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All Journal Jurnal Ilmiah Farmasi International Journal of Biosciences and Biotechnology BIOTROPIA - The Southeast Asian Journal of Tropical Biology Farmasains : Jurnal Ilmiah Ilmu Kefarmasian WIDYABHAKTI Jurnal Ilmiah Populer JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Karinov Jurnal Kefarmasian AKFARINDO Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento Jurnal Mandala Pengabdian Masyarakat COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Usadha Abdi Samulang : Jurnal Pengabdian Kepada Masyarakat Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Bali Medical and Wellness Journal
Ni Luh Kade Arman Anita Dewi
Department Of Natural Medicine, Faculty Of Pharmacy, Universitas Mahasaraswati Denpasar
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Identifikasi Senyawa Fitokimia dan Uji Aktivitas Antioksidan pada Cascara (Coffea arabica L.) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Handani, Dewa Ayu Sri; Dewi, Ni Luh Kade Arman Anita; Megawati, Fitria; Tirtayasa, Gede Agus Ari
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.12181

Abstract

Cascara refers to the dried husk of coffee cherries. It has garnered significant attention in recent research due to its phytochemical composition and potential health benefits. Several studies have highlighted the presence of bioactive compounds and the antioxidant activity exhibited by cascara. This study aims to investigate the phytochemical content and antioxidant potential of cascara. The cascara was extracted using the maceration method with 96% ethanol, followed by phytochemical screening for alkaloids, flavonoids, tannins, saponins, terpenoids, steroids, and quinones using standard color reactions in test tubes. Antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, with ascorbic acid as a reference compound. The phytochemical profile of the extract was identified using gas chromatography-mass spectrometry (GC-MS). The findings indicated that cascara contains alkaloids, flavonoids, tannins, saponins, and triterpenoids. GC-MS analysis identified caffeine, hexadecanoic acid (methyl ester), and hexadecanoic acid (ethyl ester) as the predominant compounds in cascara. The antioxidant activity test using the DPPH method demonstrated that the ethanol extract of cascara possesses moderate antioxidant potential, with an average IC50 value of 108.49 ± 1.28 ppm. Ascorbic acid, the reference compound used in this study, yielded an IC50 of 2.53 ppm, categorized as very strong. This research underscores cascara’s potential as a valuable source of antioxidants with significant health benefits, influenced by geographic factors affecting its bioactive compound profile. Consequently, cascara holds promise for further development as a raw material for functional health-promoting products.
PHYTOCHEMICAL PROFILING OF PURNAJIWA FRUIT (Kopsia arborea Blume.) EXTRACTS AND ANTIBACTERIAL ACTIVITY AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Apriliani, Ni Luh Putri; Dewi, Ni Kadek Dwi Purnama; Ni Luh Kade Arman Anita Dewi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1767

Abstract

Purnajiwa (Kopsia arborea Blume.) contains diverse phytochemicals with notable antibacterial potential. This study aimed to characterize and quantify the phytochemicals of Kopsia arborea fruit extracts obtained by maceration and Soxhlet extraction with methanol and evaluate their antibacterial activity against MRSA through phytochemical screening, GC-MS analysis, spectrophotometric quantification of flavonoids, alkaloids, and phenolics, and disc diffusion assay at 100 ?g/mL concentration. The findings indicated that the Soxhlet extraction produced a superior yield (19.47 ± 0.58%) compared to maceration (11.09 ± 0.65%). Phytochemical analysis revealed the presence of alkaloids, flavonoids, phenolics, tannins, saponins, and triterpenoids, with no qualitative differences between the two extracts. Quantitative analysis demonstrated higher concentrations of alkaloids, flavonoids, and phenolics in the Soxhlet extract, with values of 88.58 ± 3.76, 46.50 ± 1.04, and 57.87 ± 0.44 ?g/mL, respectively, compared to the maceration extract (50.46 ± 3.86, 26.22 ± 0.27, and 30.49 ± 0.31 ?g/mL, respectively). GC-MS analysis identified 13 alkaloid compounds in the Soxhlet extract and 12 in the maceration extract. Antibacterial assays revealed that the mean inhibition zone diameter against MRSA was 11.69 ± 0.28 mm for the Soxhlet extract and 12.61 ± 0.27 mm for the maceration extract, respectively. In conclusion, Soxhlet extraction yielded higher concentrations of alkaloids, phenolic compounds, and flavonoids; however, GC-MS analysis revealed that the macerated extract exhibited a higher AUC of alkaloid compounds than that of Soxhlet extraction. Moreover, the macerated extract demonstrated superior antibacterial activity, indicating that maceration has greater potential for development as an antibacterial agent than Soxhlet extraction.
Review: Pemanfaatan Tanaman sebagai Fitoterapi pada Diabetes Mellitus Dewi, Ni Luh Kade Arman Anita; Prameswari, Putu Nimas Diyah; Cahyaningsih, Erna; Megawati, Fitria; Agustini, Ni Putu Dewi; Juliadi, Debby
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5562

Abstract

Diabetes is a chronic disease that occurs due to high levels of sugar in the blood, this can occur when the pancreas does not produce enough insulin (a hormone that regulates blood sugar or glucose), or when the body cannot effectively use the insulin it produces. Management of DM patients can be carried out with non-pharmacological and pharmacological therapies. The method used in the journal review was to search for the keyword "diabetes mellitus herbal medicine" for clinical studies on plant-derived products for the treatment of diabetes mellitus. Search terms included “phytotherapy”, “phytochemicals”, “medicinal plant products”, “herbal medicine”, and “diabetes mellitus”. Involving plant-derived compounds and pigmentation as outcome measures were included. In this review article, 30 journals were collected from which the objectives and results of the research in the journal were obtained. The goal is as an alternative management treatment to control blood sugar levels. For some of the compounds we discuss, among others: Flavonoids, Allicin, Lectins, Alkaloids, Andrographolid, Curcumin, Cinnamaldehyde, peptides, Phenolics, Tannins.
Kajian Etnofarmasi Kelompok Masyarakat Banjar Kepisah Sumerta Kelod Denpasar Dewi, Ni Luh Kade Arman Anita; Adi Lestari, Ni Putu Wisnu; Suradnyana, I Gede
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7390

Abstract

Ethnopharmacy is a part of pharmaceutical science that includes understanding medicinal plants used and studying how certain ethnic or community communities use drugs. Studies on ethnopharmaceuticals have never been carried out on the community in the Sumerta Kelod area, especially the Banjar Keseparat community. Where there are still many Banjar Keseparat people who use plants as medicine. This research is a descriptive research. Data collection was done by interview method. The sampling technique in this study used a non-probability sampling method. The results showed that ethnopharmaceutical research that had been carried out in Banjar Kejuangan, Sumerta Kelod obtained in general 12 types of plants that were located in Banjar Kejuangan, Sumerta Kelod. Where the plant parts used were 67% leaves, 17% rhizomes, 8% stems, and 8% flowers. The method of processing plants with the highest frequency was by boiling, which was 92%. The most frequently used method of using ethnopharmaceutical plants is by drinking, which is equal to 83%, and the most frequently used indication for medicinal plants is to treat joint problems, such as muscle pain and gout (28%).
Ethnobotanical Study and Hedonic Evaluation with Cost Analysis of Banana (Musa paradisiaca L.) Stem Serum Preparation as an Anti-Aging Solution Megawati, Fitria; Dewi, Ni Luh Kade Arman Anita; Agustini, Ni Putu Dewi; Antara, I Putu Satria; Ekayanti, Ni Luh Firda; Darmayanti, Ni Wayan
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6872

Abstract

In skincare, particularly facial serums, the utilization of natural ingredients is crucial in addressing various skin issues, notably combating the effects of free radicals that contribute to wrinkles. This study explores the potential of banana (Musa paradisiaca L.) stem extract as an active ingredient in serum formulation due to its rich anthocyanin content known for antioxidant properties. Hedonic testing and cost analysis serve as initial steps in the marketing mix of a product. This research aims to assess the hedonic preferences of various M. paradisiaca stem serum formulations and analyze the production costs. A descriptive research method employing survey and observational techniques was utilized for data collection and descriptive analysis. Hedonic testing was conducted to gauge the personal preferences of panelists toward M. paradisiaca stem serum formulations. Three formulations (F1 with 4%, F2 with 8%, and F3 with 12% M. paradisiaca extract) were evaluated by 40 panelists. Cost analysis of serum production employed quantitative descriptive analysis, computing the cost per unit using a variable costing method. The hedonic evaluation results showed that F1 formulation was highly preferred (79.3%), followed by F2 (73.2%), and F3 (66.8%). Cost analysis using the variable costing method revealed a total production cost of IDR 614,000.00 for 10 packages of M. paradisiaca stem serum formulation, translating to an approximate unit price of IDR 61,400.00.
Peningkatan Produktivitas BumDesa Melalui Pendampingan Perijinan dan pemasaran Produk UMKM Unggulan Desa Pecatu, Bali Sasadara, Maria Malida; Yuda, Putu Era Sandhi Kusuma; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Tirtayasa, Gede Agus Ari
ABDI SAMULANG: Jurnal Pengabdian Kepada Masyarakat Vol 5 No 1 (2026): JANUARI| ABDI SAMULANG
Publisher : Yayasan Habiburrahman Jamalu Bina Ummat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61477/abdisamulang.v5i1.84

Abstract

UMKM Boga Sari Pecatu is a community-based small enterprise fostered by BUMDesa Catu Kwero Sedana Pecatu, specializing in the production of herbal goods. To enhance the productivity of the BUMDesa, the village has designated several flagship products for wider market development, including instant ginger powder to be produced by UMKM Boga Sari Pecatu. Although the UMKM has produced several items, it faces key challenges such as the absence of production permits, limited production facilities that hinder scale‐up, the lack of product branding, and the absence of standardized bookkeeping practices. Through this community service initiative, the implementing team carried out several programs to address these issues, including assistance in fulfilling PIRT registration requirements, procurement of a ginger grater machine to support larger‐scale instant ginger powder production, development of a UMKM logo along with packaging design and labelling, and training on simple bookkeeping practices applicable to small enterprises. The program, conducted by the Faculty of Pharmacy, Universitas Mahasaraswati Denpasar, proceeded smoothly and according to plan. The major focuses included permit facilitation, provision of production equipment, and strengthening of product branding through the development of logos and packaging labels. The outcomes indicate improved partner understanding of PIRT procedures and benefits, although the permit issuance process is still ongoing. In terms of branding, the UMKM now possesses a new logo and compliant packaging label design, enhancing product readiness for broader distribution. Bookkeeping training likewise improved partner knowledge, as reflected in the differences between pre-test and post-test scores
Penguatan Literasi Kesehatan Melalui Informasi Cerdas Menggunakan Tanaman Obat Sebagai Pengobatan Mandiri Di LPKA Kelas II Karangasem Megawati, Fitria; Dewi, Ni Luh Kade Arman Anita; Agustini, Ni Putu Dewi; Sari, Gusti Ayu Putu Laksmi Puspa; Wiryani, Luh Santhi Utami
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 2 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i2.959

Abstract

Pokok permasalahan dalam kegiatan pengabdian ini adalah bagaimana meningkatkan produktivitas sumber daya manusia, khususnya warga binaan di Lembaga Pembinaan Khusus Anak Kelas II Karangasem. Warga binaan membutuhkan bekal pengetahuan dan keterampilan yang dapat mendukung kemandirian mereka setelah menyelesaikan masa binaan. Upaya nyata peningkatan kapasitas dilakukan melalui promosi kesehatan yang berfokus pada literasi pemanfaatan tanaman obat sebagai pengobatan mandiri. Tujuan dari kegiatan ini adalah memberikan pengetahuan serta pelatihan pembuatan buku saku cerdas yang berisi informasi tentang tanaman obat, sehingga dapat menjadi panduan praktis bagi warga binaan. Solusi yang ditawarkan adalah penyuluhan berupa edukasi mengenai jenis tanaman obat, manfaatnya, serta cara pemanfaatannya, disertai pelatihan pembuatan buku saku. Hal ini diyakini lebih efektif dan efisien dalam meningkatkan pengetahuan sekaligus produktivitas warga binaan, terutama dalam bidang kesehatan mandiri berbasis tanaman obat. Metode pengabdian dilaksanakan melalui ceramah, diskusi, tanya jawab, dan pelatihan praktik. Evaluasi efektivitas kegiatan dilakukan dengan desain pre-experimental one group pretest-posttest untuk mengukur peningkatan pengetahuan dan keterampilan warga binaan. Hasil kegiatan menunjukkan adanya peningkatan literasi kesehatan, baik dalam aspek pengetahuan tentang jenis tanaman obat, manfaat, maupun cara pengolahannya. Selain itu, warga binaan memperoleh keterampilan praktis melalui kegiatan mengenali, memilih, dan mengolah tanaman obat secara langsung. Program ini juga menghasilkan promosi kesehatan berbasis komunitas yang dapat disebarkan kembali oleh warga binaan di lingkungan masing-masing. Kesimpulannya, pengabdian ini berhasil meningkatkan kapasitas warga binaan melalui literasi cerdas pemanfaatan tanaman obat. Pengetahuan dan keterampilan yang diperoleh menjadi bekal penting pasca binaan untuk mendukung kemandirian serta produktivitas mereka di masyarakat.
ETHNOBOTANICAL STUDY OF MEDICINAL PLANT USAGE DURING COVID-19 PANDEMIC: A COMMUNITY-BASED SURVEY IN INDONESIA Nayaka, Ni Made Dwi Mara Widyani; Yuda, Putu Era Sandhi Kusuma; Sanjaya, Dwi Arymbhi; Ernawati, Desak Ketut; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Sasadara, Maria Malida Vernandes
BIOTROPIA Vol. 30 No. 2 (2023): BIOTROPIA Vol. 30 No. 2 August 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.2.1784

Abstract

Before the availability of a vaccine, Indonesian population relied on traditional medicines to prevent COVID-19. Any species used by indigenous people could lead to further investigations in modern pharmacology, to preserve ancient knowledge, and to plan for plants’ conservation. The study aimed to discover and record species, methods of preparation, route of administration, and motivation in using medicinal plants by the Indonesian population during the COVID-19 pandemic. Participants of survey were selected from the people who live in Java and Bali for responding to an online structured questionnaire. Relative Frequency of Citation (RFC) was employed in the quantitative analysis of the collected data. The pharmacological relevance of the five plants with the highest RFC was further reviewed. The results showed that respondents used 59 plants from 28 families. Five species with the highest RFC were Curcuma longa (0.707), Zingiber officinale (0.674), Cymbopogon citratus (0.269), Kaempferia galanga (0.174), and Curcuma zanthorrhiza (0.165). Most plants were prepared by boiling (77.97%) and administered orally as a single ingredient or mixed with other herbals. Respondents believed that the plants were beneficial as immune-booster (71.26%), maintain good health (24.85%) and stamina (12.28%), and prevent viral infection, including COVID-19 (5.39%). The most commonly used plants might be scientifically based to boost immunity. However, their usage against COVID-19 and the medicinal value of herbal mixtures should be further investigated.
UJI IN VIVO TAHAP PREKLINIS TERHADAP EKSTRAK BATANG PISANG (Musa paradisiaca L.) SEBAGAI ANTIINFLAMASI TOPIKAL Dewi, Ni Luh Kade Arman Anita; Yuda, Putu Era Sandhi Kusuma; Suarnata, I Gede Agus; Sasadara, Maria Malida Vernandes
Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 2 (2021): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i2.129

Abstract

Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical damage, or microbiological substances. Banana stems (Musa paradisiaca L.) have been empirically believed for their topical anti-inflammatory properties. The purpose of this study was to scientifically evaluate the in vivo preclinical anti-inflammatory activity of banana stems. This research was designed experimentally using twenty-five albino male rats which were divided into five groups: the positive control group which received sodium diclofenac gel, the negative control group which received gel basis preparation without any active ingredient, and three experimental groups which received banana stem extract gel in three different concentrations, 5%, 10%, and 15%. Every five rats of every group were firstly injected with 1% of carrageenan, and the anti-inflammatory effect was evaluated every hour for 4 hours using a plethysmometer. The collected data were statistically evaluated. The results showed that banana stem extract gel with concentrations of 15% produced the best anti-inflammatory effect, compared to other gel concentrations. In conclusion, the preparation of 15% banana stem extract gel can be applied as potential topical anti-inflammatory preparation.
Aktivitas Anti-Inflamasi Minyak Herbal Tradisional Dari Bahan Usada Bali Pada Mencit Inflamasi Yang Diinduksi Karagenan Yuda, Putu Era Sandhi Kusuma; Mahardika, I Made Agus; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes; Nayaka, Ni Made Dwi Mara Widyani; Dewi, Ni Luh Kade Arman Anita
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 3 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i3.60529

Abstract

Peradangan sendi atau artritis merupakan salah satu penyakit inflamasi kronis yang memerlukan penggunaan obat jangka panjang. Penggunaan obat artritis seperti metotreksat dan NSAID dalam waktu lama dapat menimbulkan berbagai efek samping serius, sehingga diperlukan alternatif pengobatan yang relatif lebih aman terutama dari bahan herbal. Penelitian ini dilakukan untuk menguji aktivitas anti-inflamasi minyak herbal tradisional Usada Bali dari bahan Jahe (Zingiber officinale), Kunyit (Curcuma longa), Kencur (Kaemferia galanga), Bangle (Zingiber montanum), Cengkeh (Syzigium aromaticum) dan Kayu Manis (Cinnamomum burmanii) pada mencit inflamasi yang diinduksi karagenan melalui pengujian secara topikal. Mencit dibagi empat kelompok yang terdiri dari kelompok kontrol negatif (pembawa), kontrol positif (Natrium Diklofenak topikal), minyak herbal 150 dan 300 mg/ml. Volume peradangan kaki mencit diukur dengan alat pletismometer setiap jam selama empat jam setelah diinduksi dengan karagenan 0,5% (b/v) subplantar, kemudian diuji secara statistik (Mann-Whitney) dengan taraf kepercayaan 95%. Skrining fitokimia menunjukkan bahwa minyak herbal mengandung senyawa flavonoid, terpenoid dan steroid. Hasil uji aktivitas anti-inflamasi menunjukan adanya penghambatan peradangan yang signifikan (p<0,05) oleh minyak herbal konsentrasi 150 mg/ml maupun 300 mg/ml dengan persentase penghambatan pada jam ke-4 masing-masing sebesar 16,52% dan 11,30%, serta tidak berbeda bermakna dibandingkan kontrol positif (p>0,05). Hasil tersebut menunjukkan adanya potensi  minyak herbal Usada Bali sebagai anti-inflamasi topikal.
Co-Authors Adi Lestari, Ni Putu Wisnu Agustini, Ni Putu Dewi Antara, I Putu Satria Apriani, Rista Apriliani, Ni Luh Putri Cokorda Javandira Darmawan, I Wayan Agus Darmayanti, Ni Wayan Debby Juliadi Desak Ketut Ernawati Dewi, Ni Kadek Dwi Purnama Dwi Arymbhi Sanjaya Ekayanti, Ni Luh Firda Erna Cahyaningsih Febryna Dharma Yanti, Ni Luh Putu Fitria Megawati Gusti Ayu Putu Laksmi Puspa Sari Handani, Dewa Ayu Sri I Gede Made, Suradnyana I Made Agus Sunadi Putra Ketut Agus Adrianta Luh Risma Putri Rahayu Made Agus Deny Mahendra Putra Mahardika, I Made Agus Maria Dewi, Ni Putu Megawati, Fitri Megawati, Fitria Ni Luh Sintya Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Nyoman Wahyu Udayani Ni Putu Dewanty Suwirtawati Ni Putu Dewi Agustini Ni Putu, Puspitawati Pendet, Ni Made Diah Pusparini Prameswari, Putu Nimas Diyah Puguh Santoso puguh santoso, puguh Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Putu Era Sandhi K.Yuda Putu Era Sandhi Kusuma Yuda Sasadara, Maria Malida Sasadara, Maria Malida Vernandes Suarnata, I Gede Agus Sugijanto, Milyadi Suradnyana, I Gede Surya Rahadi, I Wayan Tirtayasa, Gede Agus Ari Wardani, I Gusti Agung Ayu Kusuma Wiryani, Luh Santhi Utami Yanti, Ni Kadek Pradnya