Article Per Year (5 Year)
p-Index From 2020 - 2025
1.817
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Kesehatan Jurnal Keperawatan dan Fisioterapi (JKF) Best Journal (Biology Education, Sains and Technology) Journal of Telenursing (JOTING) IJOEP : International Journal of Ecophysiology Journal SAGO Gizi dan Kesehatan Narra J
Ardinata, Dedi -
Department Of Physiology, Faculty Of Medicine Universitas Sumatera Utara, Medan, North Sumatera
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Anti-inflammatory and Anti-infertility Effects of Ethanol Extract of Turmeric (Curcuma longa) in Male Wistar Rats with Type 2 Diabetes Mellitus Induced by Streptozotocin-Nicotinamide-High Fat Diet Vivian, Vivian; Lim, Hadyanto; Siahaan, Jekson Martiar; Anto, Endy Juli; Ilyas, Syaffrudin; Ardinata, Dedi
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.891

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with chronic inflammation and male reproductive dysfunction. The ethanol extract of turmeric (Curcuma longa) has demonstrated potential as an alternative therapeutic agent due to its anti-inflammatory and reproductive restorative properties. This study aims to analyze the anti-inflammatory and anti-infertility effects of the ethanol extract of Curcuma longa in male Wistar rats with T2DM induced by a streptozotocin-nicotinamide-high fat diet (STZ-NA-HFD). Subjects and Method: Thirty male Wistar rats were randomized into six groups (n=5): normal control (K1), diabetic control (K2), positive control (T2DM + metformin 45 mg/kgBW, K3), and three treatment groups receiving Curcuma longa extract at doses of 50 mg/kgBW (K4), 100 mg/kgBW (K5), and 150 mg/kgBW (K6). Diabetes was induced with STZ (55 mg/kgBW) and nicotinamide (120 mg/kgBW). Blood glucose, IL-6, testosterone levels, sperm count, and sperm motility were evaluated after 21 days of treatment. Results: The turmeric extract significantly reduced blood glucose levels (p<0.001) and IL-6 concentrations from 574.06±68.99 to 214.06±78.71 ng/mL at a dose of 150 mg/kgBW (p<0.001). Normal sperm motility increased significantly at 150 mg/kgBW (20.0±2.55%) compared to the diabetic control (8.40±2.07%) (p=0.008). Conclusion: The ethanol extract of Curcuma longa demonstrated significant anti-inflammatory activity by reducing IL-6 levels and improving glycemic control. Its anti-infertility effect was reflected by enhanced sperm motility, particularly at the 150 mg/kgBW dose. These findings indicate that Curcuma longa possesses potential as an adjuvant therapy for the management of T2DM and its associated complications.
Co-Authors Agus Irwanto Agus Irwanto Amin, Mustafa M. Bintang YM Sinaga Delfitri Munir Dudut Tanjung Endy Juli Anto Fachrina, Ririe Fadhilah Hayati Farhat, Farhat Hadyanto Lim Ilyas, Syaffrudin Ketaren, Aga Shahri Putera Lubis, Andriamuri Primaputra Lubis, Yuni Suharnida Lumongga, Firiani Malisie, Ririe Fachrina Martina Evelyn R.H Muhammad Ichwan Muhammad Ichwan Mutiara, Rizka Nur Asnah Sitohang, Nur Asnah Nuraiza Meutia Pratiwi, Lisa Nabila Rambe, Andrina YM. Ririe Fachrina Malisie Ririe Fachrina Malisie Siahaan, Jekson Martiar Tanjung, Muhammad Sukri Tarigan, Amira Permata Sari Tarigan, Randi Joel Oktavianus Tri Andrianto, Yoga Fathur Ulfa, Loriana Vivian Vivian Vytra, Sunna Wardani, Retno S. Yahwardiah Siregar Yeni Vera Yetty Machrina Zahara, Devira