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All Journal Jurnal Ilmiah Farmasi International Journal of Biosciences and Biotechnology Jurnal Farmasi Udayana Farmasains : Jurnal Ilmiah Ilmu Kefarmasian WIDYABHAKTI Jurnal Ilmiah Populer Jurnal Karinov Jurnal Kefarmasian AKFARINDO Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Usadha Medical Sains : Jurnal Ilmiah Kefarmasian Bali Medical and Wellness Journal
Ni Luh Kade Arman Anita Dewi
Department Of Natural Medicine, Faculty Of Pharmacy, Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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UJI AKTIVITAS KOMBINASI KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.) DAN KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) SEBAGAI PENYEMBUHAN LUKA BAKAR DERAJAT II PADA TIKUS PUTIH (Rattus norvegicus) Wahyu Udayani, Ni Nyoman; Febryna Dharma Yanti, Ni Luh Putu; Arman Anita Dewi, Ni Luh Kade
Jurnal Kefarmasian Akfarindo Vol 8 No 2 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.241

Abstract

Luka bakar merupakan kerusakan jaringan kulit yang disebabkan oleh adanya panas. Kulit adalah organ terbesar pada permukaan tubuh dan melindungi jaringan yang ada dibawahnya. Pengobatan dengan menggunakan bahan herbal masih terus dilakukan guna meminimalisir efek samping obat. Kulit pisang kepok dan kulit buah naga merah merupakan salah satu bagian tanaman yang dapat menyembuhkan luka bakar karena memiliki senyawa flavonoid. Penelitian ini bertujuan untuk mengetahui aktivitas kombinasi krim ekstrak kulit buah pisang kepok dan kulit buah naga merah sebagai penyembuhan luka bakar derajat II pada tikus putih. Penelitian ini bersifat eksperimental laboratorium. Pengujian menggunakan 20 ekor tikus yang dibagi menjadi 5 kelompok, semua tikus dibuatkan luka bakar dan diberikan pengobatan sehari sekali. Pengukuran diameter luas luka bakar dilakukan setiap tiga hari sekali selama 14 hari. Hasil data pengukuran diuji secara statistik, menunjukan bahwa kombinasi krim ekstrak kulit pisang kepok dan kulit buah naga merah dengan persentase perbandingan yang berbeda yaitu F1 adalah 10%:7,5%, F2 adalah 15%:10%, dan F3 adalah 30%:15% memiliki aktivitas penyembuhan luka bakar. Berdasarkan hasil penelitian yang telah dilakukan kombinasi krim ekstrak kulit pisang kepok dan kulit buah naga merah dengan perbandingan 10%:7,5% sudah efektif dalam menyembuhkan luka bakar derajat II.
Karagenan Rumput Laut Merah Bali (Gracilaria sp.) sebagai Antibakteri terhadap Delapan Bakteri Patogen Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Yuda, Putu Era Sandhi Kusuma; Wardani, I Gusti Agung Ayu Kusuma; Juliadi, Debby; Putri, Ni Kadek Dila Pratiwi; Putri, Ni Kadek Nisa Leoni; Darmawan, I Wayan Agus; Yanti, Ni Kadek Pradnya
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.10349

Abstract

The increase in infection cases every year, coupled with the rise in resistance cases, increases the urgency of exploring antimicrobial agents. Gracilaria sp. is a red seaweed that is widely known as one of the potential producers of active metabolites, sulfated polysaccharides. Carrageenan is one form of sulfated polysaccharide that has antimicrobial activity. This study was conducted to evaluate the antibacterial activity of carrageenan derived from Gracilaria sp. against several pathogenic bacteria, including Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus pyogenes, and Salmonella typhi. Carrageenan was extracted from Gracilaria sp. samples obtained from the South Denpasar area (Bali) using KOH. An antibacterial activity assay of carrageenan was carried out using an agar well diffusion method with nutrient agar media. Tests were conducted at concentrations of 1 and 5 mg/mL (E. coli and S. epidermidis), 20, 30, 40 mg/mL (S. aureus, S. pyrogenes, E. faecalis, and S. typhi), 50, 75, and 100 mg/mL (P. aeruginosa and K. pneumoniae). Incubation was carried out for 24 hours at ± 37 °C. Data were analyzed statistically by one-way ANOVA and Kruskal-Wallis with a 95% confidence level. The results showed that carrageenan extracted from Gracilaria sp. exhibited significant antibacterial activity against several pathogenic bacteria, especially gram-negative bacteria. The antibacterial activity produced in this study was proportional to the increase in concentration, where the inhibitory activity produced increased as the concentration of carrageenan increased. It can be concluded that carrageenan has the potential to be an antibacterial.
Ethnobotanical Insights and Quantitative Evaluation of Medicinal Plant Utilization in Traditional Cosmetic Practices: A Community-Centered Study Dewi, Ni Luh Kade Arman Anita; Pendet, Ni Made Diah Pusparini; Apriani, Rista; Megawati, Fitri; Udayani, Ni Nyoman Wahyu; Sugijanto, Milyadi; Agustini, Ni Putu Dewi; Javandira, Cokorda
Bali Medical and Wellness Journal Vol. 2 No. 1 (2025): Bali Medical and Wellness Journal
Publisher : PT BMW Journal Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71341/bmwj.v2i1.34

Abstract

Background: Indigenous knowledge about medicinal plants used in cosmetics is an important cultural heritage that needs scientific documentation and preservation. In Terunyan Village, Bali, Indonesia, traditional ethnobotanical practices have been passed down orally through generations. Objective: This study aims to systematically record, identify, and analyze the plant species used by the community for natural cosmetic purposes, and to assess their cultural significance using ethnobotanical indices. Methods: An ethnobotanical survey was carried out using semi-structured interviews with 328 informants selected through purposive sampling. Plant specimens were collected, identified, and voucher samples stored at the Herbarium Hortus Botanicus Baliense (THBB). Quantitative analysis used Use Value (UV) and Fidelity Level (FL) to measure cultural importance and consensus. Results: A total of 24 plant species from 18 plant families were documented for cosmetic use. The most frequently cited species were Aloe vera (UV = 0.180), Cocos nucifera (UV = 0.174), and Solanum lycopersicum (UV = 0.169). Leaves were the most used plant parts (40.85%), and pounding was the main processing method (20.43%). Six species had a fidelity level of 100%, indicating strong cultural agreement. The most common applications were for hair care (35.2%), skin moisturizing (28.7%), and skin brightening (24.1%). Conclusion: This research provides the first detailed documentation of traditional cosmetic plant use in Terunyan Village. It highlights significant ethnobotanical diversity and strong cultural consensus for key species. These findings support the preservation of indigenous knowledge and lay the groundwork for sustainable development of natural cosmetic products.
Identifikasi Senyawa Fitokimia dan Uji Aktivitas Antioksidan pada Cascara (Coffea arabica L.) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Handani, Dewa Ayu Sri; Dewi, Ni Luh Kade Arman Anita; Megawati, Fitria; Tirtayasa, Gede Agus Ari
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.12181

Abstract

Cascara refers to the dried husk of coffee cherries. It has garnered significant attention in recent research due to its phytochemical composition and potential health benefits. Several studies have highlighted the presence of bioactive compounds and the antioxidant activity exhibited by cascara. This study aims to investigate the phytochemical content and antioxidant potential of cascara. The cascara was extracted using the maceration method with 96% ethanol, followed by phytochemical screening for alkaloids, flavonoids, tannins, saponins, terpenoids, steroids, and quinones using standard color reactions in test tubes. Antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, with ascorbic acid as a reference compound. The phytochemical profile of the extract was identified using gas chromatography-mass spectrometry (GC-MS). The findings indicated that cascara contains alkaloids, flavonoids, tannins, saponins, and triterpenoids. GC-MS analysis identified caffeine, hexadecanoic acid (methyl ester), and hexadecanoic acid (ethyl ester) as the predominant compounds in cascara. The antioxidant activity test using the DPPH method demonstrated that the ethanol extract of cascara possesses moderate antioxidant potential, with an average IC50 value of 108.49 ± 1.28 ppm. Ascorbic acid, the reference compound used in this study, yielded an IC50 of 2.53 ppm, categorized as very strong. This research underscores cascara’s potential as a valuable source of antioxidants with significant health benefits, influenced by geographic factors affecting its bioactive compound profile. Consequently, cascara holds promise for further development as a raw material for functional health-promoting products.
PHYTOCHEMICAL PROFILING OF PURNAJIWA FRUIT (Kopsia arborea Blume.) EXTRACTS AND ANTIBACTERIAL ACTIVITY AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Apriliani, Ni Luh Putri; Dewi, Ni Kadek Dwi Purnama; Ni Luh Kade Arman Anita Dewi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1767

Abstract

Purnajiwa (Kopsia arborea Blume.) contains diverse phytochemicals with notable antibacterial potential. This study aimed to characterize and quantify the phytochemicals of Kopsia arborea fruit extracts obtained by maceration and Soxhlet extraction with methanol and evaluate their antibacterial activity against MRSA through phytochemical screening, GC-MS analysis, spectrophotometric quantification of flavonoids, alkaloids, and phenolics, and disc diffusion assay at 100 ?g/mL concentration. The findings indicated that the Soxhlet extraction produced a superior yield (19.47 ± 0.58%) compared to maceration (11.09 ± 0.65%). Phytochemical analysis revealed the presence of alkaloids, flavonoids, phenolics, tannins, saponins, and triterpenoids, with no qualitative differences between the two extracts. Quantitative analysis demonstrated higher concentrations of alkaloids, flavonoids, and phenolics in the Soxhlet extract, with values of 88.58 ± 3.76, 46.50 ± 1.04, and 57.87 ± 0.44 ?g/mL, respectively, compared to the maceration extract (50.46 ± 3.86, 26.22 ± 0.27, and 30.49 ± 0.31 ?g/mL, respectively). GC-MS analysis identified 13 alkaloid compounds in the Soxhlet extract and 12 in the maceration extract. Antibacterial assays revealed that the mean inhibition zone diameter against MRSA was 11.69 ± 0.28 mm for the Soxhlet extract and 12.61 ± 0.27 mm for the maceration extract, respectively. In conclusion, Soxhlet extraction yielded higher concentrations of alkaloids, phenolic compounds, and flavonoids; however, GC-MS analysis revealed that the macerated extract exhibited a higher AUC of alkaloid compounds than that of Soxhlet extraction. Moreover, the macerated extract demonstrated superior antibacterial activity, indicating that maceration has greater potential for development as an antibacterial agent than Soxhlet extraction.
Review: Pemanfaatan Tanaman sebagai Fitoterapi pada Diabetes Mellitus Dewi, Ni Luh Kade Arman Anita; Prameswari, Putu Nimas Diyah; Cahyaningsih, Erna; Megawati, Fitria; Agustini, Ni Putu Dewi; Juliadi, Debby
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5562

Abstract

Diabetes is a chronic disease that occurs due to high levels of sugar in the blood, this can occur when the pancreas does not produce enough insulin (a hormone that regulates blood sugar or glucose), or when the body cannot effectively use the insulin it produces. Management of DM patients can be carried out with non-pharmacological and pharmacological therapies. The method used in the journal review was to search for the keyword "diabetes mellitus herbal medicine" for clinical studies on plant-derived products for the treatment of diabetes mellitus. Search terms included “phytotherapy”, “phytochemicals”, “medicinal plant products”, “herbal medicine”, and “diabetes mellitus”. Involving plant-derived compounds and pigmentation as outcome measures were included. In this review article, 30 journals were collected from which the objectives and results of the research in the journal were obtained. The goal is as an alternative management treatment to control blood sugar levels. For some of the compounds we discuss, among others: Flavonoids, Allicin, Lectins, Alkaloids, Andrographolid, Curcumin, Cinnamaldehyde, peptides, Phenolics, Tannins.
Kajian Etnofarmasi Kelompok Masyarakat Banjar Kepisah Sumerta Kelod Denpasar Dewi, Ni Luh Kade Arman Anita; Adi Lestari, Ni Putu Wisnu; Suradnyana, I Gede
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7390

Abstract

Ethnopharmacy is a part of pharmaceutical science that includes understanding medicinal plants used and studying how certain ethnic or community communities use drugs. Studies on ethnopharmaceuticals have never been carried out on the community in the Sumerta Kelod area, especially the Banjar Keseparat community. Where there are still many Banjar Keseparat people who use plants as medicine. This research is a descriptive research. Data collection was done by interview method. The sampling technique in this study used a non-probability sampling method. The results showed that ethnopharmaceutical research that had been carried out in Banjar Kejuangan, Sumerta Kelod obtained in general 12 types of plants that were located in Banjar Kejuangan, Sumerta Kelod. Where the plant parts used were 67% leaves, 17% rhizomes, 8% stems, and 8% flowers. The method of processing plants with the highest frequency was by boiling, which was 92%. The most frequently used method of using ethnopharmaceutical plants is by drinking, which is equal to 83%, and the most frequently used indication for medicinal plants is to treat joint problems, such as muscle pain and gout (28%).
Co-Authors Adi Lestari, Ni Putu Wisnu Adrianta, Agus Agus Adrianta Agustini, Ni Putu Dewi Apriani, Rista Apriliani, Ni Luh Putri Cokorda Javandira Darmawan, I Wayan Agus Debby Juliadi Dewi, Ni Kadek Dwi Purnama Dewi, Ni Made Sintia Dwi Arymbhi Sanjaya Erna Cahyaningsih Febryna Dharma Yanti, Ni Luh Putu Fitria Megawati Handani, Dewa Ayu Sri I Gede Made, Suradnyana I Made Agus Sunadi Putra Luh Risma Putri Rahayu Made Agus Deny Mahendra Putra Maria Dewi, Ni Putu Megawati, Fitri Megawati, Fitria Ni Luh Sintya Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Nyoman Wahyu Udayani Ni Putu Dewanty Suwirtawati Ni Putu Dewi Agustini Ni Putu, Puspitawati Pendet, Ni Made Diah Pusparini Prameswari, Putu Nimas Diyah Puguh Santoso puguh santoso, puguh Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Putu Era Sandhi K.Yuda Putu Era Sandhi Kusuma Yuda Sandhi Kusuma Yuda, Putu Era Sasadara, Maria Malida Vernandes Suarnata, I Gede Agus Sugijanto, Milyadi Suradnyana, I Gede Surya Rahadi, I Wayan Suwantara, I Putu Tangkas Tirtayasa, Gede Agus Ari Wardani, I Gusti Agung Ayu Kusuma Yanti, Ni Kadek Pradnya