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All Journal Journal of Food and Pharmaceutical Science Pharmacon Jurnal Penelitian Farmasi Indonesia JOPS (Journal Of Pharmacy and Science) Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Pharmacoscript Amalee: Indonesian Journal of Community Research & Engagement Jurnal Ners Community Development Journal: Jurnal Pengabdian Masyarakat INDRA: Jurnal Pengabdian kepada Masyarakat Journal of Artificial Intelligence and Digital Business Riset Informasi Kesehatan Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences BATOBO: Jurnal Pengabdian Kepada Masyarakat Journal of Innovative and Creativity Jurnal Medika: Medika
Rusnedy, Rahmayati
5Sekolah Tinggi Ilmu Farmasi Riau
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Aktivitas Antibakteri Isolat Jamur Endofit Kulit Batang Rimbang (Solanum torvum Swartz) terhadap Beberapa Bakteri Melzi Octaviani; Salsabila Putri; Sri Lidya Rasihe; Kolista Sisilawati; Nofriyanti Nofriyanti; Rahmayati Rusnedy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.557

Abstract

Endophytic fungi are known as a promising alternative source of antibacterials due to their ability to synthesize secondary metabolites like their host plants. Although the presence of endophytic fungi associated with Solanum torvum has been reported in previous studies, no studies have focused on fungi isolated from the bark of Solanum torvum and the correlation between the phytochemical content of its fractions and antibacterial activity. The aim of this study was to isolate endophytic fungi from the bark of Solanum torvum and test the antibacterial activity and phytochemical profiles of the fractions from the isolates against pathogenic bacteria. Endophytic fungi were isolated using direct cultivation techniques after surface sterilization. The antibacterial activity test was evaluated using the disc diffusion method against Bacillus cereus ATCC 11778, Staphylococcus aureus ATCC 12600, Escherichia coli ATCC 11775, and Salmonella typhi ATCC 14028 bacteria. Five endophytic fungal isolates were obtained and identified, namely FEST-K1 (Artrographis), FEST-K2 (Acremonium sp.), FEST-K3 (Paecilomyces sp.), FEST-K4 (Lichtheimia), and FEST-K5 (Alternaria sp.). The supernatant was then extracted and fractionated using ethyl acetate, chloroform, and n-butanol. Phytochemical analysis showed that the fungal fraction contained alkaloids, terpenoids, and saponins. FEST-K1 showed the strongest inhibitory activity against S. aureus and B. cereus, with inhibition zone diameters of 15.09 mm and 13.69 mm, respectively. In contrast, the highest activity against E. coli and S. typhi was observed in FEST-K4 (13.78 mm) and FEST-K5 (15.45 mm). One-way ANOVA statistical analysis showed that the antibacterial activity of the fungal extracts was significantly different from the positive control (p < 0.05). These results indicate that endophytic fungi derived from the bark of S. torvum are a potential source of antibacterial compounds.
Potential Drug Interactions in Outpatients with Hypertension and Comorbid Type 2 Diabetes Mellitus at Arifin Achmad Regional General Hospital Riau Province Husnawati Husnawati; Rahmayati Rusnedy; Ma'isyatul Fadillah; Reni Zulfitri
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26554

Abstract

Hypertension and diabetes mellitus are degenerative diseases that if not managed properly will lead to other disease complications. This condition can cause polypharmacy which has the potential to cause drug interactions. The purpose of this study is to determine the presence or absence of drug interactions used in the treatment of hypertension patients with comorbidities of type 2 diabetes mellitus at Arifin Achmad Hospital, Riau ProvinceThis study was conducted using a descriptive analysis design by collecting retrospective data. The samples are all outpatients diagnosed with hypertension and coexisting type 2 diabetes mellitus from January to December 2024 who met the inclusion criteria. The total sample in this study was 110 samples. In this study use one variable, drug interaction. The instrument used in this study was a patient’s medical record. The results obtained were analyzed descriptively with online media screening using Drugs.com and Medscape.com sites and textbook screening such as Stockley's Drug Information Handbook (DIH) Drug Interaction, 12th edition, 2019. The data obtained were analyzed descriptively using percentages. The results showed that there were 70 cases of potential drug interactions. The type of pharmacodynamic interaction was 100% and based on severity there were major interactions of 1,43%, moderate 92,86% and minor 5,71%. These findings indicate the potential for drug interactions in outpatients with hypertension and comorbid type 2 diabetes mellitus, particularly pharmacodynamic interactions.
Co-Authors Adriani Susanty Anfasa Mashudi, Fristio Annisa Fitri Angraini Armon Fernando Asnila Asnila Audi Ichsania Achamad Audia Ichsania Achmad Aulia Fitri Bayzhola Ditya Putri Bella Parina, Ana Benni Iskandar Cindy Patika Sari Diova Yuswidia Putra Dita Maulia Andriani Dwiki Septian Efendi, Apriyani Elvi Khairani, Mai Fadillah, Ma'isyatul Ferdy Firmansyah Ferelina Santi Fharisti Kirana Fitra Ayu Ningsih Furi, Mustika Hanifah Siti Aisyah Hery Widijanto Husnawati Husnawati Husnawati Husnawati Indah Denni Pratiwi Isma Mubina Ismail Marzuki Kismira Hidayati Kolista Sisilawati Kurniawan Putri, Nurafika Lia Gusniwinarni Liau Che Kuang Liliana Saharani Lisa Renita Ma'isyatul Fadillah Maisarah Maisarah Marisa Nurlita Melfi Madini Melka Febby Arpina Melzi Octaviani Miftahul Jannah Mira Febrina Muhtadi, Wildan Khairi Musdalifah Musdalifah Neni Frimayanti Nicky Viola Agatha Ninda Fitria Nofri Hendri Sandi Nofriyanti Noveri Rahmawati Nur Anisa Putri Lestari Qanitah Zakwani Hakim Qurnia Pratiwi, Putri Ratna Sari Dewi Reni Zulfitri Reni Zulfitri Rickha Octavia Rifath Afandi Rinita Sari S Rizka Oktawahyuni Salsabila Putri Salsabila, Aulia Shella Anggraini Silvy Arundita Sinata, Novia Siti Hizra Alpatiqa Siti Riani Sonia Gaya Srianti Sri Harti Dewi Sri Lidya Rasihe Sutriani Sutriani Syilfia Hasti Sylfia Hasti Tiara Andjelie Tika Ayu Andani Tri Daniarty Urhidayatunnisak Urhidayatunnisak viola Afrilizetira, Garnis Wahyuni Wahyuni Whulan Mudia Winda Windiati Wira Noviana, Wira Noviana Wulandari, Zertiks Zafarani, Welly