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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Majalah Kedokteran Nusantara The Journal Of Medical School Buletin Farmatera Manuju : Malahayati Nursing Journal International Journal of Nursing and Health Services (IJNHS) Sumatera Medical Journal Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan SCRIPTA SCORE Scientific Medical Journal Indonesian Journal of Global Health research Cermin Dunia Kedokteran The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Cermin Dunia Kedokteran
Putra, Imam Budi
Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Sumatera Utara, Medan
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The Effect of Honey and Zinc Cream as Topical Dressing for Epithelization in Diabetic Foot Ulcer Muhammad Husaini; Asrizal Asrizal; Imam Budi Putra
Malahayati Nursing Journal Vol 5, No 5 (2023): Volume 5 Nomor 5 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v5i5.6307

Abstract

ABSTRACT Diabetic foot ulcer is a complication that often serves Diabetes Mellitus patients. Currently, wound care has used dressings to keep the wound environment moist, but in general, foot wound care requires high costs, so it is necessary to figure out the alternative wound care that is really effective and cost-effective in wound healing. One type of alternative therapy for topical treatment of diabetic foot ulcers that can be used is topical honey. The aim of this research was to identify the effect of topical honey and zinc cream on epithelization in the treatment process for diabetic foot ulcers. This type of research is inquiries, namely intervention, and control group design. The sample consisted of 60 respondents consisting of 30 wound care groups using topical honey and 30 wound care respondents using zinc cream with the sampling technique, namely consecutive sampling. Honey was used with 87% honey concentration and lipid tissue epithelialization was measured using the Bates Jensen Wound Access Tool (BJWAT). Data analysis used the Mann-Whitney test as an alternative test for the independent t-test. The results showed that there was no significant difference in wound tissue epithelialization between the wound care group with zinc topical cream and honey topical cream (p-value> 0.05). The Conclusions which is based on the results of analytical tests, wound care using topical zinc cream and topical wound care using honey did not have a significant difference in the epithelialization process of diabetic foot ulcers, but clinically the epithelialization process of diabetic foot wounds with topical honey treatment was faster than using zinc cream. It is recommended that topical wound care using honey can be used as an alternative topical in the treatment of diabetic foot ulcers. Keywords: Diabetic Foot, Honey, Ulcer, Zinc Cream
The Effect of Fluid Management Application on Hemodialysis Patients with Excess Fluid Damanik, Candra Meriani; Putra, Imam Budi; Siregar, Cholina Trisa; Saidah Nst, Siti
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 5, No 2: December 2020
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (578.073 KB) | DOI: 10.30604/jika.v5i2.514

Abstract

Renal disease is a disorder that occurs in the kidneys. Such diseases caused by various factors, such as infections, tumours, congenital disorders, metabolic or degenerative diseases, and others. Chronic renal disease usually occurs slowly and is chronic. Patients suffering from chronic renal disease require renal replacement therapy (TPG) to maintain their life. The success of this chronic renal disease therapy depends on the patient's involvement in maintaining their diet and fluids. Fluid management experienced by hemodialysis patients is essential to decrease the risk of excess fluid and is a significant factor that can determine the success of hemodialysis therapy. This research was performed aiming to analyze the effect of implementing fluid management on the excess fluid in hemodialysis patients. This study employed a quasi-experimental design through pre-test and post-test methods using a control group. There were 90 respondents involved in this research as samples, who were divided into two groups, 45 respondents in the intervention group and another 45 respondents in the control groups. These samples were selected through purposive sampling. Furthermore, the research data were collected using fluid management guide instruments, fluid intake monitoring charts, and weight recording sheets. The results revealed that there was no effect of fluid management on IDWG values between the intervention group after fluid management and the control group of hemodialysis patients (t = -1.58; p = 0.118). The results of this study can recommend that the application of fluid management with family support can be an action to decrease excess fluid in hemodialysis patients.Abstrak: Penyakit Ginjal merupakan kelainan yang mengenai organ Ginjal. Penyakit ini timbul akibat berbagai faktor, misalnya infeksi, tumor, kelainan bawaan, penyakit metabolik atau degeneratif, dan lain-lain. Penyakit Ginjal kronik, biasanya timbul secara perlahan dan sifatnya menahun. Pasien dengan penyakit ginjal kronik membutuhkan terapi pengganti ginjal (TPG) untuk mempertahankan hidup. Keberhasilan terapi penyakit ginjal kronik sangat bergantung pada keterlibatan pasien dalam menjaga diet dan cairan. Manajemen cairan pada pasien hemodialisa sangat penting guna mengurangi resiko kelebihan cairan dan merupakan faktor penting yang dapat menentukan keberhasilan terapi hemodialisa. Tujuan dari penelitian ini adalah menganalisa pengaruh penerapan manajemen cairan terhadap kelebihan cairan pada pasien hemodialisa. Penelitian ini menggunakan desain quasi experiment dengan metode pre test dan post test with kontrol group. Sampel penelitian ini adalah 90 responden yang dibagi dalam dua kelompok, 45 kelompok intervensi dan 45 kelompok kontrol.  Teknik pengambilan sampel penelitian ini menggunakan purposive sampling. Pengumpulan data penelitian menggunakan instrumen panduan manajemen cairan, chart pemantauan intake output cairan, lembar pencatatan berat badan. Hasil penelitian menunjukkan bahwa tidak ada pengaruh manajemen cairan terhadap nilai IDWG antara kelompok intervensi setelah manajemen cairan dengan kelompok kontrol pasien hemodialisa (t = -1.58; p = 0.118).
Bacterial sensitivity pattern to antibiotics in acne vulgaris at Universitas Sumatera Utara Hospital Medan, Indonesia in 2019 Sari, Lovena; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The association between psoriasis and metabolic syndrome is appealing as the two may share a similar cross-linking systemic inflammation process. The inflammation processes occurring in obesity and psoriasis may aggravate one another. This raised the question of whether a low-calorie diet would possibly reverse the aforementioned process. This study aims to determine whether calorie restriction reduces psoriasis area and severity index (PASI) in obese patients with moderate-to-severe psoriasis receiving conventional treatment compared to no calorie restriction.Methods: We searched Pubmed/Pubmed Central, ScienceDirect, Cochrane library, EBSCOhost, and Scopus databases using keywords derived from our clinical question. The inclusion criteria were randomized clinical trial (RCT) or systematic review, published in English, and available in full-text.Results: We obtained 2 systematic reviews with meta-analyses by Ko et al. and Upala et al. Ko et al. included 6 RCTs which found that the inclusion of a low-calorie diet shows significant improvement in PASI 75 compared to standard therapy (RR 1.66; 95%CI 1.07, 2.58). Upala et al. also found significant improvement in PASI 75 in a meta-analysis of 7 RCTs (Pooled OR 2.92; 95%CI 1.39, 6.13), but shows moderately high heterogeneity between studies. Other secondary outcomes have also shown significant improvements, such as quality of life and metabolic parameters.Conclusion: The intervention of a low-calorie diet may significantly reduce PASI, improve quality of life and reduce comorbidities in obese patients with moderate-to-severe psoriasis, and thus can be recommended in psoriasis management.
Relationship between Thioredoxin Reductase (TrxR) Levels and Melasma Risanti, Rinda Chindra; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.131

Abstract

Introduction: Melasma is a common condition of acquired hypermelanosis in dermatology that often occurs in areas of the body exposed to sunlight, especially the face. Thioredoxin Reductase (TrxR) is a key antioxidant system in defense against oxidative stress through disulfide reductase activity that regulates dithiol/disulfide protein balance. High levels/activity of TrxR correlate with melanin formation and tyrosinase activity which provides additional information about the role of cellular antioxidant proteins in melanogenesis which is suspected to be related to the occurrence of melasma. The aim of this study was to determine the relationship between TrxR levels and melasma Method: This study was an observational analytical study with cross-sectional design on 30 melasma patients and 30 controls. Each patient underwent anamnesis, dermatological examination, and blood sampling to assess TrxR levels by ELISA test. These data were analyzed statistically using the Mann Whitney test. Results: This study shows that the most common distribution pattern of melasma was centrofacial in 24 people (80%). The mean TrxR level in melasma was 12.73±11.66 ng/ml. The results of the study showed that there was a relationship between high TrxR levels and melasma (p<0.001). The TrxR mean level based on the duration of suffering from melasma at <5 years was 11.4±2.89, and ≥ 5 years was 14.0±3,18 Conclusion: There is a relationship between TrxR levels and melasma.
Relationship between Plasma Fibronectin Levels and Stretch Marks Syahputri, Fitriend; Imam Budi Putra; Nelva K. Jusuf
Journal of Society Medicine Vol. 3 No. 4 (2024): April
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i4.132

Abstract

Introduction: Stretch marks or striae distensae are linear atrophic scars that form in areas of skin damage as a result of skin stretching. Mast cell degranulation and activation of macrophages occur as well as changes in the components of the extracellular matrix, including fibronectin. Fibronectin as a dimeric glycoprotein and components contained in the extracellular matrix, functions as a regulator of cellular processes, to maintain tissue and functions in the process of wound healing in tissues. The aim of this study was to determine the relationship between plasma fibronectin levels and stretch marks Methods: This study was an observational study with a cross-sectional design of 40 females with stretch marks and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess plasma fibronectin levels by ELISA test. These data were analyzed statistically using the Chi square test. Results: The mean plasma fibronectin level in stretch marks was 259.541±165.937 ng/ml. The highest age with stretch marks was 18–25 years 33 (82.5%) people. Most of them had a family history of stretch marks from their mother 20 (50%) people. The majority of stretch marks are located on gluteus regions by 10 people (25%). The result of this study showed that there was a relationship between plasma fibronectin levels causing a risk of 2.85 times for stretch marks (p = 0.041). Conclusion: There is a relationship between plasma fibronectin levels and stretch marks.
Relationship between Angiotensin Converting Enzyme (ACE) and Cellulite Annisa Astari; Putra, Imam Budi; Jusuf, Nelva Karmila
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.133

Abstract

Introduction: Cellulite is a local metabolic disorder in subcutaneous tissue characterized by changes in skin topography, occurring in parts of the body with a large accumulation of fat tissue, especially thighs, buttocks, hips, and abdomen. Angiotensin converting enzyme is a zinc metallopeptidase, distributed on the surface of endothelial cells. Increased ACE levels cause microcirculation disorders, adipocyte hypertrophy, increased extracellular matrix, and stimulate the emergence of inflammatory cytokines which will cause an increase in the inflammatory response in the tissue, stimulate fibrogenic response and influences the appearance of cellulite. The aim of this study was too determine the relationship between ACE and cellulite. Method: This study was an observational study with a cross-sectional design of 40 cellulite patients and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess ACE levels by ELISA test. These data were analyzed statistically using the Chi square test. Results: The mean ACE level in cellulite was 66.78±15.38 µg/ml. The highest age with cellulite was 26–35 years 17 subjects (42.5%). Most of them had a family history of cellulite from their mother 22 subjects (55%). The majority of cellulite are located on the femoral and gluteus regions by 27 subjects (67.5%). The result of this study showed that there was a relationship between high ACE levels causing a risk of 4.5 times for cellulite (p = 0.002). Conclusion: There is a relationship between ACE levels and cellulite.
The Aryl Hydrocarbon Receptor (AhR) Level Based on Age and Clinical Type of Melasma Danil, Rezkyana; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 7 (2024): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i7.153

Abstract

Introduction: Melasma is the most common pigmentation condition on the face due to excessive melanin production and release. The main predisposing factor for melasma is UV exposure. Aryl Hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that regulates the expression of a very large number of target genes in humans. Facial hyperpigmentation is increased in people living in air-polluted areas with particulate matter2.5  (PM2.5) concentrations. Dioxin compounds contained in PM2.5  can activate AhR signaling. This study aims to determine the aryl hydrocarbon receptor (AhR) level based on age and clinical type of melasma. Methods: This study was an observational study with a cross-sectional design of 30 women with melasma at Prof. CPL Hospital. This study was conducted after obtaining ethical clearance from the Research Ethics Commission of the University of North Sumatra and has obtained permission from the research field of Prof. Chairuddin Panusunan Lubis Hospital. All subjects underwent history taking, physical examination, dermatological examination, and blood sampling to assess AhR levels by ELISA test. Data were analyzed with Chi square test to assess AhR levels based on age, and to assess AhR levels based on clinical type of melasma with Kruskal Wallis test. Results: This study shows that the majority of melasma age is 41-50 years with the highest mean AhR level is 882,61 ng/mL, while the lowest AhR level is in the age range of 20-30 years with a mean of 271,5 ng/mL. Chi square test showed that there was a significant relationship between AhR levels and age (p < 0,001). The highest mean AhR levels in melasma subjects were centrofacial type with a mean of 795,50 ng/mL, while the lowest mean AhR levels were found in melasma subjects with malar type with a mean of 623,36 ng/mL. The Kruskal Wallis test showed that there was no significant difference in AhR levels based on the clinical type of melasma (p = 0,930). Conclusion: That increased the age, the highest AhR levels. The highest average AhR level was centrofacial type of melasma. There was no significant difference in AhR levels based on the clinical type of melasma.
Antifungal Activity of Henna Leaf Extract (Lawsonia inermis linn.) Against Inhibition of Trichophyton rubrum Fungal Growth Cause Tinea Unguium Meutia, Nanda; Putra, Imam Budi; Jusuf, Nelva Karmila
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.4768

Abstract

Tinea unguium is a common fungal nail infection. Most commonly caused by Trichophyton rubrum. It disturbs not only cosmetic figure, but also but also might have an impact on patients emotional, social and occupational functioning, lastly affecting the overall quality of life. The management of tinea unguium is still challenging. The therapy experienced many failures and recurrences. The aim of this research is to determine the presence of antifungal activity of Lawsonia inermis L. extract and to identify the extract concentration that can inhibit the fungal growth. This research is an experimental in vitro study with isolate from Microbiology Laboratory of Faculty of Medicine, Universitas Sumatera Utara. The Lawsonia inermis L. leaves extracted by maceration method. The antifungal assay was done using dilution method with various concentrations of (3,125%; 6,25%; 12.5%; 25%; 50%; 75% w/v). The mixtures of extract, suspension of Trichophyton rubrum and the media is incubated at 37C for 2-3 days. The mixture was streaked on SDA medium to determine the antifungal activity. The results indicates that Lawsonia inermis L. extracts has an antifungal effect, and with concentrations of 25%, 50% and 75% it can be use to inhibit the growth of Trichophyton rubrum qualitatively in vitro.
PREVALENSI 5 KELAINAN KULIT TERBANYAK POLIKLINIK DERMATOLOGI KOSMETIK RS USU TAHUN 2020 - 2022 Danil, Rezkyana; Jusuf, Nelva Karmila; Putra, Imam Budi
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.460

Abstract

   Pendahuluan: Dermatologi kosmetik merupakan bagian dari ilmu dermatologi yang terfokus pada permasalahan kulit dan kesehatannya. Tujuan: Mengetahui jumlah kunjungan pasien per tahun dan 5 kelainan kulit terbanyak di Poliklinik Dermatologi Kosmetik RS USU periode 2020 – 2022. Metode: Penelitian ini merupakan penelitian retrospektif dengan menggunakan data rekam medis di RS USU periode 2020 – 2022. Hasil: Jumlah pasien di Poliklinik Dermatologi Kosmetik RS USU pada tahun 2020 yaitu 342 pasien (21,8%), tahun 2021 sebanyak 811 pasien (40,8%), dan tahun 2022 sebanyak 640 pasien (26,5%). Kelainan kulit terbanyak pada tahun 2020 adalah akne vulgaris berjumlah 206 pasien (60,2%). Tahun 2021 didapatkan kelainan kulit terbanyak yaitu striae distensae berjumlah 281 pasien (34,6%). Kemudian tahun 2022 didapatkan kelainan kulit terbanyak yaitu akne vulgaris berjumlah 145 pasien (22,7%). Dalam rentang waktu tahun 2020 – 2022 didapatkan 5 kelainan kulit tertinggi dari total kunjungan pasien, yaitu akne vulgaris 527 pasien (29,4%), diikuti striae distensae 453 pasien (25,3%), penuaan kulit 211 pasien (11,7%), melasma 159 pasien (8,9%), dan selulit 120 pasien (6,7%). Kesimpulan: Penelitian ini memberikan gambaran 5 kelainan kulit tertinggi dari total kunjungan pasien di Poliklinik Dermatologi Kosmetik RS USU periode 2020 – 2022, dengan kunjungan pasien tertinggi di tahun 2021 sebanyak 811 pasien (40,8%). 
PROFIL PASIEN SELULIT DI POLIKLINIK DERMATOLOGI DAN VENEREOLOGI RUMAH SAKIT UNIVERSITAS SUMATERA UTARA MEDAN PERIODE 2020–2022: PROFIL PASIEN SELULIT DI POLIKLINIK DERMATOLOGI DAN VENEREOLOGI RUMAH SAKIT UNIVERSITAS SUMATERA UTARA MEDAN PERIODE 2020–2022 Lubis, Ade Fitriyani; Jusuf, Nelva Karmila; Putra, Imam Budi
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.462

Abstract

   Latar belakang: Selulit adalah kondisi kulit yang mengganggu estetika yang merupakan perubahan tekstur kulit menjadi bergelombang atau menyerupai kulit jeruk (orange peel) terutama di bokong, paha, panggul, dan perut. Metode: Penelitian deskriptif yang dilakukan secara retrospektif menggunakan data rekam medis pasien selulit. Hasil: Jumlah kasus pasien selulit periode 2020–2022 sebanyak 120 pasien (2,44%). Prevalensi selulit sebesar 0,63% (10 pasien) tahun 2020, 4,35% (40 pasien) tahun 2021, dan 2,89% (70 pasien) tahun 2022. Awitan kelompok usia terbanyak adalah 26–35 tahun sebanyak 61 orang (50,9%) dan terdapat riwayat keluarga selulit sebanyak 91orang (75%) dengan indeks massa tubuh (IMT) overweight sebanyak 51 orang (42,5%). Lokasi selulit terbanyak di regio femoralis dan glutaeus sebanyak 52 orang (43,3%), diikuti regio gluteus sebanyak 41 orang (33,3%). Derajat keparahan selulit paling dominan berupa derajat II dialami oleh 64 orang (53,3%). Kesimpulan: Prevalensi pasien dengan selulit yang berobat pada tahun 2020–2022 meningkat. 
Co-Authors Anita Yustina Annisa Astari Asrizal Asrizal Candra Meriani Damanik Cholina Trisa S Damanik, Candra Meriani Danil, Rezkyana Dhillon, Jesryn Dina Arwina Dalimunthe, Dina Arwina Finarsih ES, Ella Isma Aprita Lubis Jusuf, Nelva Karmila Jusuf, Nelva Karmila Kadri, Alfansuri Kamila, Rania Kartayana, Johan Kartayana, Johan Khairina Nasution Kusumawati, R. Lia Lubis, Ade Fitriyani Mendrofa, Ira Meutia, Nanda Muhammad Husaini Muhammad Ichwan Nasution, Siti Saidah Nelva K. Jusuf Nelva Karmila Jusuf Nelva Karmila Jusuf Nelva Karmila Jusuf Peggy Liberti Peggy Liberty Risanti, Rinda Chindra Ritonga, Sukhri Herianto Saidah Nst, Siti Samosir, Fauzan Azmi Hasti Habibi Sari, Lovena Setiawan Setiawan Setiawan, Setiawan Siti Saodah Syahputri, Fitriend Utama, Putri Wahdiah utami, dina rizki Utami, Dina Rizki Wardani, Meidina Kesuma Wiryadana, Michelle Yesi Ariani Yosie Anra Zega, Petra Diansari