Article Per Year (5 Year)
p-Index From 2020 - 2025
5.198
P-Index
This Author published in this journals
All Journal Jurnal Sains Materi Indonesia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY IDJP (Indonesian Journal of Pharmaceutics) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kartika Kimia Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Health and Dental Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Riset Informasi Kesehatan Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Farmasi Galenika
Fikri Alatas
Fakultas Farmasi, Universitas Jenderal Achmad Yani, Jl. Terusan Sudirman, Cimahi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

Published : 40 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 40 Documents
Search

 1   2   3   4 
IDENTIFIKASI PEMBENTUKAN KO-KRISTAL TRIKLABENDAZOL-ASAM OKSALAT DAN UJI KELARUTANNYA Fikri Alatas; Titta Hartyana Sutarna; Alya Nur Asilla; Sintia Resni Pratiwi
Pharmacoscript Vol. 5 No. 1 (2022): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v5i1.758

Abstract

Triklabendazol (TBZ) adalah suatu turunan benzimidazol yang direkomendasikan pada pengobatan fascioliasis dan memiliki kelarutan rendah di dalam air. Perbaikan sifat fisikokimia obat, termasuk kelarutan bisa dilakukan dengan cara mengubah bentuk padatannya menjadi ko-kristal. Penelitian ini bertujuan untuk mengidentifikasi pembentukan ko-kristal antara TBZ dengan asam oksalat (OXA) dan menguji kelarutannya di dalam air. Identifikasi awal terbentuknya ko-kristal TBZ-OXA dilakukan dengan membangun kurva kelarutan fasa TBZ di dalam larutan OXA (0,2-2M) dan mengamati perubahan morfologi kristal setelah campuran TBZ-OXA direkristalisasi di dalam metanol. Selanjutnya dilakukan penggilingan campuran ekimolar TBZ-OXA dengan penambahan beberapa tetes metanol. Untuk memastikan pembentukan ko-kristal, hasil penggilingan dikarakterisasi dengan difraktometer sinar-X serbuk. Prediksi rasio molar ko-kristal TBZ-OXA yang terbentuk dilakukan dengan menggunakan metode differential scanning calorimetry (DSC).  Kurva kelarutan fasa TBZ-OXA mengikuti jenis Bs, sementara habit kristal campuran ekimolar TBZ-OXA berbeda dengan habit kristal TBZ dan OXA murni setelah direkristalisasi dalam metanol. Hasil-hasil identifikasi awal ini mengindikasikan adanya interaksi antara TBZ dan OXA untuk membentuk ko-kristal. Pola difraksi sinar-X serbuk hasil penggilingan TBZ-OXA memperlihatkan adanya puncak-puncak baru yang tidak muncul pada TBZ dan OXA murni dan hilangnya puncak-puncak khas dari kedua komponen awalnya yang menegaskan terbentuknya ko-kristal TBZ-OXA. Berdasarkan termogram DSC diduga antara TBZ dan OXA membentuk ko-kristal dengan rasio molar 2:1 dengan titik lebur di 111,98°C. Ko-kristal TBZ-OXA memiliki kelarutan di dalam air 6,4 kali lipat daripada TBZ murni. Hasil-hasil penelitian ini telah mengidentifikasi pembentukan ko-kristal antara triklabendazol dan asam oksalat yang memiliki kelarutan lebih tinggi daripada triklabendazol murni.
Pembuatan dan Karakterisasi Ko-kristal Flukonazol-Resorsinol Fikri Alatas Alatas; Hestiary Ratih; Titta Hartyana Sutarna; Yoga Windu Wardhana; Dini Tereslina; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.779

Abstract

Fluconazole (FLU), an oral antifungal widely used in the treatment of vaginitis andcandidiasis, is known to have low bioavailability due to its low solubility. The purpose of this studywas to prepare and characterize co-crystal fl uconazole-resoscinol (FLU-RES). The preparation ofco-crystal was performed by grinding together the equimolar mixture of FLU-RES which is drippedwith a few ethanol. Powder X-ray diff raction, diff erential scanning calorimetry (DSC), and polarizedmicroscopy methods were performed to characterize the formation of FLU-RES co-crystal. Relevantphysicochemical properties include solubility tests in water and dissolution tests in pH 1.2; 4.5 and6.8 buff er solution. The powder X-ray diff ractogram of FLU-RES milled result showed the presenceof new peaks and loss of the main peaks of FLU and RES. The characterization of grinding result byDSC and polarized microscopy methods also showed the co-crystal formation between FLU and RES.The solubility of FLU-RES co-crystal in water is solubility two folds more than pure FLU, while itsdissolution rate is 1.67-1.72 times faster than pure FLU.
Pengaruh Disintegran dan Cara Pencampuran Terhadap Sifat Fisika Kimia Telmisartan Hestiary Ratih; Fikri Alatas; Jessie Sofia Pamudji; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1013

Abstract

Telmisartan (TMS) has a compact structure and is interlocked between crystal units. As a result, the substance has a high electrostatic force, which causes TMS to sintering when compressed into tablets. One method of overcoming sintering on TMS tablets is to add a disintegrant to the compressed tablet. The disintegrants used are derived from starch groups: Starch 1500® (S1500) and sodium starch glycolate (SSG), as well as microcrystalline cellulose (MCC) and croscarmellose sodium (CCS) groups. The purpose of this study was to examine the effects of several disintegrants on the dissolution and physicochemical properties of TMS with various treatments. TMS was varied with each disintegrant at a ratio of 1:9 % b/b. The treatment of TMS binary mixtures with various disintegrants includes physical mixtures, milled mixtures, compressed mixtures, and crushed compressed mixtures. Characterization and evaluation include PXRD and SEM testing as well as dissolution test. The characterization of PXRD and SEM in various treatments showed the effect of physicochemical properties on the TMS binary mixture with various disintegrants. The combination of TMS:CCS with a ratio of (1:9) resulted in the highest dissolution rate in all treatments.The treatment of the milled mixture produced the highest dissolution with DP60 minutes, which was around 55.86±2.47%. The addition of disintegrants to TMS with various treatments may reduce sintering but is not sufficient to meet the requirements for TMS dissolution, which dissolves within 30 minutes in phosphate buffer medium pH 7.5 with Q>75%.
Kelarutan dan Aktivitas Antimalaria Ko-Kristal Pirimetamin-Ibuprofen Fikri Alatas; Faizal Hermanto; Fitria Hanako
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.8577

Abstract

Pirimetamin merupakan salah satu obat antimalarial yang memiliki kelarutan rendah, sehingga menjadi masalah dalam ketersediaan hayatinya. Tujuan dari penelitian ini adalah untuk membuat ko-kristal pirimetamin-ibuprofen dan mengetahui pengaruhnya terhadap kelarutan dan aktivitas antimalarial pirimetamin secara in vivo. Ko-kristal pirimetamin-ibuprofen dibuat dengan metode penggilingan basah, yaitu dengan cara menggiling campuran ekimolar kedua komponen dengan penambahan beberapa tetes campuran pelarut aseton-metanol (1:1). Serbuk hasil penggilingan dikarakterisasi dengan metode powder X-ray diffraction (PXRD) dan differential scanning calorimetry (DSC), dan kelarutannya diuji di dalam air. Metode Peters digunakan untuk pengujian aktivitas antimalaria dengan menggunakan mencit terinfeksi Plasmodium berghei. Kelompok mencit terdiri dari kelompok kontrol negatif (NaCMC 0,5%), kelompok kontrol postif (pirimetamin 3,25 mg/kgbb), dan kelompok uji (ko-kristal pirimetamin-ibuprofen setara 3,25 mg/kgbb pirimetamin). Parameter persentase parasitemia dan persentase hambatan pertumbuhan parasit dihitung berdasarkan apusan darah yang diamati setiap hari selama empat hari. Hasil karakterisasi dengan PXRD dan DSC menunjukkan terbentuknya ko-kristal pirimetamin-ibuprofen. Kelarutan pirimetamin setelah dibentuk ko-kristal adalah 9,5 kali lipat daripada pirimetamin murni. Persen parasitemia pada kelompok kontrol negatif, pirimetamin murni dan ko-kristal pirimetamin-ibuprofen pada hari kedua secara berurutan sebesar 6,4%, 0,37%, dan 0% yang menunjukkan peningkatan aktivitas antimalaria akibat pembentukan ko-kristal. Hasil penelitian dapat disimpulkan, bahwa pirimetamin dapat membentuk ko-kristal dengan ibuprofen yang dapat meningkatkan kelarutannya dan berdampak peningkatan aktivitas antimalarial pirimetamin secara in vivo pada mencit.
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP- 55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36678

Abstract

The combination formulation of tuberculosis drugs may cause interactions if these drugs are givensimultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid(INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to makeINH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. Theprocess of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solventevaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21%and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules metthe requirements of the Indonesian Pharmacopoeia Edition V. The FTIR results showed that there wasno change either in the chemical composition of isoniazid or in the coating of the microencapsulation.Scanning Electron Microscopy (SEM) showed the active substance was well coated. This studyproduces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCPHP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.Keywords: HPMCP HP 50, HPMCP HP-55, isoniazid, microcapsules, solvent evaporation method
THE EFFECT OF Averrhoa Bilimbi L (BELIMBING WULUH) GEL EXTRACT ON INCREASING DEGREE OF EETH BRIGHTNESS (IN VIVO) Asih Rahaju; Zwista Yulia Dewi; Fikri Alatas; Kintan Putri Nur Shafarkiani
Journal of Health and Dental Sciences Vol. 1 No. 1 (2021): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.983 KB)

Abstract

Discoloration (extrinsic and intrinsic) reduce the beauty of someone's appearance and confidence. Discoloration affected the increased aesthetic treatment needs in dentistry. Discoloration can be treated by teeth whitening procedures. Teeth whitening can be done with dental bleaching from the application of chemicals on the surface of the teeth. However, dental bleaching has side effects such as reduce the amount of calcium, phosphate and fluoride in tooth enamel, reduce enamel hardness, enamel surface roughness, and dental hypersensitivity. Belimbing wuluh is one of the herbal ingredients to minimise the risk; it contains oxalic acid, a natural peroxide compound. This study purposed to determine the effect of belimbing wuluh gel extract in increasing the degree of teeth brightness colour by in vivo in rabbits. This study used an experimental analytic method with 27 rabbits' incisors, divided into three groups: 50% belimbing wuluh gel, 40% oxalic acid gel, and negative control group. Rabbits' incisors were previously coated in a transparent varnish on the specified area. Teeth bleaching is done for 4 hours in 14 days. Colour measurements used camera and ring-light, which MATLAB will convert. The data were analysed statistically with One way ANOVA followed by a post-hoc NSK test (p <0.05). The result showed that belimbing wuluh gel extract caused an increase in the teeth colour's brightness (p = 0.0030). So, it can be concluded that belimbing wuluh gel extract affects increasing the degree of teeth brightness. DOI : 10.54052/jhds.v1n1.p80-88
EFEK PENAMBAHAN EKSTRAK AIR KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP AKTIVITAS TABIR SURYA ETILHEKSIL METOKSISINAMAT Gladdis Kamilah Pratiwi; Fikri Alatas; Dessy Adriani Putri
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 4 No 2 (2021): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.822 KB)

Abstract

Etilheksil metoksisinamat atau oktil metoksisinamat merupakan senyawa yang sering digunakan sebagai bahan tabir surya. Namun demikian bahan tabir surya ini memiliki kelemahan karena mudah teroksidasi sehingga aktivitasnya sebagai tabir suryanya menurun. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan ekstrak air kulit buah naga merah (Hylocereus polyrhizus) sebagai antioksidan terhadap aktivitas krim tabir surya yang mengandung zat aktif etilheksil metoksisinamat. Ekstrak air kulit buah naga merah dibuat dengan cara maserasi, dan dilanjutkan dengan penentuan konsentrasi penangkal radikal bebas sebanyak 50% (IC 50) dengan metode difenilpikril hidrazil (DPPH). Ekstrak kulit buah naga merah mempunyai nilai IC50 64,0 μg/mL. Formulasi krim dibuat dengan konsentrasi ekstrak kulit buah naga merah10xIC50 (F1), 50xIC50 (F2), dan 100xIC50 (F3) serta dibandingkan dengan formula tanpa ekstrak kulit buah naga merah. Efektivitas tabir surya dilakukan dengan menentukan nilai sun protecting factor (SPF), transmisi eritema (%Te), dan transmisi pigmentasi (%Tp) sebelum dan setelah penyinaran selama lima jam dibawah sinar ultraviolet. Nilai SPF F0; F1; F2; dan F3 berturut-turut adalah 8,2; 13,0; 16,0 dan 17,0 dan menurun sebanyak 35,4; 14,7; 6,9; dan 2,9% setelah penyinaran selama 5 jam. Ekstrak air kulit buah naga merah (Hylocereus polyrhizus) dengan konsentrasi 10xIC50, 50xIC50, dan 100xIC50 efektif meningkatkan nilai SPF. Formula 3 memiliki kemampuan mempertahankan nilai SPF paling baik setelah penyinaran sinar ultraviolet selama lima jam. DOI : 10.35990/mk.v4n2.p122-131
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP-55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36513

Abstract

The combination formulation of TB drugs may cause interactions if these drugs are given simultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid (INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to make INH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. The process of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solvent evaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21% and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules met the requirements of the Indonesian Pharmacopoeia Edition V. The FTIR test showed that the microcapsules didn’t change the chemical composition of isoniazid or the coating on the microencapsulation so that it was concluded that no chemical reaction or decomposition occurred before and after the formation of the microcapsules. Scanning Electron Microscopy (SEM) showed a spherical microcapsule surface morphology and the active substance was well coated for INH: HPMCP HP-50 (2:3), while for INH: HPMCP HP-55 (2:3) the surface of the microcapsules was round but hollow. This study produces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCP HP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.
Pembentukan ko-amorf irbesartan-l-arginin dan dampaknya terhadap kelarutan dan laju disolusi irbesartan Fikri Alatas; Titta Hartyana Sutarna; Moch. Reza Pratama; Tresna Lestari
Riset Informasi Kesehatan Vol 9 No 2 (2020): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.886 KB) | DOI: 10.30644/rik.v9i2.434

Abstract

Abstrak Latar Belakang: Irbesartan (IBS) adalah antihipertensi yang bekerja menghambat sistem renin-angiotensin dan memiliki kelarutan rendah dalam air, sehingga bioavailabilitasnya terbatas. Tujuan penelitian ini adalah untuk menghasilkan ko-amorf irbesartan dengan l-arginin (ARG) dan untuk mengetahui dampaknya terhadap kelarutan dan laju disolusi irbesartan. Metode: Pembuatan kurva kelarutan fasa dilakukan dengan menentukan kelarutan IBS di dalam rentang konsentrasi 0,1-1,1M dari larutan ARG di dalam air. Ko-amorf dibuat dengan menggiling 1,716 g IBS, 0,696 g ARG, dan lima tetes metanol di dalam Retsch mortar grinder RM 200 selama 15 menit. Untuk mengetahui terbentuknya ko-amorf dilakukan karakterisasi menggunakan difraktometer sinar-X serbuk dan differential scanning calorimeter (DSC). Uji kelarutan dalam media air dilakukan di suhu ruang, sedangkan dalam media larutan dapar pH 1,2 dan 6,8 dilakukan di suhu 37±°C. Larutan dapar pH 1,2 dan 6,8 juga digunakan sebagai media pengujian laju disolusi. Hasil: Kurva kelarutan fasa IBS di dalam larutan ARG menunjukkan tipe AL. Difraktogram menunjukkan terbentuknya ko-amorf IBS-ARG setelah penggilingan. Termogram DSC hasil penggilingan juga menunjukkan telah terbentuk ko-amorf setelah penggilingan basah dengan transisi gelas (Tg) pada 82,2°C. Kelarutan ko-amorf IBS-ARG di dalam air, larutan dapar pH1,2 dan 6,8 berturut-turut 7,2, 2,0, dan 1,9 kali lebih tinggi daripada IBS murni. Laju disolusi ko-amorf IBS-ARG pada kedua media lebih cepat daripada IBS murni. Kesimpulan: Ko-amorf IBS-ARG telah sukses dibuat dengan metode penggilingan basah yang menyebabkan kelarutan dan laju disolusinya lebih baik daripada IBS murni. Abstract Background: Irbesartan (IBS) is an antihypertensive is an antihypertensive which acts to inhibit the renin-angiotensin system and has low water solubility, thus its bioavailability is limited. The aim of this study was to produce co-amorphous irbesartan-l-arginine (IBS-ARG) and to determine its impact on solubility and dissolution rate of irbesartan. Method: Preparation of phase solubility curve was carried out by determining the solubility of IBS in the concentration range 0.1-1.1 M of the ARG solution in water. Co-amorphous was prepared by grinding of 1.716 g IBS, 0.696 g ARG, and five drops of methanol in a Retsch mortar grinder RM 200 for 15 minutes. To determine the formation of co-amorphous, characterization was conduct by a powder X-ray diffractometer and a differential scanning calorimeter (DSC). The solubility test in aqueous medium was carried out at room temperature, while in the buffer solution media pH 1.2 and 6.8 was carried out at 37±0.5°C. The buffer solutions of pH 1.2 and 6.8 were also used as media for dissolution rate testing. Results: The IBS phase solubility curve in the ARG solution showed the AL type. The diffractogram showed the formation of IBS-ARG co-amorphous after wet milling. The DSC thermogram also showed that it was co-amorphous after grinding with a glass transition (Tg) at 82.2°C. The solubility of co-amorphous IBS-ARG in water, pH1.2 and 6.8 of buffer solutions were 7.2, 2.0, and 1.9 folds higher than pure IBS, respectively. The dissolution rate of IBS-ARG co-amorphous in both test media was faster than pure IBS. Conclusion: The IBS-ARG co-amorphous has been successfully prepared by the wet milling method which causes better the solubility and dissolution rate than pure IBS.
Identification of Candesartan Cilexetil-L-Arginine Co-amorphous Formation and Its Solubility Test Fikri Alatas; Erina Sifa Mutmainah; Hestiary Ratih; Titta Hartyana Sutarna; Sundani Nurono Soewandhi
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2942

Abstract

The formation of co-amorphous is one alternative that can be attempted to enhance the solubility of drugs. The study aimed to identify the co-amorphous formation between candesartan cilexetil (CAN) and l-arginine (ARG) and to know its effect on the solubility and dissolution rate of candesartan cilexetil. Initial prediction of co-crystal formation was undertaken by observing differences in crystal morphology between the candesartan cilexetil-l-arginine (CAN-ARG) mixture and each of its initial components due to crystallization in ethanol. The CAN-ARG co-amorphous was produced by the liquid-assisted grinding (LAG) method with the same molar ratio of the CAN and ARG mixture using ethanol as solvent. The co-amorphous formation of CAN-ARG was identified by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. The solubility and dissolution test was performed to know the impact of the co-amorphous CAN-ARG formation. The PXRD pattern of CAN-ARG of LAG result showed a very low peak intensity compared to pure CAN and ARG. The DSC thermogram of the CAN-ARG LAG result does not show any sharp endothermic peaks. The PXRD and DSC results reveal that CAN and ARG can form co-amorphous. The solubility and dissolution rate of candesartan cilexetil in co-amorphous CAN-ARG was better than that of pure CAN. It can be concluded, liquid-assisted grinding of CAN-ARG mixture is identified to form co-amorphous which has an impact on increasing the solubility and dissolution rate of candesartan cilexetil.
Co-Authors Abdul Azizsidiq, Fahmi Afifah Bambang Sutjiatmo, Afifah Bambang Alisha Ramadhanty Ludin Alya Nur Asilla Anggraeni Wulan Angraeni, Wulan Asih Rahaju Aulia Rachmadian Bella Dewinta Saraswati Dery Stiawan Dessy Adriani Putri Diamona Ayu Lestari Dina Apriani Dini Tereslina Dolih Gozali Dzaza Syahidatul Alamiah Elivas Simatupang Endah Wahyuni Erina Sifa Mutmainah Euis Reni Yuslianti, Euis Fahrauk Faramayuda, Fahrauk Faizal Hermanto Fani Wahyuni Fani Wahyuni, Fani Febrianti, Mia Fitria Hanako Gladdis Kamilah Pratiwi Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Hernandi Sujono Hesti Kurnia Hestiary Ratih Iis Inayati Rakhmat Ine Rosmala Dewi Ismunandar Ismunandar Jessie Sofia Pamudji Karin, Amada Kintan Putri Nur Shafarkiani Lucky Rachmawan Lucy D. N. Sasongko Lucy Sasongko Mia Agustin Moch. Reza Pratama Muliana, Muliana Mutia Alifah Rachmah Nadira Cantika Putri Ananda Nira Purnamasari, Nira Novitri Sri Rahayu Nur Achsan Al-Hakim Nurono Soewandhi, Sundani Pratama, Moch. Reza Purnamasari Nira Purwoko, Agus Qotrunnada, Daffa Raisa Fakhrona Salman Rani Sugandi Rani Sugandi, Rani Ratih Hestiary Ratih, Hestyari Regita Ayu Lestari Resina Hajar Ririn Puspadewi, Ririn Risanteni Riskasari Riskia Putri Peratiwi Riskia Putri Peratiwi, Riskia Putri Setia Permana Sintia Resni Pratiwi Suci Nar Vikasari, Suci Nar Sukmadjaja Asyarie Sundani N. Soewandhi Sundani Nurono S. Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Titta H. Sutarna Tresa Tri Rayani Tresa Tri Rayani, Tresa Tri Tresna Lestari, Tresna Woro Artati Sucipto Wulan Anggraeni Yesi Desmiaty, Yesi Yoga Windhu Wardhana Yoga Windu Wardhana Zwista Yulia Dewi