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All Journal Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmiah Kesehatan Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) BIMIKI (Berkala Ilmiah Mahasiswa Ilmu Keperawatan Indonesia) Cermin Dunia Kedokteran Khazanah: Jurnal Mahasiswa Indonesian Journal of Cancer Griya Widya: Journal of Sexual and Reproductive Health IJRETINA - International Journal of Retina Journal of Applied Holistic Nursing Science Journal of Health and Medicine JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Cermin Dunia Kedokteran Journal of Health and Therapy
Suryoadji, Kemal Akbar
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Perbaikan Pendengaran Pasien Otitis Media Efusi yang Autoinflasi: Laporan Kasus Berbasis Bukti Firmansyah, Ugiadam Farhan; Suryoadji, Kemal Akbar; Bashirudin, Jenny; Bramantyo, Brastho; Alviandi, Widayat
Cermin Dunia Kedokteran Vol 51 No 6 (2024): Cardiology
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i6.1024

Abstract

Background: Otitis media with effusion (OME) is the presence of middle ear fluid without acute ear infection signs or symptoms. OME is one of the causes of hearing loss. Chronic asymptomatic OME could be managed by careful waiting for 3 months because it is a self-limiting disease. During surveillance, autoinflation is a beneficial intervention with minimal side effects and high adherence. Objective: To evaluate the effectiveness of autoinflation to improve hearing in otitis media with effusion and hearing loss. Methods: Literature searching was conducted through PubMed, Cochrane, ScienceDirect, Scopus, and EBSCOHost with inclusion and exclusion criteria. The articles were selected and underwent critical appraisal using rapid critical appraisal of systematic review and level of evidence by the Oxford Centre for Evidence-based Medicine in 2011. Result: One systematic review and meta-analysis, or RCT, met the criteria. This article revealed a pooled estimate of RR 1.74; 95% CI [1.22-2.50] with a Z-score of 3.02 (p=0.0025). This result showed substantial significant (p=0.01) heterogeneity (I2=69%). Conclusion: OME patients with hearing loss who performed autoinflation >1 month had a 1.74 times greater chance of achieving hearing improvement than controls. Autoinflation with the Politzer method gives significant results in improving hearing loss. Large-scale RCT research is recommended to evaluate the effectiveness of autoinflation with the Politzer method or other available methods in OME patients with hearing loss.
Perbandingan Efektivitas Leflunomide dengan Methotrexate untuk Terapi Artritis Rematoid Suryoadji, Kemal Akbar; Wibowo, Pramesti Kusumadini
Cermin Dunia Kedokteran Vol 51 No 8 (2024): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i8.1053

Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by symmetrical joint involvement and extra-articular manifestations. Methotrexate and leflunomide are disease modifying anti-rheumatic drugs(DMARD) and use as treatment options for rheumatoid arthritis. This report aims to compare the effectiveness of leflunomide with methotrexate as therapy for rheumatoid arthritis. Methods: Literature search was carried out through three electronic databases: PubMed, Cochrane, and EBSCOHost with specific keywords based on PICO. Selection was in accordance with inclusion and exclusion criteria based on the clinical question. Selected literature was critically reviewed using an adapted instrument from the University of Oxford’s CEBM. Result: One systematic review and meta-analysis literature by Alfaro-Lara, et al, (2017) was obtained. The results showed a trend towards methotrexate in achieving response according to American College of Rheumatology (ACR20) (0.88 [95% CI: 0.74-1.06]; p = 0.18), reduction in joint swelling was greater with methotrexate (-0.82 [95% CI: 0.24-1.39]; p = 0.006), no significant difference in joint pain reduction (p>0.05). Liver enzyme elevations were more frequent with leflunomide (0.38 [0.27-0.53]; p = 0.007); gastrointestinal (GI) complaints were more frequent with methotrexate (1.44 [1.17-1.79]; p = 0.0007), no significant difference in the incidence of non-severe infections. Conclusion: Leflunomide has the same efficacy as methotrexate for RA therapy; more reduction of joint swelling with methotrexate. Leflunomide was associated with greater increases in liver enzymes, but fewer GI complaints.
Dampak Merokok terhadap Kesehatan Lingkungan: Sebuah Tinjauan Naratif Suryoadji, Kemal Akbar; Sutanto, Reynardi Larope; Christian, Christopher; Putra, Elza Nur Warsa; Faruqi, Muhammad; Simanjuntak, Kevin Tadeus; A’yun, Ilham Qurrota; Ali, Najma
Cermin Dunia Kedokteran Vol 51 No 3 (2024): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i3.1064

Abstract

Introduction: Smoking, which involves tobacco as the primary material, has extensive impacts on environmental and human health. This study incorporates literature and research related to the environmental impacts of smoking. Methods: This research uses the literature review method, referencing relevant sources. Document searches were conducted through Google Scholar and manual searching using the keywords “(Smoking) AND (Environmental Health).” Results: The environmental impacts of smoking are highly complex, including air pollution, littering from cigarette butts, and the effects of tobacco processing and production on land and water. Regulatory issues pose challenges in controlling the negative environmental impacts of smoking. Discussion: Air pollution resulting from smoking includes a significant increase in carbon dioxide emissions and a substantial contribution to climate change. Littering cigarette butts leads to the accumulation of harmful plastic waste in marine ecosystems and human health. Tobacco production also carries serious consequences, including deforestation, agrochemical use, and pollution. Controlling tobacco and cigarette use requires comprehensive measures, including cost regulation, advertising bans, and strict monitoring. Stronger regulations and collaborative efforts are needed to address the environmental impacts of smoking effectively. Conclusion: Smoking has significant impacts on environmental health, including air pollution, littering pollution, and the effects of tobacco production. Further efforts are necessary to control these negative impacts through effective regulations and raising public awareness of the environmental consequences of smoking.
Hubungan antara Bersepeda dan Infertilitas Pria: Tinjauan Sistematis dari Penelitian Saat Ini: Analisis Suryoadji, Kemal Akbar; Ridwan, Alifaturrasyid Syafaatullah; Fauzi, Ahmad; Sini, Kieran Pasha Ivan; Taher, Akmal
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1241

Abstract

Introduction: Cycling is a popular sport and also has various health benefits. However, cycling carries health risks, including fertility problems. This research aims to explore the association between cycling and infertility in men. Methods: This systematic review was conducted according to a PROSPERO protocol (ID: CRD42024509255) and PRISMA guidelines using the PubMed, Cochrane, and ScienceDirect databases. Keywords “(Bicycle) AND (Infertility)” are used. The risk of bias was assessed based on the Cochrane risk of bias tool for cohort studies. Results: The final two cohort studies were included with a total of 487 cyclists. Regular cycling of more than 1.5 hours/week was associated with 34% (95% CI 4-55%) lower sperm concentration compared to control. Regular cycling of more than 5 hours/week was associated with lower sperm concentration (OR 1.92, 95% CI 1.03-3.56) and lower total sperm motility (OR 2.05, 95% CI 1.19-3.56) compared to the control group. Conclusion: There is a relationship between cycling and male infertility; a decrease in sperm concentration in men who cycle at least 1.5 hours/week and lower sperm motility in men who cycle for at least 5 hours/week. The direct efect of cycling on the incidence of infertility as a consequence needs to be explored further.
Prognosis Mortalitas Pasien Tuberkulosis dengan Komorbid Diabetes Melitus Tipe 2: Analisis Suryoadji, Kemal Akbar; Fauzi, Ahmad; Ridwan, Alifaturrasyid Syafaatullah; Putra, Abdul Hafiidh Surya; Wisnu, Wismandari
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1248

Abstract

Introduction: Indonesia ranks 3rd in tuberculosis (TB) cases in the world, and data from the Ministry of Health in 2020 showed that 10%-15% of TB sufferers had diabetes mellitus (DM). TB is one of the important causes of death, and DM affects the immune system which can increase the severity and mortality of the disease. This evidence-based case report was conducted to examine the mortality risk of tuberculosis patients with DM comorbidity. Methods: An article search was conducted to answer research questions based on 3 databases: PubMed, Cochrane, and ScienceDirect with the keywords “((Tuberculosis) AND (DM type 2) AND (Mortality))”. The search was based on inclusion and exclusion criteria and a critical review was conducted according to the guidelines for prognostic studies. Result: Tuberculosis patients with type 2 DM comorbidities have a 1.51 times higher risk of mortality compared to tuberculosis patients without type 2 DM comorbidities. Conclusion: Study by Huangfu, et al, (2019) can be the best choice to answer the clinical question that the risk of death of tuberculosis patients with comorbid DM increases by 1.51 times compared to patients without DM.
Profil Sosiodemografi Wanita Hamil dengan Infeksi Saluran Kemih: Sebuah Tinjauan Sistematis dari Penelitian Saat Ini: Analisis Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Kadarusman, Adib Kamil Putra; Binathara, Geraldus Sigap Gung; As’syifa, Salsa Billa; Hakim, Surahman
Cermin Dunia Kedokteran Vol 52 No 1 (2025): Obstetri & Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i1.1250

Abstract

Introduction: Untreated UTIs during pregnancy can lead to complications for both the mother and the fetus, highlighting the importance of appropriate management. Understanding the sociodemographic profiles of pregnant women with UTIs can aid in tailored interventions and care. Methods: This systematic review followed a protocol registered in the International Prospective Register of Systematic Reviews (PROSPERO ID: CRD42024507145). Cohort cross-sectional studies focusing on the sociodemographic profiles of pregnant women with UTI were systematically searched and selected from databases such as ScienceDirect, Cochrane, Scopus, and PubMed. Eligibility criteria included relevance to sociodemographic profiles, clear extraction and statistical analysis methods, and publication in English. Data extraction and study selection were conducted independently by six researchers, with any discrepancies resolved through discussion. Results: Three studies met the inclusion criteria and were included in the systematic review. The studies conducted in the United States, Cameroon, and Bangladesh, which included 46,398 pregnant women, revealed diverse sociodemographic factors associated with UTI risk among pregnant women. Factors such as low educational attainment, low household income, and racial/ethnic disparities were identified as significant contributors to UTI prevalence in the United States. In Cameroon, although a high UTI prevalence was observed, no significant risk factors were identified. In Bangladesh, maternal undernutrition, primiparity, and low paternal education were significant risk factors for UTIs among pregnant women. Antibiotic sensitivity was varied, indicating the complexity of UTI management. Conclusion: The systematic review emphasizes the importance of considering sociodemographic factors in understanding and addressing UTI risk among pregnant women. Socioeconomic status, cultural disparities, and health-related factors play significant roles in UTI prevalence and management. An intervention to target specific sociodemographic characteristics may be necessary to effectively prevent and manage UTIs in pregnant women across different geographical and socioeconomic contexts.
Exploring the link between coffee consumption and hypertension risk Hamid, Umar Abdul; Suryoadji, Kemal Akbar
Journal of Health and Therapy Vol. 3 No. 2 (2024): Journal of Health and Therapy
Publisher : Nur Science Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53088/jht.v3i2.2370

Abstract

The relationship between coffee consumption and hypertension remains controversial, with studies reporting neutral, harmful, or protective effects. Understanding this association is particularly relevant in Indonesia, where coffee consumption is culturally prevalent, and hypertension is a leading public health concern. A 58-year-old male presented for a routine health examination and was found to have Stage 1–2 hypertension (168/83 mmHg), despite being asymptomatic with no risk factors. His daily intake included two cups of coffee. Despite initial lifestyle modifications, including sodium restriction, his blood pressure remained elevated, necessitating pharmacological therapy. A structured literature search was conducted using PubMed, ScienceDirect, and Cochrane Library databases. Two systematic reviews and meta-analyses were performed using the defined PICO criteria and the PRISMA methodology. One review reported no significant association between caffeine intake and hypertension (RR: 0.97, 95% CI: 0.90–1.05), while another found a modest inverse relationship at higher coffee consumption levels (RR: 0.97, 95% CI: 0.94–0.99). Moderate habitual coffee consumption does not appear to increase hypertension risk and may have protective cardiovascular effects.
Analisis Faktor Kepatuhan Tenaga Kesehatan terhadap Vaksinasi Influenza A di Asia: Tinjauan Naratif Suryoadji, Kemal Akbar; Wardani, Arimbi Kusuma; Setyawan, Dhanis Adrianto; Faruqi , Muhammad; Susilo , Adityo; Pohan , Herdiman T.
Medical : Jurnal Kesehatan dan Kedokteran Vol 2 No 2 (2025): Juli-Desember 2025
Publisher : Yayasan Penelitian dan Pengabdian Masyarakat Sisi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69836/medical-jkk.v3i1.565

Abstract

Influenza A is a contagious respiratory disease with a high global burden, causing 3–5 million severe cases and up to 650,000 deaths annually. Healthcare workers have a higher risk of infection, especially if unvaccinated, which increases the likelihood of transmitting the virus to vulnerable patients. Although the WHO recommends annual vaccination, global coverage remains low (41.7%) and is even lower in Asia (28.5%). This narrative review synthesizes demographic, psychosocial, and institutional factors influencing influenza A vaccination compliance among healthcare workers in Asia. Literature searches were conducted in PubMed, Scopus, and Google Scholar for English- or Indonesian-language articles published from 2020 to 2025. Four primary studies met the inclusion criteria, all originating from China. Vaccination coverage among healthcare workers varied widely (1.36%–67.5%), while willingness to vaccinate was generally higher. Facilitating factors included increased risk perception, confidence in vaccine safety and effectiveness, and easy access to vaccines. Barriers included vaccine cost, safety concerns, low personal risk perception, insufficient information or training, and limited institutional support. Influenza A vaccination compliance among healthcare workers in Asia remains low and is influenced by a combination of individual and institutional factors. Multidimensional interventions, such as providing free vaccines, offering vaccination facilities in the workplace, enhancing education, and implementing strong institutional policies, are needed to improve vaccination coverage.
Determinants of Mortality in Epithelial Ovarian Cancer: Systematic Review and Meta-analysis (Last 5 Years) Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Mulansari, Nadia Ayu; Soloan, Garry; Sini, Kieran Pasha Ivan; Wulandari, Anisa Saphira; Arifa, Vira Nur; Masrie, Marshaly Safira; Faqih, Fahrayhansyah Muhammad; Wirawan, Bintang
Journal of Applied Holistic Nursing Science Vol. 2 No. 2 (2026): February 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jahns.v2i2.375

Abstract

ABSTRACT Background: Ovarian cancer, ranking third among gynecologic cancers, poses a significant global health challenge. Despite affecting over 239,000 annually and causing 150,000 deaths, the overall survival rate is 45.6%. Variability in survival rates across different stages necessitates a detailed understanding of contributing factors. This systematic review and meta-analysis explores recent research to illuminate crucial aspects influencing epithelial ovarian cancer (EOC) patient outcomes. Methods: A protocol registered in PROSPERO (ID: CRD42024502616) guided this systematic review, focusing on cohort studies examining prognostic factors for EOC mortality. Eligibility criteria included relevance to mortality risk, clear extraction methods, and English language. A PRISMA-guided search with the keywords “((Ovarian Cancer) AND (Mortality) AND (Risk)” across Scopus, PubMed, and Cochrane. Evaluation of 66,191 samples from 16 cohort studies identified several key prognostic factors for mortality in epithelial ovarian cancer (EOC). Results: Advanced FIGO stage (III-IV) and high-grade serous histology were significant predictors of higher mortality, with stage III-IV showing a risk ratio of 3.62 (95% CI 3.35–3.91). Older age, greater inflammation (higher BMI, smoking), and bilateral tumors also increased mortality risk. Additionally, lifestyle factors like reduced physical activity and rural living, as well as treatment-related factors such as perioperative red blood cell transfusion, were associated with poorer survival outcomes. This systematic review provides comprehensive insights into the complex landscape of EOC survival. Key prognostic factors for mortality in EOC patients include advanced cancer stage, high-grade serous histology, older age, inflammation, and bilateral tumors. Treatment factors such as perioperative transfusion and neoadjuvant chemotherapy intensity also play a critical role. Conclusion: These findings highlight the need for personalized treatment strategies based on these factors to improve survival outcomes for EOC patients.
Factors That Influence Endometriosis to Become a Malignancy: A Narrative Review Kusuma, Fitriyadi; Masrie, Marshaly Safira; Suryoadji, Kemal Akbar
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1431

Abstract

Endometriosis frequently affects women of reproductive age, and epidemiologic studies suggest it may be linked to an elevated risk of malignancy. Specific histopathological criteria characterise endometriosis-associated malignancy (EAM). Endometriosis-associated ovarian cancer (EAOC) accounts for about 80% of EAM occurrences, with the remaining 20% occurring outside the ovaries. Genetic mutations, including PTEN, ARID1A, and p53 alterations, are identified in endometriosis and EAM. Factors such as postmenopausal status, older age, and hypoestrogenic conditions have also been linked to higher risks of EAM and EAOC. Due to EAM's rarity, comprehensive data remains limited. This review examines current EAM research, focusing on EAOC and its clinical relevance.
Co-Authors Abdullah, Muhammad Raoul Taufiq Achmadsyah, Armand Adishabri, Ananda Kukuh Akmal Taher Ali, Najma Andayani, Gitalisa Andi Arus Victor Andi Darma Putra Andon Hestiantoro Anggaraeni, Tricia Dewi Arifa, Vira Nur As’syifa, Salsa Billa A’yun, Ilham Qurrota Bashirudin, Jenny Binathara, Geraldus Sigap Gung Bintang Wirawan Brastho Bramantyo Christian, Christopher Djatikusumo, Ari Fadhly, RM Ali Fakhri, Aldithya Faqih, Fahrayhansyah Muhammad Faruqi , Muhammad Faruqi, Muhammad Fauzi Ahmad Muda Firmansyah, Ugiadam Farhan Fitriyadi Kusuma Gatot Purwoto Hadinata, Valencia Hamid, Umar Abdul Hariyono Winarto Hutapea, Mario Marbungaran Ikrar Hermanadi, Muhammad Isfyanto, Isfyanto Kadarusman, Adib Kamil Putra Kartiwa Hadi Nuryanto Leonedine, Tengku Viona Zohra Masrie, Marshaly Safira Metasyah, Namira Muhammad Fachrurrozy Basalamah Nadia Ayu Mulansari, Nadia Ayu Nurfateen Ashadi, Dhiya Athaullah Pohan , Herdiman T. Ponco Birowo Pratama, Satria Arief Putra, Abdul Hafiidh Surya Putra, Elza Nur Warsa Ridwan, Alifaturrasyid Syafaatullah Ridwan, Alifaturrasyid Syafatullah Rycko, Nada Salsabila Setyawan, Dhanis Adrianto Simanjuntak, Kevin Tadeus Sini, Kieran Pasha Ivan Soloan, Garry Surahman Hakim Surya Putra, Abdul Hafiidh Susilo , Adityo Suskhan, Rizki Fauzi Sutanto, Reynardi Larope Theola, Jason Tricia Dewi Anggraeni Utami, Tofan Widya Wardani, Arimbi Kusuma Wibowo, Pramesti Kusumadini Widayat Alviandi Wismandari Wisnu Wulandari, Anisa Saphira Yudanta, Anggun Rama Yudantha, Anggun Rama Yudianto, Valentino Ryu Zahra, Reihana