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All Journal Majalah Kedokteran Bandung Biomedical Journal of Indonesia Chimica et Natura Acta Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan SRIWIJAYA JOURNAL OF MEDICINE INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Health and Medical Journal Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J SULUH ABDI : Jurnal Ilmiah Pengabdian Kepada Masyarakat Neurona (Medical Scientific Journal) MESINA
Yesi Astri
Fakultas Kedokteran Universitas Muhammadiyah Palembang, Jalan KH Bhalqi 13 Ulu Plaju Palembang Indonesia 30263
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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KARAKTERISTIK PASIEN DAN POLA PENGGUNAAN OBAT ANTI BANGKITAN (OAB) PADA PASIEN EPILEPSI DI RS. MUHAMMADIYAH PALEMBANG Astri, Yesi; Yanti, Irma; Sari, Ayu Permata
Syifa'Medika Vol 13, No 2 (2023): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v13i2.4446

Abstract

Penggunaan obat anti bangkitan (OAB) secara tepat dan patuh pada pasien epilepsi dapat mengurangi frekuensi bahkan menghilangkan bangkitan dan meningkatkan kualitas hidup. Penelitian ini bertujuan mengetahui karakteristik pasien dan pola penggunaan OAB, melalui studi deskriptif dengan desain potong lintang. Data diambil melalui rekam medik pasien di polikinik Saraf RS. Muhammadiyah Palembang (RSMP) pada tahun 2020. Sampel penelitian berjumlah 45 orang. Pada penelitian ini didapatkan bahwa jenis kelamin laki-laki, usia 26-64 tahun, pendidikan terakhir SMA, onset kejang usia >18 tahun, dengan jenis bangkitan umum dan etiologi simptomatik adalah karakteristik pasien epilepsi di RS. Muhammadiyah Palembang. Dapat disimpulkan bahwa di RSMP, OAB yang digunakan pada pasien epilepsi adalah monoterapi (Fenitoin) dan politerapi (Fenitoin dan Klobazam).
HUBUNGAN ANTARA ADIKSI INTERNET DENGAN GANGGUAN KECEMASAN MENYELURUH PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERISTAS MUHAMMADIYAH PALEMBANG Amar, Ilham Kasbawan; Astri, Yesi; Artanto, Ardi
MESINA (Medical Scientific Journal) Vol 3, No 2 (2023): Medical Scientific Journal (MESINA)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v3i2.5834

Abstract

Adiksi internet didefinisikan sebagai penggunaan internet yang berlebihan atau obsesif yang dapat mengganggu kehidupan sehari-hari orang tersebut seperti gangguan pada hubungan interpersonal, kesehatan fisik dan mental. Adiksi ini dapat menyebabkan banyak efek negatif baik gangguan fisik dan gangguan psikologis seperti gangguan kecemasan menyeluruh. Penelitian ini bertujuan untuk mengetahui hubungan antara adiksi internet dengan gangguan kecemasan menyeluruh pada mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Palembang. Penelitian ini menggunakan desain cross-sectional dan didapatkan sampel berjumlah 166 mahasiswa yang telah memenuhi kriteria inklusi dan ekslusi dengan menggunakan teknik total sampling. Hasil analisis hubungan adiksi internet dan gangguan kecemasan menyeluruh yang didapatkan adalah p = 0.005. Terdapat hubungan bermakna antara adiksi internet dan gangguan kecemasan menyeluruh pada mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Palembang.
Tingkat Pengetahuan Masyarakat Tentang Potensi Bunga Rosella (Hibiscus sabdariffa L.) Sebagai Herbal Medicine di Kenten Laut Sumatera Selatan: Tingkat Pengetahuan Masyarakat Tentang Potensi Bunga Rosella (Hibiscus sabdariffa L.) Sebagai Herbal Medicine di Kenten Laut Sumatera Selatan Kaswijan, Siti Rohani; Trisnawati; Astri, Yesi; Zilda, Malika; Melianti, Agnes
DHARMA RAFLESIA Vol 22 No 2 (2024): DESEMBER (ACCREDITED SINTA 5)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/dr.v22i2.35000

Abstract

Pemanfaatan rosella sebagai herbal medicine telah banyak dilakukan dalam beberapa dekade ini. Penggunaan rosella telah diteliti sebagai antioksidan, antibakteri, dan lainnya. Pemahaman masyarakat dalam penggunaan rosella sebagai herbal medicine perlu dilakukan sebagai tindakan mengedukasi potensi dan peluang budidaya rosella, salah satunya melalui sosialisasi. Sosialisasi telah dilakukan di desa Kenten Laut, Sumatera Selatan terkait potensi, pengolahan, pemanfaatan dan pengembangan rosella sebagai herbal medicine. Hasil kegiatan dievaluasi dari responden terhadap capaian nilai berdasarkan pretest dan posttest. Menggunakan pendekatan statistik, didapatkan peningkatan nilai pemahaman responden tentang rosella sebagai herbal medicine. Hasil analisis didapatkan 25 orang responden, sebanyak 64% memiliki nilai posttest lebih besar daripada pretest. Hasil uji wilcoxon signed rank test dari nilai negative ranks menunjukkan perbedaan hasil setelah dilakukan penyuluhan dengan nilai asymp.sig. (2-tailed) pada angka 0,001. Nilai Zscore dari wilcoxon signed rank test menunjukan nilai Z (-3,300) < Ztabel(60) (P=0,05), terdapat korelasi peningkatan pengetahuan responden setelah sosialisasi. Sosialisasi lanjutan diperlukan untuk membangun kapabilitas masyarakat dalam pemanfaatan rosella sebagai herbal medicine pada usaha mikro, kecil dan menengah (UMKM) secara komersial.
Acceptance for a booster dose of COVID-19 vaccine in Indonesia: A follow-up study Harapan, Harapan; Maelani, Imelda; Anwar, Samsul; Latief, Kamaluddin; Mellinia, Sania A.; Nanda, Cut M.; Nainu, Firzan; Nirwana, Aura; Aksa, Rahmad; Sarifuddin, Sarifuddin; Astri, Yesi; Fathima, Raisha; Nalapraya, Widhy Y.; Ikram, Ikram; Mutiara, Suci; Syahraini, Aigia; Mudatsir, Mudatsir
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.803

Abstract

The coronavirus disease 2019 (COVID-19) vaccination program in Indonesia has been implemented as a key strategy to mitigate the spread of the virus within communities. The success of this program depends on public acceptance of COVID-19 vaccines, including booster doses. The aim of this study was to assess the acceptance of the COVID-19 booster dose in Indonesia and to identify factors influencing individuals' acceptance. A cross-sectional study was conducted across 34 provinces in Indonesia on June 2023. Logistic regression analysis was used to identify the factors associated with booster dose uptake. The findings revealed that 88.8% (2,049/2,308) of respondents were willing to receive a booster dose if provided free of charge by the Indonesian government. However, acceptance decreased to 61.7% when respondents were informed of a 20% likelihood of side effects, even with a reported 95% vaccine efficacy. Adjusted logistic regression analysis identified ten significant factors associated with booster dose acceptance: sex, age, religion, history of previous COVID-19 infection, type of primary vaccine received, belief in vaccine-related conspiracy theories, trust in traditional medicine conspiracies, confidence in natural immunity, perceived vaccine efficacy, and perceived vaccine effectiveness. These findings suggest that acceptance of COVID-19 booster doses in Indonesia is influenced by intrinsic and extrinsic factors, including limited knowledge of booster dose benefits and concerns about potential side effects. To enhance public acceptance, targeted health campaigns and educational initiatives should be intensified, emphasizing the safety, efficacy, and importance of booster vaccinations in controlling the COVID-19 pandemic.
The Potential of Rosella (Hibiscus sabdariffa L.) for Diabetes Mellitus Model Rats: Histopathological Focus on Pancreatic Organ Putria, Sinta Julia Liona; Rohani, Siti; Suarni, Ertati; Astri, Yesi; Mundijo, Trisnawati
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.236

Abstract

Introduction. Ethanolic extract of rosella flowers (Hibiscus sabdariffa L.) contains secondary metabolite compounds: flavonoids, alkaloids, saponins, and tannins. This study aims to determine whether the ethanol extract of rosella flowers has the potential to regenerate pancreatic β cells in white rats (Rattus norvegicus) with alloxan-induced diabetes mellitus models.  Methods. The type of research used was an in vivo laboratory experimental study with a true experimental design. The experimental animals used as test objects in this study were male rats (Rattus norvegicus L.), weighing 100-110 grams. The test objects were 30 rats, divided into 6 groups randomly, each containing 5 rats, the groups consisted of K (N), K (-), K (+), P (1), P (2), and P (3). The level of histopathological damage to the pancreas was observed with HE staining at 400x magnification, using binocular light microscope type CX23 and BX51. Results. The study showed that the ethanol preparation of rosella flower extract at a dose of 1500 mg/kgBW and 3000 mg/kgBW BB was effective in regenerating pancreatic β cells with a damage value of 0 and at a dose of 750 mg/kgBW with a damage value of 2 did not provide a maximum regeneration effect on pancreatic β cells in male white rats induced by alloxan. Conclusion. The results of this research show that the ethanol extract of rosella flowers has an influence on the regeneration of pancreatic β cells so that it can be used for supportive treatment in the management of diabetes mellitus.
Hubungan Kesehatan Kerja Dengan Tingkat Stres Karyawan Pt Sukses Citra Pangan Aflah, Anisatul; Oktariza, Rury Tiara; Purwoko, Mitayani; Astri, yesi
MESINA (Medical Scientific Journal) Vol 5, No 2 (2025): MESINA (Medical Scientific Journal)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v5i2.9405

Abstract

Abstrak Stres kerja adalah bentuk khusus dari stres yang terkait dengan tuntutan dan tekanan di lingkungan kerja. Tenaga kerja dapat terpapar bahan fisik, kimia, dan biologi serta beban kerja fisik yang melampaui kapasitas mereka, termasuk juga beban mental. Tingkat kecelakaan kerja di Indonesia masih cukup tinggi. Tujuan: Untuk mengetahui hubungan antara kesehatan kerja dengan tingkat stres karyawan PT Sukses Citra Pangan. Metode: Penelitian kuaritatif observasional analitik dengan pendekatan cross sectional. Sampel didapakan sebanyak 37 orang. Analisis data yang digunakan ialah analisis univariat dan analisis bivariat dengan uji alternatif Fisher-Exact. Hasil: Didapatkan hasil responden paling dominan ialah tingkat stress ringan sebanyak 35 orang (94,6%), yaitu 20 orang (95,2%) dengan kesehatan kerja baik dan 15 orang (93,8%) dengan kesehatan kerja yang buruk, serta didapatkan nilai p-value = 1,000 (P>0,05). Kesimpulan: Tidak terdapat hubungan signifikan antara kesehatan kerja dan tingkat stres karyawan di PT Sukses Citra Pangan Kata Kunci : Kesehatan Kerja, Tingkat Stres, PT. Sukses Citra Pangan Abstract Job stress is a special form of stress related to demands and pressure in the work environment. Workers can be exposed to physical, chemical and biological substances and physical workloads that exceed their capacity, including mental burdens. The work accident rate in Indonesia is still quite high. Objective: To determine the relationship between occupational health and stress levels of PT Sukses Citra Pangan employees. Method: Analytical observational quantitative research with a cross sectional approach. The sample obtained was 37 people. The data analysis used was univariate analysis and bivariate analysis with the alternative Fisher-Exact test. Results: The results obtained by the most dominant respondents were mild stress levels as many as 35 people (94.6%), namely 20 people (95.2%) with good work health and 15 people (93.8%) with poor work health, and the pvalue = 1.000 (P>0.05) was obtained. Conclusion: There is no significant relationship between occupational health and employee stress levels at PT Sukses Citra Pangan. Keywords: Occupational Health, Stress Level, PT. Sukses Citra Pangan
Edukasi Potensi Bunga Rosella (Hibiscus sabdariffa L.) terhadap Pencegahan Bakteri Salmonella enteritidis di Cangkang Telur Mundijo, Trisnawati; Astri, Yesi; Kahar, Fania Aulia
Suluh Abdi Vol 7, No 1 (2025): SULUH ABDI
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sa.v7i1.9632

Abstract

Dalam beberapa tahun terakhir, pemanfaatan natural product semakin berkembang seiring dengan kecenderungan back to nature. Zat yang terdapat dalam bahan alam memberikan efek sinergisme sehingga memiliki kemampuan dalam mencegah beberapa masalah kesehatan. Salah satu kekayaan hayati Indonesiabdengan khasiat yang dimiliki yaitu tanaman Rosella (Hibiscus sabdariffa L.). Masyarakat desa Pulau Panggung dan muara dua, kabupaten Muara Enim secara turun menurun telah memanfaatkan tanaman Rosella. Tidak hanya sebagai tanaman hidup yang berfungsi sebagai pagar di pekarangan, namun juga sebagai salah satu kebiasaan dengan mengkonsumsinya sebagai teh dari bunga yang diseduh dalam air panas. Kebiasaan ini dilakukan masyarakat khususnya saat musim panen di kebun. Masyarakat mempercayai bahwa dengan mengkonsumsi teh bunga Rosella, kesehatan mereka akan terjaga selama musim panen. Selain itu, literatur hasil penelitian telah banyak melaporkan bahwa tanaman Rosella memiliki banyak khasiat bagi kesehatan manusia karena memiliki kandungan zat berupa flavonoid, saponin, tanin dan alkaloid yang salah satunya berperan dalam menghambat dan mengeliminasi pertumbuhan bakteri. Etnofarmaka yang terdapat dalam tanaman Rosella ini perlu disampaikan  kepada masyarakat seiring dengan kebiasaan masyarakat dalam memanfaatkan Rosella sehingga diperlukan edukasi terkait manfaat yang terdapat dalam tanaman Rosella khususnya sebagai antibakteri.
Identification of Secondary Metabolites in Ethyl Acetate Extract of Ki Encok Plant Roots (Plumbago zeylanica Linn) and In Silico Cytotoxicity Activity Purwoko, Mitayani; Mundijo, Trisnawati; Astri, Yesi; Rohani, Siti
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50815

Abstract

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, tested in silico using the CB-Dock2 software, and evaluated for drug-likeness with SwissADME. Qualitative phytochemical tests indicate the presence of alkaloid and tannin compounds. The GC-MS test showed the presence of Plumbagin, Gamma sitosterol, and 4-ethoxybenzaldehyde. In the in silico test, docking between Gamma sitosterol, Plumbagin, and 4-ethoxybenzaldehyde with the target protein Caspase-3 has free binding energies of -8.5, -7.0, and -6.1. The Gamma sitosterol-Caspase-3 complex shows the best free-binding energy among the three ligands. Further in vitro or in vivo studies are needed to assess whether the interaction between Gamma sitosterol and Caspase-3 is inhibition or activation.
Identification of Chemical Constituents in Ethanolic Extract of Hibiscus sabdariffa L. Calyces (Roselle) by FTIR and GC-MS: Preliminary Phytochemical Screening Rohani, Siti; Martha, Fadhil Rizki; Astri, Yesi; Putria, Sinta Julia Liona
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.360

Abstract

Indonesia is widely recognized for its rich biodiversity, which has long served as a valuable resource for traditional herbal medicine. In recent years, interest in plant-based therapies has grown significantly. One such plant, Hibiscus sabdariffa L., commonly known as Rosella, is valued for its therapeutic properties. These benefits arise from the combined effects of its bioactive compounds, allowing it to address a range of health issues. Research has shown that Rosella contains notable levels of flavonoids, saponins, tannins, and alkaloids—all of which contribute to its antibacterial activity. Techniques such as Fourier-transform infrared (FTIR) spectroscopy and gas chromatography–mass spectrometry (GC-MS) are employed to identify these chemical constituents. FTIR analysis has detected functional groups like amines, fatty acids, aldehydes, carboxylic acids, and aromatic rings. Additionally, GC-MS results have indicated the presence of major compounds belonging to the methyl ester group. Noteworthy identified substances include Hexadecanoic Acid Methyl Ester, Hexadecanoic Acid Ethyl Ester, and Benzenepropanoic Acid, 3,5-Bis(1,1-Dimethylethyl)-4-Hydroxy-, Methyl Ester. A review of existing prior research suggests that these compound groups exhibit significant pharmacological potential, including the usage for antioxidant, anticancer, antibacterial, antidiabetic, and anti-inflammatory effects.
The Relationship Between Medication Adherence and Nutritional Status with Random Blood Glucose Levels Among Patients with Type 2 Diabetes Mellitus at Plaju Community Health Center Noviyanti Noviyanti; Yesi Astri; Indriyani Indriyani; Rury Tiara Oktariza; Ratih Pratiwi; Marina Dwi Putri
MESINA (Medical Scientific Journal) Vol 6, No 2 (2026): Medical Scientific Journal (MESINA)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v6i2.5832

Abstract

ABSTRACTType 2 diabetes mellitus is a group of chronic metabolic diseases characterized by hyperglycemia, which requires ongoing medical care and reduction of risk factors. Compliance with treatment in diabetic patients is a major factor in controlling blood sugar levels, so that it can affect treatment outcomes. Nutritional status is one of the problems that play a role in Diabetes Mellitus because type 2 diabetes mellitus patients with more nutritional status tend to have higher blood sugar levels than patients with normal nutritional status. This type of research is an analytic observational study using a cross-sectional design. The number of samples in this study were 120 samples. The sampling method in this study used a consecutive sampling technique. Based on the results on the variables of medication adherence with blood sugar levels, the results of bivariate analysis showed that there was a significant relationship between medication adherence and blood sugar levels in type 2 diabetes mellitus patients at the Plaju Health Center. While the results on the variable nutritional status and blood sugar levels show that there is a significant relationship between nutritional status and blood sugar levels in type 2 diabetes mellitus patients at the Plaju Health Center. Keywords : Medication Adherence, Nutritional Status, Blood Sugar Levels, Type 2 Diabetes Mellitus
Co-Authors Aflah, Anisatul Agnes Melianti Aksa, Rahmad Al Rasyid Amar, Ilham Kasbawan Ardi Artanto Ayu Permata Sari Budi Utama Dhiya Ridha Shafira Fadhil Rizki Martha Fadhilah Jasmine Shahab Fathima, Raisha Firzan Nainu Harapan Harapan Ikram Ikram Indriyani Indriyani Irma Yanti Isma Yulianti Joseph I. Sigit Kahar, Fania Aulia Kurniawan, Mohammad Latief, Kamaluddin Liza Chairani Maelani, Imelda Malika Zilda Marina Dwi Putri Martha, Fadhil Rizki Melianti, Agnes Mellinia, Sania A. Miranti Dwi Hartanti Mitayani Purwoko MUCHTAN SUJATNO Mudatsir Mudatsir Muhammad Irsan Saleh Mutiara, Suci Nalapraya, Widhy Y. Nanda, Cut M. Nirwana, Aura Noviyanti Noviyanti Nurwahyuni, Atik Oktariza, Rury Tiara Pahlawan, M Kaisar Pratrisna Yusastra Putria, Sinta Julia Liona Rakhmad Hidayat Ratih Pratiwi Renindra Ananda Aman Salim Harris Samsul Anwar Sarifuddin Sarifuddin sentani, maya dwinta Siti Hildani Thaib, Siti Hildani Siti Rohani Suarni, Ertati Syahraini, Aigia Taufik Mesiano Tiara Aninditha Tiara Aninditha Trisnawati Trisnawati Trisnawati Truly Sitorus Zilda, Malika