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All Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal Nasional Komputasi dan Teknologi Informasi JISIP: Jurnal Ilmu Sosial dan Pendidikan Pharmaceutical Journal of Indonesia Stannum : Jurnal Sains dan Terapan Kimia Aksara: Jurnal Ilmu Pendidikan Nonformal Community Development Journal: Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Journal of Vocational Nursing Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Scientific Research, Education, and Technology Journal of Pharmaceutical and Sciences.
emelda, emelda
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Efek Antidiare Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Pada Mencit Putih Jantan Fauzi, Rizal; Fatmawati, Annisa; Emelda, Emelda
Pharmaceutical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Brawijaya University

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Abstract

Diare merupakan peningkatan frekuensi dan penurunan konsistensi feses bila dibandingkan dengan kondisi usus individu normal. Tingginya angka kejadian diare akut dan kronis mendorong para peneliti untuk terus berusaha dalam menemukan obat  sebagai antidiare baru, terutama yang berasal dari tanaman. Daun kelor (Moringa oleifera Lam) mengandung tanin yang merupakan senyawa polifenol dan berperan dalam proses antidiare. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol daun kelor sebagai antidiare dengan melihat motilitas usus. Proses ekstraksi dilakukan dengan metode maserasi dengan menggunakan pelarut etanol 70%. Uji aktivitas antidiare dilakukan dengan metode transit intestinal dengan melihat perbandingan usus yang dilalui marker dengan panjang usus secara keseluruhan. Dari penelitian ini diketahui bahwa  nilai rata-rata rasio kelompok perlakuan lebih kecil dibandingkan dengan kelompok kontrol negatif (0,708).  Nilai rata-rata rasio  kelompok yang hewan mencit yang diberikan ekstrak etanol daun kelor (EEDK) dengan dosis 9,1 mg/20 g berat badan mencit adalah 0,664; kelompok dengan dosis EEDK 18,2 mg/20 g  berat badan mencit  sebesar 0,434 dan kelompok dengan dosis EEDK 36,4 mg/20 g  berat badan mencit  sebesar 0,389.  Dari nilai tersebut diketahui  ekstrak etanol daun kelor mempunyai efek antidiare melalui penghambatan motilitas usus. Efek ekstrak etanol daun kelor dalam menghambat motilitas usus paling baik pada pemberian dengan dosis 36,4 mg/20 g BB dengan nilai rata-rata rasio sebesar 0,389
Inhibition Activity Of Ethanolic Extract Of Ulva lactuca Against Staphylococcus aureus emelda, emelda; Safitri, Eka Asriani; Fatmawati, Annisa
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.7

Abstract

Staphylococcus aureus (S. aureus) is a normal flora that can cause mild skin infections, one of which is acne. Commonly used chemical treatments are antibiotics such as Clindamycin. Continuous use of antibiotics can lead to resistance. Natural ingredients that are possible can inhibit the growth of bacteria. Treatment caused by S.aureus is Ulva lactuca Linn. (Green algae). This marine biota contains compounds that have the potential to be antibacterial, including triterpenoids, flavonoids, and saponins. This study aims to compare antibacterial activity of  ethanolic extract of Ulva lactuca and Clindamycin against S. aureus bacteria. This type of research is an experimental laboratory. Ulva lactuca was extracted by maceration method using ethanol 96% solvent. Then carried out testing for antibacterial activity using the agar diffusion method by sump technique. The study was divided into 6 groups. One Clindamycin group and 5 treatment groups respectively with extract concentrations of 20%, 40%, 60%, 80%, and 100%. The test was carried out in 3 repetitions. Data analysis was processed by SPSS using the Kruskal-Wallis test to determine which groups had difference. The results showed that the ethanolic extract of Ulva lactuca was able to inhibit the growth of S. aureus bacteria with strong categories at concentrations of 20%, 40%, and 60%. Very strong category at 80% and 100% concentrations. The 100% concentration had the largest average inhibition zone diameter of 22 ± 0.577 mm which was not significantly different from Clindamycin with a significance value of 0.043 (p <0.05). This study concludes that the ethanolic extract of Ulva lactuca has activity in inhibiting the growth of S.aureus bacteria with strong to very strong categories, but statistically not as strong as Clindamycin
Pengaruh Pemberian Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Kadar Low-Density Lipoprotein (LDL) Tikus Jantan Galur Sprague dawley : Efek Antikolestrol Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Kusumawardani, Nurul; Fauzi, Rizal; Emelda, Emelda; Estiningsih, Daru; Sukma Ananda , RA Dewinta; Nabila , Lathifa
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.9

Abstract

This study aimed to determine the effect of the n-hexane fraction of Moringa leaf ethanol extract (Moringa oleifera L.) on low-density lipoprotein (LDL) levels in Sprague Dawley male rat strains fed a high-fat diet. This study used a pre-test and post-test control design on male rats of the Sprague Dawley strain. Thirty-six male white rats of the Sprague Dawley strain were given high-fat diet and then divided into six groups: group I was normal group, group II negative control was given CMC Na, Group III positive control was given Simvastatin 10 mg, Group IV, V, VI was given n-hexane fraction of ethanol extract of Moringa leaves (Dose 3,722 mg/kgBW; 7.444 mg/kgBW; 14,888 mg/kgBW). The results of measuring low-density lipoprotein (LDL) levels in animals were measured after 14 days of research as a post-test. Based on statistical analysis, there was no significant difference between the positive control group and the three treatment groups (p=1,000). The results of this study can conclude that the dose of the n-hexane fraction of Moringa leaves has a significant effect on decreasing LDL levels in male Sprague Dawley rats with the best % reduction at a dose of 14.89 mg/kg BW (61.17%), with a linear regression equation y=-0.0408x + 1.079; (R2=0.986). The results of this study indicate that the n-hexane part of Moringa leaves may reduce low-density lipoprotein levels in male white Wistar rats induced by high-fat.
Co-Authors Abd. Rasyid Syamsuri Ajat, Ajat Azizah, Abibatul Banafsaj, Zakia Irbah Calista, Avissa Dewi, Alvina Fitriya Didik Yuni Prasetya Dilla, Triani Utami Dwinta, Eliza Eliyanah, Eliyanah Estiningsih , Daru Estiningsih, Daru Fatmawati, Annisa Fauzi , Rizal Fitri, Nurwijaya Gunawan , Adhi Hafid, Pera Yulia Hafid, Perawati Haryanggita, Bariqna'im Katon Heriyani, Yeni Ichwan Ridwan Rais Juliana, Intan Kusumawardani , Nurul Kusumawardani, Nurul Lubis, Abdul Rahman Mardianna, Nova Mindari, Ellisyah Muhammad Abdurrahman Munir Nabila , Lathifa Nofrianto, Robby Norhayatun, Norhayatun Nurhidayanti, Nurhidayanti Nurinda , Eva Octaviani, Ani Pothitirat, Werayut Pratiwi, Dinda Ayu Pratiwi, Sindi Priyanti, Nita Putri Ayu Lestari Putri, Ade Lia Rahmawati, Feti Rahmi, Lisa Amelia Ramadhani, Sunainatul Ramandani , Wulan Rizal Fauzi Robby, Robby Safitri, Eka Asriani Saroya, Nadia Tus Sarwadhamana, Raden Jaka Septariani, Jumania Septiawan, Azizah Nada Solikah , Wahyu Yuliana Solikah, Wahyu Yuliana Sri Watini Stiawati , Rika Sukma Ananda , RA Dewinta Yeni Haryani, Yeni Yeni Heryani Yunitasari, Septiyani Endang