Claim Missing Document
Check
Articles

Uji Efektivitas Salep Ekstrak Etanol Daun Buni (Antidesma bunius (L.) Spreng) Sebagai Penyembuhan Luka Bakar Grade II (A) Pada Mencit I Made Agus Sunadi Putra; Ni Komang Ayu Trias Pradnyawati; I Gusti Agung Ayu Kusuma Wardani
Usadha Vol 5 No 1 (2026): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v5i1.13940

Abstract

Grade II (A) burn wounds are a common form of skin injury that require proper management to accelerate the healing process and prevent complications. The use of natural products as alternative topical therapies continues to be developed because they are considered safer and possess diverse biological activities. Buni leaves (Antidesma bunius (L.) Spreng) are known to contain bioactive compounds such as flavonoids, tannins, saponins, and alkaloids that potentially support skin tissue regeneration. This study aimed to grade II (A) burn wounds in male white mice (Mus musculus). This study employed an experimental method with a post-test only control group design. The animals were divided into five groups: negative control, positive control (Bioplacenton®), and treatment groups receiving buni leaf extract ointment at concentrations of 2.5%, 5%, and 10%. Grade II (A) burns were induced on the dorsal area of the mice, followed by treatment according to each group. Observations were conducted for 14 days by measuring wound diameter reduction and percentage of wound healing. The data were analyzed statistically using One Way ANOVA followed by a post hoc test to determine differences between treatment groups. The results showed that all concentrations of buni leaf extract ointment accelerated burn wound healing compared to the negative control, with the 10% concentration demonstrating the highest effectiveness and a statistically significant difference (p<0.05). It can be concluded that the 96% ethanolic extract ointment of buni leaves has the potential to be developed as a natural topical preparation for grade II (A) burn therapy. determine the effectiveness of a 96% ethanolic extract ointment of buni leaves in accelerating the healing of
Anti-Aging Efficacy of Mangrove Leaf Extract Cream Assessed by SPF and Collagen Density Enhancement: In Vitro and In Vivo Approaches I Gusti Agung Ayu Kusuma Wardani; Ketut Agus Adrianta; Ni Nyoman Wahyu Udayani; Meriana Barreto Amaral; Ni Made Dharma Shantini Suena
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13138

Abstract

Background: Excessive ultraviolet (UV) exposure is a major contributor to skin photoaging through oxidative stress, inflammation, and collagen degradation. Mangrove leaf extract (Xylocarpus granatum J. Koenig) contains bioactive compounds with potential photoprotective properties. In this study, the extract was formulated into an oil-in-water (O/W) cream suitable for cosmetic applications.Objective: This study aimed to determine the in vitro sun protection factor (SPF), percentage of erythema transmission (%Te), and percentage of pigmentation transmission (%Tp) of the mangrove leaf extract cream, and to evaluate its effectiveness on UVB-exposed guinea pig skin using collagen density as an anti-aging biomarker.Methods: In vitro assessments of SPF, %Te, and %Tp were performed using UV–Vis spectrophotometry. In vivo evaluation was conducted using 20 guinea pigs to examine the effect of the cream on collagen density through histopathological analysis of UVB-exposed skin.Results: The mangrove leaf extract cream exhibited strong photoprotective activity, with SPF values ranging from 20.68 ± 0.51 to 33.70 ± 0.67, %Te values from 3.13 ± 0.08 to 1.75 ± 0.03, and %Tp values from 4.40 ± 0.12 to 3.31 ± 0.03. Furthermore, the cream significantly increased collagen density (71.77 ± 5.27–81.02 ± 0.96) compared with the positive control (52.16 ± 2.32) (p < 0.05).Conclusions: The mangrove leaf extract cream provides effective protection against UVB radiation, characterized by high-protection SPF, extra-protection %Te, and sunblock-level %Tp. The 5% formulation significantly enhanced collagen density, supporting its potential as a natural anti-aging active ingredient for photoaging prevention through improved UV protection and dermal structure.
Co-Authors Darmawan, I Wayan Agus Debby Juliadi Devi, Putu Ika Divta Candra Dewa Ayu Ika Pramitha Dewi, Ni Kadek Dhea Cipta Dewi, Ni Nyoman Ayu Pramesti Dwi Widyastrini, Desak Made Erna Cahyaningsih Fitria Megawati Fitria Megawati Fitria Megawati Fredinan Yulianda Fridayana, Ni Luh Gede Erica Galuh Bela Pertiwi Galuh Bela Pertiwi Gusti Ayu Putu Laksmi Puspa Sari Herleeyana Meriyani Herleeyana Meriyani I Dewa Ayu Anom Yustari Nida I Gusti Ayu Arya Ditha Suari I Made Agus Sunadi Putra I Putu Tangkas Suwantara I Wayan Sudiarsa I Wayan Surya Rahadi Ketut Agus Adrianta Ketut Agus Adrianta Lestari, Ketut Sita Citra Mahardika, I Made Agus Mahendra, I Putu Aldy Maria Daniela Tupa Hokor Mayuni, Putri Diah Gita Megawati, Fitria Mendra, Ni Nyoman Yudianti Meriana Barreto Amaral Meriyani, Herleeyana Ni Komang Ayu Trias Pradnyawati Ni Luh Ayu Mega Ratnasari Ni Luh Kade Arman Anita Dewi Ni Luh Putu Junita Kusuma Dewi Ni Luh Putu Swari Ni Made Dharma Shantini Suena Ni Made Dwi Mara Widyani Nayaka Ni Made Sukma Sanjiwani Ni Nyoman Wahyu Udayani NI PUTU AYU MIRAH MARIATI Ni Putu Leona Yorita Dewi Ni Putu Sintia Rahayu Ni Putu Udayana Antari Ni Wayan Budi Sari Puguh Santoso Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Putu Era Sandhi Kusuma Yuda Rahadi, I Wayan Surya RR. Asih Juanita Sari, Luh De Cintya Kartika Sari, Ni Wayan Budi Sasadara, Maria Malida Vernandes Suradnyana, I Gede Made Suratmini, Putu Ayu Widiasriani, Ida Ayu Putu Wiguna, Putu Dony Saputra Wintariani, Ni Putu Yanti, Ni Kadek Pradnya