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All Journal E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Essential: Essence of Scientific Medical Journal Bali Dermatology Venereology and Aesthetic Journal
Prima Saraswati Sanjiwani Sudarsa
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran, Universitas Udayana/ RSUP Sanglah
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Focus on the dabrafenib, vemurafenib, and trametinib in the clinical outcome of melanoma: A systematic review and meta-analysis Ida Ayu Widya Anjani; Anak Agung Bagus Putra Indrakusuma; I Gede Krisna Arim Sadeva; Putri Ayu Wulandari; Luh Made Mas Rusyanti; Prima Sanjiwani Saraswati Sudarsa; I Gede Putu Supadmanaba; Desak Made Wihandani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/myphje28

Abstract

Background: Melanoma is the most severe lethal skin cancer, affecting melanin producer cells (melanocytes). Surgery is the most common treatment, whereas, for the advanced stage, the development of treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is the most frequently targeted melanoma therapy due to more than 80% of patients with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome. Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by three different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2 and Chi2 statistic Result: There are 20 studies used in this article (13 RCT and seven cohorts). The overall survival (OS) and progression-free survival (PFS) of the survey that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other treatments (chemotherapy, immunotherapy, etc.) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17; I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13; I2=99%; p<0,00001). Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other treatments for better clinical outcomes rather than monotherapy.
A case of pemphigus vulgaris in a patient with abdominal tumor as collaborative disease Prima Sanjiwani Saraswati Sudarsa; Marvin Giantoro; Luh Gede Melia Puspita Sari; I Made Setiadji
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 2 (December 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/bs6cm636

Abstract

Background: Pemphigus is an autoimmune disease with clinical manifestations of chronic intraepidermal bullae on the skin, mucosa, and loose walls.Pemphigus can be categorized into four types, namely pemphigus vulgaris (PV), pemphigus vegetans, pemphigus foliaceus, and paraneoplastic pemphigus. Pemphigus vulgaris is the most common form of with the highest epidemiology. Pemphigus vulgaris with abdominal tumors cannot be associated where abdominal tumors do not trigger the occurrence of PV. However, abdominal tumors can increase morbidity and provide poor prognosis. Case Description: A male, 46 years old, Balinese, Indonesian, came to the Sanglah Hospital Emergency Room with the chief complaint of painful sores around the body, hands, and feet since 20 days ago. Initially the patient said that there were loose, watery blister filled with serous fluid, which after a few days burst and left sores. The blister start on the feet and then spread to the hands and body. The patient was diagnosed with pemphigus vulgaris and abdominal tumors by the digestive surgery doctor. The patient had never had a similar complaint before. History of applying oil, traditional ingredients and topical drugs was denied. The patient was treated mainly with methylprednisolone and showed clinical improvement. Conclusion: We report a case of PV in a 46-year-old man with abdominal tumors. This case report is expected to add insight on how to diagnose PV, how to determine therapy, the wound healing process, how to treat wounds, prevent disease expansion, and the relationship between abdominal tumors and PV.
Co-Authors Agung Bagus S. Satyarsa Anak Agung Bagus Putra Indrakusuma Anak Agung Gde Putra Wiraguna Ariani, Luh Nyoman Arya Wisma Arim Sadeva, I Gede Krisna Aurelia Stephanie Aurelia Stephanie Desak Made Wihandani Desak Nyoman Trisepti Utami Dewi Gotama Dewi Gotama Gotama, Dewi Herman Saputra Herman Saputra Herman Saputra I G. P. Supadmanaba I Gede Krisna Arim Sadeva I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Praharsini I Gusti Ayu Tika Indriani I Made Setiadji Ida Ayu Widya Anjani Ida Ayu Widya Anjani Indrakusuma, Anak Agung Bagus Putra Komang Saputra Yadnya Luh Gede Melia Puspita Sari Luh Made Mas Rusyanti Luh Made Mas Rusyati Made Hermina Laksmi Made Swastika Adiguna Marvin Giantoro Nevristia Pratama Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Nukana, Ratih Purnamasari Nyoman Suryawati Nyoman Yoga Maya Pramita Praharsini, I Gusti Agung Pramita, Nyoman Yoga Maya Putri Ayu Wulandari Putri Ayu Wulandari, Putri Ayu Putri, Putu Winna Deyanti Putu Gde Hari Wangsa Ratih Purnamasari Nukana Stephanie, Aurelia Velava Kumar Gopal Wicaksono, Rafael Lilik Widya Anjani, Ida Ayu