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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Pharmaceutical Journal of Indonesia Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Bakti Masyarakat Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Pengabdian Masyarakat (ABDIRA) Journal of Research in Pharmacy and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Clinical and Pharmaceutical Sciences Journal Jurnal Serina Abdimas
Rahmi, Eldiza Puji
Fakultas Kedokteran UPN Veteran Jakarta
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Association between Hormonal Contraceptive Use and Hypertension Risk among Reproductive-Age Women: A Cross-sectional Study at Cileungsi Public Health Center, Indonesia Nafara Maharani Itamy, Defa; Rahmi, Eldiza Puji; Luthfiyani Citra Pradana, Dhigna; Farida Muti, Annisa
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.31400

Abstract

Hypertension remains a major public health problem that may be influenced by hormonal contraceptive use, particularly oral and injectable methods commonly used by women of reproductive age. These contraceptives have raised concerns about their potential impact on blood pressure regulation. This study aimed to investigate the association between hormonal contraceptive use and the occurrence of hypertension among women of reproductive age at the Cileungsi Public Health Centre, Bogor Regency, Indonesia. A cross-sectional study was conducted in 2024 using retrospectively collected medical record data of all hormonal contraceptive users at the facility. Total sampling was applied, and data on contraceptive type, duration of use, age, parity, and the most recent blood pressure readings were analyzed. The chi-square test was employed to examine associations between hormonal contraceptive characteristics and hypertension, with a significance level set at p < 0.05. The results revealed a significant association between contraceptive type and hypertension (p = 0.01, OR = 0.27), showing that users of oral contraceptive pills were more likely to develop hypertension than injectable users. Duration of use (p = 0.03, OR = 3.06), age (p = 0.04, OR = 0.12), and parity (p = 0.01, OR = 0.21) were also significantly associated with hypertension. Women aged ≥45 years, those with longer contraceptive use, and multiparous users exhibited a higher risk of elevated blood pressure. These findings highlight that both contraceptive-related and demographic factors contribute to hypertension risk among hormonal contraceptive users. Regular blood pressure monitoring and individualized counseling are essential, especially for oral and long-term users. This study contributes local evidence supporting safer contraceptive practices and cardiovascular risk management within primary healthcare settings.
PENDAMPINGAN KADER KESEHATAN KECAMATAN CINERE DEPOK DALAM UPAYA MENCEGAH STUNTING DENGAN METODE CARA BELAJAR INSAN AKTIF Pradana, Dhigna Luthfiyani Citra; Sartika, Luthfiah Dewi; Rahmi, Eldiza Puji; Muti, Annisa Farida; Syarifah, Andiri Niza; Ilmi, Primayanti Nurul
Jurnal Serina Abdimas Vol 1 No 4 (2023): Jurnal Serina Abdimas
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jsa.v1i4.28336

Abstract

Malnutrition in children who are stunted occurs from the baby in the womb to after birth or commonly called the First 1,000 Days of Life (HPK). Stunting prevention is more effective than stunting treatment. Therefore, the purpose of this community service is to assist health cadres of Cinere sub-district in preventing stunting. The method used in this community service is education on how to learn active people and participants are given pre-test and post-test. The activeness of community service participants is expected to make it easier to understand stunting prevention education by seeing and discussing vitamins and minerals needed in stunting prevention. The results of community service were followed by 113 people divided into 4 villages in Cinere District, Depok City. Most of the participants were mothers so that information and implementation of stunting prevention could be seen immediately. There was a significant difference of 0.000 between pretest and posttest values analyzed using the Wilcoxon test on SPSS. The results of the pre-test and post-test assessments, attitudes and understanding of health cadres in Cinere sub-district increased by an average of around 87, so it can be assumed that the participants had understood the educational material for stunting prevention in Cinere sub-district, Depok city. Kekurangan gizi pada anak yang mengalami stunting terjadi sejak bayi dalam kandungan hingga setelah lahir atau biasa disebut 1.000 Hari Pertama Kehidupan (HPK). Pencegahan stunting lebih efektif dibandingkan pengobatan stunting. Oleh karena itu tujuan dari pengabdian masyarakat ini adalah untuk mendampingi kader Kesehatan kecamatan cinere dalam mencegah kejadian stunting. Metode yang digunakan dalam pengabdian masyarakat ini yaitu edukasi cara belajar insan aktif serta para peserta diberikan pre-test dan post-test. Keaktifan para peserta pengabdian masyarakat diharapkan dapat memudahkan untuk memahami edukasi pencegahan stunting dengan melihat serta mendiskusikan vitamin dan mineral yang dibutuhkan dalam pencegahan stunting. Hasil pengabdian masyarakat diikuti 113 orang yang terbagi menjadi 4 kelurahan di Kecamatan Cinere Kota Depok. Sebagian besar peserta adalah seorang ibu sehingga informasi dan penerapan pencegahan stunting langsung dapat dilihat hasilnya. Terdapat perbedaan yang signifikan 0,000 antara nilai pretest dan posttest yang dianalisis menggunakan uji Wilcoxon pada SPSS. Hasil penilaian pre-test dan post-test sikap dan pemahaman kader kesehatan di Kecamatan Cinere meningkat rata-rata sekitar 88 sehingga dapat diasumsikan bahwa para peserta telah paham materi edukasi pencegahan stunting di kecamatan cinere kota depok.
Optimization of Ultrasonic-Assisted Extraction Parameters and Antibacterial Activity of Zanthoxylum acanthopodium D.C against Cutibacterium acnes Rahmi, Eldiza Puji; Pasaribu, Rini Sarah; Harfiani, Erna; Revina, Rika; Septama, Abdi Wira
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.5932

Abstract

Acne is a disease that has affected many populations globally. One of the causes of acne is the presence of acne-causing bacteria, namely Cutibacterium acnes, which is reportedly resistant to several antibiotics. Andaliman fruit (Zanthoxylum acanthopodium DC.) is traditionally used by Indonesian people as a spice which has antibacterial potential. This study aims to evaluate the antibacterial activity of the ethanolic extract of Andaliman fruit against C. acnes using the microdilution method. The extraction method for andaliman fruit was the Ultrasonic-Assisted Extraction with variations in frequency (30, 40, and 50 kHz) and duration (10, 15, and 20 minutes). Phytochemical screening showed the presence of flavonoids, alkaloids, tannins, steroids, and saponins in the extract. The results showed the antibacterial activity of Andaliman fruit extract against C. acnes, with the Minimum Inhibitory Concentration (MIC) observed in the extract with a frequency of 40 kHz and an extraction duration of 10 and 15 minutes at a concentration of 5000 ppm. However, the Minimum Bactericidal Concentration (MBC) test showed negative results, indicating that Andaliman extract did not have a bactericidal effect on these bacteria. Statistical analysis using the Kruskal–Wallis and Dunn tests revealed significant differences (p < 0.05) between extraction treatments and the positive control in MIC and MBC values. These findings indicate that the ethanolic extract of andaliman fruit possesses inhibitory but not bactericidal activity against C. acnes, suggesting its potential as a natural anti-acne agent for further formulation and mechanistic studies.
RATIONALITY OF ANTIBIOTIC PRESCRIPTIONS AMONG OUTPATIENTS IN THE INTERNAL MEDICINE CLINIC AT PERSAHABATAN GENERAL HOSPITAL JULY–SEPTEMBER 2023 Artanti, Astrid Nada; Maria, Ima; Rahmi, Eldiza Puji; Citra Pradana, Dhigna Luthfiyani; Diliana, Diliana
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antibiotic use has increased in both developing countries, such as Indonesia, and developed countries, such as Japan and Australia. This trend may lead to a rise in antibiotic resistance if antibiotics are used irrationally. This study aimed to evaluate antibiotic prescribing patterns using the Gyssens method among adult outpatients in the Internal Medicine Clinic at Persahabatan General Hospital during the period of July–September 2023. This was a descriptive study with a cross-sectional design. Data were collected retrospectively from the medical records of adult outpatients attending the Internal Medicine Clinic during the study period. Of the 30 patient records that met the inclusion and exclusion criteria, the age group 51–60 years represented the largest proportion of antibiotic prescriptions (46.67%). Levofloxacin was the most frequently prescribed antibiotic (30.3%). Based on the Gyssens method, 88.8% of prescriptions were classified as rational, while 11.1% were irrational. In conclusion, 88.8% of antibiotics prescribed for adult outpatients in the Internal Medicine Clinic at Persahabatan General Hospital during July–September 2023 were deemed rational according to the Gyssens method. Keywords : antibiotics, gyssens method, outpatient DOI : 10.35990/mk.v8n4.p400-411
Pharmacokinetic Evaluation of Paracetamol Co-administered with Moringa oleifera and Caesalpinia sappan Extracts Individually in Sprague Dawley Rats Pradana, Dhigna; Nur, Syifa; Hakim, Annisa Ayu Nur; Rahmi, Eldiza Puji; Muti, Annisa Farida; Abdurrahman Munir, Muhammad
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.579

Abstract

Paracetamol is frequently utilized to alleviate pain and fever due to its pharmacological properties as an analgesic and antipyretic. Consuming paracetamol drugs while self-medication might potentially lead to drug interactions when used with other medications, as well as certain foods and herbs. Moringa oleifera and Caesalpinia sappan are popular herbal plants in Indonesia, commonly used to produce herbal food and drinks. These plants contain flavonoids and phenols, which have the potential to impact the metabolism, effectiveness, and toxicity of medications, including paracetamol. This study investigated alterations in the pharmacokinetic characteristics of paracetamol when co-administered with Moringa oleifera and Caesalpinia sappan. The research utilized a true experimental approach with a posttest-only control group design and animal model study is male Sprague-Dawley rats . The control group was administered an oral dose of 9mg/200g body weight of paracetamol. By contrast, the treatment group of male Sprague-Dawley rats was administered an oral dose of 9mg/200g body weight of paracetamol, combined with a dose of 60mg/200g of Moringa leaf extract and sappan heartwood extract at 294 mg/kg body weight. At 30, 60, 120, 180, and 240 minutes, blood samples were collected from the rats' lateral tail vein. Analyzing the concentration of paracetamol in plasma was conducted using a UV-Vis spectrophotometer set at a wavelength of 244 nm. The study showed that combining sappan heartwood extract with paracetamol resulted in a substantial 453.10% increase in the volume of distribution (Vd) (p<0.05). The administration of Moringa leaf extract decreased a little effect the pharmacokinetic profile of paracetamol, as shown by the statistical analysis of the unpaired t-test (p>0.05).
Effectiveness of Anaemia Therapy in Breast Cancer Patients with Chemotherapy-Induced Anaemia at Dharmais Cancer Hospital Jakarta in 2023 Muti, Annisa Farida; Yasya Sabrinanissa; Rahmi, Eldiza Puji; Pradana, Dhigna Luthfiyani Citra
Pharmaceutical Journal of Indonesia Vol. 11 No. 2 (2026)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Introduction: Chemotherapy-induced anemia is a common complication in breast cancer patients, primarily caused by bone marrow suppression, which inhibits erythropoiesis and reduces hemoglobin levels. Effective management of anemia is crucial in improving patients' quality of life and tolerance to cancer therapy. This study aims to evaluate the clinical effectiveness of anemia therapy, including packed red cell (PRC) transfusion and erythropoiesis-stimulating agents (ESA) administration, in breast cancer patients post-chemotherapy at Dharmais Cancer Hospital in Jakarta. Methods: The study design used was a retrospective observational study with data collected from inpatient medical records throughout 2023. A total of 35 patient records were selected using total sampling technique. Hemoglobin levels before and after anemia therapy were analyzed using paired statistical tests to assess the effectiveness of the therapy. Results: The analysis results showed a statistically significant increase in hemoglobin levels after therapy was administered (p < 0.001). Conclusion: indicating that both PRC transfusions and ESA therapy effectively contributed to correcting post-chemotherapy anemia in breast cancer patients.
Effectiveness of Anaemia Therapy in Breast Cancer Patients with Chemotherapy-Induced Anaemia at Dharmais Cancer Hospital Jakarta in 2023 Muti, Annisa Farida; Yasya Sabrinanissa; Rahmi, Eldiza Puji; Pradana, Dhigna Luthfiyani Citra
Pharmaceutical Journal of Indonesia Vol. 11 No. 2 (2026)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Introduction: Chemotherapy-induced anemia is a common complication in breast cancer patients, primarily caused by bone marrow suppression, which inhibits erythropoiesis and reduces hemoglobin levels. Effective management of anemia is crucial in improving patients' quality of life and tolerance to cancer therapy. This study aims to evaluate the clinical effectiveness of anemia therapy, including packed red cell (PRC) transfusion and erythropoiesis-stimulating agents (ESA) administration, in breast cancer patients post-chemotherapy at Dharmais Cancer Hospital in Jakarta. Methods: The study design used was a retrospective observational study with data collected from inpatient medical records throughout 2023. A total of 35 patient records were selected using total sampling technique. Hemoglobin levels before and after anemia therapy were analyzed using paired statistical tests to assess the effectiveness of the therapy. Results: The analysis results showed a statistically significant increase in hemoglobin levels after therapy was administered (p < 0.001). Conclusion: indicating that both PRC transfusions and ESA therapy effectively contributed to correcting post-chemotherapy anemia in breast cancer patients.
Co-Authors Abdi Wira Septama Abdi Wira Septama Abdurrahman Munir, Muhammad Afdhal Raziq Hanania Ananda, Bella Anggita Cahya Ningrum Anggita Virginia Naulina Manurung Annisa Farida Muti Artanti, Astrid Nada Azzahra, Khayla Shifa Cahyadi, Salwa Nisrina Deskia Amanda Fitriyani Dhigna Luthfiyani Citra Pradana Dian Mega Sugiyarto Diliana, Diliana Erna Harfiani Farida Muti, Annisa Farkhani, Aulia Ferdian, Muhamad Hakim, Annisa Ayu Nur Imam Prabowo, Imam Kharazi Farand Vitonova Kusumaningrum, Alfina Aprilia Luthfiyani Citra Pradana, Dhigna Maria, Ima Marliah Saputri, Sirly Nabila, Annisa Hasna Nafara Maharani Itamy, Defa Nafis Ikhwana Nasyia Qaanita Nasywa Dwi Ayu Nur, Syifa Nurjannah, Rabbiah Putri Pasaribu, Rini Sarah Pradana, Dhigna Pradana, Dhinga Luthfiyani Primayanti Nurul Ilmi Putri Andini, Putri Ramdhan, Zeashafa Zafira Razan Fachrudin, Brooklyn Rifkia, Via Rika Revina Roqayyah Salma Ika Rahmadani Sartika, Luthfiah Dewi Shabrina, Cut Laila Nur Situmorang, Vania Clarissha Sumantri, Salsabila Syarifah, Andiri Niza Tirta Fitri Aryani Valentino, Mikhael Wandira, Salsabilla Puteri Widjaja, Tiyon Yasya Sabrinanissa