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All Journal BALI MEDICAL JOURNAL (BMJ) International Journal of Biosciences and Biotechnology E-Jurnal Medika Udayana Majalah Kedokteran Bandung Medical Journal of Indonesia Journal of Biomedicine and Translational Research Indonesian Journal of Tropical and Infectious Disease Sari Pediatri Majalah Kesehatan FKUB Bali Journal of Anesthesiology ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Kedokteran Neurosains Indonesian Archives of Biomedical Research (InABR) Jurnal Locus Penelitian dan Pengabdian Journal of Clinical Microbiology and Infectious Diseases Neurona Jurnal Widya Medika
Ni Made Adi Tarini
Department Of Clinical Microbiology, Faculty Of Medicine, Udayana University, Sanglah General Academic Hospital, Denpasar
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Public Health Other

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Rare case of human Streptococcus suis purpura fulminans at Prof. Ngoerah Hospital, Denpasar, Bali Nara Dhany, Henri; Tarini, Ni Made Adi; Putrawan, Ida Bagus Putu; Pinatih, Komang Januartha Putra
Journal of Clinical Microbiology and Infectious Diseases Vol. 4 No. 2 (2024): Available online : 1 December 2024
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v4i2.63

Abstract

Background: Streptococcus suis (S. suis) is a zoonotic bacterium capable of causing severe infections in humans, particularly those with occupational exposure to pigs or pork products. Notable manifestations include meningitis, endocarditis, sepsis, and distinct skin conditions such as purpura and necrotic lesions. Southeast Asia reports the highest incidence, correlating with prevalent pig farming practices. Though infrequent, S. suis infections can lead to severe outcomes if not promptly diagnosed and treated. Case Presentation: We present a case involving a 73-year-old Balinese man without recent exposure to pigs or pork but with a history of pork consumption six months prior. He was admitted with symptoms including skin discoloration, respiratory distress, and loss of consciousness. Physical and laboratory examinations revealed pleural effusion, pneumonia, and high procalcitonin levels. Blood cultures identified S. suis, confirmed by VITEK® 2 system with susceptibility to multiple antibiotics, except tetracycline. Despite initial treatment with ceftriaxone, azithromycin, and levofloxacin; the patient’s condition deteriorated, resulting in a fatal outcome. Conclusion: This case underscores the importance of early diagnosis and rapid antibiotic intervention in S. suis infection. Delay in hospitalization significantly impacts prognosis, and timely, targeted treatment could improve survival rates. Enhanced awareness and preventive strategies in high-risk areas are vital to reducing the incidence and mortality associated with this infection.
DETEKSI BAKTERI ATIPIKAL DARI SWAB NASOFARING PENDERITA SEPSIS NEONATORUM DI RS WAHIDIN SUDIROHUSODO MENGGUNAKAN POLYMERASE CHAIN REACTION (PCR) MULTIPLEKS Fadhilah; Sjahril, Rizalinda; Hatta, Mochammad; Bahagia, Dwi; Alasiry, Ema; Tarini, Ni Made Adi
Majalah Kesehatan Vol. 11 No. 4 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.04.1

Abstract

Sepsis neonatorum merupakan penyebab signifikan kematian neonatorum dan morbiditas jangka panjang. Infeksi bakteri atipikal berperan penting dalam sepsis neonatorum, namun sulit dideteksi dengan teknik mikrobiologi konvensional. Penelitian ini bertujuan untuk mendeteksi bakteri atipikal yaitu Chlamydia trachomatis, Mycoplasma pneumonia, Legionella pneumophila dan Ureaplasma urealyticum dengan Polymerase Chain Reaction (PCR) multipleks dari swab nasofaring pasien sepsis neonatorum yang dirawat di RS Wahidin Sudirohusodo Makassar. Penelitian ini merupakan penelitian observasional deskriptif pada neonatus dengan dugaan sepsis. Neonatus yang diduga sepsis akan diambil swab nasofaring kemudian diperiksa untuk mendeteksi Chlamydia trachomatis, Mycoplasma pneumonia, Legionella pneumophila dan Ureaplasma urealyticum menggunakan PCR multipleks. Pemeriksaan pasien sepsis neonatorum yang dirawat di NICU RS Wahidin Sudirohusodo Makassar menggunakan sampel swab nasofaring pada bulan September 2022 hingga Juni 2023 menunjukkan bahwa dari 60 pasien yang diperiksa swab nasofaring, 8 (13,33%) pasien terdeteksi infeksi tunggal bakteri atipikal  yaitu Mycoplasma pneumonia, Chlamydia trachomatis dan Legionella pneumophila serta 12 pasien (20%) di antaranya adalah infeksi multipel yaitu Mycoplasma pneumoniae dan Chlamydia trachomatis; Legionella pneumophila dan Chlamydia trachomatis; Mycoplasma pneumoniae, Chlamydia trachomatis dan Legionella pneumophila. PCR merupakan modalitas yang menjanjikan untuk mendeteksi bakteri atipikal dari swab nasofaring pasien sepsis neonatorum yang sulit diidentifikasi dengan teknik konvensional. Hal ini sangat berguna untuk memberikan terapi yang cepat dan tepat pada pasien sepsis neonatorum.
Effect of Hypervirulent Strains, Antibiotic Resistance, and Host Characteristics on Mortality of Klebsiella pneumoniae Bacteremia Patients at a Tertiary Referral Hospital in Denpasar, Indonesia Adhy Candra, I Kadek Bayu; Suranadi, I Wayan; Darwinata, Agus Eka; Tarini, Ni Made Adi; Dharmika, Ida Ayu Gde Wahyudevi; Fatmawati, Ni Nengah Dwi
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3297

Abstract

Klebsiella pneumoniae bacteremia is one of the leading causes of sepsis that has a high mortality rate. The effect of multidrug resistance and different virulence of Klebsiella pneumoniae on mortality is still controversial. This study aimed to determine the impact of hypervirulent K. pneumoniae (hvKp), MDR, and clinical characteristics on mortality of K. pneumoniae bacteremia patients. A retrospective cross-sectional study was conducted on  K.  pneumoniae bacteremia cases of patients hospitalized at Professor dr. I.G.N.G Ngoerah General Hospital from December 1, 2020, to May 31, 2021. A positive PCR of rmpA, iucA genes, and/or a positive string test was identified as hvKp. The mortality rate of 51 K. pneumoniae bacteremia patients samples (aged 0-74 years) was 72.5%, in which 9.8% (5/51) of them were hvKp and 51% of the isolates (26/51) produced the Extended Spectrum Beta Lactamase (ESBL). Furthermore, 9.8% (5/51) of the cases were carbapenem-resistant. Thus, hvKp, MDR, gender characteristics, and comorbidities do not significantly affect the mortality of K. pneumoniae bacteremia patients. Multivariate logistic regression analysis showed that sepsis (odds ratio (OR) 4.29; p=0.038) and adult age group (mean 50 years) (OR 3.75; p=0.039) are independent predictors with a significant effect on mortality of  K. pneumoniae bacteremia patients. Careful and integrated management of K. pneumoniae bacteremia patients is essential for better outcomes, especially in sepsis and elderly patients. Although hvKp prevalence is low, emerging MDR-hvKp in health facilities is a severe concern for further actions and research.
Staphylococcus Aureus Colonization On An Erythrodermic Psoriasis Patient Dave Gerald Oenarta; NN Sri Budayanti; NN Dwi Fatmawati; NM Adi Tarini
JURNAL WIDYA MEDIKA Vol. 5 No. 2 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i2.2204

Abstract

Skin plays an important role as the physical barrier and first-line immunological defense against dangerous stimuli, including bacteria. Erythroderma is a condition of excessive skin irritation causing extensive erythema and desquamation. Erythroderma itself is caused by various underlying conditions, one of them is psoriasis vulgaris. In erythroderma, there is an extensive disruption of physical barrier leading to the exposure of various bacteria, including Staphylococcus aureus. In human, this bacteria can either colonize or infect the host if exposed to open wound. It is essential to determine this as it will affect the necessity of administering antibiotics. Laboratory examinations such as complete blood count, Gram staining, and culture can help to determine the status of this bacteria. A correlation between clinical features and laboratory examinations is paramount in deciding patient management.
Tuli Sensorineural Pasca Meningitis Streptococcus Suis: Sebuah Topik Kajian Strategis Bidang Ilmu Neuroinfeksi Sudewi, AA Raka; Pramitasuri, Tjokorda Istri; Susilawathi, Ni Made; Adi Tarini, Ni Made; Mahardika, I Gusti Ngurah Kade; Sukrama, I Dewa Made
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.341

Abstract

Sensorineural deafness as a result of Streptococcus suis (S. suis) meningitis is a serious hazard to worldwide public health and one of the strategic study concerns in neuroscience. There is currently no treatment plan for sensorineural deafness brought on by S. suis meningitis that can significantly enhance quality of life. Controlling S. suis meningitis-related sensorineural deafness is therefore vital for the area of neurology. This review of the literature seeks to provide an overview of the scientific literature on the epidemiology, etiology, and features of deafness as they pertain to sensorineural hearing loss brought on by S. suis meningitis. Spiral Ganglion Neurons, hair cells in the cochlea, and brain-derived neurotrophic factor in the peripheral auditory system interact with one another in the etiology of sensorineural deafness, according to recent studies.
Uji In Silico Potensi Senyawa Aktif pada Daun Cempaka Putih (Magnolia Alba) Berbasis Molecular Docking Sebagai Antituberkulosis Widhanti, Arin Arnaz; Darwinata, Agus Eka; Tarini, Ni Made Adi; Dwija, Ida Bagus Nyoman Putra
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 12 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i12.5106

Abstract

Resistance to Isoniazid (INH), primarily caused by mutations in the katG gene responsible for drug activation, remains a significant challenge in the treatment of tuberculosis (TB) and contributes to the global burden of drug-resistant TB. This challenge has stimulated the search for alternative therapeutic strategies, particularly the development of direct inhibitors of Enoyl-Acyl Carrier Protein Reductase (InhA), which can bypass the katG-dependent activation pathway. This study aimed to evaluate the potential of ten selected bioactive compounds derived from Magnolia alba (white champaca) leaves as direct InhA inhibitors using an in silico approach. Molecular docking analysis was performed to assess the binding affinity and interaction patterns of the selected compounds with the InhA protein, with Isoniazid used as a reference control. The results showed that among the ten compounds tested, Michelenolide exhibited the strongest binding affinity, with a docking score of ?9.1 kcal/mol. Although this value did not exceed the binding affinity of Isoniazid (?9.6 kcal/mol), Michelenolide demonstrated comparable interaction stability and a binding mechanism consistent with direct InhA inhibition. These findings suggest that Michelenolide holds promise as a lead compound for the development of novel anti-tuberculosis agents targeting INH-resistant Mycobacterium tuberculosis strains. Nevertheless, preliminary toxicity predictions indicate potential carcinogenic and mutagenic risks, highlighting the need for further structural optimization, in vitro validation, and pharmacological evaluation before clinical consideration.
Co-Authors Adhy Candra, I Kadek Bayu Agung Wiwiek Indrayani Agus Eka Darwinata Anak Agung Indah Jayanthi Andi Yasmon Bagus Ngurah Putu Arhana Bahagia, Dwi Dave Gerald Oenarta Dharmika, Ida Ayu Gde Wahyudevi Dwija, Ida Bagus Nyoman Putra Ema Alasiry, Ema Fadhilah Fera Ibrahim GNR Suwardana Gusti Ayu Putu Sri Satya Mahayani I Dewa Made Sukrama I Gusti Ayu Agung Praharsini I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Kade Mahardika I Gusti Ngurah Krishna Priyaka I Komang Kari I Made Arimbawa I Putu Bayu Mayura I Putu Bayu Mayura I Wayan Gustawan I Wayan Suranadi I. K. Sukardika I.K. Suata Ida Bagus Budhi Astawa Ida Bagus Gede Suparyatha Ida Bagus Putu Putrawan Ida Bagus Subanada Ida Sri Iswari Ika Nurvidha Mahayanthi Mantra Komang Januartha Putra Pinatih Komang Reno Sutama Luh Putu Happy Sandha Made Gede Dwi Lingga Utama Maharani, Ida Ayu Komang Ananta Mardiastuti H Wahid MAYURA, I PUTU BAYU - Mochammad Hatta Nara Dhany, Henri Ni Nengah Dwi Fatmawati Ni Nyoman Sri Budayanti Ni Putu Siadi Purniti Ni Putu Sriwidyani Ni Putu Wirantari NMRP Dewi Pramitasuri, Tjokorda Istri Pusaka, Semerdanta Raka-Sudewi A. A. Riza Linda Samsuridjal Djauzi Sathya Deva, I Dewa Gde Susilawathi, Ni Made Tjokorda Istri Pramitasuri Violentina, Gusti Ayu Dianti Widhanti, Arin Arnaz YULIANDARI, PUTU