Article Per Year (5 Year)
p-Index From 2021 - 2026
3.063
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Indonesian Journal of Pharmaceutical Science and Technology ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology Jurnal Sains dan Kesehatan
Muh Ikhlas Arsul
UIN Alauddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 24 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 24 Documents
Search

 1   2   3 
Organic Nanoparticle Genotoxicity: Current Understanding and Future Testing Needs Sadaqa, Ebrahim; Setiawansyah, Arif; Nugroho, Bambang Hernawan; Hidayati, Nurul; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52943

Abstract

Organic nanoparticles derived from biocompatible materials like chitosan, alginate, and lipids have garnered immense interest for drug delivery, bioimaging, and other biomedical applications. However, as their use rapidly expands, a comprehensive evaluation of their potential genotoxicity is crucial to ensure safe implementation. This review provides an in-depth analysis of the genotoxic risks associated with these organic nanoparticles. The review elucidates how the unique physicochemical properties of organic nanoparticles can induce genetic damage through mechanisms such as direct DNA binding, oxidative stress, inflammation, and impairment of DNA repair pathways. Importantly, this genotoxicity can occur even in the absence of overt cytotoxicity, leading to heritable mutations and long-term adverse effects like cancer and reproductive abnormalities. A critical assessment of established and emerging genotoxicity testing methods, including their strengths, limitations, and opportunities for standardization, is presented. The review synthesizes findings from existing in vitro and in vivo studies, revealing the contrasting genotoxic profiles of different organic nanoparticle formulations and exposure scenarios. Furthermore, the review provides insights into the multifaceted factors influencing nanoparticle genotoxicity, guiding the strategic engineering of safer designs. This comprehensive analysis underscores the pivotal importance of rigorous genotoxicity screening in the responsible development of organic nanomaterials. By harmonizing their innovative capabilities with a commitment to genetic integrity, this review paves the way for realizing the vast potential of organic nanoparticles while safeguarding human and environmental health.
Formulasi Biskuit Ekstrak Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Terhadap Penurunan Kadar Kolesterol pada Mencit (Mus musculus) Nursyamsi Dhuha; Muhammad Ikhlas Arsul; Gebyanti Swara
Jurnal Farmasi UIN Alauddin Makassar Vol 12 No 2 (2024): Jurnal Farmasi Edisi Desember
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v12i2.53168

Abstract

Pendahuluan: Rosella merupakan salah satu tanaman obat tradisional yang memiliki berbagai khasiat diantaranya meredakan batuk, sebagai antidiabetes, antikolesterol, antibakteri, dan meningkatkan sistem imun. Bahan aktif yang terdapat pada bunga rosella adalah grossypeptin, antosianin, gluside hibiscin dan flavonoid. senyawa tersebut diketahui dapat menurunkan kadar kolesterol. Tujuan: Penelitian ini bertujuan untuk mengetahui potensi penurunan kadar kolesterol dengan menggunakan ekstrak Bunga Rosella yang dibuat dalam bentuk biskuit. Metode: Penelitian ini menggunakan mencit yang dibagi kedalam empat kelompok. Kadar kolesterol ditingkatkan dengan induksi kuning telur. Bunga rosela dibuat dalam bentuk biskuit kemudian diberikan pada mencit secara peroral. Hasil: Setelah pemberian selama tujuh hari, kadar kolesterol masing-masing mencit menunjukkan penurunan yang signifikan. Kesimpulan: Biskuit ekstrak bunga rosella dapat menurunkan kadar kolesterol pada mencit. Kata kunci: Bunga rosella, biskuit, antikolesterol
Toxicity and Alpha Glucosidase Inhibitory Activity of Roasted Kedawung Seed (Parkia timoriana) Supandi, Supandi; Hadi, Ismanurrahman; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57945

Abstract

Introduction: Kedawung (P. timoriana) seeds are empirically utilised as a traditional medicine; it also contains various phytochemical compounds, antioxidant activities as well as other beneficial pharmacological effects. In some regions in Indonesia, the utilisation of kedawung seeds is usually done by involving the roasting process. Aims: This study aims to investigate the effect of roasting on phytochemical compounds, toxicity and alpha glucosidase inhibitory effects. Method: Kedawung seeds were roasted at 150 ºC (15 minutes); then separated from the skin, powdered and macerated in ethanol. Result: The extract was phytochemically screened with the results obtained showing positive for saponins, flavonoids, alkaloids, and terpenoids. The following test is toxicity test using BSLT (Brine Shrimp Lethality Test) method as well as inhibitory activity on alpha glucosidase enzyme. The test results showed that kedawung extract had an LC50 of 78.18 ppm in the BSLT test, as well as inhibition of alpha glucosidase enzyme at 265.24 ppm. Conclusion: The results obtained show that the ethanol extract of roasted kedawung seeds still has phytochemical metabolite compounds, but is moderately toxic and has weak inhibition on alpha glucosidase
The Utilization of Sugarcane Waste As an Alternative Material of Halal Hard Capsules Shell Alwi, Zulfahmi; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.55035

Abstract

Capsules are dosage forms used to encapsulate powders, granules, pellets, liquids, and semi-solids. There are two types of capsules: soft capsules, which are usually used to encapsulate liquid and semi-solid formulas, and hard capsules, which are used to encapsulate solid formulas and non-aqueous liquids. This research aims to analyze the halal critical point of cellulose production and hard capsule shell from sugarcane waste and its handling solution, make sugarcane waste into quality halal cellulose according to pharmaceutical standards, and formulate halal cellulose into quality hard capsule shell according to pharmaceutical standards. Analyzed halal were done by material and procedure. Extraction cellulose by acetylation. Characterization of cellulose followed yield, viscosity, and swelling. Capsule shelll characterization followed size and disintegration time. This study concludes that the source of ethanol in capsule shell production is key to determining its halal status. The process must avoid using haram materials like pork, its derivatives, human body parts, khamr, blood, carrion, improperly slaughtered animals, and forbidden animals. Instead, sugarcane waste can be used to produce halal cellulose, which meets pharmaceutical standards and can be used to make hard capsule shells that are both halal and meet industry requirements.
Co-Authors Abbas, Nurfahima Afrisusnawati Rauf Afrisusnawati Rauf Agnes Lidjajah Alrayan, Reza Aminah Aminah Andi Trihadi Kusuma Arif Setiawansyah Bambang Hernawan Nugroho, Bambang Hernawan Ebrahim sadaqa Faridha Yenny Nonci Fitril Imani Gebyanti Swara Gita Susanti, Gita Hadi, Ismanurrahman Indah Nur Pratiwi Indira Wahab Irda Fidrianny Ismail, Asrul Isriany Ismail Jaya, Adrian Khairunnisa Hasbullah Latifah Rahman Latifah Rahman Luthfiana, Dewi Mamat Pratama Mardhatillah Awwaliah Muammar Fawwaz Muhamad Insanu Muhammad Rifqi Abdillah Muhammad Rusdi Mukhriani Mukhriani, Mukhriani Musafira Musafira Nadhila Farhan Nadila Putri Ningsi, Surya Nur Adliani Nur Afiah Alfrianti Nur Nur Asma Nur Azizah Syahrana Nur Pratiwi Kartikasari Nur Rezky Rutami Amir Nurfajri Syamsi Nurlina Nurlina Nursalam Hamzah Nurshalati Tahar Nursyamsi Dhuha Nurul Hidayati Pratiwi, Afrianty Ratna Sugiarna Rezky Aulia Rina Iriani Ruhul Fadila Sadaqa, Ebrahim Supandi Syamsuri Syakri Wismayani, Leni Zulfahmi Alwi