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All Journal E-Jurnal Medika Udayana JURNAL KESEHATAN PERINTIS Majalah Patologi Indonesia Health and Medical Journal Andalas obstetrics and gynecology journal Jurnal Abdi Insani jurnal abdimas saintika Nusantara Hasana Journal Scientific Journal Jurnal Pengabdian Masyarakat Bangsa Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Journal of Public Health Science (JoPHS) Frontiers on Healthcare Research
liana, nana
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MEKANISME PENSINYALAN VASCULAR ENDOTHELIAL GROWTH FACTOR DALAM PERKEMBANGAN DAN PENYEBARAN KANKER Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Saputra, Muhammad Rizki
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1598

Abstract

Vascular Endothelial Growth Factor (VEGF) is a key mediator in the process of angiogenesis, playing a crucial role in the development and spread of malignant tumors. VEGF consists of several isoforms, primarily VEGF-A, which exert their effects through receptors VEGFR-1, VEGFR-2, and VEGFR-3, as well as co-receptors neuropilin-1 and -2. Activation of VEGF signaling pathways stimulates endothelial cell proliferation, migration, and survival, increases vascular permeability, and facilitates the formation and invasion of tumor-associated blood vessels. VEGF expression is regulated by various factors, including hypoxia via HIF-1α activation, oncogenes such as KRAS and Src, and the suppression of tumor suppressor genes such as p53 and PTEN. Additionally, several growth factors including EGF, PDGF, and IGF contribute to the regulation of VEGF. VEGF signaling also promotes tumor invasion by activating proteolytic enzymes such as MMP-2, MMP-9, and uPA, which degrade the basement membrane. Due to its central role in angiogenesis and tumor invasion, VEGF is a strategic target in anti-angiogenic therapies for various types of cancer. A comprehensive understanding of the structure, function, and regulation of VEGF is essential for the development of more effective molecular therapies.
PROFIL RESPIRATORY DISTRESS PADA BAYI BARU LAHIR DI NICU RSIA SITI HAWA PADANG TAHUN 2021 Eldrian, Febiane; Liana, Nana; Aditia Permana, Yudhi; Lismawati; Helmizar, Roland
Nusantara Hasana Journal Vol. 3 No. 12 (2024): Nusantara Hasana Journal, May 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i12.1121

Abstract

Respiratory distress (RD) poses a significant issue that can lead to fatal consequences such as respiratory failure, brain damage, and an increase in morbidity and mortality among newborns. The diagnosis of RD is based on the identification of one or more signs of increased respiratory activity, including tachypnea, nasal flaring, retractions in the intercostal area, and grunting. Objective: The purpose of this research is to provide an overview of the occurrence of RD among neonatus who were hospitalized in the Neonatal Intensive Care Unit (NICU) at RSIA Siti Hawa Padang in the year 2021. Methods: This study is an analytic descriptive research. The accessible population in this study consists of newborns who were treated at the NICU of RSIA Siti Hawa Padang during the year 2021. Results: From the study findings, it was observed that 94 newborns (approximately 5.2%) experienced RD. Among them, males were more predominant, accounting for 54 infants (57%). The majority of infants had a gestational age categorized as full-term, totaling 56 infants (59.6%). Furthermore, the birth weight for the majority of newborns was within the normal range, with 65 infants (69.1%) falling into this category. Conclusion: In conclusion, the majority of newborns at NICU RSIA Siti Hawa Padang in 2021 did not experience RD. Among those affected by RD, males were predominant, and most had a gestational age categorized as full-term, indicating a low risk of prematurity. The average birth weight also tended to be within the normal range for newborns born and cared for in NICU RSIA Siti Hawa Padang in 2021.
THE PROFILE OF COLORECTAL ADENOCARCINOMA AT DR. M. DJAMIL GENERAL HOSPITAL PADANG, INDONESIA Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Jelmila, Sri Nani; Triyana, Rahma; Lismawati, Lismawati
Nusantara Hasana Journal Vol. 4 No. 1 (2024): Nusantara Hasana Journal, Juny 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i1.1132

Abstract

Colorectal carcinoma is the third most common malignancy in the world. This malignancy originates from the epithelium of the colon and/or rectum, showing glandular or mucinous differentiation, where tumor cells have penetrated the muscularis mucosae layer. The study aims to report on epidemiological, clinical, and pathological characteristics of colorectal adenocarcinoma. Methods: We performed a retrospective descriptive study of 140 cases of colorectal adenocarcinoma in the gastroenterology and general surgery departments of M. Djamil General Hospital Padang, Indonesia conducted from January 2022 to December 2022. Data collection using medical records of patients in M. Djamil General Hospital Padang, Indonesia. We reported different data: Age, sex, site, and differentiation grade of the tumor. Results: Our study included 140 patients 80 males (57,1%) and 60 females (42.9%), with a median age range of 51-60 years. The tumors were found in the rectum 82 (58.6%), distal colon 37(26.4%), and proximal colon 21(15.0%). The differentiation grade was majority low grade 117 (83.6%). Conclusion: In conclusion, our result showed that colorectal adenocarcinoma is highest in the male population with an age range of 61-70 years. The most common site of adenocarcinoma is rectum. A low grade is the most differentiated grade. Keywords: colorectal adenocarcinoma, anatomical location, differentiation grade, profile
Transformasi Teratoma Matur Mediastinum Menjadi Mucinous Adenocarcinoma Disertai Sitologi Sikatan Bronkus Positif Liana, Nana; Yenita, Yenita
Health and Medical Journal Vol 5, No 2 (2023): HEME May 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i2.1281

Abstract

Pendahuluan: Teratoma matur adalah germ cell tumor yang paling banyak ditemukan di mediastinum yaitu 50-70%. Namun kejadian transformasi keganasan non germ cell masih sangat jarang hanya sekitar 6% dari germ cell tumor. Laporan Kasus: Kami melaporkan kasus pasien perempuan usia 43 tahun datang dengan keluhan sesak nafas dan massa kistik multilokular di mediastinum anterior. Pasien menjalani tindakan torakotomi eksplorasi dan eksisi tumor dengan diagnosis histopatologi teratoma matur. Sepuluh bulan setelah operasi pasien datang dengan benjolan baru di suprasternum. Biopsi massa di suprasternum menunjukkan metastasis mucinous carcinoma. Pemeriksaan CT-Scan toraks tampak adanya pulmoner metastase dari tumor mediastinum anterior (residif). Pada sitologi sikatan bronkus juga ditemukan metastase mucinous adenocarcinoma. Setelah dilakukan review pada sediaan awal ditemukan fokus mucinous adenocarcinoma dalam teratoma matur mediastinum dan radang granulomatosa ekstensif yang menandakan ruptur kista. Kesimpulan: Teratoma matur dapat mengalami transformasi keganasan dari komponen non germ cell. Untuk mengetahui asal komponen mucinous adenocarcinoma dibutuhkan pemeriksaan imunohistokimia CK7, CK20 dan TTF1. Pada kasus ini didapatkan CK7 positif, CK 20 negatif dan TTF1 negatif, sehingga disimpulkan komponen mucinous adenocarcinoma berasal dari teratoma matur di mediastinum yang mengalami transformasi keganasan
Extra Gastrointestinal Stromal Tumor Pada Ovarium, Kasus Jarang Liana, Nana; Nizar, RZ; Asri, Aswiyanti; Novianti, Hera; Friadi, Andi
Andalas Obstetrics And Gynecology Journal Vol. 4 No. 2 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.2.173-182.2020

Abstract

Objective : This article objective is to describe a woman with extra gastrointestinal stromal tumor (extra GIST) in ovary; Method : A case report and literature review; The author reports a woman 54 years old with complaints of swelling in the abdomen. Tumors suspected originate from ovary with an extension to abdominal wall. The patient had history of previous ovarian tumor surgery with pathological anatomy diagnosis was thecoma. Working diagnosis of the patient was residif ovarian malignancy and then suboptimal debulking was performed. Microscopically, ovarian tumors appear cellular and diffuse, partially arranged fascicles. Cells with rounded-spindle nuclei, mitosis ≥ 4 per 10 HPF. The conclusion was malignant thecoma which metastasizes to peritoneum and omentum. Differential diagnosis were GIST and leiomyosarcoma. Immunohistochemistry examination was performed with  Calretinin and CD117 to rule out the differential diagnosis. Calretinin were negative  and CD117 were strongly positively smeared. Based on the morphology and positive CD117 results, diagnosis was extra GIST of ovary.; Conclusion: Extra GIST in the ovary is an unusual location so that it can be misdiagnosed as a gynecological disorder. The differential diagnosis at this location is quite limited including thecoma, fibrothecoma and leiomyosarcoma.Keywords: extra gastrointestinal stromal tumor, ovary, thecoma
EDUKASI EFEK PENGGUNAAN GAWAI TERHADAP KESEHATAN TUBUH DAN MENTAL Ruhsyahadati; Liana, Nana; Tri Yana, Rahma; Susanti, Melya; Helmizar, Roland; Nani Jelmila, Sri; Puspita, Dian; Tri Septiana, Vina
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1650

Abstract

The integration of gadgets into daily life has become unavoidable, especially among children and teenagers. These devices offer numerous advantages, such as facilitating access to information and communication. However, overuse can harm physical and mental well-being. Studies have shown that excessive gadget use can cause posture issues, eye strain, obesity, and developmental problems both psychologically and socially in young individuals. To combat these negative effects, the Faculty of Medicine at Baiturrahmah University in Padang organized an educational initiative at the Babussalam Muhammadiyah Mosque. This program, aimed at elementary school students in a Ramadan boarding school, utilized interactive presentations, discussions, and quizzes to educate participants about responsible gadget use. Thirty-five students aged 10-13 attended, showing improved understanding of the adverse effects of gadget overuse and learning tips for maintaining eye health and proper posture. The students were highly engaged and appreciated the information. Overall, educating young people about the implications of gadget use enhances their awareness and promotes healthier usage habits, mitigating potential health risks.
PENYULUHAN MENGENAI PENTINGNYA KEBUTUHAN ZAT GIZI DENGAN POLA MAKAN SEHAT BAGI MASYARAKAT DI AULA KANTOR BUPATI PADANG PARIAMAN Saputra, Muhammad Rizki; Yurizali, Bun; Malik, Rifkind; Helmizar, Roland; Dhuha, Alief; Suharni, Suharni; Triyana, Rahma; Ruhsyahadati, Ruhsyahadati; Liana, Nana; Adelin, Prima
Jurnal Abdimas Saintika Vol 6, No 2 (2024): November Jurnal Abdimas Saintika
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jas.v6i2.2958

Abstract

ABSTRAKLatar Belakang : Gizi merupakan salah satu aspek penting dalam kehidupan manusia. Asupan nutrisi yang seimbang dan optimal sangat penting untuk menjaga kesehatan, meningkatkan kualitas hidup, serta mendukung pertumbuhan dan perkembangan yang optimal. Gizi yang baik sangat penting untuk memperkuat sistem kekebalan tubuh. Asupan nutrisi seimbang dapat meningkatkan ketahanan tubuh terhadap infeksi, sedangkan kekurangan vitamin dan mineral tertentu dapat melemahkan sistem kekebalan dan meningkatkan risiko infeksi.Metode : Metode yang digunakan dalam kegiatan penyuluhan ini meliputi presentasi, diskusi, serta sesi tanya jawab mengenai pentingnya memenuhi kebutuhan zat gizi dengan pola makan sehat.Hasil: Kegiatan penyuluhan mengenai pentingnya kebutuhan zat gizi dengan pola makan sehat di Kantor Bupati Padang Pariaman diikuti oleh masyarakat sekitar. Pelaksanaan kegiatan ini dihadiri sebanyak 62 orang. Selama penyampaian presentasi materi, Masyarakat dengan semangat memeperhatikan narasumber. Setelah itu, banyak pertanyaan yang muncul mengenai kebutuhan gizi perhari dan juga pola makan yang seimbang. Kata Kunci: Zat Gizi, Pola Makan Sehat, Padang Pariaman. ABSTRACTBackground: Nutrition is one of the important aspects of human life. Balanced and optimal nutritional intake is necessary to maintain health, improve quality of life, and support optimal growth and development. Good nutrition is essential to strengthen the immune system. Balanced nutritional intake can increase the body's resistance to infection, while deficiencies in certain vitamins and minerals can weaken the immune system and increase the risk of infection. Method: This counseling activity uses presentations, discussions, and question-and-answer sessions to discuss   the importance of meeting nutritional needs with a healthy diet. Results: The surrounding community attended counseling activities regarding the importance of nutritional needs and a healthy diet at the Padang Pariaman Regent's Office. 62 people attended the implementation of this activity. During the presentation of the material, the community enthusiastically paid attention to the resource person. After that, many questions arose regarding daily nutritional needs and a balanced diet. Keywords: Nutrients, Healthy Diet, Padang Pariaman.
Asupan Magnesium, Kalsium dan Vitamin D dengan Premenstrual Syndrome Jelmila, Sri Nani; Hasni, Dita; Liana, Nana
JURNAL KESEHATAN PERINTIS Vol. 10 No. 2 (2023): Jurnal Kesehatan Perintis
Publisher : LPPM UNIVERSITAS PERINTIS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33653/jkp.v10i2.1031

Abstract

Premenstrual sindrom (PMS) sering terjadi pada fase luteal siklus menstruasi pada wanita usia subur. PMS memberikan dampak terhadap produktivitas, kesehatan mental dan kualitas hidup penderitanya. PMS dapat mempengaruhi prestasi belajar pada mahasiswi. Tujuan penelitian ini adalah untuk melihat hubungan asupan magnesium, kalsium dan vitamin D dengan premenstrual sindroma. Penelitian ini merupakan penelitian analitik observasional dengan design cross sectional. Sampel penelitian ini berjumlah 100 orang yang merupakan mahasiswi Fakultas Kedokteran Universitas Baiturrahmah. Sampel diambil secara consecutive sampling. Analisis data menggunakan uji Mann Whitney. Hasil penelitian ini didapatkan 62% responden dengan asupan magnesium kurang, 93% responden dengan asupan kalsium kurang, 94% responden dengan asupan vitamin D kurang dan 69% responden mengalami PMS ringan. Hubungan asupan magnesium dengan PMS didapatkan nilai p=0,48, hubungan asupan kalsium dengan PMS didapatkan nilai p=0,86 dan hubungan asupan vitamin D dengan PMS didapatkan nilai p=0,72. Kesimpulan dari penelitian ini adalah sebagian besar responden dengan asupan magnesium, kalsium dan vitamin D kurang. Responden terbanyak mengalami PMS ringan. Tidak terdapat hubungan asupan magnesium, kalsium dan vitamin D dengan PMS.
The Profile of Gastrointestinal Stromal Tumors (GISTs) at Dr. M. Djamil General Hospital Padang, Indonesia: A Descriptive Study on 28 Patients Aliska, Gestina; Novianti, Hera; Angraini, Desti; Liana, Nana; Nova, Riki; Rustam, Erlina
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p19-23.2024

Abstract

Background: Gastrointestinal stromal tumors (GISTs) are the most frequently seen mesenchymal neoplasm in the digestive system. GISTs was originally described as smooth muscle tumor in the 1980s but advances in molecular diagnostic methods and immunohistochemistry moved GISTs into a different category from smooth muscle tumors. The study aims to report on epidemiological, clinical, immunochemical, and therapeutic characteristics of GISTs. Methods: We performed a retrospective descriptive study of 28 cases of GIST in the gastroenterology and general surgery departments of M. Djamil General Hospital Padang, Indonesia was conducted from January 2019 to December 2021. Data collection using medical records of patients in M. Djamil General Hospital Padang, Indonesia. We reported different data: Age, sex, symptoms, site, and immunohistochemistry of the tumor.  Results: Our study included 28 patients 18 males (64,3%) and 10 females (35.7%), with a median age range of 51-60 years. The presenting symptoms were abdominal mass (53.6%), abdominal pain (14.3%), bloody or dark-colored stools (14.3%), constipation (7.1%), fatigue (7.1%), and nausea and vomiting in 1 case (3.6%). Sixteen patients (57.1%) had a primary tumor and twelve patients (42.9%) had further metastatic lesions. The tumors were found in the stomach (21.4%), small intestine (14.3%), rectum (14.3%), and in other sites such as the retroperitoneal, liver, and distal pancreas. The immunohistochemical study was performed in seven cases (expression of  CD117 and DOG1), in four cases  CD117 was positive, while in three cases CD117 was negative. In two cases, the expression of DOG1 was positive, while in one case, it was negative. Eighteen patients with GIST (64.3%) underwent surgical procedures. A combination of surgical and chemotherapy was prescribed in 9 patients (32.1%). The chemotherapy regimen prescribed is imatinib. One patient is inoperable and has received symptomatic treatment. Conclusion : In conclusion, our result showed that GISTs are highest in the male population with an age range of 51-60 years. The most common symptom of GISTs is abdominal mass. Patients who have been diagnosed with GIST by histopathological examination do not always show positive expression in the immunohistochemical study. Surgical resection was indicated in the majority of patients, and a combination of surgery and chemotherapy is also prescribed as a treatment for patients with GIST.
Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Liana, Nana; Hilbertina, Noza; Devianti, Loli; Yetti, Husna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
Co-Authors Adelin, Prima Aditia Permana, Yudhi Ajisman, Ruhsyahadati Aliefia, Desi Amanah Fauziah, Suci Andi Friadi Anggraini, Debie Angraini, Desti Aswiyanti Asri Devianti, Loli Dhuha, Alief Dian Puspita Eldrian, Febiane Erlina Rustam Gestina Aliska Haiga, Yuri Hasni, Dita Helmizar, Roland Husna Yetti Jelmila, Sri Nani Lismawati Lismawati, Lismawati Malik, Rifkind Melya Susanti Muhammad Rizki Saputra, Muhammad Rizki Mutiya Rahmi, Rafiqa Nani Jelmila, Sri Nizar, RZ Nova, Riki Novianti, Hera Noza Hilbertina, Noza Nurwiyeni Oktora, Meta Zulyanti Oktora, Meta Zulyati Oktora, MetaZulyati Putriyuni, Anandia Rasyid, Lismawati Reza, Tia Riyada, Fauziatul Ruhsyahadati Ruhsyahadati, Ruhsyahadati Suharni Suharni Suharni Tasya, Cerint Iralloza Tri Septiana, Vina Tri Yana, Rahma Triyana, Rahma Yenita . Yurizali, Bun