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All Journal Tadris: Jurnal keguruan dan Ilmu Tarbiyah JURNAL ILMIAH PENDIDIKAN FISIKA AL BIRUNI Indonesian Journal of Science and Technology Al-Jabar : Jurnal Pendidikan Matematika International Journal of Electronics and Communications Systems International Journal of Hydrological and Environmental for Sustainability International Journal of Applied Mathematics, Sciences, and Technology for National Defense Biomedical Research and Theory Letters
Palupi, Endah Kinarya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics

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Integrative Approach to Dengue Hemorrhagic Fever: Clinical Management and Preventive Strategies Yune, Tria; Hawila, Ovi; Dwi, Pradita; Aulia, Puteri; Azizah, Putri; Binta, Putri; Palupi, Endah Kinarya
Biomedical Research and Theory Letters Vol. 1 No. 1 (2025): Biomedical Research and Theory Letters
Publisher : CV. FOUNDAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/brtl.v1i1.71

Abstract

Dengue Hemorrhagic Fever (DHF) is a viral disease transmitted by Aedes aegypti mosquitoes, presenting with a wide spectrum of clinical manifestations ranging from mild fever to severe complications such as bleeding and shock. This case report describes a 12-year-old patient who presented to the Satellite Inpatient Health Center Bandar Lampung with a three-day history of high fever, headache, joint pain, skin rash, and nausea, accompanied by a positive history of mosquito bites in a dengue-endemic area. A holistic diagnostic approach was applied, including clinical history, physical examination, and symptomatic assessment. The patient was managed with fluid therapy consisting of 1500 ml oral fluids within six hours and intravenous infusion of Ringer Lactate solution (500 cc at a rate of 20 drops per minute). Preventive measures included hospitalization for observation, avoidance of mosquito bites through nets and protective clothing, fogging, and environmental sanitation. Pharmacological therapy was prescribed, including paracetamol 500 mg three times daily, ambroxol 30 mg twice daily, vitamin C 500 mg once daily, antacid 30 ml three times daily, intravenous fluids 500 cc at 20 tpm, ranitidine 150 mg twice daily, and domperidone 10 mg twice daily. Physical examination revealed a body temperature of 39°C, petechial rash, and joint tenderness, while other parameters were within normal limits. The patient reported no history of vomiting, smoking, or alcohol consumption. Following intervention, fever and pain subsided, skin rash improved, and overall clinical condition stabilized. Preventive measures were effective in reducing mosquito exposure, while supportive therapy minimized the risk of complications. This case confirms that Aedes aegypti mosquito bites caused dengue virus infection in the patient, and demonstrates that a holistic management strategy combining pharmacological therapy, fluid replacement, preventive measures, and psychosocial support can effectively reduce symptoms and prevent complications. The novelty of this report lies in its integrative approach, emphasizing early recognition and comprehensive management as essential strategies to improve patient outcomes and reduce the burden of dengue in endemic areas.
Production and Characterization of Bioethanol from Tobacco Stalks via Acid Hydrolysis and Fermentation Irfan, Akhmad; Muslihat, Adi; Sunaryo; Jumini , Sri; Mustofa, Ikrom; Wacano, Dhandhun; Raju; Machmud, Amir; Palupi, Endah Kinarya
International Journal of Hydrological and Environmental for Sustainability Vol. 5 No. 1 (2026): International Journal of Hydrological and Environmental for Sustainability
Publisher : CV FOUNDAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/ijhes.v5i1.1030

Abstract

The increasing demand for energy and the environmental impacts of fossil fuel consumption have encouraged the development of renewable and sustainable energy sources. Bioethanol derived from lignocellulosic biomass represents a promising alternative fuel due to its renewability and reduced competition with food resources. This study investigates the potential of tobacco stalks, an underutilized agricultural residue, as a feedstock for bioethanol production through acid hydrolysis and fermentation processes. Dried tobacco stalks were hydrolyzed using 1 M sulfuric acid at 110 °C for 3 h to produce fermentable sugars, followed by batch fermentation using Saccharomyces cerevisiae with variations in yeast concentration and fermentation time. The fermentation products were purified by simple distillation and characterized using refractometry, density measurement, GC–MS, and bomb calorimetry. The hydrolysis process yielded a sugar concentration of 7.6%. Refractometric analysis indicated ethanol concentrations in the range of 64–68% (v/v), while density measurements suggested lower effective ethanol purity due to residual water and non-ethanol components. GC–MS analysis confirmed ethanol as the dominant compound, with relative contents ranging from approximately 52% to 73%, accompanied by acetic acid and minor volatile by-products. The calorific value of the produced bioethanol ranged from 4,825 to 4,983 kcal/kg and increased with fermentation time. The results demonstrate that tobacco stalks have considerable potential as a lignocellulosic feedstock for bioethanol production, although further process optimization is required to enhance ethanol purity and overall conversion efficiency.
Co-Authors Abdurahman Abdurrahman Adi, Langit Cahya Aldhiantoro, Gustav Irgi Amir Machmud, Amir Andika, Windi Dwi Antomi Saregar Astika, Ruri Tria Atmapradhana, Tedi Aulia, Puteri Azizah, Putri Baarik, Moh. Hisni Alfan Binta, Putri Christina, Athalia Dewi, Dinda Rahma Dwi, Pradita Hawila, Ovi I Made Astra Iqbal, Mochamad Irfan, Akhmad Irzaman, Irzaman Iskandar Tsani, Iskandar Jumini , Sri Khazali Fahmi Kusumadjati, Adhi Kusumasari, Brenda Ariesty Mada Sanjaya WS Makmuri Makmuri Maulidi, Ikhsan Muhamad Syazali Munifah Munifah, Munifah Muslihat, Adi Mustofa, Ikrom Naqiya, Sadiyana Yaqutna Oktaviana, Aditya Tri Pinardi, Kuntjoro Putri Abdul, Annisa Mutiara Rachmawati, Ro'fah Nur Rahmad Junaidi, Rahmad Raju Rofiqul Umam Salman Alfarisi Siregar, Rahmat Nawi Sri Sumarni Sunaryo Tortop, Hasan Said Trinugraha, Afi Candra Wacano, Dhandhun Wahyudianto, Benny Yakin, Khusnul Yasin, Muhamad Yongthong, Keodouangdy Yudha Satya Perkasa, Yudha Satya Yune, Tria