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All Journal Jurnal Kedokteran Syiah Kuala International Journal of Community Service Learning JPBIO (Jurnal Pendidikan Biologi) Jurnal Biomedika dan Kesehatan Science Midwifery Jurnal Dharma Bhakti Ekuitas Bioscientist : Jurnal Ilmiah Biologi The Avicenna Medical Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti
Faradilla, Meutia Atika
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The Relationship Between Nutritional Status with Malondialdehyde (MDA) and Vitamin D Level Anastasya, Karina Shasri; Faradilla, Meutia Atika; Satyasari, Daniella; Larasari, Andira
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.47151

Abstract

Background: Nutritional status has been found to be correlated with malondialdehyde (MDA) profiles in the blood. MDA is a marker of oxidative stress in the body and is the final product of lipid peroxidation chain reactions. The long-term undernutrition and excess status will be closely related to metabolic disorders and degenerative diseases. Street cleaning staff are often exposed to free radicals that will improve lipid peroxidation, which will also break down into MDA. Vitamin D serum levels have an inverse correlation with adipose tissue mass, where the higher the BMI and body fat mass of a person, the lower the levels of vitamin D serum. The purpose of this study was to determine the relationship of nutritional status with MDA and vitamin D levels in the blood. Methods: This research will be conducted from July 2024 to February 2025, using a cross-sectional design at the Faculty of Medicine, Trisakti University, with the target population being the street cleaning staff in Jakarta. The samples were taken by consecutive sampling for all street cleaning staff who met the inclusion and exclusion criteria, with a total of 76 samples. Results: The results showed that there was no significant relationship between nutritional status with MDA and vitamin D, but there was a significant relationship between vitamin D and MDA (r=0.190; p=0.047). Conclusion: Higher BMI is associated with a relative reduction in muscle mass percentage and a substantial increase in visceral adiposity, irrespective of sex. These findings suggest that BMI alone may not adequately represent body composition or metabolic risk and support the routine use of body composition assessment as a complementary tool in clinical obesity evaluation. Keywords: Nutritional status, MDA, vitamin D
Association between MC4R rs17782313 genotype and body fat percentage as an indicator of obesity among Indonesian adults Faradilla, Meutia Atika; Yohana, Yohana; Yastani, Deasyka; Handayani, Astri; Suweino, Suweino
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art5

Abstract

Background: Obesity is influenced by both environmental and genetic factors, including variation in the melanocortin-4 receptor (MC4R) gene, which plays a role in appetite regulation and energy balance. Identifying genetic risks, particularly whether obesity linked to inherited dysregulation of appetite, is crucial for early intervention and personalized prevention strategies.Objectives: This study aimed to examine the association between MC4R genotype and body fat percentage as an indicator of obesity among Indonesian adults. Methods: A cross-sectional study was conducted among 79 Indonesian adults aged 21–56 years in Jakarta. Participants were consecutively recruited and screened based on predefined inclusion and exclusion criteria. Anthropometric data, including height and weight, were obtained using a standardized stadiometer and digital scale to calculate body mass index (BMI). Body fat percentage (BFP) was assessed using bioelectrical impedance analysis (BIA) with an Omron Karada Scan device. Genomic DNA was extracted from venous blood samples, and the MC4R rs17782313 polymorphism was genotyped using the polymerase chain reaction– fragment length polymorphism (PCR-RFLP) method. Statistical analyses were performed to assess the association between genotypes and body fat percentages. Results: Most participants were classified as overweight (36.1%) or obese (41.7%) based on BMI. The genotypic distribution of rs17782313 was TT (48.1%), CT (39.2%), and CC (12.7%). Higher body fat percentages were significantly more common among individuals carrying the C allele. The CC genotype demonstrated the strongest association with obesity, with an odds ratio (OR) of 4.00 (95% CI: 1.02–15.64, p=0.04) compared to the wild-type TT genotype. Conclusion: Variations in the MC4R rs17782313 gene are associated with increased body fat percentage and a higher risk of obesity among Indonesian adults. Individuals carrying the risk allele may have greater susceptibility to excess fat accumulation, underscoring the importance of incorporating genetic factors into obesity prevention and management strategies.
Co-Authors Anastasya, Karina Shasri Darwin Dalimunthe Deasyka Yastani Dita Setiati Eveline Margo, Eveline Ferina, Mutiara Handayani, Astri Jimmy Panji Wirawan Kurniasari Kurniasari Kurniasari Kurniasari Kurniasari Larasari, Andira Liman, Patricia Budihartanti Mahardieni, Karlina Meiyanti Meiyanti Meiyanti, Meiyanti Monica Dwi Hartanti, Monica Dwi Rahmansyah, Mulia Salma, Nabila Maudy Satyasari, Daniella Suweino Suweino, Suweino Tungka, Endrico Xavierees Xavierees, Endrico Yahwardiah Siregar Yenny Yohana Yohana Yohana Yuliana Yuliana