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All Journal Jurnal Kesehatan Andalas Berkala Ilmu Kesehatan Kulit dan Kelamin Biomedical Journal of Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Review Pendidikan dan Pengajaran (JRPP) Health and Medical Journal JURNAL PENELITIAN PERAWAT PROFESIONAL Indonesian Journal of Global Health research Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Indonesia Sosial Sains Eduvest - Journal of Universal Studies Detector: Jurnal Inovasi Riset Ilmu Kesehatan Journal of General Procedural Dermatology and Venereology Indonesia Prosiding Seminar Nasional Unimus Seroja Husada: Jurnal Kesehatan Masyarakat Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Gardenia Akhyar
Andalas University
Aerospace Engineering Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Biomedical Journal of Indonesia

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The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Afdhila , Irhamni Nur; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Abstract

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.
The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Irhamni Nur Afdhila; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Vol 7, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Abstract

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.
Co-Authors Abdiana Abdiana, Abdiana Adissa Benanda Afdal Afdal, Afdal Afdhila , Irhamni Nur Afriani, Nita Agustin Vira Agustin Vira Alimuddin Tofrizal Alvarino Alvarino Amel Yanis Amelin, Fitrisia Andani Eka Putra Andrini Ariesti Andrini Ariesti Anum, Qaira Ashal, Taufik Asri, Ennesta Astria Rima Rara Yuswir Astria Rima Rara Yuswir Benanda, Adissa Cimi Ilmiawati, Cimi Dedy Kurnia Desmawati Desmawati Desviorita, Rika Endrinaldi Ennesta Asri Ennesta Asri Erlina Rustam Fathiyyatul Khaira, Fathiyyatul Fauzana Nazifah Fikri Fadhil Fortuna, Fory Gusti Revilla Hendriati, Hendriati Husna, Annisa Tamara Husna, Annisaul I. Izrul Ida Rahmah Burhan Indah Indria Sari Indah Indria Sari Irdawati Izrul Irdawaty Izrul Irhamni Nur Afdhila Izrul, Irdawaty Jefrizal Wirman Julita Julita Julita Julita Julizar Julizar Kemala Sayuti Kurnia, Dedy Lestari, Rahmi M. Ashar Maimi, Afaf Aqil Mardhiati Mardhiati Masrul Meligasari L Gaya Muhamad Firdaus Mutia Sari Nagara, Adianto Jaya Nailatul Fadhila Netti Suharti, Netti Novian Novian Novian Novian Nur, Fauziah Nurul Izzah Putri, Biomechy Oktomalio Rahma Ledika Veroci Raveinal Rendra Darma Satria Rendra Darma Satria Rika Desviorita Rika Desviorita Rina Gustia Rina Gustia Riri Prima Yolanda Rizki Dwayana Rizki Dwayana Rizkia Chairani Asri Salwa Azzahra Satya Wydya Yenny Selfi Renita Rusjdi Shafiqah Zawira Syamel Muhammad Tiffany, Begum Tofrizal Tutty Ariani Tutty Ariani Vesri Yossy Vitresia, Havriza Yenni Raflis Yola Fadilla Yosse Rizal Yulistini, Yulistini Yusticia Katar Yustini Alioes Zafira, Qory