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All Journal Jurnal Kedokteran Brawijaya Jurnal NERS Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Kesehatan Jurnal Keperawatan dan Fisioterapi (JKF) Best Journal (Biology Education, Sains and Technology) Journal of Telenursing (JOTING) IJOEP : International Journal of Ecophysiology Journal SAGO Gizi dan Kesehatan Narra J
Ardinata, Dedi -
Department Of Physiology, Faculty Of Medicine Universitas Sumatera Utara, Medan, North Sumatera
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Relationship Of Incidence Of Frailty With Metformin Consumption Habits In Elderly Type-2 Diabetes Mellitus Patients. Irwanto, Agus; Ardinata, Dedi; Malisie, Ririe Fachrina
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.7649

Abstract

Type 2 diabetes (T2DM) was characterised with insulin resistance and deficiency, furthermore with advancing age the was also an increase in insulin resistance. Clinical studies has proven that insulin resistance and T2DM increase the incidence of frailty syndrome in the elderly. Oral antidiabetics metformin was associated with the inhibition of aging process. Eventhough, there was limitless literature and theorical that showed the relationship of metformin therapy to frailty syndrome. This study aimed to explore the possibility of metformin protective effect on frailty syndrome. This research method uses structured descriptive analysis with literature review. Article Data both original article, research article, Review article and case report are collected to be analyzed in accordance with the purpose of the title and writing of this article. Type 2 Diabetes mellitus is characterized by insulin resistance and deficiency which had happened several decades earlier, in addition to the incidence of insulin resistance will also increase. On some clinical studies that have been conducted, insulin resistance and type 2 Diabetes mellitus, it has been shown to increase the number of occurrences of frailty syndrome in old age. Conclusion Metformin was shown to have protective effect against frailty syndrome in elderly diabetic
Effectiveness of virtual reality positive self-talk on changes in brain wave activity among patients with breast cancer undergoing chemotherapy: a randomized controlled trial Harahap, Ikhsanuddin Ahmad; Nasution, Azizah; Harahap, Urip; Ardinata, Dedi
Jurnal Ners Vol. 21 No. 1 (2026): VOLUME 21 ISSUE 1 (FEBRUARY 2026)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v21i1.78907

Abstract

Introduction: Patients with breast cancer undergoing chemotherapy often experience pain, cognitive impairments, and changes in brainwave activity. This study evaluated the efficacy of Virtual Reality Positive Self-Talk (VR-PST) on changes in brain wave activity in breast cancer patients undergoing chemotherapy. Methods: A single-blind randomized controlled clinical trial was conducted involving 92 patients with breast cancer undergoing chemotherapy, who were randomly assigned to the VR-PST intervention group (n = 46) and the control group (n = 46). Participants in the VR-PST group received five intervention sessions conducted over a two-week period, consisting of structured cognitive self-talk presented in a virtual reality environment (VR-PST), while the control group received standard care. Brain wave activities in both groups were measured using the Muse 2 electroencephalographic (EEG) device before and after the intervention. Results: There were shifts in brain waves from delta to alpha waves in both groups, indicating relaxation; however, the VR-PST group showed a more dominant increase in beta waves. The VR-PST group demonstrated a trend toward greater cognitive activation; however, Fisher’s Exact Test showed that the difference between the groups was not statistically significant (p = 0.052). Conclusions: Although the difference was not statistically significant, the observed trend of increased beta-wave activity in the VR-PST group suggests a possible enhancement of cognitive activation. However, this finding should be interpreted with caution, and further studies are required to confirm this effect.
Regulatory Role of SIRT1 in Skeletal Muscle Hypertrophy: Molecular Implications Rahman, Dara Hanifa; Ardinata, Dedi; Sari, Mutiara Indah
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol. 8 No. 2 (2026): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/k6g79c98

Abstract

Background: Skeletal muscle hypertrophy is an adaptive process influenced by molecular signals and metabolic conditions. Sirtuin 1 (SIRT1), a NAD-dependent deacetylase, plays a crucial role in regulating skeletal muscle growth and regeneration through its interaction with key pathways such as mTOR, PGC-1?, FOXO, and myogenic factors. Aim: This literature review summarizes the current scientific evidence on the role of SIRT1 in muscle hypertrophy, including its effects on mitochondrial efficiency, oxidative stress reduction, and suppression of catabolic genes such as atrogin-1 and MuRF1. Method: A literature search was conducted using databases such as PubMed, ScienceDirect, and Google Scholar, focusing on articles from the last 10 years. Result: These findings indicate that SIRT1’s effects are highly context-dependent, varying with cellular energy status and external stimuli such as exercise or caloric restriction. Rather than directly inducing hypertrophy, SIRT1 facilitates a favorable cellular environment that enables sustained muscle growth. Conclusion: These insights offer promising potential for the development of molecular-based therapies to preserve or enhance muscle mass, particularly in aging populations or pathological conditions.
Co-Authors Agus Irwanto Amin, Mustafa M. Bintang YM Sinaga Delfitri Munir Dudut Tanjung Endy Juli Anto Fachrina, Ririe Fadhilah Hayati Farhat, Farhat Hadyanto Lim Harahap, Ikhsanuddin Ahmad Ilyas, Syaffrudin Ketaren, Aga Shahri Putera Lubis, Andriamuri Primaputra Lubis, Yuni Suharnida Lumongga, Firiani Malisie, Ririe Fachrina Martina Evelyn R.H Muhammad Ichwan Muhammad Ichwan Mutiara, Rizka Nasution, Azizah Nur Asnah Sitohang, Nur Asnah Nuraiza Meutia Pratiwi, Lisa Nabila Rahman, Dara Hanifa Rambe, Andrina YM. Ririe Fachrina Malisie Sari, Mutiara Indah Siahaan, Jekson Martiar Tanjung, Muhammad Sukri Tarigan, Amira Permatasari Tarigan, Randi Joel Oktavianus Tri Andrianto, Yoga Fathur Ulfa, Loriana Urip Harahap Vivian Vivian Vytra, Sunna Wardani, Retno S. Yahwardiah Siregar Yeni Vera Yetty Machrina Zahara, Devira