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Utilization rhizome of jahe merah (Zingiber officinale Roscoe) as a bioreductant in the manufacture of gold nanoparticles with addition of polyvinylpyrrolidone 90 (PVP K90) as a stabilizer Titta Hartyana Sutarna; Fikri Alatas; Nira Purnamasari; Mutia Alifah Rachmah
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.1964

Abstract

Thel making of gold nanoparticlels (AuNPs) by thel biosyntheltic melthod using plants as biorelductors is onel of thel nanoparticlel synthelsis melthods that is beling carrield out belcausel it is elnvironmelntally frielndly and non-toxic to thel body. Elxtract rhizomel of Reld Gingelr ( Zingibelr officinalel Roscoel ) contains selcondary meltabolitels that function as antioxidants that can bel useld as biorelductor in thel making of gold nanoparticlels. Thel relselarch belgan with thel elxamination of IC50, thel manufacturel of gold nanoparticlels and thel addition of PVP K90 stabilizelr. Thel formation of gold nanoparticlels was madel in selvelral concelntrations, namelly 600 g/mL, 900 g/mL and 1200 g/mL. Theln thel relsults of thel synthelsis of gold nanoparticlels welrel charactelrizeld by visual obselrvation solution color, UV-Vis spelctrophotomeltry, particlel sizel analyzelr and polarization microscopel. Thel relsults obtaineld arel all variations in concelntration can form gold nanoparticlels, but 600 g/mL was choseln belcausel it has thel smallelst particlel sizel compareld to othelr concelntrations. Howelvelr, belcausel gold nanoparticlels elasily and quickly aggrelgatel to form largelr particlel sizels, in this study a stabilizelr in thel form of Polyvinylpyrrolidonel 90 (PVP K90) was addeld. PVP K90 was useld with various concelntrations of 0.5%, 1%, 2% and 5%. Gold nanoparticlels that havel beleln addeld to PVP K90 arel charactelrizeld by visual obselrvation thel color changel of thel solution, thel maximum wavellelngth with spelctrophotomeltry UV-Vis and particlel sizel distribution with a particlel sizel analyzelr, thel relsults obtaineld arel thel addition of 1% concelntration of PVP K90 melt all standards as a stabilizelr of gold nanoparticlels with elxtract rhizomel of reld gingelr.
Karakteristik Fisik dan Laju Difusi In Vitro Sediaan Transdermal Patch Domperidon Menggunakan Polimer Turunan Metil Metakrilat-Asam Metakrilat Purnamasari, Nira; Sutarna, Titta Hartyana; Angraeni, Wulan; Karin, Amada; Qotrunnada, Daffa; Alatas, Fikri
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.235

Abstract

Sediaan patch transdermal merupakan pilihan yang tepat untuk menghindari proses metabolisme lintas pertama pada zat aktif domperidon. Tujuan penelitian ini adalah untuk mengetahui karakteristik fisik dan laju difusi in vitro sediaan transdermal patchdomperidon yang dibuat dengan menggunakan dua matriks polimer turunan metil metakrilat-asam metakrilat, yaitu Eudragit E100 dan Eudragit L 100-55. Sediaan patch transdermal domperidon dipreparasi dengan metode penguapan pelarut menggunakan variasi konsentrasi Eudragit E100 dan Eudragit L100-55 5-20%. Evaluasi karakteristik fisik patch meliputi organoleptis, ketebalan, kandungan lembab, keseragaman bobot, dan ketahanan lipat, dan uji kekuatan mekanik. Uji difusi in vitro dilakukan menggunakan metode flow-through menggunakan sel difusi Franz yang dimodifikasi. Transdermal patch dengan polimer Eudragit E100 menunjukkan homogenitas baik tanpa adanya kristalisasi domperidon diperoleh pada konsentrasi 10% (F2) dan 20% (F3), sementara transdermal patch dengan polimer Eudragit L100-55 menunjukkan homogenitas baik hanya di konsentrasi 20% (F6). Ketahanan lipat dan kandungan lembab seluruh formula menunjukkan hasil yang memenuhi persyaratan ketahanan lipat dan kandungan lembab yang baik. Persentase elongasi dan tensile strength transdermal patch dengan polimer Eudragit E100 cenderung meningkat dengan kenaikan konsentrasi polimer, sementara transdermal patch dengan polimer Eudragit L100-55 menunjukkan penurunan persentase elongasi dan kenaikan tensile strength dengan meningkatnya konsentrasi polimer. Penurunan Laju difusi in vitro transdermal patchterjadi ketika konsentrasi polimer ditingkatkan, baik pada transdermal patch yang menggunakan Eudragit E100 maupun Eudragit L100-55.
Formulation and Physical Evaluation of Sleeping Mask Gel Preparation of Mahogany Leaf Extract (Swietenia Mahagoni (L.) Jacq) As Antioxidant Ratih, Hestiary; Sutarna, Titta Hartyana; Febrianti, Mia; Alatas, Fikri; Purnamasari, Nira
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.265

Abstract

Antioxidants are used to neutralize free radicals. Mahogany leaves (Swietenia mahagoni (L.) Jacq) contain flavonoid chemicals that exhibit antioxidant properties. The purpose of the study was to determine the physical characteristics and antioxidant activity of sleeping mask gel preparations with the addition of mahogany leaf extract. Mahogany leaf extract is made using the maceration process. Determination of antioxidant activity using the DPPH method. The formulation is made by varying the concentration of mahogany leaf extract into 4 formulas, F0 (bases, F1 (0.0195%, IC50), F2 (0.0975%, 5xIC50) and F3 (0.195%, 10xIC50). There were several tests used to evaluate formulas, including homogeneity, dispersion, viscosity, pH, and organoleptic (odor, color, and shape) testing. IC50 value of mahogany leaf extract was 19.48 μg / mL. Mahogany leaf extract antioxidant gel sleeping mask preparations F0, F1, F2 and F3 was evaluated such as organoleptic testing requirements, homogeneity and pH produced between 6.15-6.65 including the skin's normal pH range of 4.0-7.0 during 28-day storage. F2 exhibits the best antioxidant stability, with an inhibition value of 54.59%.
NANOSTRUCTURE LIPID CARRIER TECHNOLOGY IN DRUG DELIVERY: ROUTE OF ADMINISTRATION, PREPARATION METHOD, CHARACTERIZATION, AND APPLICATION FOR ANTI-AGING Muliana, Muliana; Alatas, Fikri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1319

Abstract

The new method, known as nanostructured lipid carrier (NLC) in drug delivery systems, has the potential to increase therapeutic efficacy, stability, and bioavailability. This systematic literature review aimed to provide a detailed summary of NLC technology in drug delivery systems, including routes of administration, preparation methods, characterization, and utilization for the delivery of anti-aging active ingredients in cosmetics. To collect scholarly articles on NLCs, we employed a systematic search method using Google Scholar and PubMed. After the screening process, 53 pertinent papers out of 102 articles were chosen for descriptive analysis. NLC exhibit significant promise in many drug delivery applications, including oral, topical, parenteral, and transmucosal routes, with many benefits, including improved bioavailability, stability, and drug penetration through the skin, cornea, and brain. Moreover, NLC technology has been effectively applied for the administration of drugs, including anti-aging drugs. Topical anti-aging preparations generally use synthetic or natural active ingredients. However, synthetic ingredients are often less stable and can irritate skin. NLC can protect and control the release of active ingredients, thereby reducing the risk of irritation. NLC can also improve the penetration of active ingredients into the deeper layers of the skin, allowing it to reach the dermis layer, which is responsible for most skin aging. The efficient absorption capacity of NLC technology in topical preparations presents new opportunities for anti-aging cosmetic product development owing to its effectiveness in skin penetration. Keywords: Nanostructured Lipid Carrier (NLC), drug delivery system, drug penetration, anti-aging
PENGARUH PENAMBAHAN CROSPOVIDONE DALAM PEMBUATAN TABLET ORALLY DISINTEGRATING TABLET LORATADIN SECARA GRANULASI BASAH DAN KEMPA LANGSUNG Anggraeni Wulan; Purnamasari Nira; Alatas Fikri; Ratih Hestiary; Aulia Rachmadian
Pharmacoscript Vol. 6 No. 1 (2023): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v6i1.1188

Abstract

Sediaan Orally Disintegrating Tablet (ODT) merupakan sistem penghantaran obat dengan disintegrasi yang cepat dalam waktu kurang dari 60 detik. ODT umumnya menggunakan bahan penghancur yang dapat mempercepat hancurnya tablet dalam rongga mulut tanpa melalui proses pembentukan gel, antara lain crospovidone. Penelitian ini bertujuan mengetahui pengaruh penambahan crospovidone dalam pembuatan ODT loratadin dengan metode granulasi basah dan kempa langsung terhadap sifat fisik tablet, seperti kerapuhan, kekerasan, waktu pembasahan, waktu hancur serta profil disolusi tablet. Penambahan crospovidone dengan metode granulasi basah dilakukan secara intragranular dan ekstragranular. Secara intragranular crospovidone dicampurkan dengan eksipien lain untuk membentuk granul, sedangkan secara ekstragranular, crospovidone dicampurkan dengan granul kering. Berbeda dengan metode granulasi basah, pada metode kempa langsung, crospovidone dicampurkan langsung dengan bahan-bahan lainnya. Hasil penelitian menunjukan bahwa penambahan crospovidone dalam pembuatan ODT loratadin secara intragranular, ekstragranular dan kempa langsung mempengaruhi sifat fisik tablet seperti kerapuhan, kekerasan, waktu pembasahan, waktu hancur serta profil disolusi tablet. Penambahan crospovidone secara kempa langsung merupakan metode yang paling efektif dalam menghasilkan Orally Disintegrating Tablet loratadine dengan waktu hancur yang paling singkat yaitu 57 detik.
Karakteristik Selulosa Mikrokristal dan Proses Delignifikasi pada Isolasinya dari Berbagai Sumber Limbah Alami: Characteristics of Microcrystalline Cellulose and Delignification Process on Its Isolation from Various Natural Waste Sources Fikri Alatas; Setia Permana
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2005

Abstract

The use of microcrystalline cellulose in the pharmaceutical field is generally used as an excipient in tablet dosage forms. Microcrystalline cellulose is produced from the process of isolating alpha cellulose from various natural wastes through several stages of the process. One of the stages of the isolation process is the separation of lignin from cellulose or known as the delignification process which is the most difficult process stage. This literature review aims to determine the characteristics of microcrystalline cellulose and its isolation process from various natural wastes. This review article was written based on 38 national and international journal articles published in the last 10 years (2013-2023) after being screened based on inclusion and exclusion criteria. Microcrystalline cellulose can be analyzed using the Fourier transform infrared (FTIR) method, powder X-ray diffraction (PXRD), scanning electron microscope (SEM), and differential scanning calorimetry (DSC) and the results of the analysis can show identity, purity, crystallinity index, and morphology. Most alkali treatments in the delignification process use sodium hydroxide and/or sodium sulfite followed by a bleaching process with sodium chlorite or hydroxy peroxide depending on the part of the plant. The delignification process for soft plant parts, such as leaves and fruit skin, generally uses sodium hydroxide and sodium chlorite solutions, while for harder plant parts, for example stems, sodium hydroxide and sodium sulfite are usually used. Keywords:          microcrystalline cellulose, cellulose sources, characteristics, delignification   Abstrak Pemanfaatan selulosa mikrokristal dalam bidang farmasi umumnya digunakan sebagai eksipien dalam bentuk sediaan tablet. Selulosa mikrokristal dihasilkan dari proses isolasi selulosa alfa berbagai limbah alami melalui beberapa tahapan proses. Salah satu tahap proses isolasi adalah pemisahan lignin dari selulosa atau delignifikasi yang merupakan tahapan proses yang paling sulit. Kajian literatur ini bertujuan untuk mengetahui karakteristik khas selulosa mikrokristal dan proses delignifikasi dari berbagai limbah alami. Artikel review ini ditulis bersumber dari 38 artikel jurnal nasional dan internasional yang terbit pada 10 tahun terakhir (2013-2023) setelah dilakukan penapisan berdasarkan kriteria inklusi dan eksklusi. Selulosa mikrokristal dapat dianalisis dengan metode Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), dan differential scanning calorimetry (DSC) dan hasil analisis tersebut bisa menunjukkan identitas, kemurnian, indeks kristalinitas, dan morfologinya. Sebagian besar perlakuan alkali pada proses delignifikasi menggunakan natrium hidroksida dan atau natrium sulfit yang dilanjutkan dengan proses pemutihan dengan natrium klorit atau hidroksi peroksida yang bergantung pada bagian tanamannya. Proses delignifikasi di bagian tanaman yang lunak, seperti daun dan kulit buah umumnya menggunakan larutan natrium hidroksida dan natrium klorit, sementara untuk bagian tanaman yang lebih keras, seperti batang menggunakan natrium hidroksida dan natrium sulfit. Kata Kunci:         selulosa mikrokristal, sumber selulosa, karakteristik, isolasi, delignifikasi
Penggunaan Metolose 90-SH100 Sebagai Basis Gel Ekstrak Etanol Herba Pegagan (Centella Asiatica L.) Untuk Penyembuh Luka Terbuka pada Tikus Fikri Alatas
JURNAL FARMASI GALENIKA Vol 9 No 1 (2022): Jurnal Farmasi Galenika Vol 9 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v9i1.212

Abstract

Turunan selulosa banyak digunakan sebagai basis gel karena biokompatibilitasnya, viskositasnya yang bervariasi, dan kemampuannya dalam menyerap eksudat luka. Metolose 90SH-100 adalah salah satu turunan selulosa yang memiliki viskositas 100.000 cPs. Penelitian ini bertujuan memformulasi sediaan gel ekstrak ektanol herba pegagan (Centella asiatica L.) dengan menggunakan basis Metolose 90SH-100, menguji stabilitas fisik dan mengetahui efektivitasnya sebagai penyembuh luka terbuka pada tikus. Ekstrak etanol herba pegagan disiapkan dengan teknik maserasi. Formula gel ekstrak pegagan 5% dibuat dengan variasi konsentrasi Metolose 90SH-100 berturut-turut 4% (F1), 5% (F2), dan 6% (F3). Evaluasi fisiki meliputi organoleptik, pH, viskositas, dan daya sebar. Formula terbaik diuji stabilitas fisiknya selama 28 hari dan efektivitasnya sebagai penyembuh luka terbuka pada tikus. Gel ekstrak etanol herba pegagan 5% dengan konsentrasi Metolose 90SH-100 4% (F1) memiliki sifat fisik terbaik. Viskositas, pH dan daya sebar F1 stabil selama 28 hari penyimpanan pada suhu ruang dalam kondisi wadah tertutup. Hasil pengujian efektivitas penyembuh luka terbuka pada tikus menunjukkan kelompok uji (gel ekstrak etanol pegagan 5%) memiliki kecepatan penyembuhan luka terbuka lebih cepat daripada kelompok kontrol (basis gel) (P<0,05). Kecepatan penyembuhan luka kelompok uji setara dengan kelompok pembanding (povidone-iodine 10%) (P≥0,05).
Karakterisasi Pembentukan Ko-kristal Tenoksikam-Asam Malat dan Evaluasi Kompresibilitas dan Tabletabilitasnya Fikri Alatas; Dzaza Syahidatul Alamiah; Nira Purnamasari
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.320

Abstract

Tenoxicam is a non-steroidal anti-inflammatory drug which has poor compressibility and compactibility. One way to change the compressibility and compactibility of a material is to use co-crystallization techniques The aim of this research is to characterize the formation of co-crystal between tenoxicam and malic acid and evaluate their compressibility and tabletability. Tenoxicam-malic acid co-crystal were prepared using the ultrasound-assisted solution co-crystallisation (USSC) method with the addition of ethanol solvent at the same molar ratio. The USSC result was characterized by polarization microscopy, powder X-ray diffraction, and thermal analysis methods. Evaluation of compressibility and tabletability (tensile strength and elactic recovery) was carried out on tenoxicam-malic acid co-crystal and intact tenoxicam. Characterization of the USSC result indicated the formation of tenoxicam-malic acid co-crystal, which were characterized by crystal habit, powder X-ray diffraction patterns, and DSC thermograms that were specific and different from intact tenoxicam and malic acid. Compressibility evaluation results show that the tenoxicam-malic acid co-crystal is in the good flow properties category, while the intact tenoxicam is in the poor flow properties category. The tensile strength of tenoxicam-malic acid co-crystal is higher than that of intact tenoxicam at the same compression strength (40 kg/cm2). Tenoxicam-malic acid co-crystal showed lower elastic recovery compared to intact tenoxicam. These results can be concluded that tenoxicam-malic acid co-crystals have been successfully prepared using the USSC method and have better compressibility and tabletability than intact tenoxicam.
Pemanfaatan Tanaman dalam Sediaan Kosmetika Sebagai Antioksidan dan Anti-Tirosinase: Narrative Review Resina Hajar; Fikri Alatas
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.10822

Abstract

Studies on the antioxidant activity of various plants growing in Indonesia have been widely conducted, however, information relating to testing its activity as an anti-tyrosinase and its formulation in cosmetic preparations is still limited. This literature review explores the use of plants with antioxidant and anti-tyrosinase activity and their development in cosmetic dosage forms. The method for searching references in national and international journals is carried out with the help of the Google Scholar and PubMed search engines published in the last 10 years (2014-2023). After screening by paying attention to inclusion and exclusion criteria, 32 journal articles were used to write this article. Antioxidant and anti-tyrosinase activities are found in almost all parts of the plant, which are generally extracted by maceration with ethanol solvent. Various methods for testing antioxidant activity in vitro are generally based on the presence of a redox reaction between a free radical reagent and an antioxidant which is analyzed spectrophotometrically, while testing anti-tyrosinase activity, is generally tested based on reducing the amount of dopachrome formed in the presence of anti-tyrosinase. The use of plants with antioxidant and anti-tyrosinase activity in cosmetic preparations has been carried out, although it is still limited to conventional preparations, such as creams and gels.
Perbaikan Kelarutan Albendazol Melalui Pembentukan Kristal Multikomponen dengan Asam Malat: Improvement of Albendazole Solubility Through Multicomponent Crystal Formation with Malic Acid Alatas, Fikri; Abdul Azizsidiq, Fahmi; Hartyana Sutarna, Titta; Ratih, Hestyari; Nurono Soewandhi, Sundani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.571 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14998

Abstract

An effort to improve the solubility of albendazole (ABZ), an anthelmintic drug has been successfully carried out through the formation of multicomponent crystal with dl-malic acid (MAL). Construction of phase solubility curve of ABZ in MAL solution and crystal morphological observations after recrystallization in the acetone-ethanol (9:1) mixture were performed for initial prediction of multicomponent crystal formation. ABZ-MAL multicomponent crystal was prepared by wet grinding or also known as solvent-drop grinding (SDG) with acetone-ethanol (9:1) mixture as a solvent followed by characterization of the multicomponent crystal formation by powder X-ray diffraction and Fourier transform infrared (FTIR) methods. The solubility of ABZ-MAL multicomponent crystal was tested in water at ambient temperature and in pH 1.2, 4.5 and 6.8 of buffered solutions at 37°C. The phase solubility curve of the ABZ in the MAL solution showed type Bs. The ABZ-MAL mixture has a different crystalline morphology than pure ABZ and MAL after recrystallization in the acetone-ethanol mixture (9:1). The powder X-ray diffraction pattern and the FTIR spectrum of ABZ-MAL from SDG different from intact ABZ and MAL powder X-ray diffraction patterns and these results can indicate the ABZ-MAL multicomponent crystal formation. The ABZ-MAL multicomponent crystal has better solubility than pure ABZ in all media used. These results can be concluded that ABZ-MAL multicomponent crystal can be prepared by solvent-drop grinding method with acetone-ethanol (9:1) mixture as a solvent and can increase the solubility of albendazole.
Co-Authors Abdul Azizsidiq, Fahmi Afifah Bambang Sutjiatmo, Afifah Bambang Alisha Ramadhanty Ludin Alya Nur Asilla Anggraeni Wulan Angraeni, Wulan Asih Rahaju Aulia Rachmadian Bella Dewinta Saraswati Dery Stiawan Dessy Adriani Putri Diamona Ayu Lestari Dina Apriani Dini Tereslina Dolih Gozali Dzaza Syahidatul Alamiah Elivas Simatupang Endah Wahyuni Erina Sifa Mutmainah Euis Reni Yuslianti, Euis Fahrauk Faramayuda, Fahrauk Faizal Hermanto Fani Wahyuni Fani Wahyuni, Fani Febrianti, Mia Fitria Hanako Gladdis Kamilah Pratiwi Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Hernandi Sujono Hesti Kurnia Hestiary Ratih Iis Inayati Rakhmat Ine Rosmala Dewi Ismunandar Ismunandar Jessie Sofia Pamudji Karin, Amada Kintan Putri Nur Shafarkiani Lucky Rachmawan Lucy D. N. Sasongko Lucy Sasongko Mia Agustin Moch. Reza Pratama Muliana, Muliana Mutia Alifah Rachmah Nadira Cantika Putri Ananda Nira Purnamasari, Nira Novitri Sri Rahayu Nur Achsan Al-Hakim Nurono Soewandhi, Sundani Pratama, Moch. Reza Purnamasari Nira Purwoko, Agus Qotrunnada, Daffa Raisa Fakhrona Salman Rani Sugandi Rani Sugandi, Rani Ratih Hestiary Ratih, Hestyari Regita Ayu Lestari Resina Hajar Ririn Puspadewi, Ririn Risanteni Riskasari Riskia Putri Peratiwi Riskia Putri Peratiwi, Riskia Putri Setia Permana Sintia Resni Pratiwi Suci Nar Vikasari, Suci Nar Sukmadjaja Asyarie Sundani N. Soewandhi Sundani Nurono S. Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Titta H. Sutarna Tresa Tri Rayani Tresa Tri Rayani, Tresa Tri Tresna Lestari, Tresna Woro Artati Sucipto Wulan Anggraeni Yesi Desmiaty, Yesi Yoga Windhu Wardhana Yoga Windu Wardhana Zwista Yulia Dewi