity; molecular docking
Formulation and Characterization of Edible Film with Concentration Various of Sodium Carboxymethyl Cellulose from Kepok Banana (Musa paradisiaca L.) Bark and Plasticizer Ningsi, Surya; Abbas, Nurfahima; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.45330

Abstract

Introduction: Bark of kepok banana (Musa paradisiaca L.) contains high cellulose that can be synthesized into sodium carboxymethyl cellulose (Na-CMC). Na-CMC can be used as a raw material for the preparation of edible film. Aims: The purpose of this study was to determine the concentration of sodium carboxymethyl cellulose from kepok banana bark combine with plasticizer to produce edible films with good characteristics and quality. Methodology: Edible films were made with varying concentrations of 6%, 10%, and 14% Na-CMC; 4% glycerol and 9% sorbitol as plasticizer. Edible films were made using casting method and characterized including organoleptic test, thickness, pH, water absorption, elongation, and tensile strength. Result: Edible film made is in the form of thin layer, transparent white in color, and odorless; thickness 0,10±0,01-0,38±0,01 mm; pH 7,1±0,08-7,7±0,04; moisture content 35,47-91,97%; elongation 16,33±3,66-53,29±6,13%; and tensile strength 0,0528±0,00-3,9871±0,04 MPa.. Conclusion: Different concentrations of Na-CMC and plasticizer affect the characteristics produced. The best result based on Japanese Industrial Standard (JIS) is formula F5 with 10% Na-CMC concentration and 9% sorbitol as plasticizer
Effects of Enhancment Span-60 of Vernonia amygdalina Leaves Extract-loaded Niosomes Pratiwi, Afrianty; Syahrana, Nur Azizah; Ismail, Isriany; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.45956

Abstract

Introdiction: Niosomes are a promising drug carrier because of their bilayer structure and the fact that they are produced by the self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are non-toxic, biodegradable, and compatible with human cells. Aims: This research aimed to create niosomes from V. amygdalina leaves and investigate how span 60 addition affects niosome properties. Methods: Extraction V. amygdalina using maceration, niosomes synthesized using a thin-film hydration process, and characterization performed by SEM, particle size, polydispersity index, zeta potential, and FTIR. Conclusion: V. amygdalina succesfully to loaded into niosomes. Span-60 with various concentration affected of characterization of niosomes. Increased span-60 increasing particle size, polydispersity index, and %EE.
Aaptamine Enhanced Doxorubicin Activity on B-Cell Lymphoma 2 (Bcl-2): A Multi-Structural Molecular Docking Study Setiawansyah, Arif; Susanti, Gita; Alrayan, Reza; Hadi, Ismanurrahman; Ikhlas Arsul, Muhammad; Luthfiana, Dewi; Wismayani, Leni; Hidayati, Nurul
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.46796

Abstract

Doxorubicin, a widely used chemotherapeutic agent, targets Bcl-2, but its efficacy can be limited by drug resistance. Its combination with natural derived compound can be a therapeutic approach to overcome this problem. This study aimed to investigate the molecular interactions and binding affinities of aaptamine and doxorubicin with Bcl-2 using molecular docking simulations, and to evaluate the potential synergistic effects of their combination. Molecular docking studies were performed to predict the binding modes and affinities of aaptamine and doxorubicin along with their combination to Bcl-2. Molecular docking simulation results showed that aaptamine binds to the BH3 binding groove of Bcl-2, forming key interactions with residues like Asp70, Tyr67, Phe112 and Glu111. Aaptamine stabilized the binding of doxorubicin to Bcl-2 through hydrophobic bonding and van der Waals interactions, resulting in enhanced binding affinity. The combination of aaptamine and doxorubicin exhibits synergistic anticancer effects by enhancing the binding affinity of doxorubicin to Bcl-2. Molecular docking simulations provided insights into the stabilizing interactions between aaptamine, doxorubicin, and Bcl-2, suggesting a potential strategy for overcoming Bcl-2-mediated drug resistance in cancer. However, further in vitro investigation is needed to be implemented.
Studi Pustaka: Pengaruh Metode Ekstraksi Terhadap Kualitas Gelatin dari Ikan dengan Pretreatment Asam dan Basa Jaya, Adrian; Ismail, Isriany; Arsul, Muhammad Ikhlas
Jurnal Farmasi UIN Alauddin Makassar Vol 12 No 1 (2024): Jurnal Farmasi Edisi Mei
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v12i1.38150

Abstract

Pendahuluan: Gelatin ikan merupakan gelatin alternatif yang bersifat multifungsi yang diperoleh dari hidrolisis kolagen dari bagian ikan meliputi sisik, kulit maupun tulang dengan metode ekstraksi tertentu. Tujuan: Untuk mendapatkan informasi dari berbagai sumber literatur mengenai pengaruh metode ekstraksi gelatin ikan terhadap kualitas gelatin dalam upaya mengembangkan metode yang paling efisien dalam produksi gelatin ikan. Metode: Penulisan artikel ini adalah literature review yaitu sebuah pencarian literatur baik international maupun nasional yang dilakukan dengan menggunakan database pubmed, sciencedirect, dan google schoolar. Penelusuran dan analisis artikel menggunakan metode PICO (Population, Intervention, Comparison, Outcome). Hasil: Terdapt 28 artikel yang memenuhi kriteria untuk selanjutnya dilakukan analisis dengan melihat metode ekstraksi gelatin dan karakteristik gelatin. Kesimpulan: Semakin tinggi suhu ekstraksi, semakin rendah nilai Gel strength dan kadar abu dari gelatin yang dihasilkan. Semakin tinggi suhu ekstrkasi maka semakin tinggi nilai viskositas. Pada hasil analisis diperoleh bahwa pH optimum diperoleh pada ekstraksi gelatin berada pada kisaran 4,5-6,5.
Analisis Perbandingan Angka Bakteri Coliform antara Air Minum Isi Ulang Langsung di Depot dengan Air Minum Isi Ulang yang Beredar di Pasaran Muhammad Rifqi Abdillah; Arsul, Muhammad Ikhlas; Afrisusnawati Rauf; Mukhriani
Jurnal Farmasi UIN Alauddin Makassar Vol 10 No 1 (2022): Jurnal Farmasi Edisi Juni
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v10i1.51026

Abstract

Pendahuluan: Depot air minum isi ulang (DAMIU) merupakan tempat pengisian air minum atau industri penyedia air bersih siap minum. Berdasarkan keputusan Menteri perindustrian dan perdagangan DAMIU hanya boleh mengisi wadah yang dibawa konsumen dan tidak boleh melakukan stok air yang sudah dikemas dalam wadah karena beresiko tercemar bakteri, namun saat ini banyak depot yang melakukan stok bahkan mengedarkan air isi ulang ke toko. Tujuan:Penelitian ini bertujuan untuk menganalisa perbedaan angka cemaran bakteri Coliform air minum yang diambil langsung dari depot dan air minum isi ulang yang diedarkan ke toko. Metode: Penentuan cemaran bakteri Coliform dilakukan dengan teknik filtrasi membran. Sampel pada penelitian terdiri dari 2 kelompok yaitu kelompok depot dan kelompok toko yang masing-masing kelompok memiliki 10 sampel. Hasil: Penelitian menunjukkan bahwa seluruh sampel uji mengandung bakteri coliform. Berdasarkan uji statistik terdapat perbedaan yang signifikan antara kedua kelompok sampel uji. Kesimpulan: Hasil yang diperoleh menunjukkan resiko cemaran mikroba tinggi yang tidak memenuhi peryaratan BPOM, sehingga perlu dilakukan pengujian secara berkala dan melakukan standarisasi persyaratn hygiene untuk memperolej kualitas air minum yang berkualitas, bersih, bebas mikroba dan sehat untuk masyarakat.
Studi Literatur Tanaman Buni (Antidesma Bunius L. Spreng) Sebagai Antidiabetik Ismail, Asrul; Mukhriani; Muh. Ikhlas Arsul; Rezky Aulia
Jurnal Farmasi UIN Alauddin Makassar Vol 10 No 1 (2022): Jurnal Farmasi Edisi Juni
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v10i1.51080

Abstract

Abstrak Pendahuluan: Obat tradisional banyak digunakan di masyarakat sebagai pengobatan alternatif karena sudah teruji khasiatnya. Pemanfaatan tanaman buni (Antidesma Bunius L. Spreng) sebagai antidiabetes belum banyak diketahui oleh masyarakat, kandungan yang terdapat dalam tanaman buni (Antidesma Bunius L. Spreng) mendorong peneliti untuk mengidentifikasi secara ilmiah. Tujuan: Penelitian ini dilakukan untuk mengetahui kandungan dan aktivitas farmakologi tanaman buni sebagai antidiabetes. Metode: Jenis penelitian ini ialah studi literatur dengan analisis jurnal atau artikel ilmiah menggunakan kata kunci yang berkaitan dengan Antidesma bunius L. Spreng dan Antidesma bunius L. Spreng for antidiabetes menggunakan metode PICOS melalui kriteria inklusi dan kriteria eksklusi. Hasil: Berdasarkan kajian studi literatur diperoleh gambaran bahwa daun buni (Antidesma Bunius L. Spreng memiliki kandungan flavonoid, tannin, fenol, alkaloid, saponin, steroid, protein, dan triterpenoid yang memiliki aktivitas sebagai antiinflamasi, sebagai inhibitor enzim glucosidase, antibakteri dan antikanker. Kesimpulan: Dari analisis beberapa jurnal, tanaman buni secara umum memiliki kandungan flavonoid, steroid, saponin, tanin, alkaloid, polifenol serta triterpenoid. Senyawa yang memiliki aktivitas sebagai antidiabetes adalah senyawa flavonoid. Kata kunci: Antidabetik, Obat Tradisional, Tanaman buni (Antidesma bunius L. Spreng), PICOS
Parang Romang (Boehmeria virgata (Frost.) Guill.): Correlation of Phytochemistry with Antioxidant and Xanthine Oxidase Inhibitory Activities Arsul, Muhammad Ikhlas; Fidrianny, Irda; Insanu, Muhamad
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.457-464

Abstract

Secondary metabolites such as phenolic and flavonoid from the plant are essential in their activity, especially activities related to the prevention of oxidation and the inhibition of xanthine oxidase. One plant that is believed to have prevention of oxidation and XOI and correlates with secondary metabolites is parang romang. The purpose of this study is to assess the antioxidant capacity and xanthine oxidase inhibitory activities of parang romang, and to examine their relationship with the TPC and TFC. Total phenolic and flavonoid were measured for all parts, and the DPPH, FRAP, and CUPRAC methods determined antioxidant capacity. The activity of xanthine oxidase inhibition was also assessed. Flavonoids, alkaloids, and coumarin were found in parang romang. The steroid/triterpenoid was found in the stem, leaves, and flower; saponin was in the roots and flower; quinone and tannin were only in the roots. The root gave the highest of TPC, while the flower had the highest TFC. The highest antioxidant capacity was found in roots, leaves, flowers, and stems. The highest xanthine oxidase inhibitory was given by leaves (9.74±0.14 µg/ml), followed by flower, steam, and rood. The correlation was shown between the phenolic and flavonoid quantities and the actions of antioxidants and xanthine oxidase inhibitors.
Analisis Kualitatif dan Kuantitatif Antioksidan Parang Romang: Qualitative and Quantitative Antioxidant Analysis of Parang Romang Muhammad Ikhlas Arsul; Nurshalati Tahar; Afrisusnawati Rauf
Jurnal Sains dan Kesehatan Vol. 4 No. 4 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i4.1230

Abstract

Antioxidants can be found naturally in plants, animals, and microbes, or they can be produced chemically. The selection of plants to find the new bioactive compounds are carried out through ethnobotany and chemotaxonomic approaches. One plant that can be developed as an antioxidant is parang romang (Boehmeria virgata). This study aimed to identify an antioxidant activity on the roots, stems, leaves, and flowers of parang romang plant qualitatively and quantitatively. The parang romang plant used was obtained from Malino Regency, South Sulawesi. The roots, stems, leaves, and flowers were extracted using the reflux method and then concentrated using a rotary evaporator. Each part was analyzed for its chemical content and activity qualitatively and quantitatively. Qualitative analysis was carried out with sitroborat, folin ciocalteu, DPPH, FRAP, and CUPRAC reagen, while quantitative analysis was carried out by spectrophotometry using the DPPH method. The roots, stems, leaves, and flowers were detected to contain phenolic, and flavonoid compounds and have antioxidant activity based on qualitative analysis. The antioxidant activity of parts of the parang romang plant is classified as strong to very strong, with an AAI value of 1.5 - 4.54. All parts of the plant tested have antioxidant activity.  
Korelasi Kadar Fenol dan Flavonoid terhadap Indeks Aktivitas Antioksidan Ekstrak Batang Vernonia amygdalina: Correlation of Phenol and Flavonoid Content with Antioxidant Activity Index of Vernonia amygdalina Stem Extracts Mardhatillah Awwaliah; Mukhriani Mukhriani; Nur Asma; Muhammad Ikhlas Arsul
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1959

Abstract

Bitter leaf (in Africa) is the most widely cultivated species of the genus Vernonia which is the most prominent in the family Asteraceae that has been studied in Africa. African leaves have been widely used for traditional medicine and/or treating various human diseases. This study aimed to determine the bioactive compounds that correlate to the antioxidant activity of V. amygdalina stem. Extraction of V. amygdalina stem was carried out by reflux method. Determination of total phenol and flavonoid content was done spectroscopically. Antioxidant activity was measured based on antioxidant activity index (AAI) using DPPH and CUPRAC methods. Correlation coefficient between bioactive compounds and antioxidant activity using Pearson's correlation method. The results showed the antioxidant activity index of V. amygdalina stem showed strong to very strong activity. The ethyl acetate extract showed the highest total phenol and flavonoid levels. The phenol and flavonoid content of V. amygdalina stem extract showed a strong and significant correlation to the antioxidant activity index with a positive r value Kata Kunci:         AAI, DPPH, CUPRAC, pearson’s correlation   Abstrak Daun afrika merupakan spesies yang paling banyak dibudidayakan dari genus Vernonia yang paling menonjol dalam famili Asteraceae yang telah dipelajari di Afrika. Daun afrika telah banyak digunakan untuk pengobatan tradisional dan/atau mengobati berbagai penyakit pada manusia. Tujuan dari penelitian ini adalah untuk mengetahui senyawa bioaktif yang berkorelasi terhadap aktivitas antioksidan dari batang V. amygdalina. Ekstraksi batang V. amygdalina dilakukan dengan metode refluks. Penentuan kadar  fenol dan flavonoid total dilakukan secara spektroskopi. Aktivitas antioksidan diukur berdasarkan indeks aktivitas antioksidan (AAI) dengan metode DPPH dan CUPRAC. Koefisien korelasi antara senyawa bioaktif dan aktivitas antioksidan menggunakan metode korelasi pearson’s. Hasil penelitian menunjukkan indeks aktivitas antioksidan batang V. amygdalina menunjukkan aktivitas yang kuat hingga sangat kuat. Kadar fenol dan flavonoid total tertinggi ditunjukkan pada ekstrak etil asetat. Kadar fenol dan flavonoid ekstrak batang V. amygdalina menunjukkan korelasi kuat dan signifikan terhadap indeks aktivitas antioksidan dengan nilai r positif. Kata Kunci:         AAI, DPPH, CUPRAC, korelasi pearson’s
Co-Authors Abbas, Nurfahima Afrisusnawati Rauf Afrisusnawati Rauf Agnes Lidjajah Alrayan, Reza Aminah Aminah Andi Trihadi Kusuma Arif Setiawansyah Bambang Hernawan Nugroho, Bambang Hernawan Ebrahim sadaqa Faridha Yenny Nonci Fitril Imani Gebyanti Swara Gita Susanti, Gita Hadi, Ismanurrahman Indah Nur Pratiwi Indira Wahab Irda Fidrianny Ismail, Asrul Isriany Ismail Jaya, Adrian Khairunnisa Hasbullah Latifah Rahman Latifah Rahman Luthfiana, Dewi Mamat Pratama Mardhatillah Awwaliah Muammar Fawwaz Muhamad Insanu Muhammad Rifqi Abdillah Muhammad Rusdi Mukhriani Mukhriani, Mukhriani Musafira Musafira Nadhila Farhan Nadila Putri Ningsi, Surya Nur Adliani Nur Afiah Alfrianti Nur Nur Asma Nur Azizah Syahrana Nur Pratiwi Kartikasari Nur Rezky Rutami Amir Nurfajri Syamsi Nurlina Nurlina Nursalam Hamzah Nurshalati Tahar Nursyamsi Dhuha Nurul Hidayati Pratiwi, Afrianty Ratna Sugiarna Rezky Aulia Rina Iriani Ruhul Fadila Sadaqa, Ebrahim Supandi Syamsuri Syakri Wismayani, Leni Zulfahmi Alwi