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EDUKASI PEMBUATAN JAMU YANG BAIK DAN AMAN PADA KELOMPOK JAMU GENDONG DI KOTA BENGKULU Suci Rahmawati; Nori Wirahmi; Camelia Dwi Putri Masrijal; Rose Intan Permasari; Oky Hermansyah; Samwilson Slamet
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 6, No 7 (2023): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v6i7.2252-2256

Usaha Jamu Gendong (UJG) is a herbal medicine business carried out by individuals using traditional medicine ingredients in the form of fresh liquid to be sold directly to consumers. This service activity was aimed to increasing knowledge and providing skills on how to make good and safe jamu for UJG group in Bengkulu City. This activity was carried out on October 22, 2022 with 20 participants. This service activity is carried out using discussion and demonstration methods. Evaluation of activities is carried out by giving questionnaire sheets given before and after the activity. The results of the questionnaire evaluation obtained that the average score of 20 participants before and after the activity was 90.6 and 99.2, respectively. From the implementation of the activities, it can be concluded that there is an increase in the knowledge of the herbal medicine group regarding how to make good and safe traditional medicines.

INCREASING COMPETENCE OF PHARMACY AND PHARMACY TECHNICAL PERSONNEL IN DETECTING HARMFUL CONTENT IN SKIN CARE PRODUCTS Riana Versita; Myran Nur Hinsany; Novi Yantih; Dwi Kurnia Putri; Dian handayani; Nori Wirahmi; Ikhsan, Ikhsan
Journal of Community Service Vol 6 No 1 (2024): JCS, June 2024
Publisher : Ikatan Dosen Menulis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56670/jcs.v6i1.221

Each skin care product has different active ingredients. In fact, Natural skin care products also contain their own active ingredients ingredients. The ingredients used in making skin care must pay attention to the safety of the user. This is not uncommon in skin care Products in circulation contain dangerous chemicals such as mercury, hydroquinone, speech, lead, etc. Pharmacy Technical personnel and pharmacists have an important role in this matter detecting harmful ingredients in skin care. Therefore, D3 Pharmacy Study Program, Faculty of Mathematics and Natural Sciences Bengkulu University of Science with Lentera Nakes as a form of community service, there is an online socialization of the National Pharmacy Seminar which will be held will be held on December 10, 2023 at 10.00 until it ends theme of Competency of Pharmaceutical Technical Personnel and Pharmacists in Detecting Dangerous Ingredients for Skin Care. This seminar can have a big impact on competency from the participants and understanding of dangerous ingredients in cosmetics

A FORMULASI GEL DARI EKSTRAK ETANOL 96% DAUN CENGKEH (Syzygium aromaticum L.) Meva Parasari; Rose, Rose Intan Perma Sari; Farid; Nori Wirahmi; Oky Hermansyah
Jurnal Kefarmasian Akfarindo Vol 8 No 2 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.246

Daun cengkeh merupakan bagian dari tanaman cengkeh yang jarang sekali dimanfaatkan berbanding sebaliknya dengan bunga cengkeh yang lebih dominan digunakan. Daun cengkeh mengandung komponenfenolik yang tinggi yaitu senyawa eugenol 70%-80% senyawa ini bersifat antibakteri. Tujuan penelitian ini adalah untuk mengetahui formulasi sediaan gel dari ekstrak etanol 96% daun cengkeh (Syzygium aromaticumL.) dan untuk melihat karakteristik dari sediaan gel ekstrak etanol 96% daun cengkeh (Syzygium aromaticumL.). Pembuatan ekstrak etanol 96% daun cengkeh menggunakan metoda maserasi. Sediaan gel dibuat dengan variasi konsentrasi ekstrak F0 (0%), F1 (10%), F2 (20%), F3 (30%). Selanjutnya dilakukan evaluasi sifat fisik meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji viskositas, dan uji stabilitas yang dilakukan selama 4 minggu. Hasil pengujian randemen ekstrak yang diperoleh adalah 14,37%. Uji pH menunjukkan gel memiliki rata-rata pH berkisar antara 4,62 - 6,01; uji daya sebar berkisar antara 5,6-7 cm; uji viskositas berkisar antara 6.256,45 – 8.232,63 cps; dan uji stabilitas yang dilakukan pada suhu 25oC–30oC selama 4 minggu menunjukkan sediaan gel stabil.

Pelatihan Cara Penyimpanan Dan Distribusi Vaksin Yang Baik Kepada Pegawai Gudang Farmasi dinas Kesehatan Kota Bengkulu Wirahmi, Nori; Versita, Riana; Ikhsan, Ikhsan
Jurnal PADAMU NEGERI (Pengabdian pada Masyarakat Bidang Eksakta) Vol. 4 No. 2 (2023)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/padamunegeri.v4i2.824

The World Health Organization (WHO) has established Covid-19 (Coronavirus Disease 2019) as a public health emergency of international concern (Public Health International Concern) which carries a risk of transmission between countries. Cases of Covid-19 have been identified since February 26 2020 in Indonesia. The spread of the SARS-CoV-2 virus as the cause of Covid-19 disease is increasingly becoming massive throughout the world, including in Indonesia, it has even entered Bengkulu Province. The ferocity of this virus in attacking the respiratory tract has caused thousands of medical and paramedical personnel and even civil society to suffer and die. The method of this community service activity is the method of providing training on vaccine CDOB materials and practices and managing the vaccine cold chain. Then monitoring of the vaccine distribution process was carried out after training for officers. Finally, an evaluation was carried out with a pretest and filling in the vaccine distribution report by the officer. This activity was carried out with 3 students. The next activity is that on October 30, 2021 an online evaluation will be carried out by filling out a Google form to see the level of understanding of the Bengkulu City Health Service Pharmacy Warehouse employees regarding Proper Vaccine Storage and Distribution. The evaluation results obtained showed a good score where all participants received maximum scores. The Community Service Activity on Training on Proper Storage and Distribution of Vaccines to Employees of the Bengkulu City Health Service Pharmacy Warehouse has been carried out well and received a very good response from the participants. It is recommended to conduct other trainings that can improve health, both in the health environment and to the wider community.Keyword : Vaccine, Covid-19, Department of Health

DOCKING MOLECULAR SENYAWA PADA TANAMAN FAMILI APIACEAE SEBAGAI PENGHAMBAT ENZIM XANTHINE OXIDASE Oktaviani, Tiara; Hermansyah, Oky; Ikhsan, Ikhsan; Rahmawati, Suci; Wirahmi, Nori
Jurnal Farmasi Higea Vol 16, No 1 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i1.593

Asam urat merupakan produk metabolisme dari purin yang dikonversi oleh enzim xanthine oxidase didalam tubuh. Peningkatan kadar asam urat dalam darah karena metabolisme purin yang berlebihan dapat mengakibatkan penumpukan kristal monosodium urat pada persendian yang memicu terjadinya penyakit gout. Tujuan penelitian ini adalah untuk memprediksi potensi senyawa aktif pada herbal famili apiaceae yang dapat menghambat kerja enzim xanthine oxidase. Penelitian ini dilakukan secara in silico dengan menggunakan aplikasi Autodock Tools 1.5.6. Docking molecular dilakukan dengan ukuran pusat penambatan molekul pada x = 95,226; y = 47,251; z = 112, 78 dengan volume x, y, dan z = 40. Struktur kristal enzim xanthine oxidase dengan kode 3BDJ sebagai makromolekul dan sebagai ligan uji 10 senyawa aktif Famili Apiaceae. Dari hasil penelitian secara in silico didapatkan bahwa senyawa aktif pada tanaman seledri (Apium graveolens) yaitu apigenin memiliki potensi sebagai anti asam urat karena dari hasil simulasi menunjukkan bahwa senyawa ini memiliki nilai energi ikatan -10,28 dimana nilainya lebih baik dibandingkan dengan ligan uji lainnya termasuk pada senyawa pembanding alupurinol, nilai Ki-nya 29,31nM, memiliki 2 ikatan hidrogen dan terikat pada 10 residu asam amino.

SKRINING FITOKIMIA INFUSA DAUN SUNGKAI (Peronema canescens Jack.) DENGAN METODE REAKSI WARNA Rahmawati, Suci; Marliza, Marliza; Sari, Rose Intan Perma; Wirahmi, Nori; Oktoviani, Oktoviani; Sipriyadi, Sipriyadi
Jurnal Pharmacopoeia Vol 2 No 2 (2023): September 2023
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v2i2.482

Sungkai (Peronema canescens Jack) was used traditionally as a medicine to help relieve fever, malaria and flu. In general, people was used sungkai leaves in the form as infusion. This study was aimed to screening of secondary metabolite of Sungkai leaf infusion using the color reaction method. The sample in this study was sungkai leaf that obtained from Bengkulu city. The infusion was obtained by boiling 10 gram of sungkai leaf simplicia with 100 ml of distilled water for 15 minutes at 90 0C until a concentration of 10% (w/v) was obtained. Secondary metabolite screening was carried out using the color reaction method to identify alkaloids, flavonoids, saponins, tannins and steroids. Phytochemical screening using specific reagents with the test was repeated three times. The results were showed that sungkai leaves infusion was positive in alkaloid test as evidenced by the presence of white precipitate with Mayer reagent, brown precipitate with Wagner reagent, and orange precipitate with Dragendorff reagent. Positive results were also shown in flavonoid, saponin and tannin tests. While, negative result was seen in steroid test using Liebermann Burchard reagent. In this study it can be concluded that sungkai leaf infusion positively contains alkaloids, flavonoids, saponins and tannins.

FORMULASI DAN EVALUASI SEDIAAN NANOEMULGEL ZINK OKSIDA DENGAN VARIASI KONSENTRASI CARBOPOL-940 SEBAGAI GELLING AGENT Maryanti, Evi; Arifin, Muhammad; Perma Sari, Rose Intan; Wirahmi, Nori; Putri, Dwi Kurnia; Kurniawan, Tri Danang
BENCOOLEN JOURNAL OF PHARMACY Vol. 5 No. 1 (2025): April
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v5i1.41163

Sediaan nanoemulgel merupakan sediaan topikal dengan kombinasi antara fasa nanoemulsi dan basis hydrogel. Tujuan dari penelitian ini yaitu melakukan formulasi dan evaluasi sediaan nanoemulgel berbahan aktif nanopartikel ZnO (NPs ZnO) dengan variasi konsentrasi carbopol-940. NPs ZnO yang digunakan disintesis dengan metode sonokimia. Formulasi nanoemulgel dibuat dengan variasi konsentrasi carbopol-940: 0,5%, 1%, dan 1,5%. NPs ZnO yang dihasilkan memiliki kemurnian yang tinggi dengan ukuran kristal sebesar 11,929 nm. Hasil formulasi nanoemulgel dari ketiga formula (F1, F2, dan F3) memiliki tipe emulsi minyak dalam air (a/m), dengan F1 dan F2 memenuhi kriteria nilai daya sebar, pH, dan viskositas, sedangkan F3 tidak memenuhi kriteria daya sebar. Nilai daya sebar, derajat keasaman (pH), uji viskositas dari nanoemulgel berbahan aktif NPs ZnO dipengaruhi oleh konsentrasi carbopol-940.

Uji Aktivitas Ekstrak Etanol 96% Daun Senduduk Bulu (Clidemia hirta (L.) D.Don) Terhadap Khamir Candida albicans ATCC 8934 Delyvia Clara Gita; Risky Hadi Wibowo; Camelia Dwi Putri Masrijal; Nori Wirahmi; Rose Intan Perma Sari; Oky Hermansyah
Konservasi Hayati Vol 19 No 2 (2023): OKTOBER
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/hayati.v19i2.29543

Candidiasis is an infection caused by the yeast of Candida albicans. C. albicans infection often affects the vaginal area which is known as vulvovaginal candidiasis. Candidiasis can be treated using traditional medicine or herbal medicine derived from plants, one of which is senduduk bulu plant (Clidemia hirta (L.) D.Don). This study aims to determine the phytochemical screening of the ethanol extract of Senduduk Bulu (C. hirta) leaves and to determine the anti-candidiasis activity of the ethanol extract of C. hirta leaves in inhibiting the growth of the C. albicans at concentrations of 10%, 25%, 50 % and 75%. Activity test of ethanol extract of C. hirta against C. albicans was analyzed by SPSS 25 application with ANOVA test analysis. The extract was prepared by maceration method with 96% ethanol solvent. Phytochemical screening is observed by the precipitation reaction and the color change reaction. The anti-candidiasis activity test was carried out with 3 replications using the disc diffusion method. The end result of making ethanol extract of C. hirta is a dark green viscous extract, with a yield calculation of 17.96%. Phytochemical test results showed that C. hirta contained flavonoids, saponins, tannins and steroids. C. hirta extract inhibited the growth of C. albicans. The most effective concentration of C. hirta extract in inhibiting the growth of the C. albicans was 75% with an inhibition power of 28.73 mm (very strong category).

Uji Aktivitas Ekstrak Etanol 96% Daun Senduduk Bulu (Clidemia hirta (L.) D.Don) Terhadap Khamir Candida albicans ATCC 8934 Delyvia Clara Gita; Risky Hadi Wibowo; Camelia Dwi Putri Masrijal; Nori Wirahmi; Rose Intan Perma Sari; Oky Hermansyah
Konservasi Hayati Vol 19 No 2 (2023): OKTOBER
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/hayati.v19i2.29543

Candidiasis is an infection caused by the yeast of Candida albicans. C. albicans infection often affects the vaginal area which is known as vulvovaginal candidiasis. Candidiasis can be treated using traditional medicine or herbal medicine derived from plants, one of which is senduduk bulu plant (Clidemia hirta (L.) D.Don). This study aims to determine the phytochemical screening of the ethanol extract of Senduduk Bulu (C. hirta) leaves and to determine the anti-candidiasis activity of the ethanol extract of C. hirta leaves in inhibiting the growth of the C. albicans at concentrations of 10%, 25%, 50 % and 75%. Activity test of ethanol extract of C. hirta against C. albicans was analyzed by SPSS 25 application with ANOVA test analysis. The extract was prepared by maceration method with 96% ethanol solvent. Phytochemical screening is observed by the precipitation reaction and the color change reaction. The anti-candidiasis activity test was carried out with 3 replications using the disc diffusion method. The end result of making ethanol extract of C. hirta is a dark green viscous extract, with a yield calculation of 17.96%. Phytochemical test results showed that C. hirta contained flavonoids, saponins, tannins and steroids. C. hirta extract inhibited the growth of C. albicans. The most effective concentration of C. hirta extract in inhibiting the growth of the C. albicans was 75% with an inhibition power of 28.73 mm (very strong category).

Formulation and Test of Burns Healing Effects of Preparations Cream Extract Leaf Nangka Kuning (Vincetoxicum villosum (Blume) Kuntze) Oktoviani, Oktoviani; Masrijal, Camelia Dwi Putri; Slamet, Samwilson; Wirahmi, Nori; Versita, Riana; Sari, Rose Intan Perma
Indonesian Journal of Health Research and Development Vol. 2 No. 1 (2024): Indonesian Journal of Health Research and Development
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/ijhrd.v2i1.159

V. villosum (Blume) Kuntze shows inhibition of the growth of Pseudomonas aeruginosa which is usually the cause of infection in burn wounds. The aim of this research was to formulate V. villosum (Blume) Kuntze leaf extract into a cream preparation and determine the time needed for V. villosum (Blume) Kuntze leaf extract cream to heal burn wounds in rabbits. This research was a type of experimental research. The research was conducted at the University of Bengkulu Laboratory in September 2022-August 2023. The equipment used was the Ohaus Starter 3100 brand pH meter and the NDJ-8S viscometer. The materials used are V. villosum (Blume) Kuntze leaf extract, mice, ethanol solvent. Oil-in-water (O/W) phase cream formulation with 3 variations of stearic acid and triethonolamine emulsifiers (15:4), (16:3) and (17:2). Then the three formulas were evaluated for their preparations which included organoleptic tests, homogeneity tests, pH tests, adhesion tests, spreadability tests, viscosity tests and descriptive stability tests. The activity test against burn wound infections used rabbits consisting of groups K1 (without treatment), K2 (given 0.2% hyaluronic acid cream), P1 (given 2% V. villosum (Blume) Kuntze leaf extract), and P2 (given 2% V. villosum (Blume) Kuntze leaf extract cream). Groups K2, P1 and P2 showed perfect wound healing on day 12. Meanwhile group K1 experienced incomplete wound healing until day 14. Based on the results of the study it can be concluded that the cream formulations I, II and III were declared stable at a temperature of 25º and the extract cream Kuntze V. villosum (Blume) Kuntze leaves showed complete wound healing in 12 days. The results of the Kruskal Wallis test obtained p value = 0.670 > 0.05, which means there is no difference in the length of the healing process for all treatments.

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