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All Journal UNEJ e-Proceeding Nusantara Medical Science Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Alam dan Lingkungan Indonesian Journal of Obstetrics & Gynecology Science Alami Journal (Alauddin Islamic Medical) Journal Media Kesehatan Politeknik Kesehatan Makassar Jurnal Biomedika Jurnal Riset Kesehatan Poltekkes Depkes Bandung Celebes Health Journal Indian Journal of Forensic Medicine & Toxicology JUMANTIK (Scientific Journal of Health research) Majalah Anestesia & Critical Care (MACC) Physical Therapy Journal of Indonesia Journal of Clinical Microbiology and Infectious Diseases
Firdaus Hamid
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Development of a diagnostic scoring system for gouty arthritis of the knee: A retrospective case–control study Jorvin Kurniawan Tandiarta; Muhammad Sakti; Henry Yurianto; Firdaus Hamid; Idrus Andi Paturusi; Nur Rahmansyah
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.347

Abstract

Background: Gouty knee arthritis (GKA) is a frequent yet often under-recognised cause of knee pain, especially where synovial crystal analysis or advanced imaging is not readily available. This study aimed to design and validate a practical scoring system to aid the diagnosis of GKA in patients presenting with knee pain, by identifying key associated risk factors and supporting earlier clinical recognition. Methods: A retrospective case-control study was conducted involving 77 adults experiencing knee pain, with 38 cases of GKA and 39 controls. Risk factors for GKA were identified and analyzed through statistical methods to develop a predictive scoring system. Results: The analysis revealed several key risk factors associated with GKA. Older age showed a trend toward higher likelihood of GKA in univariable analysis (odd ratio (OR) = 1.08, 95% confidence interval (CI): 0.96–1.21), whereas in multivariable analysis only higher serum uric acid levels remained an independent predictor of GKA. Elevated serum uric acid levels were another strong predictor, with those having higher uric acid levels showing 2.48 times higher likelihood of developing GKA (OR = 2.48, 95% CI: 1.29-4.77). On the receiver operating characteristic (ROC) analysis, gender and history of medication did not show any discrimination towards GKA. The scoring system developed from variables such as age, serum uric acid, leukocyte count, erythrocyte sedimentation rate, periarthricular tophi, history of chronic diseases, history of alcohol consumption, and knee joint bilaterality showed excellent diagnostic performance. Additionally, the area under the curve (AUC) in the ROC analysis was 0.969 (0.933-1.000), which indicates a high level of accuracy in predicting GKA. When compared to traditional diagnostic method such as serum uric acid level (AUC = 0.938), the predictive model was superior. Conclusion: The newly developed scoring system offers an effective, non-invasive method for early detection of GKA, potentially improving clinical management and patient outcomes. For rehabilitation and physiotherapy practice, earlier recognition of gouty knee using this non-invasive score may support appropriate protection during inflammatory flares, guide progression of loading programmes, and help prioritize rheumatology or orthopaedic referral in patients with knee pain.
Diagnostic Challenges in Non-albicans Candida Bloodstream Infection in an Immunocompromised Patient: A Case Report Valentine Hursepuny; Yunialthy Dwia Pertiwi; Utma Laela Warka; Nadyah; Baedah Madjid; Andi Rofian Sultan; Mochammad Hatta; Firdaus Hamid
Journal of Clinical Microbiology and Infectious Diseases Vol. 6 No. 1 (2026): Available online : 1 June 2026
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v6i1.64

Abstract

Introduction: Candidemia has increased in recent years, leading to prolonged hospital stay, increased healthcare costs, and high mortality. Patients with underlying conditions such as malignancy and those requiring invasive medical devices are at higher risk of Candida bloodstream infection. Therefore, this study aims to describe a rare case of non-albicans Candida bloodstream infection in an immunocompromised patient, with emphasis on diagnostic challenges and clinical implications of discordant laboratory identification in guiding appropriate management. Case Description: A 48-year-old female with cervical cancer undergoing chemotherapy and hemodialysis via a right-thigh double-lumen catheter presented to the emergency department with prolonged vaginal bleeding, oliguria, nausea, and significant weight loss. Laboratory findings revealed leukocytosis and renal impairment. She received a combination of ceftazidime, moxifloxacin, and metronidazole in the ICU. The patient had multiple invasive devices, including intravenous catheters, parenteral nutrition, and urinary catheters. Blood culture performed on day 15 of hospitalisation identified Candida lipolytica, which was sensitive to voriconazole, amphotericin B, and flucytosine. Moreover, PCR and phylogenetic sequencing were performed to ensure accurate species identification. Despite the final identification and clinical management efforts, the patient’s clinical condition continued to deteriorate, and she eventually succumbed after three weeks of hospitalisation. Conclusion: This case highlights a rare non-albicans Candida bloodstream infection in an immunocompromised patient, emphasising the diagnostic challenges associated with accurate species identification. A stepwise diagnostic approach with culture, proteomic, and molecular confirmation, including PCR and phylogenetic analysis, is essential to ensure accurate identification and optimal clinical management.
Co-Authors A. Kaisar Adiwijaya Putra A.M. Takdir Musba Aan Yulianingsih Aan Yulianingsih Anwar Ade Rifka Junita Agussalim Bukhari Ahyar Ahmad Ahyar Ahmad Alamsyah Ambo Ala Husain Alfian Zainuddin Alfina Baharuddin Aminuddin Aminuddin Andi Alfian Zainuddin Andi Alfian Zainuddin Andi Asadul Islam Andi Ihwan Andi Meutiah Ilhamjaya Andi Nursanty Padjalangi Andi Rofian Sultan Andi Rofian Sultan Andi Zsazsa Rafiatul Mukhlis Arif Santoso Arif Santoso Arsyi Adliah Anwar Awaluddin Awaluddin Baedah Madjid Baedah Madjid Besse Afriana Arif Bukhari, Agussalim Burhanuddin Bahar Burhanuddin Bahar Burhanuddin Bahar Burhanuddin Bahar Dario A Nelwan Dianawaty Amiruddin Eddy Hartono Eddyman W Ferial Efendi Lukas Elizabeth Catherine Jusuf Erwin Chandra Evi Damayanti Faridha Ilyas Fatmawati Annisa Syamsuddin Febyan Rasmin Kotto Fonny Josh Hardjono Sumarlie Henry Yurianto Hursepuny, Valentine Idrus Andi Paturusi Irawati Djaharuddin Irawaty Djaharuddin Jorvin Kurniawan Tandiarta Junus Asiu Bulu Baan Kenny Edward Yap Khairuddin Djawad Lisa Tenriesa M. Sabir Madonna Damayanthie Datu Misriyani Misriyani Mochammad Hatta Mochammad Hatta Mochammad Hatta Mochammad Hatta Muh. Nasrum Massi Muh. Ramli Ahmad Muhammad Nassrum Massi Muhammad Reza Primaguna Muhammad Sakti Mustika Hutabarat Sari Mustika Sari Hutabarat Nadyah Nasrudin Andi Mappeware Nita Mariana Noor Ramadhaniah Novita Prastiwi Nur Indah Purnamasari Nur Rahmansyah Nur Surya Wirawan Nusratuddin Abdullah Priady Wira Prasetia Ressy Dwiyanti Rizalinda Sjahril Rizalinda Sjahril Rizalinda Sjahril Rizalinda Sjahril Rizalinda Sjahril Rosdiana Natzir Rossana Agus Sachraswaty Rachman Samrichard Rambulangi Sharvianty Arifuddin Siska Nuryanti Siti Fitrah Irmiyanti Hamid Solly Aryza Sri Wahyu Sri Wahyuni Sulmiati Sulmiati Suryani As’ad Syahruni Syahrir TOKA, WAHYUNITA DO Utma Laela Warka Valentine Hursepuny Veni Hadju Wahyuni Alinengsih Yoeke Dewi Rasita Yulfa Rizki Amita Yunialthy Dwia Pertiwi