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All Journal HAYATI Journal of Biosciences Indonesian Journal of Pharmaceutical Science and Technology ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology Jurnal Sains dan Kesehatan
Muh Ikhlas Arsul
UIN Alauddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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PENGARUH VARIASI KOMBINASI PVP K30 DAN EUDRAGIT RS-100 TERHADAP SIFAT FISIK DAN UJI IN VITRO PROPRANOLOL PATCH Muh. Ikhlas Arsul; Latifah Rahman
Jurnal Farmasi UIN Alauddin Makassar Vol 5 No 3 (2017): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v5i3.4351

Abstract

Telah dilakukan penelitian tentang pengaruh variasi kombinasi PVP K30 dan Eudragit RS-100 terhadap sifat fisik dan uji in vitro propranolol patch. Penelitian ini bertujuan untuk mengetahui apakah polimer jenis pvp dan eudragit dapat membentuk patch dengan sifat fisik yang baik dan mengetahui laju pelepasan  propranolol patch. Pengujian patch meliputi ketebalan patch, keseragaman kandungan, moisture content dan pengujian pelepasan secara in vitro menggunakan franz diffusion cell. Ketiga formula yang dibuat dapat membentuk patch dengan sifat fisik yang baik. Hasil uji pelepasan secara in vitro diperoleh formula dengan konsentrasi optimum propranolol patch yaitu PVP dan Eudragit 1:9 menghasilkan 20,14 µg/ml.
PENGUJIAN AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL KULIT BUAH SEMANGKA MERAH (Citrullus lanatus(Thunb.) Matsum. & Nakai) TERHADAP BAKTERI Propionibacterium acnes Syamsuri Syakri; Muh. Ikhlas Arsul; Nurlina Nurlina
Jurnal Farmasi UIN Alauddin Makassar Vol 7 No 2 (2019): Jurnal Farmasi Volume 7 Nomor 2
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v7i2.11574

Abstract

Telah dilakukan Pengujian aktivitas antibakteri ekstrak etanol 96% kulit buah semangka merah (Citrullus lanatus (Thunb.) Matsum. & Nakai) Terhadap Bakteri  Propionibacterium acnes . Penelitian ini bertujuan untuk mengetahui  kemampuan kulit buah semangka merah yang diekstraksi dengan etanol 96% sebagai agen antibakteri, khususnya terhadap bakteri penyebab jerawat Propionibacterium acne. Metode difusi kertas cakram digunakan untuk mengetahui aktivitas antibakteri dari ekstrak etanol 96% kulit buah semangka merah. Antibiotik klindamisin sebagai kontrol positif dan DMSO digunakan sebagai pembanding aktivitas antibakteri. Digunakan 4 konsentrasi yaitu 250, 500, 750, dan 1000 pmm. Kulit buah semangka merah menunjukan adanya aktivitas antibakteri terhadap  Propionibacterium acne pada konsentrasi optimum yang digunakan yaitu 1000 ppm dengan rata-rata diameter zona hambat 0,5 mm. Dari penelitian ini dapat disimpulkan bahwa ekstrak kulit buah semangka merah memiliki aktivitas antibakteri terhadap Propionibacterium acne dengan kategori lemah.
Kadar Fenolik dan Flavonoid Total Ekstrak Etanol Daun Anggur (Vitis vinifera L) Mukhriani Mukhriani; Muh Rusdi; Muh Ikhlas Arsul; Ratna Sugiarna; Nadhila Farhan
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 2 No 2 (2019)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.603 KB) | DOI: 10.24252/djps.v2i2.11503

Abstract

Telah dilakukan penelitian mengenai analisis kadar fenolik dan flavonoid total ekstrak daun anggur (Vitis vinifera L) dengan metode Spektrofotometri UV-Vis. Penelitian ini bertujuan untuk menentukan kadar fenolik dan flavonoid total dalam ekstrak etanol daun anggur. Sampel diekstraksi dengan metode maserasi menggunakan pelarut etanol. Penentuan kadar fenolik total ekstrak menggunakan pembanding asam galat dengan beberapa variasi konsentrasi. Penentuan kadar flavonoid total menggunakan pembanding kuersetin. Nilai absorbansi diukur dengan spektrofotometer. Nilai absorbansi kemudian dimasukkan ke dalam persamaan regresi linier. Hasil penelitian menunjukkan kadar total fenolik dan kadar total flavonoid dalam ekstrak berturut-turut adalah sebesar 95,28 mg GAE/g dan 4,07 mg QE/g.
Potensi Mie dari Labu Kuning (Cucurbita moschata Durch) dalam Menurunkan Kadar Glukosa Darah Muh Ikhlas Arsul; Nur Rezky Rutami Amir; Ruhul Fadila; Indah Nur Pratiwi; Fitril Imani
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 2 No 2 (2019)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.286 KB) | DOI: 10.24252/djps.v2i2.11703

Abstract

Penelitian ini bertujuan untuk mengetahui potensi labu kuning dalam menurunkan kadar gula darah setelah dibuat dalam bentuk makanan (mie). Labu terlebih dahulu dikupas lalu diiris tipis-tipis kemudian dikeringkan. Setelah kering labu dijadikan tepung dengan cara digiling dan diayak. Tepung labu kemudian diolah menjadi mie dengan mencapurkan dengan tepung kaya protein dan telur lalu digiling hingga membentuk mie. Mie dibuat dengan perbandingan tepung labu 57, 67, dan 75% terhadap total bahan padat. Mie dengan kandungan tepung labu 75% menunjukkan penurunan kadar glukosa darah tertinggi yaitu 60 mg/dL dengan indeks glikemik 69,56. Dari hasil pengujian hedonik, responden sebagian besar menyukai mie yang terbuat dari labu kuning.
Kemuning Leaves Extract Gel (Murraya panicula L.): A Study of Quality and Efficacy in Healing Burns Khairunnisa Hasbullah; Faridha Yenny Nonci; Muh. Ikhlas Arsul
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13984

Abstract

This study aims to determine the activity of kemuning leaves extract in healing burns, and efficacy and quality of the extract in gel dosage form. The research was started with kemuning leaves extraction used maceration method with ethanol 96%, ethyl acetate and n-hexane as solvent. Each extract was activity tested for healing burn in rabbits. The extract that is most effective in wound healing then formulated into gel. The gel preparations were made in 3 variations of concentration, namely 5% (FI), 10% (FII), and 15% (FIII), with basis by carbopol 940 gel, triethanolamine, and methyl paraben. Then, gels were tested for efficacy and quality. The efficacy test follows the activity test procedure. Gel quality test includes organoleptic, pH, viscosity, dispersibility, and homogenity. The activity test showed that ethanol 96% extract, ethyl acetate and n-hexane healed burns in 13,3; 14,3; and 15,3 days, respectively. While the results of the gel efficacy test for FI, FII and FIII were 13,6; 11,6; and 9,6 days, respectively. In general, all gels have good qualities in every parameter, except the viscosity of FII and FIII which is slightly higher. Based on the results of the research, ethanol 96% extract was the most effective in healing burn. In addition, FIII gel has the best efficacy with good qualities except viscosity.
Bioavailability Study of Propranolol Patch Muh Ikhlas Arsul; Latifah Rahman; Agnes Lidjajah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.19498

Abstract

Bioavailability is a measure of the rate and amount of drug or active ingredient that is absorbed by a drug product and available at the site of action. By definition, the bioavailability of a drug when administered intravenously is 100%. However, when a drug is given by a different route of administration, its overall bioavailability will decrease (since the drug is not completely absorbed and metabolized first pass effect) or may vary from patient to patient. Bioavailability is very important in pharmacokinetics. One of them is that bioavailability needs to be taken when calculating the doses for administering a drug other than by intravenous route. The aim of this study was to describe the bioavailability of propranolol in patch preparations. Propranolol is made in patch formulations using menthol, PEG, and various combinations of PVP and Eudragit. PVP and Eudragit each dissolved in alcohol and then mixed until homogeneous. Propranolol was dissolved with a menthol solution and then mixed into a solution of PVP and Eudragit. Finally, PEG is added to the solution and stirred until homogeneous and then poured into the patch mold. The patches produced were then measured for each patch and bioavailability assay. The patch formula produced can be used transdermally, but of the three formulas, the F3 formula with a ratio of PVP K30 and Eudragit RS-100 3: 7 gives the best results with a tmax of 2 hours, Cmax 79.33 µg / ml and AUC 49.07 µg hours / ml.
Antituberculosis Activity of Parang Romang (Boehmeria virgata (Forst.) Guill) Stem Extract Muhammad Rusdi; Muhammad Ikhlas; Nur Pratiwi Kartikasari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 1 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i1.21359

Abstract

Parang Romang (Boehmeria virgata (Forst.) Guill) is one of the plants empirically used by the people of South Sulawesi. This study aimed to test the activity of Parang Romang Extract against Mycobacterium tuberculosis. The 96% ethanol extract obtained was fractionated by the liquid-solid extraction method: obtained n-Hexan soluble extract and n-Hexan insoluble extract. Samples of 96% ethanol extract, soluble extract of n-Hexan and insoluble extract of n-Hexan were made in series of concentrations of about 25, 50, 75, and 100 µg/ml. The inhibition test of Mycobacterium tuberculosis used the MODS method on the Mycobacterium tuberculosis strain H37RV. Color reagents then identify extracts that provide inhibition. The results of the minimum inhibition concentration of Mycobacterium tuberculosis showed that a 100 µg/ml of n-Hexan soluble extract was able to inhibit the growth of Mycobacterium tuberculosis strain H37RV.
Total phenolic, flavonoid, and antioxidant capacity of bajakah (Spatholobus littoralis Hassk) Muhammad Ikhlas Arsul; Nurfajri Syamsi; Nadila Putri; Nur Afiah Alfrianti Nur; Mukhriani; Nursalam Hamzah
Current Research on Bioscences and Biotechnology Vol. 4 No. 1 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.4.1/VRJ3X4LF

Abstract

The bajakah (Spatholobus littoralis Hassk.) is one of the typical plants from Kalimantan Island, which has potential as a drug, one of which using as an antioxidant is due to the secondary metabolites contained therein. The aims of the research are to estimate the total phenolic content, total flavonoid content, and antioxidant capacity of the bajakah by different methods. Extraction was carried out by reflux method using a solvent gradient of n-hexane, ethyl acetate, and ethanol 96%. Phenols and flavonoid content were calculated using spectroscopy. Antioxidant capacity was measured against ascorbic acid and Trolox using the CUPRAC, DPPH, and FRAP methods and reported as mg Trolox equivalent (TEAC) and ascorbic acid equivalent (AEAC) per gram extract. The ethanol extract showed the highest antioxidant capacity for the CUPRAC and FRAP methods, the n-hexane extract for the DPPH method on both varieties of bajakah tampala. Each method provides significantly different antioxidant capacity values. The CUPRAC and FRAP methods found the highest antioxidant capacity in the white variety of bajakah ethanol extract. Meanwhile, in the DPPH method, saw the highest antioxidant capacity in the red variety of n-hexane bajakah extract. DPPH and CUPRAC give a positive correlation with TPC, where CUPRAC assay produced higher values than FRAP and DPPH assays.
Evaluation of Antioxidant Activity of Vernonia amygdalina Leaves and Its Flavonoid-Phenolic Content Muammar Fawwaz; Mamat Pratama; Musafira Musafira; Indira Wahab; Rina Iriani; Aminah Aminah; Andi Trihadi Kusuma; Muhammad Ikhlas Arsul
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 2 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i2.41617

Abstract

Bitter leaf, Vernonia amygdalina (VA), is used in various alternative medicine in several countries,including Indonesia. This study aims to evaluate the antioxidant activity of VA leaves by three differentin vitro methods. The antioxidant activity was evaluated by radical scavenging of 1,1-diphenyl-2-picryl-hydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidantcapacity (CUPRAC). The antioxidant capacity by FRAP and CUPRAC methods were expressed asmg of quercetin equivalents (QE) per g extract (mgQE/g) and mg of ascorbic acid equivalents (AAE)per g extract (mgAAE/g), respectively. All methods were measured by UV-Visible spectrophotometryat maximum wavelength. The results exhibited that VA leaves ethanolic extract contains flavonoidphenolic.The VA leaves ethanolic extract has an antioxidant activity by scavenging the DPPH methodwith the half inhibition concentration (IC50) was 8,22 μg/mL. The antioxidant capacity of VA leavesethanolic extract by FRAP and CUPRAC methods was 21,03 mgQE/g and 160,64 mgAAE/g extract,respectively. The VA leaves ethanolic extract has a powerful antioxidant potency which might correlateto the flavonoid-phenolic content in the extract.
Xenograft Models for Preclinical Assessment of Anticancer Therapies: A Comprehensive Review Ebrahim sadaqa; Muhammad Ikhlas Arsul
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38677

Abstract

Introduction: Xenograft models play a pivotal role in preclinical studies for assessing the efficacy of anticancer medications. In this comprehensive review, we present an overview of current advancements and future prospects in xenograft research, focusing on their significance in guiding drug development and clinical translation. Aim: Our aim is to conduct an in-depth review of xenograft models, their utility in evaluating anticancer drug effectiveness and ultimately improve patient outcomes. Methods We conducted an in-depth literature search using databases such as ScienceDirect, Google Scholar and PubMed with keywords including "xenograft model, cancer CDX PDX." We then reviewed and analyzed relevant studies that utilized xenograft models in order to highlight key findings and contributions made through such models. Results: Our analysis showcases the essential role of xenograft models in assessing the efficacy of anticancer drugs. We discuss the benefits and limitations of these models, emphasizing their importance in guiding drug development and clinical decision-making. Conclusion: Xenograft models remain invaluable tools in preclinical cancer research despite their inherent limitations, with researchers continually striving to refine and enhance these models to ensure their reliability in an ever-evolving field of cancer therapeutics. Utilizing xenograft models allows researchers to evaluate anticancer drug activity more accurately while striving for improved patient outcomes.
Co-Authors Abbas, Nurfahima Afrisusnawati Rauf Afrisusnawati Rauf Agnes Lidjajah Alrayan, Reza Aminah Aminah Andi Trihadi Kusuma Arif Setiawansyah Bambang Hernawan Nugroho, Bambang Hernawan Ebrahim sadaqa Faridha Yenny Nonci Fitril Imani Gebyanti Swara Gita Susanti, Gita Hadi, Ismanurrahman Indah Nur Pratiwi Indira Wahab Irda Fidrianny Ismail, Asrul Isriany Ismail Jaya, Adrian Khairunnisa Hasbullah Latifah Rahman Latifah Rahman Luthfiana, Dewi Mamat Pratama Mardhatillah Awwaliah Muammar Fawwaz Muhamad Insanu Muhammad Rifqi Abdillah Muhammad Rusdi Mukhriani Mukhriani, Mukhriani Musafira Musafira Nadhila Farhan Nadila Putri Ningsi, Surya Nur Adliani Nur Afiah Alfrianti Nur Nur Asma Nur Azizah Syahrana Nur Pratiwi Kartikasari Nur Rezky Rutami Amir Nurfajri Syamsi Nurlina Nurlina Nursalam Hamzah Nurshalati Tahar Nursyamsi Dhuha Nurul Hidayati Pratiwi, Afrianty Ratna Sugiarna Rezky Aulia Rina Iriani Ruhul Fadila Sadaqa, Ebrahim Supandi Syamsuri Syakri Wismayani, Leni Zulfahmi Alwi