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All Journal Health Science Journal of Indonesia PUJANGGA: Jurnal Bahasa dan Sastra Jurnal Masharif al-Syariah: Jurnal Ekonomi dan Perbankan Syariah Jurnal Ilmiah AL-Jauhari Jurnal Studi Islam dan Interdisipliner Eksakta : Berkala Ilmiah Bidang MIPA Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Akrab Juara : Jurnal Ilmu-ilmu Sosial Indian Journal of Forensic Medicine & Toxicology JKMM Equilibrium Journal of Chemical Engineering Dimensi Matematika : Jurnal Pendidikan dan Pembelajaran Matematika Jurnal Rekayasa Sipil (e-journal) KREATIF: Jurnal Pengabdian Masyarakat Nusantara Jurnal Pengabdian Masyarakat Waradin Jurnal Pengabdian Masyarakat Indonesia Sejahtera Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran Perspektif: Jurnal Pendidikan dan Ilmu Bahasa IJAE
Fadilah Fadilah
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Journal : Eksakta : Berkala Ilmiah Bidang MIPA

 1 
Connecting the Dots: Transcriptomic Approaches and Relationship between Myocardial Infarction and Breast Cancer Miftahul Khair Akbar; Fadilah Fadilah; Arief Aulia Rahman
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/478

Abstract

Myocardial infarction, resulting from coronary blood vessel blockage, inflicts lasting damage on the heart muscle. Meanwhile, breast cancer ranks among the most diagnosed cancers, causing millions of deaths annually. Mouse model research suggests that myocardial infarction induces systemic changes, fostering cross-disease communication that expedites breast cancer. Using GEO2R for transcriptomic analysis, Cytoscape for protein-protein interaction (PPI), and EnrichR for enrichment analysis, we explored the myocardial infarction-breast cancer relationship with datasets from GEO. We identified 3,300 differentially expressed genes, including 6 commonly upregulated and 18 commonly downregulated genes. PPI and enrichment analyses revealed RAD51 genes associated with homologous recombination pathways (P-value 0.02032). Additionally, 4 genes (RAD51, KIF4A, DTL, and DLGAP5) were linked to CD105+ endothelial cells (P-value 0.00002216), connecting myocardial infarction and breast cancer. Nevertheless, further testing is needed for accurate results and to support this study's transcriptomic analysis.
Co-Authors Abdul Bashit Al Fikri Amelia Rika Fadillah Anita Anggraeni Anna Surgean Veterini Arifin Seweng Arnawati Arnawati Azizah Rachmawati Bambang Suprapto Candra Pratama Cindy ApriliaEkaPrasanty Darmawansyah Darmawansyah Debby Desmarini Diana Romdhoningsih Dopa Lista Elfira Diah Ayu Febriani Elvina Kurniasari Fahisatul Jannah Fahrul An'nas Al Kamal Fathurrohim Fathurrohim Feriawan Tan Fiza Asri Fauziah Habibah Gemilang Ramadhan Syahputraningrat Ghea Safiraventa Anggreini Halimah Madania Rahman Hera Damayanti Khairunisa Khairunisa Luluk Yunaini Mafruroh Mafruroh Malika Diah Puspita Sari Miftahul Khair Akbar Mohamad Ali Mohammad Ali Mujtahid Kaavessina Murdani Abdullah Novia Dewi Nur'asiah Nur'asiah Nursaidah Ahmad Nurul Hidayatun Priyanda R Puji Sari R. Bilqis Bunga Nirwana Rachmat Setiyadi Rahman, Arief Aulia Rahmawati Andayani Refanza Nurfikhri Ridwan Tohopi Riskia Putri Risma Handayani Rizki Amalia Rizki Amalia Rizki Awaluddin Rosdiana Dwiyanti Sakti Hutabarat Saniati Saniati Santi Tri Wijayanti Shifa Annisa Nabila Sisi Anoli Putri Siti Khaerunnisa Sofy Meilaini Sperisa Distantina Sperisa Distantina Sumarta Dinata Susanti Susanti Tia Anggraini Silalahi Tiurmasi Saulina Sirait Tiwi Tamara Tri Agina Sapira Usiono Usiono Viona Rohmah Armia Gita Kusuma Winda Amelia Putri Yuani Setiawati