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Isnaeni
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Journal : Camellia

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Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells Diyah, Nuzul Wahyuning; Warsito, Gita Miranda; Isnaeni; Hidayati, Shabrina Wahyu
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20903

Abstract

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.
Review Artikel : Desain dan Karakteristik Self Nano Emulsifying Drug Delivery System (SNEDDS) Hanistya, Ria; Sari, Annisa Kartika; Wahyuningsih, Etik; Samlan, Karima; Wiputri, Oktaviany Irma; Isnaeni; Dessidianti, Rachma
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20965

Abstract

Objective: Sistem Nanoemulsi Penghantaran Obat (Self-Nanoemulsifying Drug Delivery System/SNEDDS) merupakan salah satu pendekatan inovatif dalam penghantaran obat yang bertujuan meningkatkan kelarutan dan bioavailabilitas obat-obatan yang sulit larut dalam air. Bioavalabilitas merupakan kunci penting dalam penyerapan obat dari saluran pencernaan sehingga peningkatan bioavailabilitas dapat memperbaiki profil kinetika obat dalam tubuh. Review terhadap SNEDDS pada artikel ini bertujuan untuk mengulas mengenai keunggulan SNEDDS, desain formulasi dan memahami karakteristik SNEDDS yang baik sebagai sebuah bentuk sistem pengahantaran obat. Methods: jenis metode penelitian yang digunakan pada artikel ini adalah literature review dengan cara mengumpulkan artikel dalam bentuk jurnal mengenai topik desain formulasi dan karakteristik SNEDDS. Results: SNEDDS dibuat dengan menggabungkan berbagai minyak, surfaktan, dan co-surfaktan. Keberhasilan formulasi dari SNEDDS membutuhkan ketelitian yang besar dalam pemilihan komposisi formulasi. Studi preformulasi seperti solubilitas, efisiensi emulsifikasi harus dilakukan untuk menentukan pilihan yang tepat dalam formulasi SNEDDS. Conclusion: Dalam rentang tahun 2005-2020, penelitian dan pengembangan SNEDDS telah menunjukkan potensinya dalam meningkatkan kelarutan dan bioavailabilitas obat-obat yang sulit larut dalam air. Meskipun masih ada tantangan yang perlu diatasi, SNEDDS memiliki potensi yang besar dalam meningkatkan efisiensi terapi obat.
The Physicochemical properties and in silico binding interaction with gyrase B of antibacterial compounds from aquous extract of Hibiscus sabdariffa L. Diyah, Nuzul Wahyuning; Andini, Khairunnisa; Isnaeni
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 1 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i1.22874

Abstract

Hibiscus sabdariffa L. (Hs) is recognized to have various pharmacological activities such as antibacterial, antiedema, anti-fungal, antihypertensive, anti-inflammatory, and antiviral. The aquous extract of Hs’ calyx which is rich in polyphenols and flavonoids displayed antibacterial activity against several bacteria so that the compounds are important to be developed further as antibacterial agents. This study aims to find out which compounds contained in the extract have the antibacterial potency based on in silico interaction with gyrase B. Physicochemical descriptors of ten compounds were evaluated before molecular docking study, and the docking simulation was executed with Autodocktools 1.5.6. The selected compounds based on Lipinski’s Rules and their lower DG0 were subjected to prediction of pharmacokinetic and toxicity (ADMET) using pKCSM online tool. The results gave five test compounds showed the higher binding affinity on gyrase B compared to quercetin which served as inhibitor of the enzyme. The glycosides displayed better scores due to the existence of more hydroxyl groups. The potential aglycones were myricetin and delphinidin. According to the ADMET parameters, the two compounds have the best profile where they were neither hepatotoxic nor carcinogenic and also safer due to the higher LD50. In conclusion, the myricetin and delphinidin generated better binding interaction than the ligand inhibitor of gyrase B which indicated that they have higher potential as antibacterial agents.
Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells Diyah, Nuzul Wahyuning; Warsito, Gita Miranda; Isnaeni; Hidayati, Shabrina Wahyu
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20903

Abstract

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.
Review Artikel : Desain dan Karakteristik Self Nano Emulsifying Drug Delivery System (SNEDDS) Hanistya, Ria; Sari, Annisa Kartika; Wahyuningsih, Etik; Samlan, Karima; Wiputri, Oktaviany Irma; Isnaeni; Dessidianti, Rachma
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20965

Abstract

Objective: Sistem Nanoemulsi Penghantaran Obat (Self-Nanoemulsifying Drug Delivery System/SNEDDS) merupakan salah satu pendekatan inovatif dalam penghantaran obat yang bertujuan meningkatkan kelarutan dan bioavailabilitas obat-obatan yang sulit larut dalam air. Bioavalabilitas merupakan kunci penting dalam penyerapan obat dari saluran pencernaan sehingga peningkatan bioavailabilitas dapat memperbaiki profil kinetika obat dalam tubuh. Review terhadap SNEDDS pada artikel ini bertujuan untuk mengulas mengenai keunggulan SNEDDS, desain formulasi dan memahami karakteristik SNEDDS yang baik sebagai sebuah bentuk sistem pengahantaran obat. Methods: jenis metode penelitian yang digunakan pada artikel ini adalah literature review dengan cara mengumpulkan artikel dalam bentuk jurnal mengenai topik desain formulasi dan karakteristik SNEDDS. Results: SNEDDS dibuat dengan menggabungkan berbagai minyak, surfaktan, dan co-surfaktan. Keberhasilan formulasi dari SNEDDS membutuhkan ketelitian yang besar dalam pemilihan komposisi formulasi. Studi preformulasi seperti solubilitas, efisiensi emulsifikasi harus dilakukan untuk menentukan pilihan yang tepat dalam formulasi SNEDDS. Conclusion: Dalam rentang tahun 2005-2020, penelitian dan pengembangan SNEDDS telah menunjukkan potensinya dalam meningkatkan kelarutan dan bioavailabilitas obat-obat yang sulit larut dalam air. Meskipun masih ada tantangan yang perlu diatasi, SNEDDS memiliki potensi yang besar dalam meningkatkan efisiensi terapi obat.
The Physicochemical properties and in silico binding interaction with gyrase B of antibacterial compounds from aquous extract of Hibiscus sabdariffa L. Diyah, Nuzul Wahyuning; Andini, Khairunnisa; Isnaeni
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 1 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i1.22874

Abstract

Hibiscus sabdariffa L. (Hs) is recognized to have various pharmacological activities such as antibacterial, antiedema, anti-fungal, antihypertensive, anti-inflammatory, and antiviral. The aquous extract of Hs’ calyx which is rich in polyphenols and flavonoids displayed antibacterial activity against several bacteria so that the compounds are important to be developed further as antibacterial agents. This study aims to find out which compounds contained in the extract have the antibacterial potency based on in silico interaction with gyrase B. Physicochemical descriptors of ten compounds were evaluated before molecular docking study, and the docking simulation was executed with Autodocktools 1.5.6. The selected compounds based on Lipinski’s Rules and their lower DG0 were subjected to prediction of pharmacokinetic and toxicity (ADMET) using pKCSM online tool. The results gave five test compounds showed the higher binding affinity on gyrase B compared to quercetin which served as inhibitor of the enzyme. The glycosides displayed better scores due to the existence of more hydroxyl groups. The potential aglycones were myricetin and delphinidin. According to the ADMET parameters, the two compounds have the best profile where they were neither hepatotoxic nor carcinogenic and also safer due to the higher LD50. In conclusion, the myricetin and delphinidin generated better binding interaction than the ligand inhibitor of gyrase B which indicated that they have higher potential as antibacterial agents.
Co-Authors Afifah, Widiyanti Akmal Andini, Khairunnisa Annisa Kartika Sari Avianto, Primadi Baharuddin Hafid Begum Fauziyah Budiastuti Cayati Dessidianti, Rachma Diyah, Nuzul Wahyuning Dwi Handayani Etik Wahyuningsih Fatkhul Ulum Fikriyah, Nuril Firdausi, Nur Haliza Hanistya, Ria Herra Studiawan Hidayati, Shabrina Wahyu Ida Nurlaeli Ikram, Muhammad Iwan Sugihartono Julham Hukom Magfirah, Anisa Maykel Manawan MMSI Irfan ,S. Kom Mohammad Yuwono Mustamir Muzakky, Fuad Mytra, Prima Nurjannah, Elok Siti Nurqadriani Oktaviany Irma Wiputri Perdana, Dyah Adila Prastika, Marsha Fendria Rahmat Setiawan Mohar Ramadhani, Firmansyah Ardian Sabaruddin Sabaruddin Sabillah, Bellona Mardhatillah Samlan, Karima SITI FATIMAH SRY WAHYUNI, SRY Suriyati Suriyati Syeha Lutfiah Triandana, Jenita Warsito, Gita Miranda