Article Per Year (5 Year)
p-Index From 2021 - 2026
3.533
P-Index
This Author published in this journals
All Journal KOVALEN: Jurnal Riset Kimia CHEMPUBLISH JOURNAL Majalah Farmaseutik CHEESA: Chemical Engineering Research Articles Jurnal Kreativitas PKM Pharmaceutical Journal of Indonesia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Inovasi Farmasi Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi dan Sains Indonesia (JFSI) Environmental and Toxicology Management (ETM) Gemakes: Jurnal Pengabdian Kepada Masyarakat FASKES : Jurnal Farmasi, Kesehatan, dan Sains JI-KES (Jurnal Ilmu Kesehatan)
Muadifah, Afidatul
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search
Journal : CHEMPUBLISH JOURNAL

 1 
Antibacterial Activity of Combination of Betel Leaf Extract and Star Fruit Using Hydroextraction Method Tilarso, Dara Pranidya; Muadifah, Afidatul; Handaru, Windu; Pratiwi, Putri Indah; Khusna, Mursyidah Lathifatul; Tarigan, Indra Lasmana
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.21736

Abstract

Antibacterial compounds are bioactive substances capable of inhibiting bacterial growth by disrupting the metabolism and cellular processes of pathogenic microorganisms. Natural plant-derived compounds have been widely explored for their antibacterial properties, with star fruit (Averrhoa bilimbi L.) and betel leaf (Piper betle) recognized for their potent antimicrobial effects. This study aimed to evaluate the antibacterial activity of a combination of star fruit and betel leaf extracts against Escherichia coli and Staphylococcus aureus, two clinically significant bacterial pathogens. The extraction process was performed using hydro-extraction at different temperatures (40°C, 50°C, 60°C, and 90°C) to determine the optimal conditions for bioactive compound yield. Antibacterial activity was assessed using the disc diffusion method, measuring inhibition zones to indicate bacterial susceptibility. The results demonstrated that the optimal inhibitory effect occurred at 50°C, producing an inhibition zone of 19.75 mm for Staphylococcus aureus and 11.75 mm for Escherichia coli. These findings suggest that temperature plays a critical role in maximizing the antibacterial potential of plant extracts. The study highlights the potential application of star fruit and betel leaf extracts as natural antibacterial agents, particularly against Gram-positive and Gram-negative bacteria. Further research is recommended to explore the mechanism of action, phytochemical composition, and potential synergy of these extracts in antimicrobial formulations.
Comparative Study of Macerated and Soxhlet-Extracted Moringa Oleifera Leaf Extracts: LC-MS-Based Metabolomic Profiling, Antioxidant Activity, and In Silico Target Prediction Muadifah, Afidatul; Sulastri, Sulastri; Sowe, Momodou Salieu; Lintang, Anggun; Warni, Tri
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36870

Abstract

Moringa leaves (Moringa oleifera L.) are rich in secondary metabolites such as flavonoids, alkaloids, tannins, saponins, and terpenoids, which function as natural antioxidants. This study aimed to analyze the metabolite profile of M. oleifera leaf extracts obtained through two extraction techniques using LC-MS, evaluate their antioxidant activity via the DPPH assay, and predict the interaction between NADPH oxidase (as a receptor) and key plant-derived compounds through molecular docking. LC-MS results indicated that the maceration method yielded 101 secondary metabolites, with flavonoid derivatives comprising 70.99% of the extract, dominated by five key compounds including Kaempferol 3-O-robinobioside and Luteolin-7-glucoside. In contrast, the Soxhlet method resulted in 83 identified compounds, with a higher proportion of flavonoids (75.61%), and prominent compounds including quercetin-3-O-glucoside and Kaempferol 3-(6G-malonylneohesperidoside). Antioxidant testing with DPPH at concentrations of 10, 50, and 100 ppm revealed the Soxhlet extract had a stronger activity (IC₅₀ = 14.328 ppm) compared to the macerated extract (IC₅₀ = 32.092 ppm), with statistically significant differences (p < 0.05). Molecular docking demonstrated that Kaempferol 3-(6G-malonylneohesperidoside) exhibited the strongest binding affinity to NADPH oxidase (-10.1 kcal/mol), followed by other flavonoid derivatives. These findings underscore the antioxidant potential of M. oleifera, particularly from Soxhlet extraction, and suggest its promising application in pharmaceutical development as a natural antioxidant source.
Secondary Metabolites of The Fabaceae Plant Family A Review of Extraction Methods, Molecules and Bioactivity Sowe, Momodou Salieu; Etonihu, Anayo Christian; Tarigan, Indra Lasmana; Muadifah, Afidatul
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36964

Abstract

Traditional medicine helps manage and treat various illnesses worldwide, particularly in Africa and Asia. For example, Traditional Indonesian Medicine (Jamu), Traditional Indian Medicine (Ayurveda), and Traditional African Medicine use a range of indigenous herbs to treat health conditions like fevers, malaria, diarrhea, diabetes mellitus, Asthma, and hypertension. Alkaloids, flavonoids, saponins, terpenoids, and polyphenols are bioactive substances with anti-inflammatory, antibacterial, and antioxidant effects in plants. The Fabaceae family consists of flowering plants, peas, legumes, woody trees, and shrubs. Fabaceae plants are widely used across Africa and Asia for traditional medicinal purposes. In addition, Fabaceae plants have significant economic value as a source of wood for the timber industry. This review highlights extraction methods, isolated molecules, and antimicrobial and antioxidant activity of Fabaceae plants found in Africa and Asia. We also detailed secondary metabolite molecules extracted from Fabaceae plant body parts and their identified bioactivities. This review compiles scientific information on the phytochemicals and pharmacological properties of plants in the Fabaceae family that could be useful for future drug candidate investigations.
Calcium Reduction Using Variations of Thickness and Retention Time of Cocoa Shell Activated Carbon Muadifah, Afidatul; Santoso, Arif; Ngibad, Khoirul; Martha, Rahma Diyan; Kholifah, Siti Nurriyatul
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.24768

Abstract

High levels of hardness can lead to increased cases of kidney stones. Hardness levels can be reduced by using activated carbon from the cocoa rind as an adsorbent. The purpose of this research was to determine the variation of activated carbon thickness and optimum retention time in reducing the calcium content of dug well water, to determine the percent decrease in calcium ion levels at the optimum variation, and to determine the significance of the difference in the decreased in calcium levels between the treatment groups. The research method used the principle of adsorption of activated carbon from cocoa shells to calcium ions, which are activated by KOH. There were ten treatment samples with different variations of activated carbon thickness and retention time. The results showed that the thickness of activated carbon of 60 cm with a retention time of 50 minutes had the optimum ability to reduce the calcium content of dug well water. The percentage decrease in calcium levels reached 89,041 % with a decreased concentration of 234 ppm. The result of the statistical test showed a significance value of 0,05. The conclusion of the research is that activated carbon of cocoa shells can reduce calcium levels to the levels of soft water hardness, with variations in activated carbon thickness and retention time having a significant effect.
Uji Efektivitas Antioksidan Moisturizer Ekstrak Daun Randu (Ceiba Pentandra (L.) Gaertn.) dengan Metode DPPH Muadifah, Afidatul; Tilarso, Dara Pranidya; Putri, Amalia Eka; Sowe, Momodou Salieu
Chempublish Journal Vol. 8 No. 1 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i1.33234

Abstract

Dry skin can often cause psychological discomfort. Moisturizer is a preparation that is used to improve dry skin. Kapok plant (Ceiba pentandra L. Gaertn) can be used as an active ingredient of moisturizer and can be used as a treatment, where the chemical content in kapok leaves are flavonoids, saponins, alkaloids, phenolic compounds, tannins and terpenoids as antioxidants. This study aims to determine the antioxidant activity of kapok leaf extract and moisturizer preparations with DPPH method using UV-Vis spectrophotometer, physical quality of preparations and antioxidant activity of moisturizer preparations using DPPH method. Kapok leaf extract was made in various concentrations, namely 20 ppm, 40 ppm and 60 ppm. The IC50 value of kapok leaf extract is 67.4007 ppm which has strong antioxidant activity. Then variations in the concentration of kapok leaf extract were put into the formulation of moisturizer preparations, the results of moisturizer preparations of kapok leaf extract and vitamin C met the requirements of the physical quality test. The moisturizer preparation was continued and tested for antioxidant activity using the DPPH method with ascorbic acid as a comparison. The results of the IC50 value on the kapuk leaf extract moisturizer preparation are 110.065 ppm which is classified as having moderate antioxidant activity and while the vitamin C moisturizer preparation is 9.8417 ppm which is classified as having very strong antioxidant activity.
Co-Authors Arif Santoso Choirul Huda Danar Danar Datin An Nisa Sukmawati Etonihu, Anayo Christian Handaru, Windu Hariani Nurjanah, Mutia Ima, Ernisa Afidatul Imanez, Ketzia Adrian Indah Pratiwi, Putri Indra Lasmana Tarigan Jannah Triarini, Lailatul Jovanncha, Czellicya Karel Damayanti, Novita Kharisma, Mei Nabila Revina Kholifah, Siti Nurriyatul Khusna, Mursyidah Lathifatul Kristijono, Ary Kumalasari, Nurul Chamidah Lestari, Nasa Bela Dwi Lintang, Anggun Maida, Margarita Claudya MARTHA, RAHMA DIYAN Mashudi Mashudi Ngibad, Khoirul Nurjanah, Mutia Hariani Parbuntari, Hesty Pratiwi, Putri Indah Putri, Amalia Eka Rahma Diyan Martha Rahmawati, Desti Linda Dwi Rizki Amalia, Laily Safitri, Yunita Diyah Salsabila, Nabila Putri Sandi Mahesa Yudhantara Sari, Trianita Sowe, Momodou Salieu Sulastri Sulastri Susanto, Nindita Clourisa Clourisa Amaris Tilarso, Dara Tilarso, Dara Pranidya Ulayya, Nida Asma Ummah, Ratih Salimil Warni, Tri Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Wiwik Handayani