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ANDRIA AGUSTA
Research Center For Biology, Indonesia Institute Of Sciences (LIPI), Cibinong, Bogor 16911, Indonesia
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Chemical Compositions and Antibacterial Effect of Essential Oil of Key Lime Leaves (Citrus Aurantifolia Swingle: Rutaceae) Jamal, Yuliasri; Pariwidjayanti, Aris Medta; Agusta, Andria
ANNALES BOGORIENSES Vol 16, No 2 (2012): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3848.842 KB) | DOI: 10.1234/67

Abstract

Steam distillation of essential oil from fresh leaves of Key Lime (Citrus aurantifolia Swingle) gave 0.4% yellow essential oil with distinctive fragrance. Five out of 40 components of the essential oil were identified as the major components with content above 5%, they were geranial (10.3%), limonene (10.2%), neral (8.94%), caryophyllene (5.72%), and citronellal (5.41%). The essential oil was active against four bacterial test, Bacillus subtilis NBRC 3134, Staphylococcus aureus NBRC 14276, Micrococcus luteus NBRC 14218, and Escherecia coli NBRC 14237. B. Subtilis was the most sensitive bacterium with the widest inhibition area at 50% concentration of essential oil. Minimum Inhibition Concentration (MIC) value of essential oil against B. Subtilis was 0.125%.
ANTIBACTERIAL SCREENING OF THE CULTURE OF ENDOPHYTIC FUNGAL EXTRACTS ISOLATED FROM CINNAMON STICK (Cinnamomum burmannii [Nees & T. Nees] Blume) Praptiwi, -; Ilyas, Muhammad; Wulansari, Dewi; Agusta, Andria
Teknologi Indonesia Vol 38, No 1 (2015)
Publisher : LIPI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jti.v38i1.159

Abstract

Pathogenic bacterial resistance to antibacterial agents used in the treatment of recent formal systems have undergone significant increase. It is necessary to get a source of new antibacterial agents to overcome resistance. Endophytic fungi have been known as one of the organisms that have the ability to produce a variety of bioactive metabolites. In this study, 26 endophytic fungi have been isolated from various parts of Cinnamomum burmannii plant. The results of antibacterial activity screening of endophytic fungal extracts byTLC bioautography method without elution showed that as many as 18 extracts inhibited the growth of Staphylococcus aureus InaCC-B4 with the diameter of inhibition zone (DIZ) were in the range of 5.00 to 16.00 mm. On the other hand, the number of extracts that could inhibit the growth of Escherichia coli InaCC-B5 were 24 extracts with the DIZ were in the range of 4.00 to 28.00 mm. A detailed analysis of eluted TLC-bioautography method showed the chemical compounds of extracts that were responsible for antibacterial activity.
Production, Post-Harvest and Marketing of Kaffir Lime (Citrus hystrix DC) In Tulungagung, Indonesia Budiarto, Rahmat; Poerwanto, Roedhy; Santosa, Edi; Efendi, Darda; Agusta, Andria
Journal of Tropical Crop Science Vol 6 No 02 (2019): Journal of Tropical Crop Science
Publisher : Department of Agronomy and Horticulture, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.259 KB) | DOI: 10.29244/jtcs.6.02.138-143

Abstract

Kaffir lime (Citrus hystrix DC) is one of the Citrus species that is popular as food spices in Indonesia. This study was aimed at describing the production system, post-harvest handling, marketing and evaluating the product variation of kaffir lime cultivated in the Tulungagung district, East Java Province, Indonesia. Data was collected through a survey by interviewing kaffir lime farmers, distributors and customers in June 2018. Kaffir lime is cultivated by local farmers using traditional and conventional agriculture practices. The farmer used good quality seedlings as planting materials and applies animal manure or compost to the trees. Kaffir lime is grown on rain-fed land; fertilizers and pesticides are applied sparingly. The kaffir lime leaves could be harvested twice a year in different seasons. Better leaf quality can be obtained during the rainy seasons. The leaf production per tree is estimated at about 100 gram per plant per season. Post-harvest handling involved sorting, packing and marketing without any cooling treatment. The standard gate price of kaffir lime leaf in June 2019 was IDR 6,000-7,000, IDR 9,000-10,000 at the collector level, IDR 11,000-12,000 at wholesaler, and IDR 14,000-16,000 at small retailers. Leaves were distributed to traditional market in Tulungagung, neighbouring districts such as Kediri, Trenggalek and Blitar, and also to capital cities such Jakarta. The main product of kaffir lime is the fresh leaf for food seasoning and as a raw material to produce essential oil and dry leaf powder. The stems have been used for fuel in home industries. The fruits of kaffir lime are rarely found in the market and have great potentials for essential oil production and recently, a promising commodity for export.
FITOKIMIA DAN FARMAKOLOGI CENDANA (Santalum album L.) Agusta, Andria; Jamal, Yuliasri
BERITA BIOLOGI Vol 5, No 5 (2001)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.015 KB) | DOI: 10.14203/beritabiologi.v5i5.1463

Abstract

Dalam peradaban timur, cendana telah digunakan secara tradisional semenjak 4000 tahun yang Ialu. Minyak atsiri yang diperoleh dari kayu cendana digunakan dalam upacara keagamaan dan sebagai obat-obatan. Dalam kebudayaan barat, cendana hanya digunakan sebagai bahan parfum kelas utama. Bam setelah tahun 1920-an, sejalan dengan perkembangan aromaterapi, bangsa barat mulai memanfaatkan cendana sebagai bahan obat-obatan. Minyak atsiri adalah substansi kimia yang membuat cendana menjadi berharga, baik secara ekonomi, bahan obat dan bahan parfum. Setiap bagian tumbuhan cendana memiliki kandungan minyak atsiri yang bervariasi. Bagian akar memiliki kandungan minyak tertinggi, yaitu 10 %, kemudian diikuti oleh bagian teras batang (4-8 %) dan ranting (2-4 %). Delapan puluh sampai 90% dari minyak cendana terdiri dari senyawa santalol dengan isomer a-santalol dan p-santalol sebagai komponen utama. Dalam perdagangan intemasional, minyak cendana kelas satu haruslah mengandung santalol minimal 90% dari kandungan total minyaknya. Dalam aromaterapi minyak cendana dikenal sebagai salah satu bahan alami yang berkhasiat sebagai sedatif, relaksasi dan mengatasi kasus insomnia serta serangan asma. Laporan terakhir juga menyebutkan bahwa minyak cendana bersifat menghalangi efek karsinogenik dari zat kimia. Alpha-santalol sebagai komponen utama minyak cendana dapat mengurangi kasus papiloma (tumor kulit) sebesar 32 %.
KERAGAMAN JENIS JAMUR ENDOFIT PADA PANDAN WANGI (PANDANUS AMARYLIFOLIUS) DAN AKTIVITAS ANTIJAMUR METABOLIT YANG DIPRODUKSINYA Jamal, Yuliasri; Ilyas, Muhamad; Kanti, Atit; Agusta, Andria
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 14, No 2 (2009): June 2009
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (351.303 KB) | DOI: 10.24002/biota.v14i2.2685

Abstract

The whole nine isolates of endophytic fungi have been obtained from leaves and roots of pandan wangi (Pandanus amarylifolius) collected from Bogor Botanical Garden. Identification of the fungi isolates were conducted based on their morphological characteristics, and revealed that one fungus belongs to the genus of Fusarium, one of Dreschlera, and 7 fungi isolates belong to Coelomycetes. The ethyl acetate extract of the fungi cultures in PDB and GYP media showed a diverse secondary metabolite profiles. Ethyl acetate extract derived from the culture of PWA-2 fungus in GYP medium showed an antifungal activity against Saccharomyces cerevisiae, but not to Fusarium oxysporum and Candida tropicalis. The GC-MS analysis of the active extract showed eugenol as an active component.
Produksi Metabolit Utama (-)-Citrinin, pada Kultur Jamur Endofit Penicillium sp dari Tanaman Teh Agusta, Andria; Jamal, Yuliasri
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 13, No 3 (2008): October 2008
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.756 KB) | DOI: 10.24002/biota.v13i3.2570

Abstract

Endophytic fungi have been recognized as source of broad range biological active metabolites with high chemical structure diversity. The purpose of this research is to isolate and characterize major metabolite produce by the endophytic fungi Penicillium sp isolated from a tea plant. Cultivation of endophytic fungus Penicillium sp (AB2245443) in liquid medium PDB on a rotary shaker at 100 rpm, temperature 25 – 30oC for 7 days, produced a yellow metabolite. Separation of metabolite through chromatography technique and followed by chemical structure elucidation based on MS, IR, NMR spectra and published data showed that the yellow metabolite is (-)-citrinin.
TOKSISITAS AKUT ORAL DUA SENYAWA BISANTRAKUINON (+)-2,2’-EPISITOSKIRIN A DAN (+)-1,1’-BISLUNATIN [ORAL ACUTE TOXICITY OF TWO BISANTHRAQUINONES (+)-2,2’-EPICYTOSKYRIN A AND (+)-1,1’-BISLUNATIN] Praptiwi, Praptiwi; Nurkanto, Arif; Wulansari, Dewi; Agusta, Andria
BERITA BIOLOGI Vol 14, No 1 (2015)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v14i1.1858

Abstract

Bisanthraquinones (+) - 2,2'-epicytoskyrin A and (+) -1,1'bislunatin produced by the endophytic fungus Diaporthe sp. GNBP-10 showed potent antibacterial activity on in-vitro test and have the opportunity to become new antibiotics candidates. The aspects of safety and toxicity of drug candidates have to be examined before applying to human. This study was conducted to determine the safety aspects of the compounds through acute oral toxicity testing in mice (Mus musculus). Acute toxicity of (+) - 2,2'-epicytoskyrin A and (+) - 1,1'-bislunatin evaluated by the method of Up and Down Procedure with limit test at a dose of 2000 mg / kg. Results of acute toxicity test showed that the LD50 of (+) - 2,2'-epicytoskyrin A and (+) - 1,1'-bislunatin were of 1638.87 mg / kg and > 2000 mg / kg respectively. Administration of (+)- 2,2'-epicytoskyrin A resulted in increased miliari multifocal hepatitis, fatty degeneration and necrosis of liver cells, and the renal tubule epithelial degeneration. Administration of (+) - 1,1'-bislunatin at a dose of 2000 mg / kg resulted in multifocal accumulation of inflammatory cells in the liver and degeneration of cells in the islets of Langerhans although not resulting in death. The administration of those compounds indicated the changes in the organs, but based on the UN/ECE classification of LD50 value showed that (+) 2,2'- epicytoskyrin A and (+) -1,1'-bislunatin included as low acute toxicity substance.
SKRINING AWAL AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN EKSTRAK SEMUT (INSECTA: FORMICIDAE) DARI GARUT - JAWA BARAT Efendy, Oscar; Fathoni, Ahmad; Praptiwi, Praptiwi; Royyani, Mohammad Fathi; Wulansari, Dewi; Agusta, Andria
BERITA BIOLOGI Vol 18, No 2 (2019)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v18i2.3621

Abstract

Studies on the therapeutic use of insects and insect products have been neglected compared to the use of other animals or plants.This study aims to determine the antibacterial and antioxidant potential of ants extracts. Preliminary study related to antibacterial and antioxidant screeningof 17 extracts of ant colonies that belongs to 8 species were performed by Thin Layer Chromatography (TLC)-Bioautography. Antioxidant activity was measured by DPPH free radical scavenging method. The antibacterial activity was done against three pathogenic bacteria, i.e Bacillus subtilis InaCC B-1, Staphylococcus aureus InaCC B-4 and Escherichia coli InaCC B-5 were performed by non-eluted TLC-autobiography assay. The minimum inhibitory concentration (MIC) and IC50 values of DPPH radical scavenging activity of active extracts were determined by microdilution in 96-well microplate. The results showed 6 extracts active against B.subtilis, 5 extracts active against S.aureus. The lowest MIC value was 512 µg/ ml.  Ten extracts had the antioxidant activity with various IC50 values. The extracts of ants might be used as bioactive resources for antibacterial and antioxidant.  
ANALISIS KOMPONEN KIMIA DAUN WATI {PIPER METHYSTICUM FORST. F) Agusta, Andria; Jamal, Yuliasri; Chairul, Chairul
BERITA BIOLOGI Vol 4, No 2&3 (1998)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v4i2&3.1276

Abstract

Wati(Piper methysticum Forst.f.)leaves has been used as narcotic in some parts of Irian Jaya since longtime ago. The GCMS analysis of wati leaves organic extracts(hexane,chloroform, methanol)has detected 48 components consisted alkanes,oxygenated hydrocarbons, fatty acid, steroids and alkaloids,including 5 major components, i.e. dihydro kawain,anisol p-undecyl, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-on, levulinic acid and one of unknown component.Forty-three other minor components will be discussed.
SENYAWA ANTIBAKTERI DAUN BELAWAN PUTIH (TRISTANIOPSIS WHITEANA) Handayani, Dewi; S. Achmadi, Suminar; Agusta, Andria
JURNAL BIOLOGI INDONESIA Vol 10, No 1 (2014): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v10i1.334

Abstract

Isolation of antibacterial compounds from chloroform extract of belawan putih (Tristaniopsis whiteana) leaves hasbeen done. The bioautography analysis of the extract against Escherichia coli and Staphylococcus epidermidis,subsequently followed by isolation and purification of active compounds led us to obtain two pure compounds,compound 1 and 2. Futhermore, the compound 2 was identified as betulinic acid based on their spectroscopic dataincluding ultraviolet spectrum, infrared spectrum, 1D- and 2D-NMR spectra. In addition, this is the first report ofthe occurrence of this compound in the plant of Tristaniopsis whiteana and the genus of Tristaniopsis.Keywords: antibacterial, active compound, leaves, Tristaniopsis whiteana
Co-Authors A.A. Ketut Agung Cahyawan W Ahmad Fathoni AHMAD FATHONI Ahmad Fathoni Andi Saptaji Kamal Anita, Syahfitri Antonius Herry Cahyana Antonius Herry Cahyana ARIEF NURKANTO Arif Nurkanto Arif Nurkanto Arif Nurkanto Atit Kanti Chairul Chairul Chairul Chairul DEWI WULANSARI Dewi Wulansari Dwinna Rahmi Edi Santosa Efendi, Darda Efendi, Sintia Frisky Efendy, Oscar Efendy, Oscar Effendi, Oscar Farida, Yunahara HEDDY JULISTIONO Heddy Julistiono Herjuno Ari Nugroho, Herjuno Ari Inanpi Hidayati Sumiasih, Inanpi Hidayati Kartika D. Palupi Kartika Dyah Palupi Kartika Dyah Palupi Kartika Dyah Palupi Keim, Ary P Koraag, Alfa Michael Gabriel Lestari, Vera Budi Listyaningsih, Febrianti Listyaningsih, Febrianti Marlin Megalestin Raunsai Mohammad Fathi Royyani, Mohammad Fathi Muhamad Ilyas Muhamad Ilyas, Muhamad Muhammad Ilyas Muhammad Ilyas N.L.P. Rischa Phadmacanty Palupi, Kartika D. Pariwidjayanti, Aris Medta Partomuan Simanjuntak Phadmacanty, N.L.P. Rischa Pipit Irawati Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi, Praptiwi, - Putra, Aldho Pramana Rahmat Budiarto Roedhy Poerwanto Royani, M Fathi S. Achmadi, Suminar S. Achmadi, Suminar Sri Yuliani Suryati Suryati Tarigan, Elsera Br. Tiwi, Praptiwi Wartika Rosa Farida Wellyzar Sjamsuridzal Yuliasri Jamal YULIASRI JAMAL