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All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Mathematical and Fundamental Sciences BioWallacea Journal of Biological Research KOVALEN: Jurnal Riset Kimia Jurnal Kimia Riset Al-Kimia Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research GERVASI: Jurnal Pengabdian kepada Masyarakat JKPK (Jurnal Kimia dan Pendidikan Kimia) Dimasejati: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara International Journal Of Science, Technology & Management (IJSTM) Jurnal Mandala Pengabdian Masyarakat Jurnal Pijar MIPA Journal Of Human And Education (JAHE) Makara Journal of Science
Muhamad Jalil Baari
Department Of Chemistry, Faculty Of Science And Technology, Universitas Sembilanbelas November Kolaka, Jl. Pemuda, Kolaka 93511, Indonesia
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LC-MS/MS Metabolite Profiling of Meistera aculeata (Roxb.) Škorničk. & M.F. Newman (Susube) and Preliminary Brine Shrimp Lethality Screening Megawati, Megawati; Baari, Muhamad Jalil; Sabandar, Carla Wulandari
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 11, No 1 (2026): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v11i1.113611

Abstract

Meistera aculeata (Roxb.) Škorničk. & M.F. Newman is a species of the Zingiberaceae family distributed in Southeast Sulawesi, Indonesia, particularly in Konawe Regency. The fruits are traditionally consumed and used as a culinary spice by the Tolakinese community. However, information regarding its metabolite composition and biological activities remains limited. This study aimed to profile putative metabolites using LC–MS/MS and to evaluate preliminary lethality using the Brine Shrimp Lethality Test (BSLT). Dried powders of rhizomes, stems, leaves, and fruits were extracted by maceration with methanol. Metabolite annotation was performed using LC–MS/MS, while cytotoxic potential was assessed through BSLT. The analysis tentatively detected 13 metabolites dominated by flavonoids, phenylpropanoids, and terpenoids. Methanol extracts of rhizomes, stems, leaves, and fruits showed toxic activity with LC₅₀ values of 56.6 ± 9.9, 70.1 ± 8.1, 71.6 ± 9.3, and 115.5 ± 13.5 μg/mL, respectively, compared with K₂Cr₂O₇ as a positive control (LC₅₀ 11.5 ± 1.6 μg/mL). Literature comparison suggests that although these metabolites have been reported in other plant species, their occurrence in M. aculeata is reported here for the first time. The BSLT results indicate preliminary cytotoxic activity, suggesting the presence of bioactive compounds. These findings support further chemotaxonomic and pharmacological investigations to identify potential marker compounds and expand knowledge of metabolites within the Zingiberaceae family, particularly the genus Meistera.
Co-Authors Abd Gani Baeda Agusriyadin, Agusriyadin Alif, Alfiah Amalyah Febryanti Amin, Rana Triana Andas, Netty Huzniati Apriliya, Ella Arif Prasetya Awal, Samsi Benu, Didi Prasetyo Bunbun Bundjali Bunbun Bundjali Carla Sabandar Carla Wulandari Sabandar Deana Wahyuningrum Dian Permana Evodius Nasus Faradisa Anindita Fazira, Yuli Febryanti, Amalyah Finarisnawati, Finarisnawati Fitria Mukti, Elisa Gaby Nanda Kharisma Hairia, Warda Hardiyanti, Devi Hasan Eldin Adimu Hasidu, La Ode Abdul Fajar Ica Aprilia Seleng Ilham Antariksa Tasabaramo Inda, Inda Indriani, Windi Kamaruddin, Harni Sartika Kamur, Sudarwin Khafidzah Yusuf Kurniawan, Muhammad Akbar S Kurniawan, Muhammad Akbar S. La Harimu La Na’ani Maharani Mbuli, Firnayanti Megawati , Megawati Megawati - Megawati Megawati Megawati, Megawati mubarak, azhar aras Muh Syahruddin Muh. Ansar Azali Muhammad Rayzhal Faturahman Muhammad Syaiful Na'ani, L.A. Nasrudin Nasrudin Na’ani, La Nun Ainun Arap Nur Afifa Nurliana Nurliana Nurmira, Nurmira Ramad Arya Fitra Ravensky Yurianty Pratiwi Retno Wahyuningrum Rezkiya Nur Insani Rina Hardianti Pratiwi Rina Rembah Risnawati, Fina Rizki Kumalasari Sabila, Laili Cahyani Salim Salim Samaria, Siti Sarimuddin, Sarimuddin Sariyanti, Sariyanti Sri Gita Handayani Susianti Susianti Syamsul Arifin Waangkaali Wahyuni Hakim Yayang Rahmadani