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Formulation and Physical Evaluation of Sleeping Mask Gel Preparation of Mahogany Leaf Extract (Swietenia Mahagoni (L.) Jacq) As Antioxidant Ratih, Hestiary; Sutarna, Titta Hartyana; Febrianti, Mia; Alatas, Fikri; Purnamasari, Nira
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.265

Abstract

Antioxidants are used to neutralize free radicals. Mahogany leaves (Swietenia mahagoni (L.) Jacq) contain flavonoid chemicals that exhibit antioxidant properties. The purpose of the study was to determine the physical characteristics and antioxidant activity of sleeping mask gel preparations with the addition of mahogany leaf extract. Mahogany leaf extract is made using the maceration process. Determination of antioxidant activity using the DPPH method. The formulation is made by varying the concentration of mahogany leaf extract into 4 formulas, F0 (bases, F1 (0.0195%, IC50), F2 (0.0975%, 5xIC50) and F3 (0.195%, 10xIC50). There were several tests used to evaluate formulas, including homogeneity, dispersion, viscosity, pH, and organoleptic (odor, color, and shape) testing. IC50 value of mahogany leaf extract was 19.48 μg / mL. Mahogany leaf extract antioxidant gel sleeping mask preparations F0, F1, F2 and F3 was evaluated such as organoleptic testing requirements, homogeneity and pH produced between 6.15-6.65 including the skin's normal pH range of 4.0-7.0 during 28-day storage. F2 exhibits the best antioxidant stability, with an inhibition value of 54.59%.
NANOSTRUCTURE LIPID CARRIER TECHNOLOGY IN DRUG DELIVERY: ROUTE OF ADMINISTRATION, PREPARATION METHOD, CHARACTERIZATION, AND APPLICATION FOR ANTI-AGING Muliana, Muliana; Alatas, Fikri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1319

Abstract

The new method, known as nanostructured lipid carrier (NLC) in drug delivery systems, has the potential to increase therapeutic efficacy, stability, and bioavailability. This systematic literature review aimed to provide a detailed summary of NLC technology in drug delivery systems, including routes of administration, preparation methods, characterization, and utilization for the delivery of anti-aging active ingredients in cosmetics. To collect scholarly articles on NLCs, we employed a systematic search method using Google Scholar and PubMed. After the screening process, 53 pertinent papers out of 102 articles were chosen for descriptive analysis. NLC exhibit significant promise in many drug delivery applications, including oral, topical, parenteral, and transmucosal routes, with many benefits, including improved bioavailability, stability, and drug penetration through the skin, cornea, and brain. Moreover, NLC technology has been effectively applied for the administration of drugs, including anti-aging drugs. Topical anti-aging preparations generally use synthetic or natural active ingredients. However, synthetic ingredients are often less stable and can irritate skin. NLC can protect and control the release of active ingredients, thereby reducing the risk of irritation. NLC can also improve the penetration of active ingredients into the deeper layers of the skin, allowing it to reach the dermis layer, which is responsible for most skin aging. The efficient absorption capacity of NLC technology in topical preparations presents new opportunities for anti-aging cosmetic product development owing to its effectiveness in skin penetration. Keywords: Nanostructured Lipid Carrier (NLC), drug delivery system, drug penetration, anti-aging
PENGARUH PENAMBAHAN CROSPOVIDONE DALAM PEMBUATAN TABLET ORALLY DISINTEGRATING TABLET LORATADIN SECARA GRANULASI BASAH DAN KEMPA LANGSUNG Anggraeni Wulan; Purnamasari Nira; Alatas Fikri; Ratih Hestiary; Aulia Rachmadian
Pharmacoscript Vol. 6 No. 1 (2023): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v6i1.1188

Abstract

Sediaan Orally Disintegrating Tablet (ODT) merupakan sistem penghantaran obat dengan disintegrasi yang cepat dalam waktu kurang dari 60 detik. ODT umumnya menggunakan bahan penghancur yang dapat mempercepat hancurnya tablet dalam rongga mulut tanpa melalui proses pembentukan gel, antara lain crospovidone. Penelitian ini bertujuan mengetahui pengaruh penambahan crospovidone dalam pembuatan ODT loratadin dengan metode granulasi basah dan kempa langsung terhadap sifat fisik tablet, seperti kerapuhan, kekerasan, waktu pembasahan, waktu hancur serta profil disolusi tablet. Penambahan crospovidone dengan metode granulasi basah dilakukan secara intragranular dan ekstragranular. Secara intragranular crospovidone dicampurkan dengan eksipien lain untuk membentuk granul, sedangkan secara ekstragranular, crospovidone dicampurkan dengan granul kering. Berbeda dengan metode granulasi basah, pada metode kempa langsung, crospovidone dicampurkan langsung dengan bahan-bahan lainnya. Hasil penelitian menunjukan bahwa penambahan crospovidone dalam pembuatan ODT loratadin secara intragranular, ekstragranular dan kempa langsung mempengaruhi sifat fisik tablet seperti kerapuhan, kekerasan, waktu pembasahan, waktu hancur serta profil disolusi tablet. Penambahan crospovidone secara kempa langsung merupakan metode yang paling efektif dalam menghasilkan Orally Disintegrating Tablet loratadine dengan waktu hancur yang paling singkat yaitu 57 detik.
Pemanfaatan Tanaman dalam Sediaan Kosmetika Sebagai Antioksidan dan Anti-Tirosinase: Narrative Review Resina Hajar; Fikri Alatas
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.10822

Abstract

Studies on the antioxidant activity of various plants growing in Indonesia have been widely conducted, however, information relating to testing its activity as an anti-tyrosinase and its formulation in cosmetic preparations is still limited. This literature review explores the use of plants with antioxidant and anti-tyrosinase activity and their development in cosmetic dosage forms. The method for searching references in national and international journals is carried out with the help of the Google Scholar and PubMed search engines published in the last 10 years (2014-2023). After screening by paying attention to inclusion and exclusion criteria, 32 journal articles were used to write this article. Antioxidant and anti-tyrosinase activities are found in almost all parts of the plant, which are generally extracted by maceration with ethanol solvent. Various methods for testing antioxidant activity in vitro are generally based on the presence of a redox reaction between a free radical reagent and an antioxidant which is analyzed spectrophotometrically, while testing anti-tyrosinase activity, is generally tested based on reducing the amount of dopachrome formed in the presence of anti-tyrosinase. The use of plants with antioxidant and anti-tyrosinase activity in cosmetic preparations has been carried out, although it is still limited to conventional preparations, such as creams and gels.
Perbaikan Kelarutan Albendazol Melalui Pembentukan Kristal Multikomponen dengan Asam Malat: Improvement of Albendazole Solubility Through Multicomponent Crystal Formation with Malic Acid Alatas, Fikri; Abdul Azizsidiq, Fahmi; Hartyana Sutarna, Titta; Ratih, Hestyari; Nurono Soewandhi, Sundani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.571 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14998

Abstract

An effort to improve the solubility of albendazole (ABZ), an anthelmintic drug has been successfully carried out through the formation of multicomponent crystal with dl-malic acid (MAL). Construction of phase solubility curve of ABZ in MAL solution and crystal morphological observations after recrystallization in the acetone-ethanol (9:1) mixture were performed for initial prediction of multicomponent crystal formation. ABZ-MAL multicomponent crystal was prepared by wet grinding or also known as solvent-drop grinding (SDG) with acetone-ethanol (9:1) mixture as a solvent followed by characterization of the multicomponent crystal formation by powder X-ray diffraction and Fourier transform infrared (FTIR) methods. The solubility of ABZ-MAL multicomponent crystal was tested in water at ambient temperature and in pH 1.2, 4.5 and 6.8 of buffered solutions at 37°C. The phase solubility curve of the ABZ in the MAL solution showed type Bs. The ABZ-MAL mixture has a different crystalline morphology than pure ABZ and MAL after recrystallization in the acetone-ethanol mixture (9:1). The powder X-ray diffraction pattern and the FTIR spectrum of ABZ-MAL from SDG different from intact ABZ and MAL powder X-ray diffraction patterns and these results can indicate the ABZ-MAL multicomponent crystal formation. The ABZ-MAL multicomponent crystal has better solubility than pure ABZ in all media used. These results can be concluded that ABZ-MAL multicomponent crystal can be prepared by solvent-drop grinding method with acetone-ethanol (9:1) mixture as a solvent and can increase the solubility of albendazole.
Utilization rhizome of jahe merah (Zingiber officinale Roscoe) as a bioreductant in the manufacture of gold nanoparticles with addition of polyvinylpyrrolidone 90 (PVP K90) as a stabilizer Sutarna, Titta Hartyana; Alatas, Fikri; Purnamasari, Nira; Rachmah, Mutia Alifah
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.1964

Abstract

Thel making of gold nanoparticlels (AuNPs) by thel biosyntheltic melthod using plants as biorelductors is onel of thel nanoparticlel synthelsis melthods that is beling carrield out belcausel it is elnvironmelntally frielndly and non-toxic to thel body. Elxtract rhizomel of Reld Gingelr ( Zingibelr officinalel Roscoel ) contains selcondary meltabolitels that function as antioxidants that can bel useld as biorelductor in thel making of gold nanoparticlels. Thel relselarch belgan with thel elxamination of IC50, thel manufacturel of gold nanoparticlels and thel addition of PVP K90 stabilizelr. Thel formation of gold nanoparticlels was madel in selvelral concelntrations, namelly 600 g/mL, 900 g/mL and 1200 g/mL. Theln thel relsults of thel synthelsis of gold nanoparticlels welrel charactelrizeld by visual obselrvation solution color, UV-Vis spelctrophotomeltry, particlel sizel analyzelr and polarization microscopel. Thel relsults obtaineld arel all variations in concelntration can form gold nanoparticlels, but 600 g/mL was choseln belcausel it has thel smallelst particlel sizel compareld to othelr concelntrations. Howelvelr, belcausel gold nanoparticlels elasily and quickly aggrelgatel to form largelr particlel sizels, in this study a stabilizelr in thel form of Polyvinylpyrrolidonel 90 (PVP K90) was addeld. PVP K90 was useld with various concelntrations of 0.5%, 1%, 2% and 5%. Gold nanoparticlels that havel beleln addeld to PVP K90 arel charactelrizeld by visual obselrvation thel color changel of thel solution, thel maximum wavellelngth with spelctrophotomeltry UV-Vis and particlel sizel distribution with a particlel sizel analyzelr, thel relsults obtaineld arel thel addition of 1% concelntration of PVP K90 melt all standards as a stabilizelr of gold nanoparticlels with elxtract rhizomel of reld gingelr.
Penggunaan Metolose 90-SH100 Sebagai Basis Gel Ekstrak Etanol Herba Pegagan (Centella Asiatica L.) Untuk Penyembuh Luka Terbuka pada Tikus Alatas, Fikri
JURNAL FARMASI GALENIKA Vol 9 No 1 (2022): Jurnal Farmasi Galenika Vol 9 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v9i1.212

Abstract

Turunan selulosa banyak digunakan sebagai basis gel karena biokompatibilitasnya, viskositasnya yang bervariasi, dan kemampuannya dalam menyerap eksudat luka. Metolose 90SH-100 adalah salah satu turunan selulosa yang memiliki viskositas 100.000 cPs. Penelitian ini bertujuan memformulasi sediaan gel ekstrak ektanol herba pegagan (Centella asiatica L.) dengan menggunakan basis Metolose 90SH-100, menguji stabilitas fisik dan mengetahui efektivitasnya sebagai penyembuh luka terbuka pada tikus. Ekstrak etanol herba pegagan disiapkan dengan teknik maserasi. Formula gel ekstrak pegagan 5% dibuat dengan variasi konsentrasi Metolose 90SH-100 berturut-turut 4% (F1), 5% (F2), dan 6% (F3). Evaluasi fisiki meliputi organoleptik, pH, viskositas, dan daya sebar. Formula terbaik diuji stabilitas fisiknya selama 28 hari dan efektivitasnya sebagai penyembuh luka terbuka pada tikus. Gel ekstrak etanol herba pegagan 5% dengan konsentrasi Metolose 90SH-100 4% (F1) memiliki sifat fisik terbaik. Viskositas, pH dan daya sebar F1 stabil selama 28 hari penyimpanan pada suhu ruang dalam kondisi wadah tertutup. Hasil pengujian efektivitas penyembuh luka terbuka pada tikus menunjukkan kelompok uji (gel ekstrak etanol pegagan 5%) memiliki kecepatan penyembuhan luka terbuka lebih cepat daripada kelompok kontrol (basis gel) (P<0,05). Kecepatan penyembuhan luka kelompok uji setara dengan kelompok pembanding (povidone-iodine 10%) (P≥0,05).
Karakterisasi Pembentukan Ko-kristal Tenoksikam-Asam Malat dan Evaluasi Kompresibilitas dan Tabletabilitasnya Alatas, Fikri; Syahidatul Alamiah, Dzaza; Purnamasari, Nira
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.320

Abstract

Tenoxicam is a non-steroidal anti-inflammatory drug which has poor compressibility and compactibility. One way to change the compressibility and compactibility of a material is to use co-crystallization techniques The aim of this research is to characterize the formation of co-crystal between tenoxicam and malic acid and evaluate their compressibility and tabletability. Tenoxicam-malic acid co-crystal were prepared using the ultrasound-assisted solution co-crystallisation (USSC) method with the addition of ethanol solvent at the same molar ratio. The USSC result was characterized by polarization microscopy, powder X-ray diffraction, and thermal analysis methods. Evaluation of compressibility and tabletability (tensile strength and elactic recovery) was carried out on tenoxicam-malic acid co-crystal and intact tenoxicam. Characterization of the USSC result indicated the formation of tenoxicam-malic acid co-crystal, which were characterized by crystal habit, powder X-ray diffraction patterns, and DSC thermograms that were specific and different from intact tenoxicam and malic acid. Compressibility evaluation results show that the tenoxicam-malic acid co-crystal is in the good flow properties category, while the intact tenoxicam is in the poor flow properties category. The tensile strength of tenoxicam-malic acid co-crystal is higher than that of intact tenoxicam at the same compression strength (40 kg/cm2). Tenoxicam-malic acid co-crystal showed lower elastic recovery compared to intact tenoxicam. These results can be concluded that tenoxicam-malic acid co-crystals have been successfully prepared using the USSC method and have better compressibility and tabletability than intact tenoxicam.
PENGARUH KOMBINASI HIDROKSIPROPIL METIL SELULOSA DAN CARBOPOL® 940 TERHADAP SIFAT FISIK DAN STABILITAS ANTIOKSIDAN GEL SLEEPING MASK EKSTRAK KAYU SECANG Al-Hakim, Nur Achsan; Pratiwi, Gladdis Kamilah; Alatas, Fikri; Rahayu, Novitri Sri
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 1 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Perawatan kulit menjadi salah satu upaya dalam mencegah penuaan dini, diantaranya dengan memanfaatkan bahan alami sebagai sumber antioksidan. Kayu secang (Caesalpinia sappan L.) merupakan salah satu tumbuhan yang mengandung antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kombinasi bahan pembentuk gel hidroksipropil metil selulosa (HPMC) dan Carbopol® 940 pada formulasi gel sleeping mask ekstrak kayu secang terhadap sifat fisik dan stabilitas antioksidannya. Sediaan gel sleeping mask dibuat dengan lima variasi rasio HPMC dan Carbopol® 940, yaitu 5:0 (F1), 0:5 (F2), 2,5:2,5 (F3), 3:2 (F4), dan 3,5:1,5 (F5). Evaluasi fisik sediaan meliputi organoleptik, pengukuran pH dan viskositas, homogenitas, uji daya sebar, serta penentuan stabilitas fisik aktivitas antioksidan sediaan gel sleeping mask. Aktivitas antioksidan ditetapkan menggunakan metode 2,2-difenil-1-pikrilhidrazil (DPPH). Hasil evaluasi fisik sediaan gel sleeping mask menunjukkan bahwa F5 merupakan formula yang terbaik dan stabil selama penyimpanan 28 hari, dan memenuhi parameter ideal sediaan kosmetik topikal, serta memiliki aktivitas antioksidan yang stabil. Penelitian ini menunjukkan bahwa ekstrak kayu secang dapat diformulasikan menjadi sediaan gel sleeping mask dan dengan memodifikasi agen pengental dalam formulasi menghasilkan sediaan yang baik dan stabil, serta penelitian ini menjadi pertimbangan ilmiah sebagai terapi alternatif dalam upaya mencegah penuaan dini. Kata kunci : antioksidan, Carbopol® 940, ekstrak kayu secang, HPMC, gel sleeping mask DOI : 10.35990/mk.v7n1.p45-56
PENGARUH PENGGUNAAN DUA TIPE ENKAPSULAT PHARMACOAT TERHADAP KARAKTERISTIK MIKROKAPSUL ASAM ASKORBAT Pratiwi, Gladdis Kamilah; Alatas, Fikri; Ratih, Hestiary; Sutarna, Titta Hartyana; Bintary, Dyan; Prianto, Ulla L. F.
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 4 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Asam askorbat, suatu vitamin yang larut dalam air, dapat teroksidasi oleh faktor lingkungan dan pembuatan mikrokapsul dengan enkpasulat yang tepat menjadi sangat penting untuk meningkatkan karakteristiknya. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan dua tipe enkapsulat Pharmacoat terhadap karakteristik mikrokapsul asam askorbat. Mikrokapsul asam askorbat dibuat dengan metode penguapan pelarut dengan menggunakan variasi konsentrasi dua tipe Pharmacoat sebagai enkapsulat, yaitu F1 dan F2 menggunakan Pharmacoat 606 dengan rasio asam askorbat-Pharmacoat 606 berturut-turut 1 : 1 dan 2 : 3, sementara F3 dan F4 menggunakan Pharmacoat 615 dengan rasio asam askorbat : Pharmacoat 615 berturut-turut 1 : 1 dan 2 : 3. Etanol digunakan sebagai pelarut polimer dan asam askorbat, parafin cair sebagai fase minyak, dan Span 80 sebagai emulgator. Karakteristik mikrokapsul yang dievaluasi, meliputi penetapan kadar air, uji perolehan kembali, distribusi ukuran partikel mikrokapsul, uji stabilitas terhadap paparan cahaya, dan morfologi mikrokapsul menggunakan Scanning Electron Microscopy (SEM). Hasil evaluasi menunjukkan seluruh formula mikrokapsul memiliki kadar air adalah sekitar 1-3 %, dan distribusi ukuran partikel mikrokapsul pada rentang 250-500 μm. Efisiensi penjeratan mikrokapsul F1, F2, F3, dan F4 berturut-turut adalah 75,67, 86,88, 82,02, dan, 93,72%. F4 memiliki efektivitas paling naik dalam mengurangi oksidasi asam askorbat dari pararan cahaya. Fotomikrograf SEM menunjukkan F4 memiliki morfologi paling baik. Kesimpulannya, mikrokapsul yang dibuat dengan rasio asam askorbat: Pharmacoat 615 (2 : 3) menunjukkan stabilitas terhadap paparan cahaya dan morfologi paling baik. Kata kunci : asam askorbat, mikrokapsul, Pharmacoat® 606, Pharmacoat® 615 DOI : 10.35990/mk.v7n4.p331-340
Co-Authors Abdul Azizsidiq, Fahmi Afifah Bambang Sutjiatmo, Afifah Bambang Alisha Ramadhanty Ludin Alya Nur Asilla Anggraeni Wulan Angraeni, Wulan Asih Rahaju Aulia Rachmadian Bella Dewinta Saraswati Bintary, Dyan Dery Stiawan Dessy Adriani Putri Diamona Ayu Lestari Dina Apriani Dini Tereslina Dolih Gozali Dzaza Syahidatul Alamiah Elivas Simatupang Endah Wahyuni Erina Sifa Mutmainah Euis Reni Yuslianti, Euis Fahrauk Faramayuda, Fahrauk Faizal Hermanto Fani Wahyuni Fani Wahyuni, Fani Febrianti, Mia Fitria Hanako Gladdis Kamilah Pratiwi Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Hernandi Sujono Hesti Kurnia Hestiary Ratih Iis Inayati Rakhmat Ine Rosmala Dewi Ismunandar Ismunandar Jessie Sofia Pamudji Karin, Amada Kintan Putri Nur Shafarkiani Lucky Rachmawan Lucy D. N. Sasongko Lucy Sasongko Mia Agustin Moch. Reza Pratama Muliana, Muliana Nadira Cantika Putri Ananda Nira Purnamasari, Nira Nur Achsan Al-Hakim Nurono Soewandhi, Sundani Pratama, Moch. Reza Pratiwi, Gladdis Kamilah Prianto, Ulla L. F. Purnamasari Nira Purwoko, Agus Qotrunnada, Daffa Rachmah, Mutia Alifah Rahayu, Novitri Sri Raisa Fakhrona Salman Rani Sugandi Rani Sugandi, Rani Ratih Hestiary Ratih, Hestyari Regita Ayu Lestari Resina Hajar Ririn Puspadewi, Ririn Risanteni Riskasari Riskia Putri Peratiwi Riskia Putri Peratiwi, Riskia Putri Setia Permana Sintia Resni Pratiwi Suci Nar Vikasari, Suci Nar Sukmadjaja Asyarie Sundani N. Soewandhi Sundani Nurono S. Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Syahidatul Alamiah, Dzaza Titta H. Sutarna Tresa Tri Rayani Tresa Tri Rayani, Tresa Tri Tresna Lestari, Tresna Woro Artati Sucipto Wulan Anggraeni Yesi Desmiaty, Yesi Yoga Windhu Wardhana Yoga Windu Wardhana Zwista Yulia Dewi