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All Journal Majalah Kedokteran Bandung Biomedical Journal of Indonesia Chimica et Natura Acta Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan SRIWIJAYA JOURNAL OF MEDICINE Health and Medical Journal Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Narra J SULUH ABDI : Jurnal Ilmiah Pengabdian Kepada Masyarakat (Medical Scientific Journal) MESINA
Yesi Astri
Fakultas Kedokteran Universitas Muhammadiyah Palembang, Jalan KH Bhalqi 13 Ulu Plaju Palembang Indonesia 30263
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Acceptance for a booster dose of COVID-19 vaccine in Indonesia: A follow-up study Harapan, Harapan; Maelani, Imelda; Anwar, Samsul; Latief, Kamaluddin; Mellinia, Sania A.; Nanda, Cut M.; Nainu, Firzan; Nirwana, Aura; Aksa, Rahmad; Sarifuddin, Sarifuddin; Astri, Yesi; Fathima, Raisha; Nalapraya, Widhy Y.; Ikram, Ikram; Mutiara, Suci; Syahraini, Aigia; Mudatsir, Mudatsir
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.803

Abstract

The coronavirus disease 2019 (COVID-19) vaccination program in Indonesia has been implemented as a key strategy to mitigate the spread of the virus within communities. The success of this program depends on public acceptance of COVID-19 vaccines, including booster doses. The aim of this study was to assess the acceptance of the COVID-19 booster dose in Indonesia and to identify factors influencing individuals' acceptance. A cross-sectional study was conducted across 34 provinces in Indonesia on June 2023. Logistic regression analysis was used to identify the factors associated with booster dose uptake. The findings revealed that 88.8% (2,049/2,308) of respondents were willing to receive a booster dose if provided free of charge by the Indonesian government. However, acceptance decreased to 61.7% when respondents were informed of a 20% likelihood of side effects, even with a reported 95% vaccine efficacy. Adjusted logistic regression analysis identified ten significant factors associated with booster dose acceptance: sex, age, religion, history of previous COVID-19 infection, type of primary vaccine received, belief in vaccine-related conspiracy theories, trust in traditional medicine conspiracies, confidence in natural immunity, perceived vaccine efficacy, and perceived vaccine effectiveness. These findings suggest that acceptance of COVID-19 booster doses in Indonesia is influenced by intrinsic and extrinsic factors, including limited knowledge of booster dose benefits and concerns about potential side effects. To enhance public acceptance, targeted health campaigns and educational initiatives should be intensified, emphasizing the safety, efficacy, and importance of booster vaccinations in controlling the COVID-19 pandemic.
The Potential of Rosella (Hibiscus sabdariffa L.) for Diabetes Mellitus Model Rats: Histopathological Focus on Pancreatic Organ Putria, Sinta Julia Liona; Rohani, Siti; Suarni, Ertati; Astri, Yesi; Mundijo, Trisnawati
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.236

Abstract

Introduction. Ethanolic extract of rosella flowers (Hibiscus sabdariffa L.) contains secondary metabolite compounds: flavonoids, alkaloids, saponins, and tannins. This study aims to determine whether the ethanol extract of rosella flowers has the potential to regenerate pancreatic β cells in white rats (Rattus norvegicus) with alloxan-induced diabetes mellitus models.  Methods. The type of research used was an in vivo laboratory experimental study with a true experimental design. The experimental animals used as test objects in this study were male rats (Rattus norvegicus L.), weighing 100-110 grams. The test objects were 30 rats, divided into 6 groups randomly, each containing 5 rats, the groups consisted of K (N), K (-), K (+), P (1), P (2), and P (3). The level of histopathological damage to the pancreas was observed with HE staining at 400x magnification, using binocular light microscope type CX23 and BX51. Results. The study showed that the ethanol preparation of rosella flower extract at a dose of 1500 mg/kgBW and 3000 mg/kgBW BB was effective in regenerating pancreatic β cells with a damage value of 0 and at a dose of 750 mg/kgBW with a damage value of 2 did not provide a maximum regeneration effect on pancreatic β cells in male white rats induced by alloxan. Conclusion. The results of this research show that the ethanol extract of rosella flowers has an influence on the regeneration of pancreatic β cells so that it can be used for supportive treatment in the management of diabetes mellitus.
Hubungan Kesehatan Kerja Dengan Tingkat Stres Karyawan Pt Sukses Citra Pangan Aflah, Anisatul; Oktariza, Rury Tiara; Purwoko, Mitayani; Astri, yesi
MESINA (Medical Scientific Journal) Vol 5, No 2 (2025): MESINA (Medical Scientific Journal)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v5i2.9405

Abstract

Abstrak Stres kerja adalah bentuk khusus dari stres yang terkait dengan tuntutan dan tekanan di lingkungan kerja. Tenaga kerja dapat terpapar bahan fisik, kimia, dan biologi serta beban kerja fisik yang melampaui kapasitas mereka, termasuk juga beban mental. Tingkat kecelakaan kerja di Indonesia masih cukup tinggi. Tujuan: Untuk mengetahui hubungan antara kesehatan kerja dengan tingkat stres karyawan PT Sukses Citra Pangan. Metode: Penelitian kuaritatif observasional analitik dengan pendekatan cross sectional. Sampel didapakan sebanyak 37 orang. Analisis data yang digunakan ialah analisis univariat dan analisis bivariat dengan uji alternatif Fisher-Exact. Hasil: Didapatkan hasil responden paling dominan ialah tingkat stress ringan sebanyak 35 orang (94,6%), yaitu 20 orang (95,2%) dengan kesehatan kerja baik dan 15 orang (93,8%) dengan kesehatan kerja yang buruk, serta didapatkan nilai p-value = 1,000 (P>0,05). Kesimpulan: Tidak terdapat hubungan signifikan antara kesehatan kerja dan tingkat stres karyawan di PT Sukses Citra Pangan Kata Kunci : Kesehatan Kerja, Tingkat Stres, PT. Sukses Citra Pangan Abstract Job stress is a special form of stress related to demands and pressure in the work environment. Workers can be exposed to physical, chemical and biological substances and physical workloads that exceed their capacity, including mental burdens. The work accident rate in Indonesia is still quite high. Objective: To determine the relationship between occupational health and stress levels of PT Sukses Citra Pangan employees. Method: Analytical observational quantitative research with a cross sectional approach. The sample obtained was 37 people. The data analysis used was univariate analysis and bivariate analysis with the alternative Fisher-Exact test. Results: The results obtained by the most dominant respondents were mild stress levels as many as 35 people (94.6%), namely 20 people (95.2%) with good work health and 15 people (93.8%) with poor work health, and the pvalue = 1.000 (P>0.05) was obtained. Conclusion: There is no significant relationship between occupational health and employee stress levels at PT Sukses Citra Pangan. Keywords: Occupational Health, Stress Level, PT. Sukses Citra Pangan
Edukasi Potensi Bunga Rosella (Hibiscus sabdariffa L.) terhadap Pencegahan Bakteri Salmonella enteritidis di Cangkang Telur Mundijo, Trisnawati; Astri, Yesi; Kahar, Fania Aulia
Suluh Abdi Vol 7, No 1 (2025): SULUH ABDI
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sa.v7i1.9632

Abstract

Dalam beberapa tahun terakhir, pemanfaatan natural product semakin berkembang seiring dengan kecenderungan back to nature. Zat yang terdapat dalam bahan alam memberikan efek sinergisme sehingga memiliki kemampuan dalam mencegah beberapa masalah kesehatan. Salah satu kekayaan hayati Indonesiabdengan khasiat yang dimiliki yaitu tanaman Rosella (Hibiscus sabdariffa L.). Masyarakat desa Pulau Panggung dan muara dua, kabupaten Muara Enim secara turun menurun telah memanfaatkan tanaman Rosella. Tidak hanya sebagai tanaman hidup yang berfungsi sebagai pagar di pekarangan, namun juga sebagai salah satu kebiasaan dengan mengkonsumsinya sebagai teh dari bunga yang diseduh dalam air panas. Kebiasaan ini dilakukan masyarakat khususnya saat musim panen di kebun. Masyarakat mempercayai bahwa dengan mengkonsumsi teh bunga Rosella, kesehatan mereka akan terjaga selama musim panen. Selain itu, literatur hasil penelitian telah banyak melaporkan bahwa tanaman Rosella memiliki banyak khasiat bagi kesehatan manusia karena memiliki kandungan zat berupa flavonoid, saponin, tanin dan alkaloid yang salah satunya berperan dalam menghambat dan mengeliminasi pertumbuhan bakteri. Etnofarmaka yang terdapat dalam tanaman Rosella ini perlu disampaikan  kepada masyarakat seiring dengan kebiasaan masyarakat dalam memanfaatkan Rosella sehingga diperlukan edukasi terkait manfaat yang terdapat dalam tanaman Rosella khususnya sebagai antibakteri.
Identification of Secondary Metabolites in Ethyl Acetate Extract of Ki Encok Plant Roots (Plumbago zeylanica Linn) and In Silico Cytotoxicity Activity Purwoko, Mitayani; Mundijo, Trisnawati; Astri, Yesi; Rohani, Siti
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50815

Abstract

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, tested in silico using the CB-Dock2 software, and evaluated for drug-likeness with SwissADME. Qualitative phytochemical tests indicate the presence of alkaloid and tannin compounds. The GC-MS test showed the presence of Plumbagin, Gamma sitosterol, and 4-ethoxybenzaldehyde. In the in silico test, docking between Gamma sitosterol, Plumbagin, and 4-ethoxybenzaldehyde with the target protein Caspase-3 has free binding energies of -8.5, -7.0, and -6.1. The Gamma sitosterol-Caspase-3 complex shows the best free-binding energy among the three ligands. Further in vitro or in vivo studies are needed to assess whether the interaction between Gamma sitosterol and Caspase-3 is inhibition or activation.
Identification of Chemical Constituents in Ethanolic Extract of Hibiscus sabdariffa L. Calyces (Roselle) by FTIR and GC-MS: Preliminary Phytochemical Screening Rohani, Siti; Martha, Fadhil Rizki; Astri, Yesi; Putria, Sinta Julia Liona
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.360

Abstract

Indonesia is widely recognized for its rich biodiversity, which has long served as a valuable resource for traditional herbal medicine. In recent years, interest in plant-based therapies has grown significantly. One such plant, Hibiscus sabdariffa L., commonly known as Rosella, is valued for its therapeutic properties. These benefits arise from the combined effects of its bioactive compounds, allowing it to address a range of health issues. Research has shown that Rosella contains notable levels of flavonoids, saponins, tannins, and alkaloids—all of which contribute to its antibacterial activity. Techniques such as Fourier-transform infrared (FTIR) spectroscopy and gas chromatography–mass spectrometry (GC-MS) are employed to identify these chemical constituents. FTIR analysis has detected functional groups like amines, fatty acids, aldehydes, carboxylic acids, and aromatic rings. Additionally, GC-MS results have indicated the presence of major compounds belonging to the methyl ester group. Noteworthy identified substances include Hexadecanoic Acid Methyl Ester, Hexadecanoic Acid Ethyl Ester, and Benzenepropanoic Acid, 3,5-Bis(1,1-Dimethylethyl)-4-Hydroxy-, Methyl Ester. A review of existing prior research suggests that these compound groups exhibit significant pharmacological potential, including the usage for antioxidant, anticancer, antibacterial, antidiabetic, and anti-inflammatory effects.
Co-Authors Aflah, Anisatul Aksa, Rahmad Amar, Ilham Kasbawan Artanto, Ardi Ayu Permata Sari Budi Utama Chairani, Liza Fathima, Raisha Firzan Nainu Harapan Harapan Ikram Ikram Irma Yanti Joseph I. Sigit Kahar, Fania Aulia Kaswijan, Siti Rohani Latief, Kamaluddin Maelani, Imelda Martha, Fadhil Rizki Melianti, Agnes Mellinia, Sania A. Miranti Dwi Hartanti Mitayani Purwoko, Mitayani MUCHTAN SUJATNO Mudatsir Mudatsir Muhammad Irsan Saleh Mundijo, Trisnawati Mutiara, Suci Nalapraya, Widhy Y. Nanda, Cut M. Nirwana, Aura Oktariza, Rury Tiara Pahlawan, M Kaisar Pratrisna Yusastra Putria, Sinta Julia Liona Samsul Anwar Sarifuddin Sarifuddin sentani, maya dwinta Siti Hildani Thaib, Siti Hildani Siti Rohani Suarni, Ertati Syahraini, Aigia Trisnawati Truly Sitorus Zilda, Malika