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ANDRIA AGUSTA
Research Center For Biology, Indonesia Institute Of Sciences (LIPI), Cibinong, Bogor 16911, Indonesia
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Journal : BERITA BIOLOGI

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KOMPOSISI KIMIA MINYAKASTIRI PALA WEGIO {Myristica fatua Houtt.) Jamal, Yuliasri; Agusta, Andria
BERITA BIOLOGI Vol 7, No 3 (2004)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.456 KB) | DOI: 10.14203/beritabiologi.v7i3.1065

Abstract

Aril and seeds of "pala wegio" {Myristica fatua Houtt),as one of endemic plants from Moluccas, contained 0.81% and 0.73%essential oils respectively.Gas Chromatography & Mass Spectrometry (GCMS) analyses indicated two similar major components (>10%) in aril and seeds essential oils of "pala wegio", (-) a-Copaene (aril 36.11% & seeds 29.81%) and caryophyllene (aril 18.05% & seeds 34.62%).However, the seeds essential oil had the third major component unindentified with 17.58% content.
FITOKIMIA DAN FARMAKOLOGI CENDANA (Santalum album L.) Agusta, Andria; Jamal, Yuliasri
BERITA BIOLOGI Vol 5, No 5 (2001)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.015 KB) | DOI: 10.14203/beritabiologi.v5i5.1463

Abstract

Dalam peradaban timur, cendana telah digunakan secara tradisional semenjak 4000 tahun yang Ialu. Minyak atsiri yang diperoleh dari kayu cendana digunakan dalam upacara keagamaan dan sebagai obat-obatan. Dalam kebudayaan barat, cendana hanya digunakan sebagai bahan parfum kelas utama. Bam setelah tahun 1920-an, sejalan dengan perkembangan aromaterapi, bangsa barat mulai memanfaatkan cendana sebagai bahan obat-obatan. Minyak atsiri adalah substansi kimia yang membuat cendana menjadi berharga, baik secara ekonomi, bahan obat dan bahan parfum. Setiap bagian tumbuhan cendana memiliki kandungan minyak atsiri yang bervariasi. Bagian akar memiliki kandungan minyak tertinggi, yaitu 10 %, kemudian diikuti oleh bagian teras batang (4-8 %) dan ranting (2-4 %). Delapan puluh sampai 90% dari minyak cendana terdiri dari senyawa santalol dengan isomer a-santalol dan p-santalol sebagai komponen utama. Dalam perdagangan intemasional, minyak cendana kelas satu haruslah mengandung santalol minimal 90% dari kandungan total minyaknya. Dalam aromaterapi minyak cendana dikenal sebagai salah satu bahan alami yang berkhasiat sebagai sedatif, relaksasi dan mengatasi kasus insomnia serta serangan asma. Laporan terakhir juga menyebutkan bahwa minyak cendana bersifat menghalangi efek karsinogenik dari zat kimia. Alpha-santalol sebagai komponen utama minyak cendana dapat mengurangi kasus papiloma (tumor kulit) sebesar 32 %.
TOKSISITAS AKUT ORAL DUA SENYAWA BISANTRAKUINON (+)-2,2’-EPISITOSKIRIN A DAN (+)-1,1’-BISLUNATIN [ORAL ACUTE TOXICITY OF TWO BISANTHRAQUINONES (+)-2,2’-EPICYTOSKYRIN A AND (+)-1,1’-BISLUNATIN] Praptiwi, Praptiwi; Nurkanto, Arif; Wulansari, Dewi; Agusta, Andria
BERITA BIOLOGI Vol 14, No 1 (2015)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v14i1.1858

Abstract

Bisanthraquinones (+) - 2,2'-epicytoskyrin A and (+) -1,1'bislunatin produced by the endophytic fungus Diaporthe sp. GNBP-10 showed potent antibacterial activity on in-vitro test and have the opportunity to become new antibiotics candidates. The aspects of safety and toxicity of drug candidates have to be examined before applying to human. This study was conducted to determine the safety aspects of the compounds through acute oral toxicity testing in mice (Mus musculus). Acute toxicity of (+) - 2,2'-epicytoskyrin A and (+) - 1,1'-bislunatin evaluated by the method of Up and Down Procedure with limit test at a dose of 2000 mg / kg. Results of acute toxicity test showed that the LD50 of (+) - 2,2'-epicytoskyrin A and (+) - 1,1'-bislunatin were of 1638.87 mg / kg and > 2000 mg / kg respectively. Administration of (+)- 2,2'-epicytoskyrin A resulted in increased miliari multifocal hepatitis, fatty degeneration and necrosis of liver cells, and the renal tubule epithelial degeneration. Administration of (+) - 1,1'-bislunatin at a dose of 2000 mg / kg resulted in multifocal accumulation of inflammatory cells in the liver and degeneration of cells in the islets of Langerhans although not resulting in death. The administration of those compounds indicated the changes in the organs, but based on the UN/ECE classification of LD50 value showed that (+) 2,2'- epicytoskyrin A and (+) -1,1'-bislunatin included as low acute toxicity substance.
SKRINING AWAL AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN EKSTRAK SEMUT (INSECTA: FORMICIDAE) DARI GARUT - JAWA BARAT Efendy, Oscar; Fathoni, Ahmad; Praptiwi, Praptiwi; Royyani, Mohammad Fathi; Wulansari, Dewi; Agusta, Andria
BERITA BIOLOGI Vol 18, No 2 (2019)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v18i2.3621

Abstract

Studies on the therapeutic use of insects and insect products have been neglected compared to the use of other animals or plants.This study aims to determine the antibacterial and antioxidant potential of ants extracts. Preliminary study related to antibacterial and antioxidant screeningof 17 extracts of ant colonies that belongs to 8 species were performed by Thin Layer Chromatography (TLC)-Bioautography. Antioxidant activity was measured by DPPH free radical scavenging method. The antibacterial activity was done against three pathogenic bacteria, i.e Bacillus subtilis InaCC B-1, Staphylococcus aureus InaCC B-4 and Escherichia coli InaCC B-5 were performed by non-eluted TLC-autobiography assay. The minimum inhibitory concentration (MIC) and IC50 values of DPPH radical scavenging activity of active extracts were determined by microdilution in 96-well microplate. The results showed 6 extracts active against B.subtilis, 5 extracts active against S.aureus. The lowest MIC value was 512 µg/ ml.  Ten extracts had the antioxidant activity with various IC50 values. The extracts of ants might be used as bioactive resources for antibacterial and antioxidant.  
ANALISIS KOMPONEN KIMIA DAUN WATI {PIPER METHYSTICUM FORST. F) Agusta, Andria; Jamal, Yuliasri; Chairul, Chairul
BERITA BIOLOGI Vol 4, No 2&3 (1998)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v4i2&3.1276

Abstract

Wati(Piper methysticum Forst.f.)leaves has been used as narcotic in some parts of Irian Jaya since longtime ago. The GCMS analysis of wati leaves organic extracts(hexane,chloroform, methanol)has detected 48 components consisted alkanes,oxygenated hydrocarbons, fatty acid, steroids and alkaloids,including 5 major components, i.e. dihydro kawain,anisol p-undecyl, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-on, levulinic acid and one of unknown component.Forty-three other minor components will be discussed.
SKRINING DAN ISOLASI METABOLIT AKTIF ANTIBAKTERI KULTUR JAMUR ENDOFIT DARI TUMBUHAN Albertisia papuana Becc. Ahmad Fathoni; Muhammad Ilyas; Antonius Herry Cahyana; Andria Agusta
BERITA BIOLOGI Vol 12, No 3 (2013)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v12i3.639

Abstract

Totally 15 isolates of endophytic fungi were obtained from leaves and young stems of a medicinal plant Albertisia papuana Becc.(Menispermaceae). The antibacterial screening of the ethyl acetate extract derived from the fungi cultures in potato dextrose broth (PDB)were performed on a non eluted Thin Layer Chromatography Bioautography assay (TLC bioautography assay). From the screening test, itwas found that the ethyl acetate extract of the fungus Xylaria sp. DAP-KRI-5 culture showed strong antibacterial activity against Staphylococcus aureus. The isolation of active metabolite based on the bioautography guided assay from ethyl acetate extract of the Xylaria sp. DAP-KRI-5, led us to identify phloroglucinol as a main antibacterial compound. The chemical structure of phloroglucinol was deduced from it spectral data, including UV-Vis, 1H and 13C-NMR, GC-MS and published data elsewhere.
AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN EKSTRAK IXORA CUMINGIANA Kartika Dyah Palupi; Praptiwi Praptiwi; Dewi Wulansari; Andria Agusta
BERITA BIOLOGI Vol 19, No 1 (2020)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v19i1.3777

Abstract

Plants from Ixora genus exhibit a variety of pharmacological activities including antioxidant, antibacterial, and antitumor activities. This plants may contain many interesting bioactive compounds, especially phenolics and terpenoids groups. Ixora cumingiana is one of the Ixora species whose pharmacological effect has not been explored comprehensively. This study aimed to evaluate the antibacterial and antioxidant activity of eight extracts from bark and leaf of I. cumingiana. The plant samples were successively extracted using n-hexane, dichloromethane, ethyl acetate and methanol. The antibacterial evaluation was carried out against Staphylococcus aureus and the antioxidant activity was evaluated using a radical scavenging assay against 1,1-diphenyl-2-picrylhydrazyl (DPPH). Initial activity screening was performed using thin layer chromatography-bioautography followed by the determination of minimum inhibitory concentration (MIC) and the determination of antioxidant activity index (AAI) using microdilution technique. The dichloromethane extract of the bark as well as the n-hexane and dichloromethane extract of the leaf of I. cumingiana exhibited moderate antibacterial effect with MIC value of 128, 128, and 256 µg/ml, respectively. The methanol extract from the bark displayed a strong antioxidant activity (AAI = 1.5±0.13) and possessed the highest total phenolic content (43±0.91 mg AGE/ g extract). These experimental results showed that I. cumingiana is potential to be developed as an antioxidant agent rather than as an antibacterial agent. 
KOMPOSISI KIMIA MINYAKASTIRI PALA WEGIO {Myristica fatua Houtt.) Yuliasri Jamal; Andria Agusta
BERITA BIOLOGI Vol 7, No 3 (2004)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v7i3.1065

Abstract

Aril and seeds of "pala wegio" {Myristica fatua Houtt),as one of endemic plants from Moluccas, contained 0.81% and 0.73%essential oils respectively.Gas Chromatography & Mass Spectrometry (GCMS) analyses indicated two similar major components (>10%) in aril and seeds essential oils of "pala wegio", (-) a-Copaene (aril 36.11% & seeds 29.81%) and caryophyllene (aril 18.05% & seeds 34.62%).However, the seeds essential oil had the third major component unindentified with 17.58% content.
KOMPOSISI MINYAK ATSIRI DARI TIGA JENIS TUMBUHAN RUTACEAE Andria Agusta; Yuliasri Jamal
BERITA BIOLOGI Vol 4, No 5 (1999)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v4i5.1251

Abstract

Rutaceae is one of the essential oil resources that is very potential for medicinal, perfumery and other use This study was conducted to analyze the essential oil components resulted from water distillation of kalamanjarik leaves (Micromelum minutum), jeruk \epara leaves ILimnocitrus litoralis) and the leaves and the stem bark of malapotung (Evodia qlabra). The results showed the leaves of kalamanjarik contained approximately 0,70%, jeruk jepara 0,21%, malapotung leaves 0,17% and the stem bark contained 0,50 % essential oils. GCMS analyses of the essential oils gave 3 major components of kalamanjarik leaves i.e /J-pinene (24,41%j, bergamiol (23,01%) and nerolidol (18,90%) and 2 major components of jeruk jepara leaves i.e fl-mircene (70.55) and /t-pinene (24,06 %). Essential oil of malapotung leaves consisted of 39,8J% ct-pinene, 14,26 % 1aR(1aa,4a/3,7a,7aa,7ba)decahydro -1,1,7-lrimethyl-4-methylene-1H-cycloprope azulene and 16,62% S-cadinene as major components, while the stem bark had only one major component, u-pinene (68,37 %) The minor components of the four essential oils will be discussed.
FITOKIMIA DAN FARMAKOLOGI CENDANA (Santalum album L.) Andria Agusta; Yuliasri Jamal
BERITA BIOLOGI Vol 5, No 5 (2001)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v5i5.1463

Abstract

Dalam peradaban timur, cendana telah digunakan secara tradisional semenjak 4000 tahun yang Ialu. Minyak atsiri yang diperoleh dari kayu cendana digunakan dalam upacara keagamaan dan sebagai obat-obatan. Dalam kebudayaan barat, cendana hanya digunakan sebagai bahan parfum kelas utama. Bam setelah tahun 1920-an, sejalan dengan perkembangan aromaterapi, bangsa barat mulai memanfaatkan cendana sebagai bahan obat-obatan. Minyak atsiri adalah substansi kimia yang membuat cendana menjadi berharga, baik secara ekonomi, bahan obat dan bahan parfum. Setiap bagian tumbuhan cendana memiliki kandungan minyak atsiri yang bervariasi. Bagian akar memiliki kandungan minyak tertinggi, yaitu 10 %, kemudian diikuti oleh bagian teras batang (4-8 %) dan ranting (2-4 %). Delapan puluh sampai 90% dari minyak cendana terdiri dari senyawa santalol dengan isomer a-santalol dan p-santalol sebagai komponen utama. Dalam perdagangan intemasional, minyak cendana kelas satu haruslah mengandung santalol minimal 90% dari kandungan total minyaknya. Dalam aromaterapi minyak cendana dikenal sebagai salah satu bahan alami yang berkhasiat sebagai sedatif, relaksasi dan mengatasi kasus insomnia serta serangan asma. Laporan terakhir juga menyebutkan bahwa minyak cendana bersifat menghalangi efek karsinogenik dari zat kimia. Alpha-santalol sebagai komponen utama minyak cendana dapat mengurangi kasus papiloma (tumor kulit) sebesar 32 %.
Co-Authors A.A. Ketut Agung Cahyawan W Agus Budiawan Naro Putra Ahmad Fathoni AHMAD FATHONI Ahmad Fathoni Andi Saptaji Kamal Anita, Syahfitri Antonius Herry Cahyana Antonius Herry Cahyana ARIEF NURKANTO Arif Nurkanto Arif Nurkanto Arif Nurkanto Atit Kanti Chairul Chairul Chairul Chairul DEWI WULANSARI Dewi Wulansari Dwinna Rahmi Edi Santosa Efendi, Darda Efendi, Oscar Efendi, Sintia Frisky Efendy, Oscar Efendy, Oscar Effendi, Oscar Elsera Br Tarigan, Elsera Br Evana Evana, Evana - Farida, Yunahara Hafid, Lukman Hartutiningsih-M. Siregar HEDDY JULISTIONO Heddy Julistiono Herjuno Ari Nugroho, Herjuno Ari Inanpi Hidayati Sumiasih, Inanpi Hidayati Kamal, Andi Saptaji Kartika D. Palupi Kartika Dyah Palupi Kartika Dyah Palupi Kartika Dyah Palupi Keim, Ary P Koraag, Alfa Michael Gabriel Lestari, Vera Budi lina marlina, lina Listyaningsih, Febrianti Listyaningsih, Febrianti Marlin Megalestin Raunsai Mohammad Fathi Royyani, Mohammad Fathi Muhamad Ilyas Muhamad Ilyas, Muhamad Muhammad Ilyas Muhammad Ilyas N.L.P. Rischa Phadmacanty Octavia Siti Nurhayati Palupi, Kartika D. Pariwidjayanti, Aris Medta Pariwidjayanti, Aris Medta Partomuan Simanjuntak Phadmacanty, N.L.P. Rischa Pipit Irawati Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi, Praptiwi, - Pratiwi Pratiwi Putra, Aldho Pramana Putri, Ade Lia R. Subekti Purwantoro Rahmat Budiarto Rahmawati Ridwan Raunsai, Marlin Megalestin Roedhy Poerwanto Rofiq, Muhamad Abdul Royani, M Fathi S. Achmadi, Suminar S. Achmadi, Suminar Siti Aisyah Sri Yuliani SUDARMONO SUDARMONO Suryati Suryati Tarigan, Elsera Br. Taruna Shafa Arzam, Taruna Shafa Tiwi, Praptiwi Wartika Rosa Farida WELLYZAR SJAMSURIDZAL Yuliasri Jamal YULIASRI JAMAL