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All Journal Media Kesehatan Masyarakat Indonesia Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Medical Journal of Indonesia Jurnal Kesehatan Melayu Spektra: Jurnal Fisika dan Aplikasinya Indonesian Journal of Obstetrics & Gynecology Science Jurnal Surya Masyarakat Acta Biochimica Indonesiana Journal Of Widya Medika Junior Care : Jurnal Ilmiah Ilmu Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Surya Masyarakat Unri Conference Series: Community Engagement Narra J Prosiding Konferensi Nasional PKM-CSR jabdimasunipem Jurnal Natur Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Arfianti Arfianti
Departemen Biologi Kedokteran Fakultas Kedokteran Universitas Riau
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Hubungan Kadar Vitamin D dan Gangguan Fungsi Hati pada Pasien Hepatitis B Kronik Sherin Alifia Hendri; Arfianti Arfianti
Jurnal Ilmu Kedokteran Vol 15, No 1 (2021): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v15i1.2021.12-20

Abstract

Vitamin D plays an important role in the pathogenesis of chronic hepatitis B (CHB) through regulating immune response. This study aimed to determine the relationship between vitamin D levels and impaired liver function in CHB patients. This was an observational analytical study conducted from March to October 2019. We included 36 CHB patients aged 38.31±12.98 years and consisted of 16 men and 20 women. Vitamin D levels were measured by enzyme-linked immune assay (ELISA) method while albumin and bilirubin levels were examined by colorimetric assay. Vitamin D levels were in normal limits in 80.6% and insufficiency/deficiency in 19.4% of CHB patients. ALBI ratio scores were good in 75% and moderate-poor in 25% of subjects. Furthermore, there was no significant association between vitamin D levels and the ALBI ratio. In conclusion, this study shows that there is no relationship between plasma vitamin D levels and impaired liver function in CHB patients.
IL-10 Promoter Polymorphism Distribution among HBsAg-Reactive and HBsAg-Nonreactive Blood Donors Rahmat Azhari Kemal; Arfianti Arfianti; Reni Oktora; Bebe Gani; Fauzia Andrini Djojosugito; Winarto Winarto
Majalah Kedokteran Bandung Vol 52, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (694.508 KB) | DOI: 10.15395/mkb.v52n1.1812

Abstract

Hepatitis B surface antigen (HBsAg) serves as a serological marker for Hepatitis B virus (HBV) infection. People with HBV asymptomatic infection might readily donate blood due to the lack of clinical manifestations. Host immunity contributes to susceptibility and progression of infection. A polymorphism in IL-10 gene promoter, rs1800896, might contribute to host immunity. This study was conducted on May 2019 – January 2020 in Faculty of Medicine, University of Riau on  70 blood samples from donors  in the Indonesian Red Cross Pekanbaru. Out of these samples, 35 were reactive for HBsAg and 35 donors were nonreactive. Genotyping of rs1800896 was conducted using Amplification Refractory Mutation System (ARMS-PCR). In total, The distribution of AA (74.3%), AG (24.3%), and GG (1.4%) genotypes revealed in this study seemed to be similar to genotype distribution among East and South-East Asian populations. While no significant difference was observed on age mean and gender distribution, a significant difference was identified in  genotype distribution between HBsAg status (p-value 0.028) with the percentage of AA genotype was higher among HBsAg-nonreactive donors (85.7%) compared to reactive donors (62.9%). More studies should be conducted to characterize HBsAg-reactive blood donors, including the donor characteristics and the viral genotypes. Such studies should contribute to hepatitis B management in Indonesia. Distribusi Polimorfisme Promoter IL-10 pada Donor Darah dengan HBsAg Reaktif dan Nonreaktif di Pekanbaru Hepatitis B surface antigen (HBsAg) merupakan penanda serologis infeksi virus hepatitis B (HBV). Individu dengan infeksi HBV asimptomatik dapat melakukan donasi darah karena tidak adanya gejala klinis. Imunitas inang berkontribusi pada kerentanan dan perkembangan infeksi. Polimorfisme pada promoter gen IL-10, rs1800896, dapat berkontribusi pada imunitas inang. Penelitian dilakukan pada bulan Mei 2019 – Januari 2020 di Fakultas Kedokteran Universitas Riau. Sampel diambil adalah 70 darah donor dari Palang Merah Indonesia Pekanbaru, 35 sampel reaktif HBsAg dan 35 sampel nonreaktif. Genotipe rs1800896 dilihat berdasarkan Amplification Refractory Mutation System (ARMS-PCR). Pada populasi studi ini, distribusi genotipe AA (74.3%), AG (24.3%), dan GG (1.4%) sesuai populasi Asia Timur dan Tenggara. Walaupun tidak terdapat perbedaan pada rerata umur dan distribusi jenis kelamin, penelitian ini menemukan perbedaan signifikan pada distribusi genotipe antar kelompok status HBsAg (p-value 0.028), yaitu persentase genotipe AA lebih tinggi pada kelompok donor dengan HBsAg nonreaktif (85.7%) dibandingkan kelompok reaktif (62.9%). Studi lebih lanjut perlu dilakukan untuk karakterisasi donor darah dengan HBsAg reaktif, termasuk gneotipe donor dan virus. Informasi tersebut diharapkan dapat bermanfaat pada manajemen hepatitis B di Indonesia.
Putative and pretreatment drug resistance mutations in reverse transcriptase gene among untreated chronic hepatitis B patients at Arifin Achmad Regional District Hospital, Riau, Indonesia Arfianti Arfianti; Fauzia Andrini Djojosugito; Maisaroh Maisaroh; Hendra Asputra; Dita Kartika Sari; Tubagus Odih Rhomdani Wahid
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.68

Abstract

Background: Mutations within the hepatitis B virus (HBV) reverse transcriptase (RT) gene have been associated with drug resistance against nucleos(t)ide analogs (NAs). Objective: This study aimed to identify mutations in the RT gene among patients with chronic hepatitis B (CHB) before receiving antiviral therapy and its relationship with the HBV genotypes. Methods: A total of 26 HBV DNA was extracted from the blood plasma of CHB patients. HBV RT gene was amplified and sequenced using the Sanger dideoxy sequencing method. The HBV genotype was determined through phylogenetic analysis using the Maximum Likelihood method. Results: The study subjects comprised 14 CHB patients without complications and 12 CHB patients with cirrhosis/hepatoma. CHB patients with cirrhosis/hepatoma were older than those without complications. The HBV genotypes comprised 15 (57.7%) genotype C and 11 (42.3%) genotype B. All treatment-naïve CHB patients did not demonstrate any classical NA resistance mutations within the RT gene. However, several putative and pretreatment resistance mutations, including F221Y, N238H, and V224I, were high frequency in more than 40% of study subjects. In addition, F221Y and N238H/Q mutations were frequently observed in genotype B, while V224 I was only found in patients infected with genotype C (p=0.000). Conclusions: There was no evidence of classical RT gene mutations associated with NA resistance in treatment-naïve patients with CHB. However, several putative and pretreatment mutations were identified as genotype-specific mutations and may contribute to antiviral resistance against NAs.
Peningkatan derajat kesehatan masyarakat Bagan Sinembah melalui pengelolaan sampah rumah tangga menjadi barang bernilai ekonomi Huriatul Masdar; Fifia Chandra; Arfianti Arfianti; Yulia Irvani Dewi
Unri Conference Series: Community Engagement Vol 1 (2019): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.1.158-162

Abstract

Household waste if not managed properly can cause various health problems. Good management of household waste can have economic value and improve the economy of community. Organic waste can be processed into compost that is useful for agricultural land while non-organic waste can be recycled into high-value items. This waste management problem also occurred in Bagan Sinembah Subdistrict, Rokan Hilir Regency. Through community service activities at University of Riau, socialization of organic and non-organic waste management, composting training and decoupage art applications on used goods in households were conducted. The level of success of this activity is considered good in quality, but the quantity of trainees is still lacking. Increasing the number of target communities needs to be done so that the waste management efforts at Bagan Sinembah become more optimal.
Peningkatan Kapasitas Kader Posyandu Desa Tambang Dalam Deteksi Stunting Pada Anak Arfianti Arfianti; Nurhasanah Nurhasanah; Suri Dwi Lesmana; Yuliati Yuliati; Erika Erika; Ariza Julia Paulina; Dedi Afandi
Prosiding Konferensi Nasional Pengabdian Kepada Masyarakat dan Corporate Social Responsibility (PKM-CSR) Vol 3 (2020): Peran Perguruan Tinggi dan Dunia Usaha Dalam Pemberdayaan Masyarakat Untuk Menyongsong
Publisher : Asosiasi Sinergi Pengabdi dan Pemberdaya Indonesia (ASPPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.856 KB) | DOI: 10.37695/pkmcsr.v3i0.792

Abstract

Stunting merupakan kondisi malnutrisi kronis pada anak yang ditandai dengan tinggi badan anak berada di bawah 2 standar deviasi dibawah grafik pertumbuhan anak. Stunting menjadi masalah kesehatan yang serius terutama di negara-negara berkembang, termasuk di Indonesia. Kampar merupakan salah satu wilayah prioritas penanganan stunting di Provinsi Riau dengan 10 lokus stunting yang telah diidentifikasi. Desa Tambang Kecamatan Tambang merupakan desa di Kabupaten Kampar dengan prevalensi stunting cukup tinggi yaitu memiliki 42 balita. Tujuan dari kegiatan pengabdian ini adalah meningkatkan pengetahuan dan keterampilan kader Desa Tambang dalam melakukan penilaian status gizi anak balita. Pengabdian dilakukan pada bulan Juli 2020 di Kantor Camat Tambang. Metode pelatihan meliputi ceramah, tanya jawab, studi kasus dan praktek langsung pengukuran tinggi dan berat badan anak balita. Topik pelatihan meliputi stunting dan strategi pencegahan stunting di desa, penilaian status gizi anak balita serta kebutuhan gizi ibu hamil dan anak balita. Pelatihan diikuti oleh 25 kader posyandu yang ada di Desa Tambang. Hasil evaluasi kegiatan menggunakan kuesioner pre-test dan post-test menunjukkan terdapat peningkatan pengetahuan kader posyandu tentang stunting dan strategi pencegahannya.
Edukasi dan Pelatihan Tanaman Obat Keluarga di Kelurahan Sri Meranti, Pekanbaru Rahmat Azhari Kemal; Arfianti Arfianti; Ulfah Ulfah; Bayu Fajar Pratama
Jurnal Surya Masyarakat Vol 6, No 1 (2023): November 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.6.1.2023.11-15

Abstract

A family medicinal plant is a group of plants that have health benefits for family health. However, its utilization should be increased. During the COVID-19 pandemic, public interest in traditional herbal medicine increases. Therefore, it has to be balanced with increased knowledge of family medicinal plants as well as knowledge of good practices in the utilization and care of the plants. Education and training of family medicinal plants were conducted for representatives of Sri Meranti District, Pekanbaru City, Riau. Education on types of family medicinal plants and how to properly utilize them was delivered online via the Zoom Meeting platform. The education was followed by training on how to plant and care for the family's medicinal plants. Participants were also given seedlings of family medicinal plants for their yards. After the education, participants’ knowledge of how to utilize family medicinal plants increased. With the increased knowledge as well as the seedlings provided, people in the Sri Meranti district are expected to cultivate and utilize family medicinal plants properly.
EDUKASI DAN SKRINING KESEHATAN PERNAPASAN PADA PENYINTAS COVID-19 DI WILAYAH KERJA PUSKESMAS RUPAT UTARA Rahmat Azhari Kemal; Piki Setri Pernantah; Suyanto; Arfianti; Zarfiardy Aksa Fauzi
Jurnal Abdimas Universitas Insan Pembangunan Indoneisa Vol. 2 No. 1 (2024): Abdimas Unipem
Publisher : LPPM Universitas Insan Pembangunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58217/jabdimasunipem.v2i1.25

Abstract

Pasien Covid-19 dapat memiliki gejala yang berkepanjangan setelah dinyatakan negatif SARS-CoV-2. Kondisi ini disebut sebagai long Covid. Kualitas kesehatan masyarakat penyintas Covid-19 tersebut perlu ditingkatkan. Kecamatan Rupat Utara merupakan salah satu daerah pesisir dan perbatasan di Kabupaten Bengkalis, Provinsi Riau. Lokasi tersebut menyebabkan relatif sulitnya akses ke layanan kesehatan tersier. Oleh karena itu, tujuan dari kegiatan pengabdian kepada masyarakat ini adalah memberikan edukasi dan skrining kesehatan pernapasan pada penyintas Covid-19. Kegiatan pengabdian ini dilaksanakan dengan metode pemberian edukasi berupa pemaparan materi long Covid dan pentingnya vaksinasi Covid-19, pengenalan senam pernapasan, serta pemeriksaan spirometri pada penyintas Covid-19. Hasil dari kegiatan ini adalah meningkatnya pengetahuan warga mengenai long Covid dan vaksinasi Covid-19. Masyarakat juga mengetahui dan dapat mempraktikkan senam pernapasan untuk meningkatkan kesehatan pernapasan. Hasil skrining spirometri menunjukkan peserta memiliki kesehatan pernapasan yang baik. Melalui kegiatan ini, masyarakat terutama penyintas Covid-19 di Rupat Utara dapat memiliki kualitas kesehatan yang baik setelah sembuh dari Covid-19.
Edukasi dan Pelatihan Tanaman Obat Keluarga di Kelurahan Sri Meranti, Pekanbaru Kemal, Rahmat Azhari; Arfianti, Arfianti; Ulfah, Ulfah; Pratama, Bayu Fajar
Jurnal Surya Masyarakat Vol 6, No 1 (2023): November 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.6.1.2023.11-15

Abstract

A family medicinal plant is a group of plants that have health benefits for family health. However, its utilization should be increased. During the COVID-19 pandemic, public interest in traditional herbal medicine increases. Therefore, it has to be balanced with increased knowledge of family medicinal plants as well as knowledge of good practices in the utilization and care of the plants. Education and training of family medicinal plants were conducted for representatives of Sri Meranti District, Pekanbaru City, Riau. Education on types of family medicinal plants and how to properly utilize them was delivered online via the Zoom Meeting platform. The education was followed by training on how to plant and care for the family's medicinal plants. Participants were also given seedlings of family medicinal plants for their yards. After the education, participants’ knowledge of how to utilize family medicinal plants increased. With the increased knowledge as well as the seedlings provided, people in the Sri Meranti district are expected to cultivate and utilize family medicinal plants properly.
KARAKTERISTIK FUNGSI HATI BERDASARKAN RATIO ALBUMIN-BILIRUBIN PADA PENDERITA HEPATITIS B KRONIK Arfianti Arfianti; Fauzia Andrini Djojosugito
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 2 (2021): EDITION JULY 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i2.2096

Abstract

Hepatitis B kronik (HBK) merupakan penyakit nekroinflamasi hati yang disebabkan oleh infeksi virus hepatitis B (VHB). Penderita HBK berisiko mengalami gangguan fungsi hati yang ditandai oleh gangguan sintesis albumin and sekresi bilirubin. Ratio albumin-bilirubin (ALBI) dilaporkan berhubungan dengan prognosis penderita sirosis. Penelitian ini bertujuan untuk mengkarakterisasi ratio ALBI pada penderita HBK di Rumah Sakit Umum Daerah (RSUD) Arifin Ahmad Provinsi Riau. Populasi penelitian ini adalah 75 pasien HBKdi Poli Penyakit Dalam RSUD Arifin Achmad Provonsi Riau yang terdiri dari 36 penderita HBK tanpa sirosis, 26 penderita HBK dengan sirosis dan 13 penderita HBK dengan hepatoma. Kadar albumin dan bilirubin total serum diukur menggunakan kit komersial dan dikelompokkan menjadi 3 grade. Hasil penelitian menunjukkan rerata umur penderita HBK adalah 45.313.3 tahun (minimum-maksimum, 18-73 tahun), dan penderita HBK dengan sirosis dan hepatoma lebih tua secara bermakna dibanding penderita HBK tanpa sirosis (P
Unveiling the impacts of metformin on hepatocellular carcinoma: A bioinformatic exploration in cell lines Soraya, Soraya; Arfianti, Arfianti; Adikusuma, Wirawan; Irham, Lalu M.; Hamidy, Muhammad Y.; Winarto, Winarto; Rangkuti, Ina F.; Darmawi, Darmawi
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.968

Abstract

The most common type of liver cancer is hepatocellular carcinoma (HCC), accounting for 75–85% of cases. Despite its associated side effects, sorafenib remains the standard treatment for HCC. Given the critical need to improve therapeutic efficacy while minimizing adverse effects, alternative drugs must be thoroughly investigated. Numerous studies indicate that combining sorafenib with metformin results in a more favorable treatment profile. The aim of this study was to employ bioinformatics methodologies to elucidate the molecular pathways and genetic underpinnings of metformin's efficacy in HCC treatment. Genes associated with metformin and its action against HCC (Huh-7 and HepG2 cells) were acquired from the NCBI-GEO data collection by utilizing pre-determined keywords. Subsequently, pathways implicated in metformin-mediated HCC treatment were analyzed through the Kyoto Encyclopedia of Genes and Genomes (KEGG). Our analysis revealed the involvement of multiple pathways, with metabolic pathways implicated in 80% of the total cases. Neurodegenerative pathways were involved in only around 60% of the total cases. These findings align with the multifaceted mechanisms of metformin’s action, encompassing adenosine monophosphate-activated protein kinase activation, apoptosis induction, insulin regulation, anti-inflammatory responses, and modulation of cell proliferation. This comprehensive investigation sheds light on the intricate molecular landscape underpinning metformin's therapeutic efficacy in HCC, thereby informing potential avenues for optimizing treatment strategies.
Co-Authors Andi Zainal Ardini, Nadiah Yamanza Ariza Julia Paulina Armi, Wahyuli Bayu Fajar Pratama Bebe Gani Dani Rosdiana Darmawi Darmawi Dedi Afandi Deyana, Frilly Dita Kartika Sari Djojosugito, Fauzia A. Elda Nazriati Erika Erika Fauzia Andrini Fifia Chandra Fifia Chandra Hamidy, Muhammad Y. Hendra Asputra Hendri, Sherin Alifia Huriatul Masdar Ibrahim, Sundus Indrati, Agnes R. Irham, Lalu M. Ismawati Ismawati Ismawati Ismawati Kesumah, Dewi Iramayana Sandra Khairunisa, Siti Q. Labecka, Magda Lazuardi Umar Maisaroh Maisaroh Muhammad Beni Septima Nababan, Heru Maranatha Nasronudin Nasronudin Nukman Moeloek Nurfi Pratiwi, Nurfi Nurul Humairah Arfiza Piki Setri Pernantah Purnomo Soeharso Rachman, Brian E. Rahmat Azhari Kemal Rahmondia N. Setiadi Ramadhani, Nur'aina ID Rangkuti, Ina F. Reni Oktora Riefni Silara Dini Rina Amtarina Rita Endriani Rudi Wisaksana S, Donel S.Pd. M Kes I Ketut Sudiana . Saputra, Nicko Pisceski Kusika Sherin Alifia Hendri Simanjuntak, Arya Marganda Siregar, Fajri M. Soraya Soraya Suri Dwi Lesmana Suyanto Suyanto TB Odih Rhomdani Wahid Tetty M Linda Tri Muhti Puja Kesuma Ulfah Ulfah Ulfah Ulfah Winarto Winarto Winarto Winarto Wirawan Adikusuma Yuhendri, Vitriyanna Mutiara Yulia Irvani Dewi Yulia Wardany Yuliati Yuliati Zarfiardy Aksa Fauzi