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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) NERS Jurnal Keperawatan Oto Rhino Laryngologica Indonesiana Majalah Patologi Indonesia Andalas obstetrics and gynecology journal PREPOTIF : Jurnal Kesehatan Masyarakat Berita Kedokteran Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Hafni Bachtiar
Bagian Ilmu Kesehatan Masyarakat Fakultas Kedokteran Universitas Andalas
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Relationship Between Magnesium Level in Pregnancy with Gestational Diabetes Mellitus Ambelina, Syntia; Djanas, Dovy; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.102-111.2021

Abstract

Introduction : Magnesium is one of important micronutrients in pregnancy. Pregnant women needs higher magnesium intake than non-pregnant women at similar age. Decreased blood and cellular magnesium level was related to insulin resistance.Objective : To determine relationship between mean magnesium level in pregnant women with incidence of gestational diabetes mellitus.Methods : This was quantitative analytic study using cross sectional comparative design conducted in 8 Primary Health Care in Padang and 5 General Hospital in West Sumatra. This study was done from December 2019 until March 2020. Total sample collected was 36 samples consisted of 18 pregnant mother with gestational diabetes mellitus and 18 control sample with normal pregnancy, both were in gestational age between 24-28 weeks. Statistical analysis was done using independent sample T-test.Results : Mean magnesium level of pregnant mother with gestational diabetes mellitus was 1.85 ± 0.12 mg/dL, while in control sample was 2.10 ± 0.15 mg/dL. Statistical result using independent sample T-test showed significant correlation between mean magnesium level and incidence of gestational diabetes mellitus with p <0.001 (p value <0.05)Conclusion : Magnesium level during pregnancy is related to gestational diabetes mellitus incidence.Keywords: magnesium level, pregnant women, gestational diabetes mellitus
Correlation Between Levels of Interleukin-6 in Peritoneal Fluid With Degree of Pain, Adhesion, and Endometriosis Fertility Index Score in Endometriosis Prima, Angga Trifianda; Hendry, Dedy; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.193-205.2021

Abstract

Introduction : Endometriosis is a benign gynecological disorder characterized by the presence of endometrial tissue and stroma outside the uterine cavity. Several theories have been proposed to explain the occurrence of endometriosis, one of which is the theory of inflammation. Endometriosis lesions can produce inflammatory cytokines, resulting in their increased levels in the peritoneal fluid. This process causes disruption in pelvic anatomy, ovarian function, prostaglandin production and growth factor production that causes pain, adhesions and infertility. Interleukin-6 (IL-6) is an important and potential inflammatory cytokine in assisting the diagnosis of endometriosis. These cytokines act as activating macrophages that can stimulate endometrial cell proliferation and modulate the secretion of other cytokines such as IL-10, IL-13 and TNF-α which augments the inflammatory process. High levels of IL-6 in the peritoneum are relatedto advanced endometriosis associated with pain, severe pelvic adhesions and embryotoxic effects leading to infertility. The effect of IL-6, both local and systemic, on the growth of endometriosis lesions and its associated symptoms is great that this cytokine is considered an important marker.Objective : This study aims to determine the relationship between local inflammatory factors (IL-6 in peritoneal fluid) obtained during laparoscopy with the degree of pain, the degree of adhesions and the correlation with the Endometriosis Fertility Index (EFI) score in endometriosis patients.Material and methods : This is a quantitative analytic research with a cross sectional study design which was conducted on 22 patients with endometriosis. Prior to the laparoscopy, historical factor (EFI score) was recorded and an assessment of the pain scale was performed by filling out a questionnaire. Intraoperatively, the peritoneal fluid was obtained. If the peritoneal fluid was found, it was taken directly with a volume of 3-5 cc using 10 cc syringe. If no fluid was found, peritoneal rinsing was performed using 0.9% NaCl fluid, then 3-5 cc fluid was aspirated using a 10 cc syringe. Subsequently, an examination was carried out using the RayBio Human IL-6 ELISA Kit. During the laparoscopy procedure, the degree of adhesion of the pelvic organs was assessed by looking at the shape and how the adhesions can be separated. Surgical factor (EFI score) was assessed intraoperatively to obtain data for the least function score, AFS endometriosis score and AFS total score. Statistical analysis was performed using paired t test and correlation test.Results : The mean age of the respondents was 34.86 ± 6.11 years, 81.8% were nulliparous, 100% were married, 100% experienced both primary and secondary infertility and 81.8% had no prior pregnancy history. In the study, it was found that IL-6 levels of peritoneal fluid were higher in patients with the degree of severe pain (P <0.05) compared to moderate with the results of 32.58 ± 7.31 pg/ml and 25.39 ± 2.70 pg/ml. IL-6 levels were found to be higher in grade three adhesions than grade two (P <0.05) with results of 32.78 ± 6.65 pg/ml and 23.86 ± 2.18 pg/ml. The mean peritoneal fluid IL-6 levels were 30.75 ± 7.01 pg/ml and the mean EFI score was 4.09 ± 2.09. The correlation of IL-6 levels in peritoneal fluid with EFI score showed a value of r = -0.448 which had moderate strength and a negative pattern, indicating that the higher the IL-6 level of peritoneal fluid, the lower the EFI score (P <0.05).Conclusion : There is a relationship between IL-6 levels of peritoneal fluid in endometriosis with the degree of pain and the degree of adhesion, where IL-6 levels were found to be higher in the degree of severe than moderate pain (P <0.05), higher in third degree adhesions than second degree ( P <0.05). There was a correlation between IL-6 levels of peritoneal fluid with EFI score (P <0.05) with a negative pattern of moderate strength analysis results (r = -0.448).Keywords: Endometriosis, Interleukin-6, Degree of Pain, Degree of Adhesion, Endometriosis Fertility Index Score
Factors Related to the Success of IVF Program in Morula BMC Clinic Padang Dewi, Nurmala Sari; Hendri, Dedy; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.50-57.2022

Abstract

Introduction: Infertility is the failure of a couple to get pregnant 12 months after having regular sex without contraception. One in seven couples even have to be treated using Assisted Reproductive Technology (TRB). The most widely used TRB is In Vitro Fertilization (IVF). In general, the success rate is in the range of 40-50%. In Indonesia, there are 32 clinics providing IVF program with a success rate of 30-40%. The success rate of IVF is influenced by multi variables that affect directly or indirectly including age, Antral Follicle Count (AFC), Anti Mullerian Hormone (AMH), basal Follicle Stimulating Hormone (FSH), number of egg cells, egg quality, sperm quality, embryo quality, and endometrial thickness. Objectives: This study aims to determine the factors associated with the success of IVF programMethods: This study used a cross-sectional analytic study design which was conducted on 77 medical records of patients undergoing IVF program at Morula Clinic BMC Padang from January 2018-December 2020. All data were then analyzed using univariate, bivariate and multivariate analysis with appropriate statistical test; Results: The average age of the study subjects was (33.4 ± 3.93) years, the average length of infertility was (6.73 ± 3.69) years, the most used antagonist protocols (88.16%), with the most common causes of infertility being factors sperm (48.9%) and overweight BMI (36.4%). From the bivariate analysis, it was found that the factors related to the number of eggs were age (r = -0.349), AFC (r = 0.471), FSH (p 0.02), and AMH (p < 0.01) with the dominant factor being AMH. Egg quality was related to AFC (p 0.007) and FSH (p 0.002), with the dominant factor being AFC. Embryo quality correlated with egg quality (p < 0.01). Meanwhile, the success of implantation was dominantly related to the embryo quality factor (0.034); Conclusion: The most dominant factor to the success of IVF program is the quality of the embryo.Keywords: IVF, IVF success
The relationship delay in referral with maternal mortality Dr. M. Djamil central general hospital Padang Hasjmy, Ibnu Razi Mulya; Ferry, Ferdinal; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.71-81.2022

Abstract

Introduction: Maternal mortality is maternal death during pregnancy, childbirth, and 42 days after delivery. Maternal Mortality Rate (MMR) is the number of maternal deaths per 100,000 live births. There was an increase in MMR in Indonesia on 2012 compared to 2007 which is 228 per 100,000 population. There were 17 maternal deaths at Dr. M. Djamil Hospital throughout 2019. Delay in referral can cause death for both mother and infantObjectives: This study aims to determine the relationship between delay in referral and maternal mortality in obstetric emergencies that came to the emergency unit at Dr. M. Djamil Hospital, Padang.Methods: This study used a cross-sectional comparative study design conducted on 90 pregnant women who visited Dr. M. Djamil Padang Hospital from January - February 2021. All data were then analyzed using univariate and bivariate analysis with appropriate statistical tests.Results: The mean age of the study subjects was 25.34 ± 5.99 years old with 12.21% of sample were nullipara, 21.27% primipara, 61.83% multipara, and 4.58% grande multipara. From the questionnaire, 54.3% were late to refer. From the medical records, it was found that in the group who died, 94.5% experienced a delay in referral and bivariate analysis showed a relationship between late referral and maternal mortality (p = 0.000).Conclusion: There is a significant relationship between late referral and maternal mortality at Dr. M. Djamil Central General Hospital PadangKeywords: Maternal Mortality Rate; late referrals; pregnant women
EFEK SUPLEMEN KAPSUL JAHE MERAH TERHADAP REFLUX LARINGOFARINGEAL: Red Ginger and LPR Asyari, Ade; Julianda, Wahyu; Aliska, Gestina; Bachtiar, Hafni; Octavia, Tri Aryanti; Diflayzer, Diflayzer
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.690

Abstract

Background: Ginger (Zingiber officinale) is a popular rhizome plant that used as a cooking and medicinal ingredient. Ginger contains many active compounds, such as phenolic and terpenes. Ginger has an anti-inflammatory effect through active ingredients, including diarylheptanoids, oleoresin, gingerol, shogaol and zingerone. Ginger powder is often used as a remedy for gastric acid reflux. In laryngopharyngeal reflux, there is a damage to the laryngopharyngeal mucosa due to irritation of gastric acid and pepsin. Purpose: To analyze the effect of red ginger powder capsule supplementation (Zyngiber officinale var. rubrum) on laryngopharyngeal reflux. Method: Non-randomized control trial study with a pretest-posttest control group design in laryngopharyngeal reflux. The patients were divided into two groups, where each group was examined for Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). The intervention group was given red ginger powder capsules and lansoprazole, while the control group was given lansoprazole only; then a month later, both groups were examined for RSI and RFS finding score. Data were analyzed statistically with a computer program and were declared significant if p<0.05. Result: There was a significant difference between RSI and RFS in the intervention group, and there was no significant difference between RSI and RFS in the control group. Meanwhile, there were significant differences in RSI and RFS between the control and intervention groups. Conclusion: There was a significant difference between the reflux symptom index and reflux finding score between the intervention group and the control group. Keywords: red ginger, Zingiber officinale var. rubrum, laryngopharyngeal reflux, reflux symptom index, reflux finding score ABSTRAK Latar belakang: Jahe (Zingiber officinale) merupakan tanaman rimpang yang populer digunakan sebagai bahan masakan dan obat. Jahe mengandung banyak senyawa aktif, seperti senyawa fenolik dan terpena. Jahe memiliki efek anti-inflamasi melalui kandungan aktifnya, antara lain diarylheptanoida, oleoresin, gingerol, shogaol dan zingeron. Bubuk jahe sering digunakan sebagai pengobatan pada kasus refluks asam lambung. Pada kelainan refluks laringofaring, terjadi kerusakan pada mukosa laringofaring akibat iritasi asam lambung dan pepsin. Tujuan: Menganalisis pengaruh suplementasi kapsul serbuk jahe merah (Zingiber officinale var. rubrum) terhadap refluks laringofaring. Metode: Menggunakan metode non-randomized control trial, dengan pendekatan pretest-posttest control group design pada refluks laringofaring. Pasien dibagi menjadi dua kelompok, dan masing-masing kelompok diperiksa indeks gejala refluks, dan skor temuan refluks. Pada kelompok intervensi diberikan kapsul serbuk jahe merah dan lansoprazole, sedangkan pada kelompok kontrol diberikan lansoprazole saja; selanjutnya, satu bulan kemudian dilakukan pemeriksaan indeks gejala refluks dan skor temuan refluks. Data dianalisis secara statistik dengan program komputer dan dinyatakan signifikan jika p<0,05. Hasil: Terdapat perbedaan yang signifikan antara indeks gejala refluks dan skor temuan refluks pada kelompok intervensi, dan tidak terdapat perbedaan yang signifikan antara indeks gejala refluks dan skor temuan refluks pada kelompok kontrol. Sementara itu, terdapat perbedaan yang signifikan pada indeks gejala refluks dan skor temuan refluks antara kelompok kontrol dan intervensi. Kesimpulan: Terdapat perbedaan yang signifikan antara indeks gejala refluks dan skor temuan refluks antara kelompok intervensi dan kelompok kontrol. Kata kunci: jahe merah, Zingiber officinale var. rubrum, refluks laringofaring, indeks gejala refluks, skor temuan refluks
Co-Authors Ade Asyari Adnani, Syahredi Syaiful Al Hafiz Apriani, Susanti Ardiles, Ardiles Ardiles, Ardiles Ariadi, Ariadi Ariwibowo, Bayu Pramudyo Asyari Daryus, Asyari Desmiwarti Desmiwarti Dewi Murni Dewi, Nurmala Sari Diflayzer, Diflayzer Djanas, Dovy Ermawati Ermawati Eryati Darwin Eti Yerizel Ferry, Ferdinal Fitriansyah, Irwin Gestina Aliska Gumilar, Rimbun Wahyu Hasjmy, Ibnu Razi Mulya Helga, Helga Hendri, Dedy Hendry, Dedy henny Mulyani Iskandar Syah Julianda, Wahyu Marni, Herti Nirmala, Vera Novialdi . Noza Hilbertina, Noza Octavia, Tri Aryanti Pradipta, Rengga Prima, Angga Trifianda Putra, Abdi Setya Putra, Raihandi Putri Sri Lasmini, Putri Sri Putri, Intan Firmana Rika Effendy Sari, Hasni Kemala Sasmita, Happi Sriyanti, Roza Syaiful Azmi Syntia Ambelina Syofyan, Yogi Utama, Bobby Indra Vera Pujani Yona, Fajriza Yuniar Lestari Yunitra, Imelda