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All Journal Journal of Engineering and Technological Sciences Jurnal Farmasi Klinik Indonesia Biology, Medicine, & Natural Product Chemistry Pharmacon PROSIDING SEMINAR KIMIA JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Acta Pharmaceutica Indonesia Jurnal Fitofarmaka Indonesia Jurnal Keperawatan Padjadjaran JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSKK (Jurnal Sains Keolahragaan dan Kesehatan) JPSCR : Journal of Pharmaceutical Science and Clinical Research Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Farmako Bahari Narra J Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Kesehatan Bakti Tunas Husada Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Kusnandar Anggadiredja
Institut Teknologi Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : PROSIDING SEMINAR KIMIA

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LITERATUR REVIEW: PENGARUH INJEKSI INTRACEREBROVENTRIKULAR STREPTOZOTOCIN PADA OTAK MENCIT SEBAGAI KANDIDAT HEWAN MODEL ALZHEIMER Daryanti, Edhita Putri; Anggadiredja, Kusnandar; Wibowo, Agung Eru; Santoso, Koekoeh
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Background: Animal models of Alzheimer's have now been developed in various studies to become potential animal models suitable for clinical conditions. Alzheimer's in clinical conditions is characterized by Amyloid βeta (Aβ) plaques and intracellular tangles of neurofibrillary tangles as well as disorders of the acetylcholinesterase enzyme in the hippocampus. Rodents used include rats and mice. Mice are used because they are efficient and parts of the brain can be penetrated with a needle without requiring surgery. Objectives: Appropriate toxicant induction is needed so that the process of developing Alzheimer's pathology is known, namely the use of Streptozotocin. Intracerebroventricular induction of strepzotocin in mice needs to be further understood. Material and Methods: The research method uses literature review with identification, screening, evaluation and interpretation of all research results collected through online search engines such as; Sciencedirect, Pubmed, GoogleScholar with keywords and meet the inclusion criteria Results: The results of the synthesis obtained selected data from 8 articles. ICV-STZ has been proven from various studies to induce Alzheimer's pathology in both young and old male mice through neuroinflammatory pathways, oxidative stress, increasing Aβ expression and hyperphosphorylation of Tau as Alzheimer's markers which are similar to clinical patients. Keywords : Alzheimer, Hewan model, Literatur review, Mencit, Streptozotocin.
Co-Authors A.R. Ryadin Afifah B. Suciatmo Afrillia Nuryanti Garmana Agung Eru Wibowo Ainina Al Shadrina Amalia, Riezki Andreanusi A Soemardj Anggraini Barlian Aryantha, Hasna Firdaus Cindra Tri Yuniar Daryanti, Edhita Putri Dian Anggraeny Dudi Dudi Dudi, Dudi Eva Kusumahati Gusdinar, Tutus Hamidah Rahman Hegar Pramastya HENI RACHMAWATI I Ketut Adnyana Ikhwan Yuda Kusuma Indah Tri Lestari Iskandar, Fery Johnner P Sitompul Johnner Sitompul koekoeh santoso Kusumahati, Eva Lia Amalia Lia Amalia Lia Amalia Linda Amalia Lisna Anisa Fitriana, Lisna Anisa Lucy Lustiani Lustiani, Lucy Nazhifa Ufamy Ni'ma, Neli Syahida Nuari, Doni Anshar Permatasari, Fitri A. Raden Retno Ariani Rafika Thahirani Safira Ramadhani, Chelsea Aulia Rizka Zu Fadhilah Salsabila Andiyanti Putri Setiawan . Setiawan Setiawan Sevi Nurafni Sitompul, Johnner Sophi Damayanti Sophi Damayanti Suciatmo, Afifah B. Sukrasno Sukrasno Sukrasno, Sukrasno Suryani Gunadharma Tiara - Berliani Triantri Kartika Putri Tursino, Tursino Tutus Gusdinar Tutus Gusdinar Ufamy, Nazhifa Wibowo, Indra Widodo, Ferri Wijayanti, Ni PAD. Wisasani, Amiiratu Muthiia Yedy Purwandi Sukmawan Zazuli, Zulfan